University Of Minnesota

This study tests whether adding a gentle brain stimulation technique (tDCS) along with computer-based thinking exercises can improve brain function and self-control in people being treated for opioid use disorder with buprenorphine. About 160 adults will either get real or fake s…

This study tests whether transplanting healthy gut bacteria can help people with alopecia areata, an autoimmune disease that causes patchy or total hair loss. Forty adults with moderate to severe hair loss will take either antibiotic and microbiota transplant capsules or a placeb…

This study tests whether capsules containing freeze-dried healthy donor gut bacteria can take root in the intestines of people with Crohn's disease. Researchers will check if the bacteria engraft in the ileum and colon, and explore changes in symptoms and inflammation. The trial …

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This pilot study tests efgartigimod, a drug that lowers harmful antibodies, in 15 adults with immune-mediated thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. Participants receive weekly infusions for 8 weeks, then are monitored for another …

This study tests whether a capsule containing healthy gut bacteria (restorative microbiota therapy) is safe and feasible for people with severe colitis caused by cancer immunotherapy. About 20 participants with steroid-resistant colitis will receive either the bacteria or a place…

This early-phase trial tests a 28-day course of two oral drugs (mirdametinib and vorinostat) in people aged 12+ with a rare, aggressive nerve tumor linked to NF1. The goal is to see if the combination is safe and can shrink or change the tumor before standard treatment (radiation…

This study compares two approaches for treating non-alcoholic steatohepatitis (NASH), a serious liver condition linked to obesity. Half of the 48 participants will receive vertical sleeve gastrectomy surgery along with lifestyle counseling, while the other half will get lifestyle…

This early-stage trial is testing whether a transplant of healthy gut bacteria can be safely given to people with primary sclerosing cholangitis (PSC), a rare liver disease. Twenty-eight adults will first take antibiotics to clear their gut, then receive capsules containing freez…

This study tests whether adding a gentle magnetic brain stimulation (TMS) to a standard behavioral therapy (CBIT) can help teens and young adults with chronic tics or Tourette syndrome better control their tics. About 60 participants aged 12–21 will receive either CBIT alone or C…

This study tests whether weighing yourself every day can help teens with obesity manage their weight. About 99 teens aged 12 to 18 will be split into three groups: usual care, usual care plus a simple scale, or usual care plus a smart scale that sends data to their doctor. The st…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study tests whether an implanted spinal cord stimulator can improve autonomic functions like blood pressure and heart rate in people with chronic cervical spinal cord injury. The device delivers electrical pulses to the spinal cord to help regulate involuntary body processes…

This early study tests whether taking capsules containing donor fecal bacteria can change the gut and skin bacteria of people with hidradenitis suppurativa (HS), a painful skin condition. Sixteen adults with HS will receive either the bacteria capsules or a placebo for three week…

This study aims to see if a mobile health program called mGlide-Care can help control high blood pressure in people with mild cognitive impairment or early Alzheimer's. Caregivers will assist participants in using the program. The study will compare blood pressure control between…

This study compares two surgeries for people with large, irreparable rotator cuff tears. One surgery smooths the bone (tuberoplasty), the other places a small balloon spacer under the shoulder. Researchers will track shoulder motion and pain relief in 40 adults to see which appro…

This study tests whether a combination of two diabetes drugs, pioglitazone and metformin, can shrink or improve precancerous patches in the mouth called oral leukoplakia. About 36 adults with high-risk lesions will take the pills twice daily for 12 weeks. The goal is to see if th…

This study is testing a special soft cast for people with diabetic foot ulcers. The cast is a multi-layer wrap that cushions the foot and leg to help the wound heal. Researchers want to see if it works well, is comfortable, and safe. About 100 adults with diabetic foot ulcers wil…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study aims to help African American adults who don't get enough sleep and have overweight or obesity. Researchers will first talk with community members to understand their sleep habits and beliefs. Then, they will test a sleep improvement program to see if it helps people s…

