University Of Minnesota

This study looked at 150 teens aged 12-17 with severe obesity who had not lost enough weight through diet and exercise alone. Researchers tested different ways of adding weight-loss medications to see which timing and sequence worked best. The main goal was to measure how much bo…

This study tested three formats (online, in-person group, and telehealth) of a parenting program called ADAPT for military families where a parent recently returned from deployment. The goal was to see which format best improves parenting skills and reduces children's risk for be…

This study tested a program called FAM, where adults with type 1 diabetes at high risk for diabetic ketoacidosis (DKA) shared their real-time glucose data with a family member or friend (a "Follower") and received personalized education. The goal was to reduce time spent with ver…

This study tested whether giving a drug called abatacept early in the hospital stay helps COVID-19 patients on low-flow oxygen recover faster. 285 adults took part. The drug aims to calm an overactive immune response. Results compare recovery time and death rates between the drug…

This study tested whether limiting when you eat (time-restricted eating) can help families with obesity lose weight. One parent and one child (ages 3-9) joined together. Some families ate only within a 10-12 hour window each day, while others focused on portion control and health…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe COVID-19 in 1,323 non-hospitalized adults at higher risk due to overweight. Participants took the drugs or a placebo early after infection. The main goal was to see if these t…

This study tested whether a full-mouth electronic toothbrush (FMET) reduces gum inflammation (gingivitis) and plaque better than a regular electronic toothbrush. 94 adults with mild to moderate gingivitis used one of three brushing methods. Researchers measured gum health and pla…

This study looked at whether eating only during a short daily window (prolonged daily fasting) can help obese adults lose weight and improve health, as an alternative to traditional calorie restriction. About 115 participants with obesity and insulin resistance followed either a …

This study looked at whether time-restricted eating (TRE) — eating only during a set daily window — can help control blood sugar and weight in adults with type 2 diabetes. 115 overweight or obese adults on metformin were followed for 24 weeks. The goal was to see if TRE is a simp…

This early study tested whether a thin, clear membrane from the back of the cornea (Descemet's membrane) can help heal the eye surface in people with limbal stem cell deficiency, a condition that causes blindness. Nineteen participants received the membrane as a patch on the eye.…

This small pilot study tested a GLP-1 medication (semaglutide) added to insulin in 8 overweight adults with cystic fibrosis-related diabetes. The main goals were to see if the drug is safe and helps with weight loss and blood sugar control. Results will guide future research on m…

This study tested whether waiving fees for youth sports programs and adding intensive family outreach could help low-income children ages 6-12 get more physical activity. About 430 kids from 20 parks in Minneapolis and Saint Paul took part over two years. The goal was to see if t…

This early-phase study tested whether giving a combination of plasmapheresis (a blood-filtering procedure) and the drug rituximab before or at the time of kidney transplant could prevent focal segmental glomerulosclerosis (FSGS) from coming back. The trial enrolled 21 children an…

This study tested whether taking fecal microbiota transplant (FMT) capsules could help prevent Crohn's disease from returning after surgery. 23 adults who had surgery for Crohn's received FMT either by capsules or colonoscopy. The goal was to see if the capsules could deliver hel…

This pilot study tested whether offering free legal services early to people with advanced colorectal cancer could reduce stress and financial worries. Twenty participants received personalized legal help from a nonprofit for six months. The study measured changes in stress, copi…

This study tested a mobile app called OPY that helps patients control pain and safely reduce opioid use after surgery. Over 3,400 adults who had outpatient surgery and received an opioid prescription used the app to track pain, get tips, and receive reminders to stop opioids. The…

This study tested whether the drug brivaracetam can reduce nerve pain in people with chronic spinal cord injury. 44 adults took either the drug or a placebo for 7 weeks. Researchers measured changes in pain intensity and how pain affected daily life, mood, and sleep.

This early study tested whether a faster schedule of transcranial magnetic stimulation (TMS) could work for major depression. Normally, TMS requires daily visits for weeks, but this study compressed the schedule. 11 adults with depression tried the accelerated approach, and resea…

This study tested a drug called brivaracetam to see if it can reduce severe nerve pain in people with chronic spinal cord injury. 24 adults with spinal cord injury and daily pain rated 9 or 10 out of 10 took either the drug or a placebo for 3 months. The goal was to check if the …

This study tested whether doing physical therapy for jaw disorders (TMD) through video calls works as well as seeing a therapist in person. Over 200 adults with jaw pain, headaches, or clicking jaws took part. The goal was to see if virtual therapy can improve symptoms and qualit…

This study tested whether injections of Xeomin (a botulinum toxin) into the muscles around the ear can reduce the ringing sensation of tinnitus. 41 adults with persistent tinnitus received either the injection or a placebo. The main goal was to see if the treatment improved their…

