University Of Minnesota

This study tests whether a single infusion of hyperimmune immunoglobulin (hIVIG) — concentrated antibodies from recovered COVID-19 patients — can help adults at high risk (age 55+ or with weakened immune systems) who have early COVID-19. Participants receive either the antibody i…

This study tests a new approach to help people recovering from opioid use disorder avoid relapse. About 90% of people in treatment relapse within a year. Researchers will use a gentle, non-invasive brain stimulation method called tDCS combined with cognitive training to see if it…

This study tests whether combining lifestyle counseling with weight-loss medication helps teens aged 12–17 with severe obesity lose weight. About 120 participants will receive counseling and medication for a year. The goal is to find a practical, effective treatment that is easie…

This study tests whether taking progesterone pills can prevent new mothers from relapsing into cigarette smoking after childbirth. Researchers will enroll 171 women who recently quit smoking during pregnancy to see if the hormone helps them stay smoke-free and reduces secondhand …

This early-phase trial tests the drug phentermine/topiramate (Qsymia) in 13 adolescents aged 12-20 who have both obesity and type 2 diabetes. The drug is already approved for weight loss in adults. The study aims to see if it can safely lower body mass index (BMI) and improve blo…

This study tests a mobile health system called mGlide that helps patients with uncontrolled high blood pressure monitor their BP at home and automatically share readings with their healthcare team. The system alerts doctors when BP goes off track, allowing for timely medication a…

This study tests a proactive, culturally tailored outreach program to help BIPOC adults who smoke quit tobacco. Researchers will enroll 700 participants from two health systems and provide personalized materials and support to connect them with proven cessation treatments. The go…

This study follows 433 people with chronic pancreatitis who undergo a surgery called TPIAT, where the entire pancreas is removed to stop pain and the patient's own insulin-producing islet cells are infused back to lower diabetes risk. Researchers track pain relief, quality of lif…

This study planned to test whether putting a thyroid hormone (T3) directly into the lungs could help people with severe COVID-19 who need a breathing machine. The goal was to reduce fluid in the lungs and shorten time on a ventilator. However, the trial was withdrawn before any p…

This pilot study tests the safety and feasibility of empagliflozin (Jardiance) in 8 overweight or obese adults with cystic fibrosis-related diabetes (CFRD) who are already on insulin. Participants will receive either the drug or a placebo in a crossover design. The goal is to gat…

This study follows 201 people who had surgery to fix a dislocating kneecap (MPFL reconstruction). Researchers want to see if the distance between certain knee bones and the height of the kneecap affect how well the surgery works. Participants will be tracked for at least two year…

This study tests whether offering small monetary rewards can help people with opioid and stimulant use disorders stay in treatment and avoid drug use. Fifty-six adults starting medication for opioid use disorder at a family medicine clinic will earn incentives for attending appoi…

This study tests whether adding a superficial cervical plexus block to standard care reduces opioid use and pain in children aged 3 months to 18 years undergoing ear surgery (cochlear implant or tympanomastoidectomy). Half the children get the block plus standard care, the other …

This pilot study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. The treatment blocks abnormal blood vessels in the knee to reduce pain and swelling. Twenty participants will be randomly assigned to either receive the …

This study tests whether a group program called Partners4Pain, which teaches mind-body skills like meditation, relaxation, and gentle exercises, can reduce pain and improve daily life for people with chronic back or neck pain. About 376 adults will be randomly assigned to either …

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

This study tests whether giving a thyroid hormone (T3) directly into the lungs can safely improve oxygen levels in adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 68 critically ill patients on ventilators will either receive the hormone or s…

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This study tests a new way of doing electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to target the brain more precisely to reduce side effects like memory loss while still helping with depression. Twenty participants will receive the new…

This study tests whether a 12-week mobile app program can improve thinking skills and motivation in people with early psychosis. About 400 participants already receiving coordinated specialty care will either use the app or continue standard care. Researchers will track changes i…

This study tests a non-invasive device that delivers sound through headphones and gentle electrical pulses to the tongue, aiming to ease tinnitus. Twenty adults with chronic tinnitus will use the device for 60 minutes daily over 12 weeks. The main goal is to see if people find th…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This study watches 300 adults having open abdominal surgery to understand why some get surgical site infections. Researchers will collect samples from the skin and gut during surgery and track patients for 30 days. By comparing those who get infections to those who don't, they ho…

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The go…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study aims to adapt a sleep-improvement program for African American adults who are overweight and sleep less than 6 hours per night. Researchers will test if the program is practical and satisfying for participants. The goal is to reduce health disparities linked to poor sl…

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with social services like housing assistance, food aid, and financial help. About 400 adults with cancer in Minnesota will use the platform for 90 days. Researchers will measure i…