This study is testing whether using radiofrequency ablation (heat to kill cancer cells) plus bone cement to stabilize the spine, followed by radiation, works better than radiation alone for people with cancer that has spread to the spine. The goal is to see if the combination red…

This study is testing whether a flash continuous glucose monitor (CGM) can help children and young adults in Uganda with type 1 diabetes keep their blood sugar in a healthy range more often than standard finger-prick testing. Half of the 180 participants will use the CGM for the …

This study tests whether a device that strengthens breathing muscles can lower blood pressure in adults with high systolic blood pressure (120 mmHg or higher). Over 6 weeks, 144 participants will use the device at different training intensities. The goal is to see if this simple,…

This study looks at whether it is safe to skip preventive antibiotics after bladder removal surgery for muscle-invasive bladder cancer. Half of the 120 participants will take nitrofurantoin daily for 10–21 days after surgery, while the other half will receive no antibiotics. The …

This study is testing whether a drug called Cytogam (CMVIG) can prevent cytomegalovirus (CMV) infection in kidney transplant patients who are switching to a new immunosuppressant. The researchers will measure antibody levels in 30 adult patients over 8 weeks to see how the drug w…

This study tests whether the drug fisetin can reduce organ failure in adults aged 65 and older who have sepsis (a severe response to infection). Researchers will give participants either one or two doses of fisetin or a placebo, and measure changes in heart, lung, and kidney func…

This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe for people with pulmonary arterial hypertension (PAH). 24 adults with PAH will be randomly assigned to receive either the bacteria capsules or a placebo.…

This study combines a mild brain stimulation technique called tDCS with computer-based cognitive training to see if it helps people with alcohol use disorder stay abstinent. Forty people who are already in a treatment program will receive 10 sessions over several weeks. Researche…

This early-phase study tests whether empagliflozin, a drug originally for diabetes, can improve left atrial function in 80 adults over 60 with hypertension and obesity who are at risk for heart failure. Participants take either a 10 mg empagliflozin tablet or a placebo daily for …

This study tests whether a soft, FDA-approved belly band can help premature babies on breathing support develop stronger abdominal muscles. Researchers will measure muscle thickness with ultrasound and see if babies reach full oral feedings earlier. About 40 premature infants bet…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This study tests whether giving probiotics to pregnant women with diabetes can improve their babies' brain development. Researchers will give 60 mothers a probiotic supplement and then measure their infants' brain responses to sounds and sights at 1 and 6 months old. The goal is …

This pilot study tests whether a left-sided stellate ganglion block using bupivacaine can lower the rate of atrial fibrillation after esophagectomy, pneumonectomy, or lobectomy. 48 adults aged 18-85 undergoing these surgeries will receive either the nerve block or a saline placeb…

This study explores whether MRI scans can safely and accurately detect cancerous or precancerous mouth lesions in people with Fanconi Anemia, a rare genetic condition that raises cancer risk. Researchers will compare MRI results to standard biopsies in 80 adult participants. If s…

This study tests whether a video camera that records the back of the eye can estimate pressure inside the skull without needles, anesthesia, or touching the eye. About 90 adults who already have a standard pressure monitor in place will participate. If successful, this could lead…

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training uses online modules, live coaching, and a buddy system where new mentors learn from experienced ones. About 96 teens age…

This study tests three school-based programs to help high school students who are at risk for behavior problems like conduct disorder. About 120 students will be randomly assigned to a mindfulness program, a mindfulness program with a mobile app, or a life skills program. Researc…

This study tests whether screening surgery outpatients for Staphylococcus aureus (staph) and giving them a 5-day decolonization treatment (nasal ointment, mouth rinse, and special soap) can prevent surgical site infections. About 250 adults scheduled for various surgeries will be…

This study tests whether the medication bupropion can help women who quit smoking during pregnancy stay smoke-free after giving birth. About 200 women will receive either bupropion or a placebo for 12 weeks after delivery. Researchers will track smoking abstinence through regular…

