Children's National Research Institute

This study is testing if adding a drug called daratumumab before a bone marrow transplant from a matched sibling can safely cure sickle cell disease. It focuses on patients who have been excluded from this curative treatment because their blood type doesn't perfectly match their …

This early-stage study is testing a new therapy for people with chronic norovirus infections who have weakened immune systems, such as after a stem cell or organ transplant. Doctors will give participants special immune cells (T-cells) trained to fight norovirus to see if the tre…

This study is testing whether providing a short, focused talk therapy to mothers experiencing depression can improve their mental health and, in turn, help them better manage their child's asthma. The research will involve about 60 Black mothers of children with asthma who report…

This early-stage study is testing a new, personalized treatment for children with aggressive brain tumors. Doctors will take a sample of the child's tumor, grow special immune cells in a lab that are trained to attack it, and then infuse those cells back into the child's brain. T…

This is a first-in-human safety study for a new, two-part cell therapy for children and young adults whose cancers have come back or haven't responded to standard treatments. Doctors will collect a patient's own immune cells, genetically modify them to better target the cancer, a…

This study is testing a new augmented reality (AR) system designed to help doctors during MRI-guided needle procedures, like biopsies or injections. The AR system projects a visual guide onto the patient, showing the doctor the best path for the needle. Researchers want to see if…

This study is testing whether a digital health survey and alert system helps doctors find more sexually transmitted infections (STIs) in teenagers. It will compare the new digital system to usual care in emergency departments. The goal is to see if this technology can improve scr…

This early-stage study is testing whether specially prepared T cells from a stem cell donor can help prevent COVID-19 in transplant patients with weakened immune systems. It will enroll 24 children and adults who recently received a transplant and are at high risk for infection. …

This study is creating a large international registry to learn more about rare brain tumors in children, teens, and young adults. It will collect tumor samples, medical records, and imaging data from up to 5,800 participants over about 10 years. The goal is to understand how thes…

This study is testing a new, non-invasive device that measures changes in a child's pupil size to try to get an objective reading of their pain. It involves 100 children and teens, aged 6 to 21, who are having planned surgery or a bone marrow transplant at Children's National Hos…