University Of Minnesota

This early-stage study is testing a new experimental flu vaccine called H1ssF, which researchers hope could provide broader protection against multiple flu strains. The trial will compare this new vaccine to the current seasonal flu shot (Flucelvax) in 112 adults, including some …

This study is testing if adding the diabetes drug empagliflozin helps people who have received a transplant of their own insulin-producing cells. It will involve 40 adults who still have some cell function after their transplant. Researchers will compare different doses of the dr…

This study aims to find better ways to treat moderate to severe histoplasmosis, a serious fungal infection. It will test if a single high-dose intravenous treatment works as well as the standard daily lower doses. It will also test if a newer oral drug (posaconazole) or a shorter…

This large study is testing whether a special nutritional drink, taken around the time of surgery, can help prevent serious complications after a broken leg is repaired. It will involve 1,000 adults with leg fractures, comparing the drink to a placebo. The goal is to see if this …

This study is testing a new telehealth program called Project REACH at syringe service sites. The goal is to see if it's a practical and acceptable way to help people who use drugs get better access to HIV prevention and treatment services. The research will involve about 121 par…

This study aims to find out how much lifestyle coaching is needed when teens with obesity take weight-loss medications. Researchers will compare different amounts of coaching to see if less-intensive programs work just as well for improving weight and health. The goal is to creat…

This study aims to see if a new combination of antibiotics (BPaLMZ) works better than the current standard treatment for tuberculous meningitis, a serious brain infection. It will involve 240 adults with HIV who have this condition. Researchers will compare how long people live a…

This early-stage study is testing a new way to use deep brain stimulation (DBS) for Parkinson's disease. It will see if a gentler, patterned electrical signal is safe and can help control movement symptoms like slowness, stiffness, and tremor. The study will involve 24 people who…

This study is testing whether advanced MRI scans can be used to monitor the health of transplanted kidneys. Researchers will scan 140 kidney transplant patients to see if MRI images can detect signs of organ rejection or other problems that cause kidney function to decline. The g…

This study aims to prevent obesity in young adults (ages 18-25) who are overweight and have a family history of obesity. Researchers will test if combining personalized lifestyle coaching with a low-dose weight management medication (Qsymia) is more effective than coaching alone …

This study is testing whether a smartphone chatbot can help people quit smoking. Researchers will enroll 120 Black or African American adults in Minnesota who want to quit. Some participants will use the chatbot app, while others will not, to see if the app is easy to use and hel…

This small study aims to see if applying heat therapy to the jaw can reduce pain and muscle fatigue during teeth clenching for people with chronic jaw pain. Researchers will enroll 10 adults with long-term jaw pain to test this simple treatment. The goal is to identify which pati…

This study is testing whether metformin, a medication typically used for diabetes, can help treat depression in people living with HIV. Researchers will enroll 600 HIV-positive adults in Uganda who have depression but aren't currently taking antidepressants. The trial will compar…

This early-stage study is testing whether a surgically implanted brain stimulation device can reduce severe, long-lasting nerve pain. It will involve about 20 adults whose pain hasn't improved with standard medications or less invasive treatments. Researchers aim to see if the de…

This study aims to help people with central vision loss, often from macular degeneration, read more easily. Researchers will test if shifting text to different parts of a person's remaining vision improves reading speed and accuracy. Participants will try different reading tasks,…

This study tests whether a combination of gentle brain stimulation (tDCS) and thinking exercises can help people who still have concentration and memory problems 3 to 12 months after a mild concussion. Researchers will compare real brain stimulation to a sham (fake) version, both…

This study tests whether providing an educational handout before surgery consultations helps transmasculine individuals make more confident decisions about keeping or removing their ovaries during gender-affirming hysterectomy. Researchers will give the handout to 250 participant…

This study aims to create and test a training program to help doctors reduce discrimination against gay men and people living with HIV. It will involve 155 sexual health doctors in Vietnam. The researchers will use trained actors posing as patients to measure stigma before and af…

This study aims to understand how high and low phosphorus diets affect how the body handles phosphorus and calcium in people with moderate chronic kidney disease (CKD). Fourteen participants will follow two different controlled diets for several weeks each, while researchers clos…

This study aims to understand how decision-making works in people with recent psychosis. Researchers will give 24 participants single doses of two different drugs (modafinil and d-serine) and a placebo during separate visits. They will use brain scans and computer games to see if…

This study aims to understand why people who quit smoking still have a higher risk of lung cancer. Researchers will track how the lungs of former smokers and non-smokers process a specific chemical to see if harmful breakdown pathways are involved. The goal is to gather informati…

This small study aims to see if a gentle, non-invasive stimulation of a nerve in the ear can affect blood sugar levels and cravings for food or movement. It will involve 8 healthy college students. The goal is to gather basic information on how the body and mind respond to this s…

This study aims to understand how throat muscle exercises might help people with obstructive sleep apnea. Researchers will measure pressure in throat muscles before and after 30 participants complete a 3-month exercise program using special devices. The goal is to learn why these…

This study aims to measure how pregnancy and breastfeeding affect the levels of CFTR modulator drugs in the body. It will enroll 30 pregnant women with cystic fibrosis who are taking these medications. The goal is to gather safety information to help doctors better counsel women …

This study will modify an existing evidence-based parental tobacco cessation intervention (the Clinical Effort Against Secondhand Smoke Exposure, or CEASE) delivered in pediatric primary care clinics to address shared tobacco use determinants and barriers to smoking cessation tre…