This study tests a smartphone chatbot designed to help Black adults quit smoking. The chatbot sends alerts during times when a person is most likely to smoke and suggests ways to handle triggers. 120 participants will be randomly assigned to use the chatbot or not, and researcher…

This study looks at whether walking in a natural setting (like a park) is better for reducing stress, anxiety, and improving mood compared to walking in a built-up commercial area. 216 adults with prediabetes will walk 150 minutes per week for six weeks in each environment, with …

This study tests whether a small vibrating device placed on the throat can reduce symptoms of unexplained chronic cough. Adults aged 18 to 88 with a cough lasting more than 8 weeks use the device at home and report changes in cough severity and quality of life. The goal is to see…

This study explores whether gentle vibrations on neck muscles can help people with cervical dystonia hold their head straighter. Fifty adults with the condition will receive different vibration intensities during a single three-hour lab visit. Researchers will measure head postur…

This study tests a new way to deliver deep brain stimulation (DBS) for essential tremor, called coordinated reset DBS. Instead of constant high-frequency pulses, it uses lower-current patterns that may work better and have fewer downsides. About 23 adults with essential tremor wh…

This study tests a small, non-invasive device that delivers mild electrical pulses to the ear to see if it can help people with chronic jaw pain (TMD). About 40 adults will use the device at home daily for a few weeks. The main goal is to see if people find it easy and comfortabl…

This study tests whether raising the heart rate with a pacemaker can improve heart failure symptoms and exercise ability in 10 people with cardiac amyloidosis who already have a pacemaker. Participants will get a personalized pacing protocol based on their height and heart functi…

This study aims to improve walking and balance in people with Parkinson's disease who already have a brain implant (deep brain stimulation). Researchers will use MRI scans and computer models to find the best settings for each person's implant. Sixty participants will test these …

This study tests whether taking a probiotic supplement (Lactobacillus casei) for 5 weeks can reduce delayed onset muscle soreness after exercise. Researchers will measure pain, pressure sensitivity, and jump performance in 24 healthy, active young adults. The goal is to see if pr…

This study tests whether shifting text to healthier parts of the visual field can help people with age-related macular degeneration read faster and make fewer mistakes. About 108 participants with central vision loss will try two different text-remapping methods. The goal is to f…

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The goal is to see if it helps reduce depression and caregiver burden, and improve quality of life over 3 months. About 150 care partners and their loved ones with de…

This study tests a telehealth program that coaches parents of children with autism to improve their child's communication and behavior while reducing parental stress. Researchers will train community providers to deliver the coaching to 90 families, including those in remote area…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study looks at whether spinal manipulation (a chiropractic-style adjustment) can help normalize how the neck bones move in people with chronic neck pain. About 60 adults with neck pain for over 12 weeks will be randomly assigned to receive spinal manipulation, a light massag…

This study tests a faster form of brain stimulation (accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. Researchers will use a smart algorithm to choose the best spot to stimulate each person's brain, based on their individual pain patte…

This study tests whether adding a pectoserratus nerve block to the standard interscalene block can better control pain and reduce opioid use after total shoulder replacement. About 110 adults aged 18 to 85 having shoulder replacement will be randomly assigned to receive either a …

This study tests whether a daily breathing exercise called alternate nostril breathing can reduce nausea and vomiting in early pregnancy. One hundred pregnant individuals in their first trimester will either practice the breathing technique three times a day for a week or receive…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can improve thinking and memory in people still having symptoms 3 to 12 months after a mild concussion. Thirty adults will receive 10 sessions over about 3 w…

This study tests if freezing the nerves between the ribs (cryoablation) provides better pain relief than a numbing catheter placed near the spine for people with multiple broken ribs. About 48 adults with more than one rib fracture will be randomly assigned to one of the two trea…

This study tests two smartphone-based programs for adults with binge eating disorders. One program uses heart rate feedback and breathing exercises, while the other uses guided body scans to help people connect with internal sensations like hunger. The goal is to reduce binge eat…

