Children's National Research Institute

This early-phase study tests a combination of two types of immune cells (B7-H3 CAR T cells and PRAME-specific T cells) in children with relapsed or treatment-resistant cancers like rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, and Wilms tumor. The main goal is to check safety a…

This early-phase trial tests a new drug (SGT-53) combined with radiation and immunotherapy (Nivolumab) in up to 18 children whose brain tumors have returned or not responded to standard treatments. The main goal is to find a safe dose and understand side effects. It is not a cure…

This early-phase study tests a personalized treatment for children under 5 with certain brain tumors. Doctors take a patient's own immune cells, train them to recognize unique markers from their tumor, and give them back to fight the cancer. The goal is to see if this approach is…

This early-phase study tests whether specially trained immune cells from a donor can safely help children with high-risk solid tumors that have not responded to standard treatments. Up to 36 children with cancers like neuroblastoma or sarcoma will receive infusions of these cells…

This early-stage study tests whether giving special immune cells (norovirus-specific T-cells) is safe for people with chronic norovirus infection who have weak immune systems due to stem cell or organ transplants or primary immune disorders. About 48 participants will receive the…

This study is testing if adding a drug called daratumumab before a bone marrow transplant from a matched sibling can safely help children and young adults with severe sickle cell disease who are usually excluded from this treatment. These patients are excluded because their immun…

This early-stage study is testing whether specially prepared T cells from donors can help prevent COVID-19 infection in immunocompromised patients who recently received a stem cell transplant. The trial will enroll 24 children and adults to test three different dose levels for sa…

This study tests whether a short-term therapy for depression, called Enhanced IPT-B, can help Black mothers of children with asthma feel better and possibly improve their child's asthma. About 60 mothers will receive either the therapy or standard care plus extra support. The goa…

This study looks at whether a digital sexual health survey can help doctors spot sexually transmitted infections (STIs) in teens more often. About 18,500 adolescents aged 15-21 visiting the emergency department will take the survey, and their STI test results will be compared to …

This study tests whether an augmented reality (AR) system can help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure will try the AR system. The goal is to see if it is safe and works well, not to treat a disease.

This study is testing a non-invasive device that measures pain by tracking changes in pupil size after gentle electrical stimulation. Researchers will enroll 100 children and teens aged 6 to 21 who are having surgery or a bone marrow transplant. The goal is to see if this device …

This study is working to create a new, objective way to measure pain in children with juvenile arthritis, lupus, or fibromyalgia. Researchers will follow 90 children for one year, collecting data during regular clinic visits. The goal is to replace the current trial-and-error app…

This study is creating a worldwide database of children, teens, and young adults with rare brain tumors. Researchers will collect medical information and tumor samples to learn more about these cancers. The goal is to find patterns that could lead to better treatments in the futu…

This study aims to create a simple, objective tool to detect nerve damage caused by the chemotherapy drug vincristine in children and teens. Researchers will test a new device on 40 patients aged 6-18 who have received vincristine for leukemia. The goal is to catch nerve problems…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…