Could a gut bacteria pill tame immunotherapy side effects?
NCT ID NCT05726396
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a capsule containing healthy gut bacteria (restorative microbiota therapy) is safe and feasible for people with severe colitis caused by cancer immunotherapy. About 20 participants with steroid-resistant colitis will receive either the bacteria or a placebo for 7 days. The goal is to see if this approach can reduce diarrhea and inflammation without the need for more immune-suppressing drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Restorative microbiota therapy (RMT) – a capsule containing healthy gut bacteria
- What this could lead to
- If it works, this could offer a new treatment for severe colitis caused by cancer immunotherapy, reducing the need for steroids or other immune-suppressing drugs.
- What could go wrong
- This is a very small early-phase trial (20 people) testing only safety and feasibility, not effectiveness. The treatment may not work, and there is a risk of infection or other side effects from the bacteria.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Essentia Health Cancer Center
RECRUITINGDuluth, Minnesota, 55805, United States
Contact Email: •••••@•••••
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Essentia Health Deer River Clinic
RECRUITINGDeer River, Minnesota, 56636, United States
Contact Email: •••••@•••••
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Essentia Health Fosston
RECRUITINGFosston, Minnesota, 56542, United States
Contact Email: •••••@•••••
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Essentia Health Hibbing Clinic
RECRUITINGHibbing, Minnesota, 55746, United States
Contact Email: •••••@•••••
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Essentia Health Sandstone
RECRUITINGSandstone, Minnesota, 55072, United States
Contact Email: •••••@•••••
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Essentia Health St. Joseph's Medical Center
RECRUITINGBrainerd, Minnesota, 56401, United States
Contact Email: •••••@•••••
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Essentia Health St. Mary's Detroit Lakes Clinic
RECRUITINGDetroit Lakes, Minnesota, 56501, United States
Contact Email: •••••@•••••
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Essentia Health Virginia Clinic
RECRUITINGVirginia, Minnesota, 55792, United States
Contact Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55414, United States
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