This study looked at 1000 adults with a new flare-up of low back pain who were at risk for long-term disability. Researchers compared spinal manipulation plus guided self-care against standard medical care. The goal was to see if these treatments could reduce pain and disability …

This study tested a non-invasive treatment called neurofeedback in 157 teens who had attempted suicide. Participants learned to control their own brain activity in real time using an MRI scanner. The goal was to see if this training could reduce suicidal thoughts and improve emot…

This pilot study tested whether adding a gentle electrical current to the brain (tDCS) during intensive speech therapy could improve language skills in 10 stroke survivors with non-fluent aphasia. Participants received both real and sham stimulation in random order, with a break …

This study tested whether special breathing exercises could help people with Long COVID who have trouble breathing and feel tired. Sixteen adults who had COVID-19 at least 4 weeks earlier and still had symptoms took part. They did diaphragmatic breathing exercises, and the resear…

This study tested whether a longer-lasting pain medicine (liposomal bupivacaine) works better than standard bupivacaine for controlling pain after breast surgery. 112 adults having partial mastectomy received one of the two medicines via ultrasound-guided injection. The goal was …

This study tested a new online coaching system designed to help people adjust to and use their hearing aids more effectively. Researchers enrolled 34 adults with hearing loss to see if adding personalized health and wellness coaching to the hearing aid fitting process would make …

This study looked at how overeating at different times of day affects inflammation and metabolism in 16 healthy adults. Researchers measured hundreds of markers in the blood to see if eating more calories in the evening is worse for the body than eating them earlier. The goal is …

This study looked at how young adults aged 18-30 with early psychosis process information from their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training to measure changes in attention and decision-ma…

This study looked at whether a specific 8-week exercise program can improve thumb joint alignment in people with thumb arthritis. It also tested if ultrasound can accurately measure joint stability compared to the standard CAT scan. 21 adults with thumb arthritis participated. Th…

This study tested an online parenting training program called GenerationPMTO to help prevent behavior problems in children. Researchers worked with 94 parents and primary care providers to see if the program was easy to access and effective. The goal was to improve parenting skil…

This study looked at lungs removed from 74 people with cystic fibrosis during transplant to see how bacteria and chemistry differ from one area to another. Researchers took samples from each lobe and used DNA sequencing to identify which bacteria were present and how active they …

This study tested whether a prevention program for adult men who have sexually abused children can work in a prison setting. Ten incarcerated men participated, and researchers measured changes in thinking and behavior patterns linked to reoffending. The goal was to see if the pro…

This study looked at how 208 children aged 11-14 react to social stress, like being judged while doing math. Researchers measured stress hormones, heart rate, and brain activity to see how parents and friends help calm them down. The goal was to understand why parental comfort be…

This study placed a continuous glucose monitor on very preterm babies (born before 31 weeks) to see how well it tracks their blood sugar levels. The goal was to learn more about high and low blood sugar and how they might affect the babies' growth and brain development over time.…

This study tested a new recorder that can measure brain activity while deep brain stimulation (DBS) is turned on during surgery for Parkinson's disease. The goal was to better understand how DBS affects the brain, which could help improve the therapy in the future. Only one perso…

This study looked at how the drug topiramate helps teenagers with severe obesity lose weight. Researchers wanted to understand why some teens lose a lot of weight while others don't. They measured drug levels in the blood and linked them to changes in BMI over 3 months. The goal …

This study looked at how people aged 15-45 with early psychosis process information about their surroundings, compared to healthy young adults. Participants completed computer tasks while their brain activity was measured using EEG and MRI. The goal was to understand brain functi…

This study looked at what kinds of nicotine replacement products menthol smokers like best when trying to quit. 60 African American adults who smoked menthol cigarettes tried six different products, including mint and non-mint gums and inhalers. After two weeks of trying them, th…

This study tested a new, non-invasive brain stimulation method called traveling wave tACS in 9 adults with epilepsy who already had brain electrodes implanted. The goal was to see if it could safely change brain activity and improve working memory. The study was small and focused…

This study looked at how bacteria grow in the nose, mouth, and lungs of 7 infants with cystic fibrosis during their first year of life. Researchers collected swabs and mucus samples to map bacterial communities. The goal was to understand how germs move through the airway, which …

This study created a registry of 655 people and families with Alport syndrome to collect health information over time. The goal was to better understand the disease and provide a foundation for future treatment studies. No experimental treatments were given; it was purely an obse…

This study tested whether brain stimulation works better when a person is actively thinking or doing a task. Fifty-one healthy adults received transcranial magnetic stimulation (TMS) while either solving a cognitive problem or doing a perceptual task. The researchers measured bra…