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck can improve leg muscle control, walking, and balance in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) version in 75 participants. The goal i…

This study tests whether a gentle brain stimulation technique (tDCS) combined with computer-based thinking exercises can improve attention, memory, and problem-solving in children aged 8 to 17 who were exposed to alcohol before birth. About 70 kids will be randomly assigned to re…

This study tests whether electrical stimulation on the surface of the brain's frontal area can ease severe depression in people who haven't gotten better with other treatments. Participants will have a pacemaker-like device surgically placed under the scalp to deliver mild pulses…

This study tests whether using positive language during epidural placement can lower pain scores compared to negative phrasing. Thirty pregnant women receiving their first epidural will be randomly assigned to hear either a positive or negative script. The goal is to see if the w…

This study compares two treatments for shoulder pain caused by arthritis or rotator cuff problems: a steroid injection into the joint versus a nerve block. Forty adults with shoulder arthritis will be randomly assigned to one of the two treatments. Researchers will track pain lev…

This study tests if freezing a specific nerve group (cryoablation of the PENG) provides better pain control 30 days after hip fracture surgery compared to the usual method (a fascia iliaca catheter). About 150 adults aged 18-85 having hip fracture repair will be enrolled. The mai…

This study tests whether adjusting the settings of an already-implanted deep brain stimulator can better control seizures in people with epilepsy that doesn't respond to medication. Researchers will try different combinations of stimulation strength, speed, and pulse width in 20 …

This study looks at whether changes in brain waves can objectively measure tinnitus improvement after using a non-invasive device. The device delivers sound through headphones and mild electrical pulses to the tongue. Twenty-four adults with chronic tinnitus will use the device d…

This study explores whether practicing QiGong—a gentle mind-body exercise—can help people with chronic low back pain by altering brain regions linked to body awareness. Sixty adults with ongoing back pain will either follow a 12-week QiGong program or do low-impact core exercises…

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study tests whether a community-based exercise program can improve walking ability and heart health in people with peripheral artery disease who have recently had a procedure to open blocked leg arteries. Researchers will enroll 30 participants and measure how long they can …

This study looks at whether special mouth and throat exercises can improve sleep apnea by strengthening the muscles that keep the airway open. Thirty adults with sleep apnea will use myofunctional therapy devices for three months. Researchers will measure muscle pressure in the t…

This study investigates why some adolescents act impulsively when experiencing negative emotions, a trait called negative urgency. Researchers will measure brain cell communication using transcranial magnetic stimulation and EEG in teens aged 13-21 with depression and suicidal th…

Researchers at the University of Minnesota are developing a new scale to measure mental body representation—how people perceive and are aware of their bodies—in adults with spinal cord injury. The study involves 80 participants, including those with and without neuropathic pain, …

This study tests whether eye-tracking tasks can detect changes in attention and learning in people with Rett syndrome who are starting a new medication called trofinetide. Researchers will compare eye movements and heart rate before and after 4 weeks of treatment in 20 participan…

This observational study will enroll 1,500 adults hospitalized with acute infections across the globe. Researchers will collect medical data and biological samples to better understand how these infections progress, what factors affect recovery, and how to design better clinical …

This study tests whether low-intensity focused ultrasound can safely target deep brain areas and improve thinking skills like attention and memory. Researchers will enroll 100 healthy adults aged 18 and older. Participants will undergo brain scans and thinking tests to measure an…

This early study is testing whether mild electrical or ultrasound stimulation on the skin can change brain activity in healthy adults. Researchers will measure brain waves using a special EEG cap during active and fake (sham) stimulation. The goal is to find reliable markers of b…

This study looks at how the brain changes over time in people with REM sleep behavior disorder, a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and thinking tests to track these changes in about 86 adults. The goal is to …

