University Of Minnesota

This study tested whether physical therapy delivered through video calls (telerehabilitation) works as well as traditional in-person therapy for people with jaw pain and headaches from TMJ disorders. Researchers compared 207 adults who received either virtual or in-person therapy…

This study tested a new surgical approach for a condition called limbal stem cell deficiency, which can lead to blindness. Doctors transplanted a thin, clear membrane from a donor cornea onto the surface of the eye in 19 patients. The goal was to see if this membrane could act as…

This study aimed to understand and reduce long periods of sitting in Black older adults with type 2 diabetes. Researchers worked with 33 participants to learn about their daily habits and co-design strategies to break up sedentary time. The goal was to see if reducing sitting cou…

This trial tested if adding a drug called abatacept to standard hospital care could help people with moderate COVID-19 pneumonia. The goal was to see if calming an overactive immune response early could speed up recovery and prevent patients from getting sicker. The study involve…

This study tested a non-invasive brain training method called neurofeedback for adolescents who have had suicidal thoughts or a recent suicide attempt. Participants aged 11-18 learned to control their own brain activity in real-time while inside an MRI scanner. The goal was to se…

This study tested whether taking fecal transplant capsules works as well as receiving it via colonoscopy to prevent Crohn's disease from returning after surgery. Researchers compared the two methods in 23 people with Crohn's who had recent bowel surgery. The goal was to see if th…

This small pilot study tested if adding a weekly GLP-1 drug (semaglutide) to insulin therapy is safe and tolerable for overweight adults with cystic fibrosis-related diabetes (CFRD). The main goal was to gather initial safety data to plan a larger future trial. Researchers also l…

This small pilot study tested whether a team-based approach could help adults with type 1 diabetes who are at high risk for a dangerous complication called diabetic ketoacidosis (DKA). Researchers had participants share their real-time glucose data with a chosen family member or …

This study tested whether a new type of electric toothbrush that cleans the whole mouth at once is better at reducing gum inflammation and plaque than a standard electric toothbrush. 94 adults with mild to moderate gum inflammation used one of the assigned brushes for 30 days. Re…

This small, early study explored whether a faster schedule of magnetic brain stimulation (aTMS) could be a practical and effective treatment for depression. It involved 11 patients and also gathered feedback from clinic staff and other patients. The goal was to see if this conden…

This study explored whether controlling when families eat, rather than just what they eat, could help manage obesity. Parents and children participated together, trying to eat all their meals within a 10-12 hour daily window for 12 weeks. Researchers compared this approach to tra…

This study tested if time-restricted eating (eating only during a specific daily window) works as well as traditional calorie counting for weight loss in obese adults. Researchers followed 115 participants for 12 weeks to see which approach led to better weight loss, fat reductio…

This study tested whether a home device that measures body water could help detect early signs of lymphedema (arm swelling) in people who have had breast cancer surgery. Researchers followed 52 participants for a year, having them use the device twice daily to track changes. The …

This study tested a new, portable ultrasound device called RAPID that takes a picture of a baby's heart in under a minute. Researchers compared the image quality from this new device to the standard heart ultrasound used in hospitals. The goal was to see if this faster, simpler d…

This study tested a program called 'Link for Equity' that trained school staff to better understand trauma and racism. The goal was to see if this training could help reduce racial and ethnic disparities in school violence and discipline. Over 1,600 staff from 12 Minnesota school…

This study tested if a combination of spinal manipulation (like chiropractic adjustment) and guided self-care coaching could prevent a recent, painful back flare-up from turning into long-term, disabling chronic pain. It involved 1,000 adults at risk for chronic pain and compared…

This study tested a new way to help parents prevent behavior problems in their young children. Researchers connected parents of 3-5 year olds with therapists for online video coaching, all through their regular pediatrician's office. The goal was to make proven parenting support …

