Two drugs better than one for kids with high blood pressure in lungs?

NCT ID NCT04039464

Completed Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed phase 3 trial tested whether giving children with pulmonary hypertension two drugs (sildenafil and bosentan) from the start works better than just one drug (sildenafil alone). The study enrolled 28 children who had not yet received long-term treatment. Researchers measured how well the children could do daily activities after 12 months and tracked any worsening of their condition. The goal is to find the best way to control this serious lung disease in kids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sildenafil (Revatio) and Bosentan (Tracleer)
What this could lead to: If it works, this could show that starting with two drugs early is better than one for controlling pediatric pulmonary hypertension and improving daily life.
What could go wrong: This is a small, completed trial with only 28 children, so results may not apply to all kids. The drugs can have side effects like liver problems or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary arterial hypertension pulmonary hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC PULMONARY HYPERTENSION

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Columbia University Medical Center

New York, New York, 10032, United States
Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
Johns Hopkins Medical Institutions

Baltimore, Maryland, 21287, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
New York Medical College

Valhalla, New York, 10595, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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