This study looks at whether using a continuous glucose monitor and a Fitbit activity tracker can help people aged 55 and older with type 2 diabetes sit less and control their blood sugar better. Researchers will track how often participants respond to prompts to stand up and how …

This study uses MRI scans to see how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Researchers will compare brain images when the stimulator is on versus off, focusing on the leg area of the brain. The goal is to understand why DBS someti…

This study is for people with rare DNA repair disorders like Cockayne syndrome, xeroderma pigmentosum, or trichothiodystrophy. Researchers will watch how symptoms like movement and balance change over time. No treatments are given—the goal is to better understand these conditions…

This study looks at why people with depression sometimes get stuck in rigid thinking patterns. Researchers will use online tests to measure cognitive flexibility in 2,500 adults. The goal is to better understand how these thinking habits relate to depression symptoms, not to prov…

This study tests whether a non-invasive sound wave technique (transcranial focused ultrasound) can successfully image brain tumors before surgery. About 15 adults scheduled for brain surgery will have ultrasound scans taken and compared to standard MRI images. The goal is to see …

This study is testing a program called Project REACH, which offers telehealth services at syringe service programs (places where people can get clean needles). The goal is to see if this makes it easier for people who use drugs to get HIV prevention (like PrEP) and addiction trea…

This study follows 80 women aged 45-55 as they go through menopause to see how their nerves and blood vessels change. Researchers will measure nerve activity and blood vessel function each year, or every six months once perimenopause starts. The goal is to understand why menopaus…

This study is testing a new type of dental MRI (ddMRI) to see if it can work as well as standard dental X-rays for diagnosing problems like crowded teeth, jaw pain, and infections. About 300 adults will get a ddMRI scan and then compare the results to their regular dental images.…

This study is for people with ALS and healthy volunteers. It uses brain and spine MRI scans and blood tests to find markers that show how the disease progresses. The goal is to develop better tools to measure ALS over time. About 90 participants will be followed for up to one yea…

This study compares two different deep brain stimulation (DBS) settings in 30 people with Parkinson's disease who already have DBS implants. The goal is to see which setting better improves walking and balance problems. Participants will try both settings, and their symptoms will…

This study looks at what happens to the heart and breathing during a hot flush in postmenopausal women. Researchers will use heating pads and warm items to trigger hot flushes in a controlled setting. They want to see if these induced flushes cause similar changes in blood pressu…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study uses a thin needle to record signals from the vagus nerve in awake adults with epilepsy who already have a vagal nerve stimulator implanted. Researchers aim to identify which nerve fibers are activated during stimulation and how different settings affect them. The goal…

This study creates a registry of up to 10,000 people who have received or donated an organ at the University of Minnesota. Researchers will collect and store health information to help answer future questions about transplants. No new treatments or procedures are being tested.

This study looks at how different parts of the brain handle mental effort in adults with epilepsy. Researchers will use tiny electrical pulses on the brain's surface while patients do thinking tasks. The goal is to create detailed maps of brain function to help guide future epile…

This study aims to understand how different brain circuits affect movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and link them to motor and…

This observational study looks at tiny particles called extracellular vesicles in people with Gaucher disease, carriers, and healthy volunteers. Researchers want to see if these particles differ between groups and if they can help explain brain inflammation linked to the disease.…

This study looks at how the brains of teens (ages 15-18) with cannabis use disorder change when they stop using cannabis for 6 weeks. Researchers will use MRI scans to measure brain activity related to reward and impulse control. Some teens will be paid to stay cannabis-free, whi…

This study tests whether giving a simple educational handout before surgery helps transmasculine people feel more confident about deciding to keep or remove their ovaries during a gender-affirming hysterectomy. About 250 participants will be randomly assigned to receive the hando…

This study looks at why women with PTSD have a higher chance of heart disease later in life. Researchers will test if beetroot juice, a natural source of nitric oxide, can improve blood vessel function in 30 premenopausal women who have experienced trauma. The goal is to understa…