This study tested whether bringing a full-service mobile grocery market to low-income neighborhoods improves people's diets and reduces food insecurity. Researchers enrolled 262 primary food shoppers living near 12 community sites. Half the sites received the mobile market first—…

This study tested a new program delivered by community health workers to help reduce secondhand smoke from shisha (hookah) in Somali American homes. Fifteen families with at least one adult who smokes shisha at home and at least one child participated. Researchers measured smoke …

This study tested a school support program called 'Link for Equity' designed to prevent violence and reduce racial disparities in discipline. It involved training school staff to better understand trauma and racial bias, and was implemented in 12 Minnesota schools with many stude…

This study tested whether making youth sports programs free and adding community outreach could help children from low-income families get more active. It involved 430 children, aged 6-12, from Minneapolis and Saint Paul over two years. Researchers compared parks that offered jus…

This study tested three different ways to deliver a parenting program designed for military families after a parent returns from deployment. Researchers wanted to see if a web-based, group-based, or telehealth format worked best to improve parenting skills and prevent negative ou…

This small, early study tested if a combination treatment given around the time of a kidney transplant could prevent a serious kidney disease called FSGS from coming back. It involved 21 children and adults with FSGS who were getting a transplant. Researchers compared giving plas…

This study tested whether an 8-week program of specialized hand exercises could improve joint alignment and reduce pain in people with thumb arthritis. It also checked if ultrasound imaging could accurately measure joint changes compared to standard CAT scans. The goal was to fin…

This study tested two different numbing medicines given during breast surgery to see which one better controls pain afterward. Researchers compared a standard numbing medicine to a newer, longer-lasting version. They measured how much opioid pain medication patients needed and tr…

This study tested whether special breathing exercises could help people with Long COVID who experience shortness of breath, chest tightness, and severe fatigue. Sixteen adults who had COVID-19 but were not hospitalized participated. Researchers compared the effects of the breathi…

This study aimed to find out which nicotine replacement products menthol smokers prefer when trying to quit. 60 African American adults who regularly smoked menthol cigarettes tried different flavored and unflavored nicotine gums and inhalers. After sampling the products for two …

This study tested a new home-based coaching program designed to help older adults with memory loss who live alone. The program involved weekly meetings with a coach to help participants stay active, safe, and socially connected at home. Researchers wanted to see if the program wa…

This study tested whether injections of a medication similar to Botox (called Xeomin) into the small muscles around the ear could help reduce the bothersome ringing sound known as tinnitus. 41 adults with persistent tinnitus received either the real injection or a placebo (fake) …

This study tested a new online coaching system designed to help people get used to their hearing aids. Researchers wanted to see if adding this support would make people more satisfied with their devices and wear them more often. They enrolled 34 adults with hearing loss to try t…

This small, early-stage study tested whether a drug called brivaracetam could reduce severe nerve pain in people with chronic spinal cord injuries. Twenty-four participants who had not found relief from other pain medications took either the drug or a placebo for three months. Th…

This small, completed pilot study explored a new approach to help people who have trouble speaking after a stroke (non-fluent aphasia). Researchers tested if combining intensive speech therapy with a gentle, non-invasive brain stimulation technique could improve participants' abi…

This small pilot study tested whether connecting people with advanced colorectal cancer to free legal services could help reduce their stress, financial strain, and improve their quality of life. Twenty participants received personalized legal care for six months while continuing…

This study tested a support program for family members caring for a loved one with both a traumatic brain injury and dementia. The program aimed to help caregivers identify their main stressors and learn better coping and communication skills. Researchers measured whether the pro…

This study tested whether two types of visual brain training could improve thinking skills in young adults with early psychosis. Researchers enrolled 152 people aged 18-30, including those with conditions like schizophrenia and those without any psychiatric diagnosis. The study w…

This study tested a small, wearable device to continuously monitor blood sugar levels in very premature babies. It involved 24 infants born before 31 weeks who were at risk for high or low blood sugar. The goal was to see how well the monitor worked and to track the babies' growt…

