New drug shows promise for easier breathing during exercise in PAH patients

NCT ID NCT04266197

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 25 times

Summary

This study looked at whether a single dose of an inhaled drug called RT234 can safely help people with pulmonary arterial hypertension (PAH) exercise longer and feel less short of breath. 42 adults with PAH took the drug and then did exercise tests. The main goals were to check safety and see if the drug improved oxygen use during exercise and walking distance.

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Contacts and locations

Locations

  • Ascension Seton Medical Center Austin

    Austin, Texas, 78705, United States

  • Augusta University

    Augusta, Georgia, 30912, United States

  • Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Baylor Scott and White Institute

    Dallas, Texas, 75246, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Mayo Clinic

    Rochester, Minnesota, 20010, United States

  • MedStar Heart and Vascular Institute

    Washington D.C., District of Columbia, 20010, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • Norton Health

    Louisville, Kentucky, 40202, United States

  • Ochsner Louisiana State University Health

    Shreveport, Louisiana, 71103, United States

  • The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • The University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • Tufts University

    Boston, Massachusetts, 02111, United States

  • UC Davis

    Sacramento, California, 95618, United States

  • UCLA

    Los Angeles, California, 90024, United States

  • University Hospital

    Cleveland, Ohio, 44106, United States

  • University of Alabama

    Birmingham, Alabama, 35294, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27514, United States

  • University of Southern California

    Los Angeles, California, 90033, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23284, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.