Two drugs better than one for kids with high blood pressure in lungs?
NCT ID NCT04039464
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed phase 3 trial tested whether giving children with pulmonary hypertension two drugs (sildenafil and bosentan) from the start works better than just one drug (sildenafil alone). The study enrolled 28 children who had not yet received long-term treatment. Researchers measured how well the children could do daily activities after 12 months and tracked any worsening of their condition. The goal is to find the best way to control this serious lung disease in kids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sildenafil (Revatio) and Bosentan (Tracleer)
What this could lead to
If it works, this could show that starting with two drugs early is better than one for controlling pediatric pulmonary hypertension and improving daily life.
What could go wrong
This is a small, completed trial with only 28 children, so results may not apply to all kids. The drugs can have side effects like liver problems or low blood pressure.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
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Johns Hopkins Medical Institutions
Baltimore, Maryland, 21287, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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New York Medical College
Valhalla, New York, 10595, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States