University Of Minnesota

This study aimed to test a specific surgical pin designed to help heal broken collarbones. It planned to measure how well the bone healed, how much function patients regained, and how satisfied they were with the results. The study was withdrawn before any participants were enrol…

This small pilot study is testing if adding the diabetes drug empagliflozin to standard insulin therapy is safe and helps control blood sugar in overweight adults with cystic fibrosis-related diabetes (CFRD). The main goal is to gather initial safety and feasibility data to see i…

This study is testing whether adding the medication lisdexamfetamine to standard lifestyle therapy helps children with severe obesity lose more weight. Children aged 6 to 12 will be randomly assigned to receive either the medication or a placebo, along with lifestyle coaching, fo…

This study is testing a refined version of electroconvulsive therapy (ECT) for people with severe, treatment-resistant depression. The goal is to see if adjusting where the electrical current is applied in the brain can provide the same relief from depression while causing fewer …

This study aimed to see if changing the physical layout and systems of HIV clinics in Uganda could make them more private and welcoming. The goal was to reduce the stigma around HIV and help patients stay connected to their care. The study was withdrawn before any participants we…

This is an early-stage study to test a smartphone app called NEAT-O. The app delivers a form of therapy (CBT) designed for people who have opioid addiction and also struggle with anxiety or depression. Researchers are testing if the app is easy to use and acceptable to 15 partici…

This study is testing two different teaching approaches to help children with developmental language disorder (DLD) learn proper grammar. Researchers are comparing a new method that directly explains grammar rules to a traditional method that focuses on practice and repetition. T…

This study is observing patients who have surgery to reconstruct a key knee ligament (MPFL) after their kneecap repeatedly dislocates. Researchers are following over 200 patients for at least two years to see if the natural shape and alignment of their knee bones affects how well…

This study is testing whether a smartphone app called mGlide can help people better control their high blood pressure. About 450 people with uncontrolled blood pressure will use the app to send daily home readings to their doctors, who get alerts if numbers go outside a safe rang…

This small, early-stage study is testing whether adding a weight loss medication (phentermine/topiramate) to standard diabetes treatment can help teens with type 2 diabetes and obesity. The goal is to see if the drug helps lower body mass index (BMI) and improves how the body use…

This study is testing if a reward program helps people with opioid or stimulant addiction stick with their treatment. Patients can earn small cash payments for attending their doctor's appointments and for having drug-free urine tests. The goal is to see if this approach, already…

This study is testing whether a 12-week mobile app program can help improve thinking skills and motivation in young adults recently diagnosed with psychosis. The program is given alongside standard care, which includes therapy and medication management. Researchers will compare t…

This study aimed to test whether putting a medication called T3 directly into the lungs could help people with severe COVID-19 who were on a ventilator. It planned to enroll patients with life-threatening breathing failure (ARDS) to see if the treatment could reduce dangerous flu…

This early-stage study aimed to test if a non-invasive brain stimulation technique could help reduce cravings in people being treated for methamphetamine addiction. The plan was to enroll 40 adults already living in a residential treatment program and randomly assign them to rece…

This study aimed to test whether specially prepared gut bacteria pills could help cancer patients who developed severe, persistent colitis (colon inflammation) from their immunotherapy drugs. The research focused on patients whose colitis didn't improve with standard steroid trea…

This study is testing if time-restricted eating, where you eat only during a set daily window, is a simpler and more sustainable way to help control blood sugar in people with type 2 diabetes compared to traditional calorie counting. It involves 115 overweight or obese adults who…

This study is testing whether proactive, culturally tailored outreach can help more Black, Indigenous, and People of Color (BIPOC) adults successfully quit smoking. Researchers are comparing standard care against an enhanced program that actively reaches out to connect 700 eligib…

This study is testing whether giving doctors real-time feedback during a colonoscopy helps them find more precancerous growths called adenomas. It involves over 4,000 colonoscopies performed by participating doctors. The goal is to improve the quality of colorectal cancer screeni…

