New drug shows promise for easier breathing during exercise in PAH patients
NCT ID NCT04266197
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a single dose of an investigational drug called RT234 in 42 adults with pulmonary arterial hypertension (PAH), a condition that makes it hard to exercise due to high blood pressure in the lungs. The main goals were to see if the drug is safe and if it improves exercise capacity, measured by tests like cycling with breathing analysis and a six-minute walk. Researchers also tracked any side effects and changes in shortness of breath.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ascension Seton Medical Center Austin
Austin, Texas, 78705, United States
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Augusta University
Augusta, Georgia, 30912, United States
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Aurora St. Luke's Medical Center
Milwaukee, Wisconsin, 53215, United States
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Baylor Scott and White Institute
Dallas, Texas, 75246, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Mayo Clinic
Rochester, Minnesota, 20010, United States
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MedStar Heart and Vascular Institute
Washington D.C., District of Columbia, 20010, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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Norton Health
Louisville, Kentucky, 40202, United States
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Ochsner Louisiana State University Health
Shreveport, Louisiana, 71103, United States
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The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, 90502, United States
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The Ohio State University
Columbus, Ohio, 43210, United States
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The University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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Tufts University
Boston, Massachusetts, 02111, United States
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UC Davis
Sacramento, California, 95618, United States
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UCLA
Los Angeles, California, 90024, United States
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University Hospital
Cleveland, Ohio, 44106, United States
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University of Alabama
Birmingham, Alabama, 35294, United States
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University of Arizona
Tucson, Arizona, 85724, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of New Mexico
Albuquerque, New Mexico, 87131, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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University of Southern California
Los Angeles, California, 90033, United States
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Virginia Commonwealth University
Richmond, Virginia, 23284, United States
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Washington University
St Louis, Missouri, 63110, United States