This study looks at how brain blood flow and balance control change across adulthood. About 102 healthy adults, from young to older, will do a single session of aerobic exercise while researchers measure brain activity and balance reactions. The goal is to better understand the l…

This study is looking at new blood markers that measure inflammation and oxidative stress in people with Gaucher disease type 1. Researchers want to see if these markers can give more information than the tests currently used. The study involves 34 adults who are stable on their …

This study looks at how a gentle vibration applied to the throat affects brain activity and voice in people with laryngeal dystonia, a condition that causes involuntary voice spasms. Researchers will use brain scans and voice recordings to understand why some people get relief fr…

This study follows 30 people aged 12 to 21 with chronic tic disorders as they go through 8 sessions of CBIT, a well-established behavioral therapy. Researchers will track tic severity, controllability, and other factors to see what predicts a good response. The goal is to underst…

This study looks at how sepsis causes lasting damage to the immune system, making people more likely to get serious infections later. Researchers will track 150 ICU patients with sepsis over 28 days, analyzing their blood cells and immune markers. The goal is to uncover the biolo…

This study investigates why people with Parkinson's disease sometimes freeze while walking or turning. Researchers will use gentle electrical stimulation to the balance system and brain wave recordings to understand the signals involved. The goal is to find biological markers tha…

This study is testing whether adding radiation after surgery for Dupuytren's contracture leads to better hand function and fewer recurrences. Researchers will follow 50 patients who are already getting this treatment and ask them to fill out a questionnaire about their hand funct…

This study watches brain activity in 25 Parkinson's patients during their planned DBS surgery. Researchers place a thin sensor strip on the brain's surface to record signals while stimulating deep brain areas. The goal is to understand how movement-related brain pathways work, wh…

This study follows children and adults with Tay-Sachs, Sandhoff, and GM1 gangliosidosis to understand how these diseases progress. Researchers will measure changes in motor skills, communication, and behavior each year. The goal is to create a clear picture of the diseases so fut…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study looks at how deep brain stimulation (DBS) affects walking and other movements that don't improve with standard Parkinson's medication. About 36 adults with Parkinson's who already have a Medtronic Percept DBS implant will wear sensors and use a smartphone app to track …

This study looks at how deep brain stimulation (DBS) — a device already used to control movement in Parkinson's disease — affects sleep. Researchers will monitor brain activity and sleep quality in 64 adults with Parkinson's who have or will get DBS implants. The goal is to under…

This pilot study is testing a new portable MRI scanner designed just for the head. Unlike traditional MRI machines, this one lets you sit upright, is much quieter, and weighs only 400 kg. Researchers will compare the images from this new scanner to those from standard MRI to see …

This study looks at why some people with Parkinson's disease suddenly feel like their feet are glued to the floor, known as freezing of gait. Researchers will use special brain recordings from already-implanted devices to compare brain activity in people with and without this sym…

This study is testing whether a special electrode placed deep in the brain can detect abnormal electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury. These waves may cause further damage. The study will involve 15 people who already need…

This study tests a new device called Peritorq that helps doctors twist and control catheters during heart procedures in children. Researchers will check if the device works safely and reliably after the main heart procedure is finished. The study involves 25 children and teens (u…

This study is testing whether a single dose of modafinil, a drug that promotes wakefulness, can change how healthy people perform decision-making tasks and alter their brain activity. Researchers will use EEG caps to measure brain waves while participants play computer-based brai…

This study looks at how chronic jaw pain (TMD) influences drinking patterns in heavy drinkers. Researchers will compare people with and without TMD pain, measuring how they drink alcohol in a lab setting and in daily life. The goal is to understand why pain increases the risk of …

This study tests if timing magnetic brain stimulation to match a person's own brain waves can improve treatment for stimulant use disorder. Researchers will enroll 50 adults who are currently in treatment and have been drug-free for at least 2 weeks. Participants will get an MRI …

This study tests whether computer models can help doctors find the best settings for deep brain stimulation (DBS) in people with essential tremor. Researchers will create personalized brain models to predict which stimulation settings work best and cause fewer side effects. The g…

