Children's National Research Institute

This early-stage trial tests whether personalized immune cells (T-cells) can safely treat young children with aggressive brain tumors. The T-cells are designed to attack unique markers found on each child's tumor. Up to 12 children under 5 with embryonal brain tumors or recurrent…

This early-stage trial tests a new type of cell therapy for children whose embryonal tumors (rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, or Wilms tumor) have returned or not responded to standard treatments. The therapy uses the patient's own immune cells, engineered to bette…

This early-phase trial is testing a combination of three treatments for children whose brain tumors have come back or not responded to standard care. The experimental drug SGT-53 delivers a normal TP53 gene to tumor cells, and is given alongside the immunotherapy Nivolumab and ra…

This early-stage study tests whether giving children with high-risk solid tumors a special type of immune cell (called TAA-T) is safe. The cells are designed to recognize and attack proteins found on tumor cells. Up to 36 children whose cancer has not responded to standard treatm…

This early-stage trial tests whether specially grown immune cells (norovirus-specific T-cells) can safely treat chronic norovirus infections in people with weakened immune systems, such as those who had a stem cell or organ transplant. The study will enroll 48 participants and gi…

This study tests whether giving a drug called daratumumab before a stem cell transplant can prevent a serious complication called pure red blood cell aplasia in children with sickle cell disease. The transplant uses a gentle, low-intensity approach and a matched sibling donor. Ab…

This study is testing a device called the AlgometRx Nociometer to see if it can measure inflammation in children with inflammatory bowel disease (IBD). The device checks how different nerve fibers respond, which may give doctors a clearer picture of disease activity. Researchers …

This study is testing whether an augmented reality (AR) system can help doctors guide needles during MRI scans. The AR system overlays digital information onto the real world, potentially making procedures like biopsies or injections more precise. Researchers will enroll 25 peopl…

This early-stage study tests whether giving specially grown immune cells (called coronavirus-specific T cells) from a donor can safely prevent COVID-19 infection in people who recently had a stem cell transplant and have weak immune systems. About 24 adults and children will rece…

This study tests whether a non-invasive sound wave procedure (focused ultrasound) can safely improve movement and quality of life in 10 children and young adults (ages 8-22) with dyskinetic cerebral palsy. The treatment targets a small area in the brain to reduce involuntary move…

This study tests whether a short-term therapy called Enhanced Brief Interpersonal Psychotherapy (IPT-B) can reduce depression in mothers of children with asthma. Sixty Black mothers who have mild to moderate depression and a child with asthma will either receive the therapy or us…

This study explores the real-life experiences of people who had Lyme disease during or before pregnancy and are now raising children. Participants fill out surveys about their health, mental well-being, and child development, then take part in an interview to share their personal…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study aims to create a simple, objective test to detect nerve damage caused by the chemotherapy drug vincristine in children and teens. Researchers will use a new device to measure nerve function and compare it to standard assessments. The goal is to help doctors adjust chem…

This observational study is working to create a more objective way to measure pain in children with juvenile idiopathic arthritis, lupus, or fibromyalgia. Researchers will follow 90 participants for one year, collecting data during regular clinic visits. The goal is to develop a …

This study is creating a large international database of children, teens, and young adults with rare brain tumors. Researchers will collect tumor samples and medical information to better understand how these tumors behave and what makes them unique. The goal is to improve diagno…

This study looks at whether using a digital sexual health survey in the emergency department helps doctors find more sexually transmitted infections (STIs) in teens aged 15-21. Researchers will compare STI detection rates when the survey is used versus standard care. The goal is …

This study tests a new device that measures pain by looking at changes in pupil size after a gentle electrical stimulation. Researchers will enroll 100 children and teens ages 6 to 21 who are having surgery or bone marrow transplant. The device is non-invasive and does not change…