University Of Minnesota

This study aimed to see if giving a thyroid hormone (T3) directly into the lungs could help people with severe COVID-19 who needed a breathing machine. The trial was planned for adults with COVID-19 and a serious lung condition called ARDS. However, the study was withdrawn before…

This study tests whether empagliflozin, a diabetes medication, is safe and tolerable for overweight adults with cystic fibrosis-related diabetes (CFRD). Eight participants will receive either the drug or a placebo, then switch after a break. The goal is to gather early data for a…

This study tests whether giving a thyroid hormone (T3) directly into the lungs can safely improve oxygen levels and reduce inflammation in people with acute respiratory distress syndrome (ARDS). About 68 adults on ventilators will either receive the hormone or standard care. The …

This study tests whether a combination of two drugs, phentermine and topiramate, can help teens aged 12 to 18 with severe obesity maintain weight loss after a meal replacement program. The body often fights weight loss by increasing appetite and slowing metabolism, making it hard…

This study tests a combination of two weight-loss drugs (phentermine and topiramate) in 13 teenagers aged 12-20 who have both obesity and type 2 diabetes. The goal is to see if the medication can safely lower body mass index (BMI) over 6 months. The drugs are already approved for…

This study follows 433 people with long-term pancreatitis who had surgery to remove the pancreas and transplant their own insulin-making cells. The goal is to see if the surgery reduces pain, improves quality of life, and helps control blood sugar. Researchers will track pain lev…

This study tests a proactive outreach program to help BIPOC adults who smoke quit tobacco. Researchers will use electronic health records to identify smokers and offer culturally tailored support, including counseling and medication. The goal is to reduce smoking rates and relate…

This study tests a program where people with opioid or stimulant use disorders earn small cash rewards for attending clinic visits and providing drug-free urine samples. The goal is to see if this approach helps them stay in treatment and reduce drug use. The study involves 56 ad…

This study tests whether a medication called lisdexamfetamine, combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight. About 44 children will be randomly assigned to receive either the drug or a placebo, along with lifestyle therap…

This study planned to test a special pin (Anser Clavicle Pin) for surgically fixing broken collarbones in 50 adults. The goal was to see how well the bone healed and how satisfied patients were. However, the study was withdrawn before any participants were enrolled, so no results…

This study tests a smartphone-based program called mGlide to help people with high blood pressure manage it better. About 395 participants, including stroke survivors and others at high risk, will use a wireless blood pressure monitor and phone to track their readings. If their n…

This study tested whether a treatment made from healthy gut bacteria (called restorative microbiota therapy) is safe and possible for people with severe colon inflammation caused by cancer immunotherapy. It was designed for patients whose colitis did not improve with steroids. Th…

This study tests a device that plays sounds customized to each person's tinnitus pitch, aiming to make the treatment more comfortable and easier to use. Twenty adults with tinnitus will use the device for 12 weeks, and researchers will measure how often they use it and how satisf…

This study tests a new way to deliver electroconvulsive therapy (ECT) for people with treatment-resistant depression. By placing electrodes on just one side of the head to better target the prefrontal cortex, researchers hope to keep the antidepressant benefits while reducing mem…

This study compares two community-based programs for adults with long-term back or neck pain. One program teaches mind-body skills like mindfulness and cognitive behavioral techniques, while the other focuses on general health and well-being. Participants attend nine weekly sessi…

This study tests a 12-session telehealth program called teleABLE that helps stroke survivors reduce sitting time and improve quality of life. 90 adults who had a stroke within the past year will either get teleABLE or a health education program. Participants wear an activity moni…

This early-stage study tests a smartphone app called NEAT-O that teaches coping skills to people with opioid use disorder who also have anxiety or depression. About 15 adults currently in medication treatment for opioid use will try the app for a few weeks. Researchers will check…

This study is testing whether a WaterPik device with a brush can improve scalp health in people with dandruff, seborrheic dermatitis, or hair loss. About 40 adults will use the device to massage and cleanse their scalp. Researchers will measure changes in flaking and redness over…

This study looks at how placing a stent to open a narrowed part of the aorta (coarctation) changes the heart's workload. Researchers will measure heart pressure and volume before and after the procedure in 21 children and adults. The goal is to understand if stenting fully improv…

This study looks at how repeated low blood sugar (hypoglycemia) changes the brain's ability to sense danger in people with type 1 diabetes. Researchers will use brain scans to measure sugar levels in the brain before and after causing mild low blood sugar episodes. The goal is to…

This study compares two ways of teaching grammar to children aged 5-9 with developmental language disorder. One method uses direct instruction (explicit), while the other relies on natural learning (implicit). The goal is to see which approach works best and for which children. R…

This study aims to develop new ways to take and analyze MRI images of the body. Researchers will test these methods in 500 healthy adults over age 18. The goal is to improve how MRI works, not to treat any disease.