This study tested whether a full-service mobile food market (a bus that sells affordable, healthy foods) can improve diet quality and reduce food insecurity in low-income neighborhoods. Researchers enrolled 262 participants from 12 community sites, randomly assigning sites to rec…

This study looked at how brain waves in the front part of the brain affect whether people tend to approach or avoid things. Researchers used a special technique that combines brain stimulation (TMS) and brain recording (EEG) to see how timing of stimulation changes behavior. 26 h…

This study tested a program called Link for Equity in 12 Minnesota schools to see if it could reduce racial/ethnic disparities in school violence. The program trained school staff to be more aware of racism and its impact on students. Researchers measured changes in bullying, fig…

This study tested a program called Home Alone for adults aged 55+ with mild memory or thinking problems who live alone. The goal was to see if the program was useful and acceptable. Participants worked with a coach in weekly one-hour sessions over 3 to 6 months, and the study mea…

This study used transcranial magnetic stimulation (TMS) to measure how the brain's motor cortex responds in 24 people who had a stroke at least 6 months earlier. Researchers compared their brain excitability to people without stroke and looked at how natural brain rhythms influen…

This study looked at whether wearing a continuous glucose monitor (CGM) can help predict low blood sugar (hypoglycemia) in adults with type 2 diabetes. 41 participants wore either a regular CGM or a hidden one for a short time. The goal was to compare how often low blood sugar ha…

This study looked at whether a home body water analyzer can help detect lymphedema early in women treated for breast cancer. Lymphedema is a common side effect causing arm swelling, and early detection is key to reversing it. Researchers followed 52 women for a year, having them …

This study tested a program where trained senior volunteers help families caring for someone with Alzheimer's or dementia. The goal was to see if these companions could connect families to helpful community services, reduce caregiver stress, and improve the person's well-being. 4…

This study tested two ways to train nursing home and assisted living staff to provide better care for LGBTQ+ residents with Alzheimer's or dementia. Over 700 staff members from Minnesota took part in either an in-person or online training program. The goal was to see if the train…

This study looked at how having a parent or a best friend nearby affects teenagers' stress levels. Researchers measured stress hormones, heart rate, and brain activity in 202 teens while they viewed emotional images. The goal was to understand how this 'social buffering' changes …

This study tested a new afterschool program where college mentors help middle school students connect their mood with their actions, especially physical activity. The goal was to see if this approach is feasible for teens with depression symptoms. 209 students from a low-resource…

This study tested a new program to help Somali families reduce shisha (hookah) smoke inside their homes. Fifteen families took part, and researchers checked if the program was easy to use and if it lowered smoke exposure by testing urine and saliva. The goal was to see if this ap…

This study looked at how past infections and damage to lymph nodes might weaken the body's long-term immune response to the yellow fever vaccine. Researchers enrolled 43 healthy adults in Uganda and Minnesota, collecting blood and lymph node samples before and after vaccination. …

This study aimed to improve genetic counseling for people of all backgrounds. Over 1,000 participants completed surveys and allowed their counseling sessions to be audio recorded. Researchers tested different counseling approaches to see which led to better patient experiences. T…

This study tested a new portable ultrasound device that takes a single heart image in under a minute from the chest area. It involved 22 infants under 1 year old with congenital heart disease. The goal was to see if the quick images were as good as standard heart ultrasound image…

This study looked at how people aged 15-45 with early psychosis process information about their environment, compared to those without a psychiatric diagnosis. Researchers tested two types of cognitive training and measured changes in brain activity and task performance using com…

This study looked at ways to help Black older adults with type 2 diabetes sit less and move more. Researchers worked with 33 participants to understand their habits and design practical strategies. The goal was to improve heart health and reduce diabetes complications.

This study aimed to create simple, reliable tools (paper and electronic) to assess the foods people have at home, focusing on items that affect health and obesity. Researchers tested these tools with 439 English- or Spanish-speaking adults who do the main grocery shopping or meal…

This study looked at how the brain develops over time in young teen girls who have hurt themselves on purpose (non-suicidal self-injury). Researchers used interviews, brain scans (MRI), and thinking tests to measure self-harm behaviors and stress responses. The goal was to learn …

This study created a registry and biobank for people with osteosarcoma, a rare bone cancer, and their family members. Researchers collected genetic samples from 362 participants to compare genes of those with and without the disease. The goal was to learn if certain genes are lin…

This study tested whether using WhatsApp group chats or educational videos could encourage first-time blood donors in Ghana to donate again. Researchers followed 882 first-time donors for 14 months to see if these community-based messages worked better than standard communication…