This study looks at how deep brain stimulation (DBS) affects brain activity in 30 people with Parkinson's disease. Researchers will measure brain signals during movement and thinking tasks, with and without DBS or medication. The goal is to understand how different brain areas wo…

This study looks at how the exact placement of deep brain stimulation (DBS) electrodes in the brain affects movement problems in people with Parkinson's disease. Researchers will study 24 participants who already have DBS implants to see which stimulation locations improve sympto…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program to a 6-week program to see which leads to better health outcomes. About 400 women who have already joined …

This study investigates how the brain processes anticipation of rewards in people with bulimia nervosa. Researchers will use brain scans (fMRI) and daily-life surveys to compare 100 participants—those with bulimia and healthy controls. The goal is to identify neural and psycholog…

This study uses a special MRI technique called magnetic resonance spectroscopy to measure brain chemicals in adults with Type 3 Gaucher disease. The goal is to find markers that show how the disease affects the brain and how it responds to treatment. About 5 participants aged 18 …

This study looks at how early menopause (before age 45) affects the nerves that control blood pressure. Researchers will measure nerve activity and blood pressure in 160 women aged 35-70. The goal is to understand why these women may have higher blood pressure and find ways to he…

This study compares a new device, CompuFlo CathCheck, to the standard X-ray method (epidurogram) for confirming that an epidural catheter is in the right spot. About 50 adults getting epidurals for surgery will participate. The goal is to see if the device works just as well as X…

This study observes oxygen levels in the airway during rigid bronchoscopy, a procedure to treat blocked airways. Researchers will measure how long it takes for oxygen to drop to a safe level when using a special ventilator mode. The goal is to reduce the risk of airway fires duri…

This study looks at two things: training primary care doctors to better refer families to parenting programs, and testing a 6-session online parent training program called Empowered Generations (eGen). Researchers want to see if these steps can reduce behavior problems in childre…

This study tests a new way to adjust spinal cord stimulation in 15 adults with chronic pain who already have spinal cord implants. Researchers will use electrical recordings called ECAPs to find the best stimulation settings. The goal is to see if this approach is feasible and ac…

This study uses powerful MRI scans to find biomarkers—measurable signs of disease—for amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Researchers will compare brain images from patients and healthy volunteers to better understand these diseases and potent…

This study looks at whether measuring nerve signals during a procedure called rhizotomy can help treat trigeminal neuralgia, a condition that causes sudden, shock-like facial pain. Researchers will test a monitoring technique in 30 adults already scheduled for the surgery. The ma…

This study is testing whether measuring nerve signals during a standard procedure for trigeminal neuralgia (a type of severe facial pain) can help doctors target the treatment more precisely. About 30 adults scheduled for the procedure will have their nerve responses recorded fro…

This study from the University of Minnesota is looking at what happens to your body when you fast for up to 60 hours, drinking only water. Researchers want to see if the changes in your blood can make cancer cells more sensitive to chemotherapy in lab tests. Fifteen healthy adult…

This study aims to understand how aging changes the brain and kidneys in healthy adults. Researchers will use advanced MRI scans and thinking tests to find links between these changes. The study involves 120 English-speaking adults with no major health conditions. Results may hel…

This pilot study in Ghana tests whether a 30-minute docudrama shown right after a first-time blood donation can increase the chance that the donor returns to give blood again. 180 first-time donors at different donation sites will either watch the docudrama or receive standard co…

This study looks at how a mother's stress might influence the makeup of her breastmilk and how that affects feeding and brain development in preterm infants. Researchers will follow 120 premature babies and their mothers from the NICU through 4 months after the due date. They wil…

This study looks at how brain circuits are connected in people with chronic temporomandibular joint (TMD) pain compared to pain-free individuals. Researchers will use MRI scans to map brain activity and structure in 95 female participants. The goal is to find patterns that could …