Tailor-Made T-Cells take on childhood brain cancer

NCT ID NCT06193759

Recruiting now Disease control Sponsor: Children's National Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests whether personalized immune cells (T-cells) can safely treat young children with aggressive brain tumors. The T-cells are designed to attack unique markers found on each child's tumor. Up to 12 children under 5 with embryonal brain tumors or recurrent ependymoma will receive the cells after standard treatment. The main goal is to check safety and find the right dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: personalized T-cells (TSA-T) targeting tumor-specific antigens
What this could lead to: If successful, this could point toward a new treatment option for young children with hard-to-treat brain tumors, potentially reducing relapse risk.
What could go wrong: This is a very early phase 1 safety trial with only 12 participants. The personalized approach is complex and may not work for everyone; side effects from the T-cells are possible.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor central nervous system primitive neuroectodermal neoplasm childhood central nervous system primitive neuroectodermal neoplasm childhood medulloblastoma embryonal tumor with multilayered rosettes ependymoma medulloblastoma Neuroectodermal Tumors, Primitive Pinealoma pineoblastoma rhabdoid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL TERATOID/RHABDOID TUMOR OF CNS EMBRYONAL BRAIN TUMOR NOT OTHERWISE SPECIFIED EMBRYONAL TUMOR OF CNS EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES EPENDYMOMA MEDULLOBLASTOMA, CHILDHOOD PINEOBLASTOMA

Contacts and locations

Locations

Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States

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