HEALTHY PARTICIPANTS

This Phase 1 trial tests the safety and tolerability of enicepatide, a potential weight-loss drug, in 36 generally healthy Chinese adults with a BMI of 23 or higher. Participants will receive either the drug or a placebo by injection, and researchers will monitor side effects and…

This study partners with 26 AME churches in South Carolina to test a 32-week walking program called Walk Your Heart to Health. About 300 adults aged 50 and older will join in-person walking groups led by church committees. Researchers will measure changes in daily steps and group…

This study is the first time the experimental drug ARO-033 is being given to humans. Its main goal is to check the safety and tolerability of single and multiple doses in healthy adult volunteers. Researchers will also measure how the drug moves through the body. This is an early…

This early-stage study tests whether the experimental drug AZD4916 is safe and how it moves through the body in 160 healthy adults, including Japanese and Chinese volunteers. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study d…

This early-stage study will enroll 24 healthy adults to find out if food or the stomach-acid-reducing drug rabeprazole changes how the body absorbs an experimental drug called HMPL-760. Participants will take HMPL-760 under different conditions (fasting, with a high-fat meal, wit…

This study aims to better understand how the brain's prefrontal cortex is organized, specifically the part linked to mood and thinking. Researchers will use advanced MRI and TMS-EEG in 34 healthy adults to map connections between brain regions. The goal is to improve targeting of…

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This study tests a new way to take CT scans of the knee while it is bearing weight, like standing. The goal is to see if this method can detect small movements of a knee replacement implant earlier than standard X-rays. The study will include 15 people, some with healthy knees an…

This study looks at whether people with migraine have different motor imagery abilities—like mentally picturing movements—compared to healthy people. Researchers will use questionnaires, mental timing tests, and brain scans to measure these abilities. They also want to see if the…

This early-stage trial will test the safety and tolerability of a single dose of STLX-2012 in 32 healthy adults aged 18-55. Participants will receive either the drug or a placebo, and researchers will monitor side effects and how the drug moves through the body. The study is not …

This early-stage trial will test 20 healthy Chinese adults to see if taking itraconazole (a common antifungal) changes how the body processes HS-10506, an experimental drug. Participants will take HS-10506 alone and then again with itraconazole. The goal is to measure drug levels…

This study compares three fiber supplements—LOAM prebiotic fiber, inulin, and a placebo—to see which causes the least intestinal gas and digestive discomfort. 125 healthy adults on low-fiber diets will take one supplement daily for four weeks. A wearable device measures gas, and …

This Phase 1 trial will test the safety and tolerability of an inhaled drug called SYH2059 in 84 healthy adults. Participants will receive either single or multiple doses of the drug or a placebo. The study aims to understand how the body processes the drug and whether it causes …

This study tests two different versions of a deuterated remdesivir oral suspension in 48 healthy Chinese adults to see how well each is absorbed. Participants will receive both forms in a random order. The goal is to find out if the new formulation works as well as the original, …

This study looks at how a special nutritional drink (ONS) affects blood sugar levels in 30 healthy adults. Participants will drink both the ONS and a sugar solution on different days, and their blood sugar will be tracked. The goal is to calculate the drink's glycaemic index, whi…

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This early-stage study is the first time AK0406 is being tested in humans. It will involve 32 healthy adults to check if the drug is safe and how the body processes it. No treatment is being given for any disease—this is purely a safety check.

This study gives 50 healthy adults a one-time dose of psilocybin (the active ingredient in magic mushrooms) or a placebo to measure changes in brain waves, blood chemicals, and empathy. Participants must have never used psychedelics before. The goal is to understand the biologica…

This study aims to see if a mobile health (mHealth) tool, combined with decision aids, can help college students in Zimbabwe better access HIV prevention and contraception services. Researchers will work with 16,000 students to develop and test the tool over several stages, inclu…

This early-stage study tests the safety and how the body processes a new drug called NBX-100 in 8 healthy adults aged 21-50. Participants receive four weekly doses and have frequent check-ups and psychological support visits. The goal is to gather safety and drug-level informatio…

This study will test how different intensities and patterns of manual pressure on the upper back affect heart rate, stress hormones, and pain sensitivity in 90 healthy adults. Participants will be randomly assigned to receive either sustained pressure at a single point, kneading …

This observational study tracks 100 adults to see how Roux-en-Y gastric bypass surgery changes gut bacteria and related metabolic products over 12 months. Participants include people having surgery, those with obesity on diet alone, and healthy normal-weight individuals. Research…

This study looks at whether a special warm-up that includes balance and coordination exercises works better than a standard warm-up for improving balance and leg strength in healthy adults who go to the gym regularly. About 46 people aged 18 to 40 will take part in 6 weeks of sup…

This Phase 1 trial will compare a single dose of QL2302, a proposed biosimilar of the asthma drug Tezspire, against the original drug in 178 healthy adults aged 18 to 45. The study is double-blinded and randomized, meaning neither participants nor researchers know who gets which …

This study looks at how different breathing patterns during strength exercises change eye pressure and blood flow in the retina. Sixty healthy adults aged 18-40 will perform exercises with normal breathing or a breath-holding technique called the Valsalva maneuver. Researchers wi…

This study looks at whether exercising at different times of day changes how we feel pain. Fifty-six healthy adults will do a 12-minute high-intensity workout in both the morning and evening. Researchers will measure pain thresholds before and after exercise to see if time of day…

This study will measure liver fat, inflammation, and organ sizes in 50 healthy adults in Singapore using MRI. The goal is to establish reference ranges that may differ by ethnicity. Participants must be at least 18 years old and self-reported healthy, with no history of heart dis…

This study tests whether a mild electrical pulse to the ear (called taVNS) can temporarily improve thinking skills like attention and memory in healthy adults aged 18-30. Each of the 60 participants will receive both the real stimulation and a fake (sham) version in separate sess…

This study tests whether plant sterols, found in some foods, change how a newly discovered protein called cholesin works. Cholesin is released from the gut after eating cholesterol and tells the liver to make less cholesterol. Researchers will give 23 healthy adults three differe…