New hope for FSGS patients: preemptive treatment may prevent kidney disease return

NCT ID NCT03763643

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This early-phase study tested whether giving a combination of plasmapheresis (a blood-filtering procedure) and the drug rituximab before or at the time of kidney transplant could prevent focal segmental glomerulosclerosis (FSGS) from coming back. The trial enrolled 21 children and adults who had FSGS and were getting a kidney transplant. The main goal was to see if this approach was feasible, with secondary goals of checking how well the kidney worked one year later.

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Contacts and locations

Locations

  • Children's Hospital of Colorado

    Aurora, Minnesota, 80045, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Cincinnati Children's Hospital

    Cincinnati, Ohio, 45229, United States

  • Duke University

    Durham, North Carolina, 27708, United States

  • Lurie Children's Hospital

    Chicago, Illinois, 60611, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • University of Alabama

    Tuscaloosa, Alabama, 35487, United States

  • University of California at Davis

    Davis, California, 95616, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45221, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

Conditions

Explore the condition pages connected to this study.