This study aimed to understand how the comforting presence of a parent or a close friend affects a teenager's stress response. Researchers measured brain activity, heart rate, and stress hormones in 202 adolescents while they completed emotional tasks in an MRI scanner, either al…

This study aimed to understand how the brain's response to social stress changes during puberty, and whether having a parent, friend, or another person nearby helps reduce that stress. Researchers at the University of Minnesota used MRI brain scans and measured stress hormones in…

This study aimed to understand how bacteria move and grow in the airways of infants with cystic fibrosis (CF). Researchers followed 7 babies with CF from birth, taking regular swab samples from their mouth, nose, and throat over two years. By analyzing these samples, they hoped t…

This small, completed study tested the feasibility of a new program designed to prevent men who have sexually abused children from doing so again. It involved 10 men in Minnesota prisons, focusing on measuring changes in their attitudes, emotional regulation, and risk factors. Th…

This study aimed to understand how the brain develops in young teenage girls who have a history of non-suicidal self-injury. Over three years, researchers followed 168 girls, tracking their behavior, stress responses, and brain structure using MRI scans. The goal was to gather kn…

This study aimed to understand how computer-based brain training affects thinking skills and brain activity in people with early psychosis. It involved 100 participants, including people with conditions like schizophrenia and healthy volunteers, who completed about 10 hours of tr…

This small study explored whether a gentle, non-invasive electrical stimulation technique could change how the brain works during memory tasks. Researchers worked with nine adults who already had electrodes implanted in their brains for epilepsy surgery planning. They measured if…

This study aimed to understand how a non-invasive brain stimulation technique works in people who have had a stroke. Researchers measured muscle responses to stimulation at different moments in the brain's natural rhythm. The goal was to gather basic knowledge to help design bett…

This study aimed to understand the genetic causes of osteosarcoma, a rare bone cancer. Researchers collected health information, saliva, blood, and other samples from 362 patients and their family members. The goal was to compare genes between people with and without the disease …

This study aimed to understand how the brain processes information in people with early psychosis. Researchers measured brain activity in 277 participants, including those with and without a diagnosis, while they played computer games. The goal was to see if differences in brain …

This study created a central registry of 655 patients and families affected by Alport syndrome, a rare genetic kidney disease. The goal was to collect information to better understand the disease and to help plan future research into potential treatments. It did not test any trea…

This study tested a new device that can measure brain activity during deep brain stimulation (DBS) surgery for Parkinson's disease. Researchers wanted to understand how DBS affects the brain to potentially improve this treatment. Only one person with Parkinson's who was already s…

This study aimed to understand why some people's immune systems don't build strong, lasting protection from vaccines. Researchers gave the yellow fever vaccine to 43 healthy adults in Uganda and Minnesota. They collected tissue and blood samples to see if other ongoing infections…

This study aimed to see if a continuous glucose monitor (a small sensor worn on the body) could help predict when people with type 2 diabetes are at risk for dangerously low blood sugar. 41 participants, considered at either high or low risk for these episodes, wore monitors that…

This study aimed to understand how bacteria live and behave in different parts of the lungs of people with late-stage cystic fibrosis (CF). Researchers examined lung tissue removed from 74 adult CF patients during transplant surgery. They mapped where different bacteria were loca…

This study aimed to understand if the timing of gentle magnetic brain stimulation, synchronized with a person's specific brain wave patterns, could influence their tendency to approach or avoid things. Researchers tested 26 healthy adults to see if stimulating the brain at differ…

This study aimed to understand if harmful stress and inflammation in the body and brain are part of Type 1 Gaucher disease. Researchers measured specific chemicals in the blood and brain of 33 adults with the disease and healthy volunteers. They also tested if taking an over-the-…

This study explored whether performing mental tasks while receiving non-invasive brain stimulation could make the stimulation more effective at changing brain activity. Researchers worked with 51 healthy adults who completed simple thinking tasks while receiving brief magnetic pu…