Sleeve gastrectomy vs. lifestyle: which tames fatty liver disease?

NCT ID NCT03587831

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches for treating non-alcoholic steatohepatitis (NASH), a serious liver condition linked to obesity. Half of the 48 participants will receive vertical sleeve gastrectomy surgery along with lifestyle counseling, while the other half will get lifestyle counseling alone. Researchers will measure liver health after 12 months to see which group improves more.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vertical sleeve gastrectomy surgery and lifestyle modification counseling
What this could lead to: If successful, this could show that adding weight-loss surgery to lifestyle changes is a safe and effective way to reduce liver damage in NASH patients.
What could go wrong: This is a small pilot study with only 48 people, so results may not apply to everyone. Surgery also carries risks like infection or complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NASH - NONALCOHOLIC STEATOHEPATITIS

Contacts and locations

Locations

Minneapolis VA Medical Center
RECRUITING

Minneapolis, Minnesota, 55417, United States
Pennington Biomedical Research Center
RECRUITING

Baton Rouge, Louisiana, 70808, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of San Fransisco
RECRUITING

San Francisco, California, 94143, United States

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