Could a diabetes drug combo stop mouth cancer before it starts?
NCT ID NCT05727761
First seen Jan 07, 2026 · Last updated May 16, 2026 · Updated 15 times
Summary
This study tests whether a combination of two diabetes drugs, pioglitazone and metformin, can shrink or improve precancerous mouth lesions called oral leukoplakia. About 36 adults with high-risk lesions will take the pills twice daily for 12 weeks. The goal is to see if the treatment reduces lesion size and lowers abnormal cell growth, potentially preventing cancer.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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HealthPartners
RECRUITINGSaint Paul, Minnesota, 55130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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