University Of Minnesota

This early-stage trial compares an experimental flu vaccine (H1ssF) with the standard seasonal flu shot (Flucelvax) in 112 adults aged 18-70. Some participants have had flu shots before, while others have never been vaccinated. The main goal is to check safety and how the immune …

This early-stage study tests a new way to deliver deep brain stimulation (DBS) for Parkinson's disease. Instead of constant high-level stimulation, the new method uses lower, patterned pulses. The goal is to see if it is safe and can improve movement problems. About 24 adults wit…

This study tests whether taking an oral supplement of conditionally essential amino acids (CEAA) for 12 months after lower leg fracture surgery can reduce serious complications like infection, bone nonunion, and muscle loss. Researchers will compare the supplement to a placebo in…

This study tests a new combination of medicines (BPaLMZ) for tuberculous meningitis, a serious brain infection. 240 adults, including those living with HIV, will receive either the new combo or standard care. Researchers will compare survival and recovery of daily function over t…

This study looks at whether a less intensive lifestyle program works as well as a more intensive one for teens with obesity who are also taking weight-loss medications. Researchers will track changes in body mass index (BMI), quality of life, and heart health. About 1,020 teens a…

This study tests whether a single high dose of an antifungal drug works better than the standard daily dose for hospitalized adults with moderate to severe histoplasmosis. It also compares a newer oral drug to the standard one, and checks if 6 months of treatment is as good as 12…

This study tests whether empagliflozin, a diabetes drug, can improve blood sugar control in people who have had islet transplants but still have partial pancreas function. About 40 adults will take either a placebo or one of two doses of the drug for 3 months. The goal is to see …

This study aims to adapt a proven smoking cessation program for Somali immigrant parents who smoke. Researchers will work with 50 parents in pediatric clinics to provide support like nicotine replacement therapy and quitline referrals. The goal is to help parents quit smoking and…

This study tests a new way to prevent obesity in teens and young adults (ages 18-25) who are at high risk due to family history and higher body weight. Participants will receive lifestyle coaching and possibly medication to help control weight gain. The goal is to stop unhealthy …

This study tests whether applying heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults will clench their teeth and receive heat therapy, and researchers will track their pain levels for 8 days. T…

This early study tests a brain stimulation technique for people with long-term nerve pain that hasn't responded to other treatments. About 20 adults will receive a surgically placed device to stimulate specific brain networks. The main goal is to see if the procedure is feasible …

This study tests whether metformin, a diabetes drug, can help treat depression in people living with HIV. Depression is common in HIV and can make it harder to stick with life-saving HIV medication. The trial will enroll 600 adults in Uganda and compare metformin to placebo, and …

This study looks at whether moving words to different parts of the visual field can help people with central vision loss read faster and more accurately. About 100 adults with dense blind spots in the center of their vision will take part. Researchers will measure reading speed a…

This study looks at how older adults (55+) with type 2 diabetes use continuous glucose monitors and activity trackers to manage their health. Researchers want to see if these devices help people sit less and improve blood sugar control. Sixty participants will wear the devices an…

This study will use advanced MRI scans to learn more about chronic kidney disease, kidney transplants, and how kidney problems may affect the brain. Researchers will scan 180 people, including healthy volunteers and those with kidney disease, to see if MRI can help track disease …

This study looks at how two medications, modafinil and d-serine, affect decision-making and brain activity in people who have had psychosis symptoms for less than five years. Participants will take a single dose of each medication or a placebo, then play computer brain games and …

This study aims to see if a special training program can help doctors in Vietnam treat people with HIV and men who have sex with men more fairly. About 155 doctors will take part, and researchers will use actors pretending to be patients to measure any changes in stigma. The goal…

This study looks at how cystic fibrosis medications (CFTR modulators) change in the body during pregnancy and after childbirth. Researchers will measure drug levels in the blood, breast milk, and umbilical cord blood of 30 women. The goal is to understand how these drugs behave i…

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Researchers will have 14 participants follow both a low-phosphorus and a high-phosphorus diet for 19 days each, then measure phosp…

This study tests whether advanced MRI scans can better monitor kidney transplant health and detect early signs of rejection. About 140 kidney transplant patients will receive special MRI exams. The goal is to see if MRI can measure kidney function and tell the difference between …

This study will test a telehealth program called Project REACH at syringe service programs. The goal is to see if it helps people who use drugs get HIV-related care, like PrEP and medication for opioid use disorder. About 121 adults who have used drugs in the past year will take …

This small study will test if a non-invasive device that gently stimulates a nerve in the ear can change blood sugar levels and cravings for food or movement. Researchers will recruit 8 healthy college students aged 18-35. The goal is to see if this approach is feasible for futur…

This study tests whether a chatbot can help Black adults quit smoking. About 120 participants will either get the chatbot or not. Researchers will see if people find the app useful and if it helps them smoke less.

This study aims to understand why people who quit smoking years ago still have a higher risk of lung cancer. Researchers will give 100 former smokers and never-smokers a vaped chemical called phenanthrene and measure how their lungs break it down. The goal is to see if former smo…