Scientists probe why some people lose vaccine protection after yellow fever shot
NCT ID NCT04269265
First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 23 times
Summary
This study looked at how past infections and damage to lymph nodes might weaken the body's long-term immune response to the yellow fever vaccine. Researchers enrolled 43 healthy adults in Uganda and Minnesota, collecting blood and lymph node samples before and after vaccination. The goal was to understand why some people may not develop lasting protection, which could help improve future vaccines.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Joint Clinical Research Centre
Kampala, 10005, Uganda
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
Conditions
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