This study aims to develop and test new methods for taking and analyzing MRI images of the body. It involves 500 healthy adults aged 18 and older. Participants will undergo MRI scans using advanced techniques to improve image quality and data analysis. There is no treatment or cu…

This study uses brain imaging to understand why some people with type 1 diabetes lose their ability to sense dangerously low blood sugar. Researchers will temporarily induce low blood sugar in participants and scan their brains to see how glucose levels change. The goal is to lea…

This study looks at how stenting a narrowed aorta (coarctation) changes the heart's workload. Researchers use a special catheter to measure pressure and volume inside the heart before and after stent placement. The goal is to understand if stenting fully improves heart function. …

This study aims to improve magnetic resonance spectroscopy (MRS), a type of brain scan that measures up to 18 different brain chemicals. Researchers are testing new methods at higher magnetic fields (3 to 7 Tesla) to get clearer and more detailed images. The study involves 30 hea…

This study follows 60 adults with Parkinson's disease who are scheduled for deep brain stimulation (DBS) surgery. Researchers will track their brain activity, movement, and thinking skills over time to learn how DBS affects the brain. The goal is to gather information, not to tes…

This study planned to test a special pin for fixing broken collarbones in 50 adults. It aimed to see how well the bone healed and how satisfied patients were. However, the study was withdrawn before any participants were enrolled.

This study tests whether a 4-day Afrocentric sexual health curriculum improves the knowledge, attitudes, and counseling skills of 310 health students in Tanzania. Participants are randomly assigned to take the course or join a waitlist. Researchers measure changes in sexual healt…

This study looks at how different tobacco products, like cigarettes, e-cigarettes, and smokeless tobacco, affect the way skin wounds heal. Researchers will measure skin temperature, blood flow, and signs of inflammation in 60 participants, including a non-smoking group. The goal …

This study was designed to measure DNA damage in cells from the mouth of smokers, vapers, and people who do not use tobacco or nicotine products. The goal was to find which types of damage might be more likely to cause oral cancer. However, the study was withdrawn before any part…

This study compares two teaching methods for children aged 5-9 with developmental language disorder. One method uses only traditional implicit teaching (like imitation and practice), while the other adds explicit rule explanations. Over 111 children will receive 32 sessions targe…

This study was designed to explore how people's vision and brain activity change when they wear colored lenses. Participants would have worn tinted lenses for several days while researchers measured color perception and brain signals. However, the trial was withdrawn before enrol…

This study looks at how exercise training changes the way muscles process fat and sugar, which is linked to insulin resistance and type 2 diabetes. Researchers will study healthy, lean, and overweight participants before and after a 16-week running or yoga program. The goal is to…

This study looks at whether a simple bedside ultrasound can accurately measure body fat and muscle in premature babies in the NICU. Researchers will compare ultrasound results with a standard method called air displacement plethysmography. The goal is to find a safe, easy way to …

This study aimed to find out how many people with trigeminal neuralgia (a severe facial nerve pain condition) also have temporomandibular disorder (TMD), which causes jaw pain. Researchers planned to follow patients from three clinics and test a questionnaire to better diagnose b…

This study aimed to see if a non-invasive brain stimulation technique called TMS could help people with methamphetamine use disorder control their cravings. Researchers planned to recruit 40 adults living in a residential treatment program and give some real stimulation and other…

The PorchLight Project tests whether training senior volunteers can improve care for people with memory loss or Alzheimer's disease. Over 340 volunteers and clients in Minnesota are taking part. The training includes online modules, a course, and monthly check-ins. Researchers wi…

This study looks at whether a blood test can help doctors know if treatment for kidney rejection is working in children who have had a kidney transplant. About 27 kids will give blood samples to check for special markers. The goal is to see if the blood test can predict and monit…

This study tests whether giving doctors real-time feedback from an AI program during colonoscopy helps them find more polyps (adenomas). Over 4,000 participants will have their colonoscopy monitored, and the AI will highlight suspicious areas on the screen. The goal is to see if …

This study planned to test whether a library of real-life intubation videos could help new anesthesia residents learn to intubate more quickly and with less stress. The researchers intended to compare residents who watched the videos with those who did not, measuring success rate…

This study looks at what causes dangerous blood clots in the legs (venous thrombosis) and lungs (pulmonary embolism) in over 21,000 African American and white adults. Researchers are using data from two long-running heart health studies to find patterns and risk factors. The goal…

This study planned to test whether changing the layout and systems of HIV clinics in Uganda could make them feel more private and welcoming, reducing stigma and improving patient retention. Researchers intended to survey patients and staff before and after renovations. However, t…