Can the eye reveal how the body reacts to nerve stimulation?

NCT ID NCT07746167

Recruiting now Knowledge-focused Sponsor: Children's National Research Institute Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This observational study looks at how the pupil of the eye reacts to increasing levels of nerve stimulation in healthy adults. Researchers will use a device called AlgometRx to deliver mild electrical stimuli and measure pupil dilation, which may reflect the body's response to pain. The goal is to understand the relationship between stimulation intensity and pupil response, which could inform future pain assessment methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: This could help refine how pain is measured objectively, potentially leading to better ways to assess and manage pain without relying solely on self-report.
What could go wrong: This is an observational study in healthy volunteers, so results may not apply to people with pain conditions. The measurements may also vary between individuals, limiting generalizability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY PARTICIPANTS

Contacts and locations

Locations

Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States

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