This study looks at how aerobic or yoga training affects the way muscles process fat and sugar, which may influence insulin resistance—a condition that can lead to type 2 diabetes. Researchers will study 64 healthy, lean, or overweight adults before and after a 16-week supervised…

This study aimed to see if giving new anesthesia residents access to a library of real intubation videos would help them learn to place breathing tubes more quickly and with less stress. The plan was to compare their success rates and stress levels to those who learned the usual …

This study aimed to measure DNA damage in mouth cells from daily smokers, daily vapers, and people who never use tobacco or nicotine. Researchers wanted to see which types of damage last longer and might lead to oral cancer. The study was withdrawn before any participants were en…

This study looks at how myofunctional therapy (exercises for the tongue and throat muscles) might help people with obstructive sleep apnea. Thirty adults will use special devices for 3 months while researchers measure muscle pressure during swallowing and breathing. The goal is t…

This study looks at whether training volunteers to visit older adults with memory loss or dementia can improve the volunteers' skills and reduce loneliness in the people they visit. About 342 volunteers and clients in Minnesota are taking part. The training is part of the volunte…

This study looks at whether a special sexual health training program helps health students in Tanzania learn more, feel more confident, and communicate better with patients. About 310 nursing, midwifery, and medical students took part. Researchers measured their knowledge, attitu…

This study looks at how people's vision and brain activity change when they wear colored lenses. Healthy adults with normal vision will wear tinted lenses, and researchers will measure how their perception of color shifts over time. The goal is to understand how the brain learns …

This study looks at whether a blood test can help doctors know if treatment for kidney rejection is working in children who have had a kidney transplant. About 27 kids will give blood samples to check for special markers. The goal is to see if these markers can predict rejection …

This study aimed to see if changing the look and feel of HIV clinics in Uganda could reduce stigma and make patients feel more welcome. Researchers planned to update clinic systems and physical spaces to improve privacy and friendliness. The study was withdrawn before any partici…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with social services like housing assistance, food support, and financial aid. About 400 adults receiving cancer treatment or in survivorship at Minnesota clinics will use the pla…

This study aimed to find out how many people with trigeminal neuralgia also have a jaw joint disorder called TMD. Researchers planned to follow patients from three clinics and test a questionnaire's accuracy. However, the study was withdrawn before enrolling anyone, so no results…

This study tests whether giving doctors real-time feedback during colonoscopy helps them find more polyps, which can prevent colorectal cancer. Over 4,000 doctors will participate. The goal is to see if this simple approach improves the quality of the exam.

This study looks at how different tobacco products, like cigarettes, e-cigarettes, and smokeless tobacco, affect the way skin wounds heal. Researchers will measure skin temperature, blood flow, and signs of inflammation in 60 participants, including a non-smoking group. The goal …

This study looks at whether the Club 25 program, where students pledge to donate blood 25 times in their life, can increase blood donations compared to the usual way of recruiting donors. About 35,000 students from 30 secondary schools in Malawi will take part, with half the scho…

This study follows 60 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery. Researchers will collect detailed information on brain activity, thinking skills, and movement before, during, and after the procedure. The goal is to learn how DBS affe…

This study looks at what causes dangerous blood clots in the legs (venous thrombosis) and lungs (pulmonary embolism) by following over 21,000 African American and white adults from two large health studies. Researchers are tracking participants over time to find patterns and risk…

This study aimed to see if a non-invasive brain stimulation technique called cTBS could reduce cravings in people recovering from methamphetamine use disorder. Researchers planned to enroll 40 adults living in a residential treatment program and use brain scans to measure changes…

This study explores a new program that supports physical activity in the first 6 weeks after a stroke. About 25 participants will use a Fitbit to track steps and meet weekly with an occupational therapist. The goal is to see if people stick with the program and find it helpful, n…

This study aims to improve magnetic resonance spectroscopy (MRS) techniques for measuring brain chemicals at high magnetic fields (3 to 7 Tesla). Researchers will test new methods on 30 healthy adults to get clearer and more detailed images. Since this is technical development, n…

This study looks at how the liver burns fat and produces sugar in people with NASH (a serious fatty liver disease) who are planning to have weight-loss surgery. Researchers will use special scans to measure these liver functions before and after surgery. The goal is to understand…

This study looks at whether a bedside ultrasound can accurately measure body fat and muscle in healthy premature babies in the NICU. Researchers will compare ultrasound results with other proven methods to see if it can track weekly changes in body composition. The goal is to hel…

This study looks at whether forming local committees made up of hospital staff, community members, and county leaders can help get blood to patients who need transfusions in Kenya. Researchers are testing this approach in three different counties. The goal is to see if these comm…