New drug may help kids with sickle cell disease get life-changing transplants despite antibody barriers
NCT ID NCT06358638
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving a drug called daratumumab before a stem cell transplant can prevent a serious complication called pure red blood cell aplasia in children with sickle cell disease. The transplant uses a gentle, low-intensity approach and a matched sibling donor. About 12 children and teens aged 2 to 24 who have antibodies against their donor's red blood cells will take part. The goal is to see if this approach improves survival and reduces complications one year after transplant.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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