Scientists probe vagus nerve in real time to improve brain stimulation

NCT ID NCT06016686

Recruiting now Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses a thin needle to record signals from the vagus nerve in awake adults with epilepsy who already have a vagal nerve stimulator implanted. Researchers aim to identify which nerve fibers are activated during stimulation and how different settings affect them. The goal is to better understand how VNS works and to guide future improvements. The study involves 60 participants and is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vagal nerve stimulation (VNS) and microneurography recordings
What this could lead to: If successful, this could help design better vagal nerve stimulators for epilepsy and other conditions.
What could go wrong: This is a small, early-phase study focused on measuring nerve signals, not testing a treatment. It may not lead to any direct patient benefit.

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY

Contacts and locations

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

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