Could a gut bacteria pill tame immunotherapy side effects?
NCT ID NCT05726396
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a capsule containing healthy gut bacteria (restorative microbiota therapy) is safe and feasible for people with severe colitis caused by cancer immunotherapy. About 20 participants with steroid-resistant colitis will receive either the bacteria or a placebo for 7 days. The goal is to see if this approach can reduce diarrhea and inflammation without the need for more immune-suppressing drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Restorative microbiota therapy (RMT) – a capsule containing healthy gut bacteria
What this could lead to
If it works, this could offer a new treatment for severe colitis caused by cancer immunotherapy, reducing the need for steroids or other immune-suppressing drugs.
What could go wrong
This is a very small early-phase trial (20 people) testing only safety and feasibility, not effectiveness. The treatment may not work, and there is a risk of infection or other side effects from the bacteria.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Essentia Health Cancer Center
RECRUITINGDuluth, Minnesota, 55805, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health Deer River Clinic
RECRUITINGDeer River, Minnesota, 56636, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health Fosston
RECRUITINGFosston, Minnesota, 56542, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health Hibbing Clinic
RECRUITINGHibbing, Minnesota, 55746, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health Sandstone
RECRUITINGSandstone, Minnesota, 55072, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health St. Joseph's Medical Center
RECRUITINGBrainerd, Minnesota, 56401, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health St. Mary's Detroit Lakes Clinic
RECRUITINGDetroit Lakes, Minnesota, 56501, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Essentia Health Virginia Clinic
RECRUITINGVirginia, Minnesota, 55792, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55414, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••