This study is testing a personalized device designed to help people manage their tinnitus, the perception of ringing or buzzing in the ears. The device combines customized sound therapy with gentle nerve stimulation. Researchers are checking how often people use the device and ho…

This study is testing whether a new support program is practical and acceptable for people recovering from a stroke. Participants will wear a Fitbit to track steps and have weekly video chats with a therapist for six weeks. The main goal is to see if people can stick with the pro…

This study is testing if a modified WaterPik device, normally used for dental cleaning, can improve scalp health. Researchers want to see if its gentle water pressure and massage action can reduce flaking from dandruff and seborrheic dermatitis. The trial will involve 40 people w…

This study is testing whether a telehealth program called 'teleABLE' can help people who've had a stroke in the past year sit less and improve their quality of life. Participants will try either the teleABLE program or a general health education program, both delivered remotely. …

This study aims to understand what causes dangerous blood clots in the lungs (pulmonary embolism) and legs (deep vein thrombosis). Researchers are following over 21,000 African American and white adults who were already part of two large heart health studies. They are collecting …

This study aimed to understand how the brain adapts when people wear colored lenses. Healthy volunteers would wear tinted lenses multiple times a day while researchers measured changes in their color perception and brain activity. The goal was to learn about the brain's ability t…

This study aims to understand how the body processes fat and sugar at rest, and how this relates to insulin resistance—a key factor in developing type 2 diabetes. Researchers are comparing overweight, sedentary adults with lean, aerobically trained adults, measuring them before a…

This study aims to understand how the liver's energy production changes in people with fatty liver disease (NASH) who are undergoing weight loss surgery. Researchers will measure how the liver burns fat and makes sugar in 30 participants before their surgery. The goal is to see i…

This study aims to develop better brain scanning technology, not to treat any condition. Researchers are testing new methods on powerful MRI machines to more precisely measure the natural chemicals in a healthy brain. The goal is to improve the tools doctors and scientists use to…

This study aims to understand why the medication topiramate helps some teens with severe obesity lose weight but is less effective for others. Researchers will measure drug levels in the blood of about 62 participants over 3.5 months to see how the body processes the medicine and…

This study aimed to understand how smoking and vaping cause DNA damage in mouth cells, which might lead to cancer. Researchers planned to compare damage levels in people who continued using these products, those who tried to quit, and non-users. The goal was to identify which typ…

This study is testing if a simple bedside ultrasound machine can be used to safely track how much fat and muscle a premature baby is gaining each week. Researchers want to see if this scan can give doctors better information about whether the baby's nutrition is working well. The…

This study is evaluating a training program for volunteers who visit and support older adults with memory loss, dementia, or Alzheimer's. The program is being tested in a real-world setting by a social service organization in Minnesota. Researchers are analyzing data to see if th…

This study aims to collect detailed information from Parkinson's disease patients who are getting deep brain stimulation (DBS) surgery. Researchers will track 60 patients over time, gathering data on their brain function, movement, and thinking skills before surgery, during the p…

This study aims to understand how different tobacco products, like cigarettes, e-cigarettes, and smokeless tobacco, affect how quickly and well skin wounds heal. Researchers will recruit 60 people who use various tobacco products, plus non-smokers for comparison. They will create…

This study was planned to understand how often people with a severe facial nerve pain condition (trigeminal neuralgia) also have a separate jaw joint and muscle pain disorder (TMD). Researchers aimed to follow patients from three clinics for 1-2 years, checking in every six month…

This study aims to see if a simple blood test can track how well treatment is working for kidney transplant rejection in children and young adults. Researchers will check if specific markers in the blood change as patients recover from a rejection episode. The goal is to find a l…

This study is testing whether a special 4-day training course on sexual health improves the knowledge, confidence, and skills of future doctors, nurses, and midwives in Tanzania. Researchers are comparing students who take the course now to those who wait, tracking their progress…

This study aimed to see if giving new anesthesia residents access to a library of real-life videos showing airway procedures would help them learn intubation faster and with less stress. It planned to compare the number of attempts, time taken, and stress levels between residents…