Cardiovascular disorder

This study tested a device called the Amplatzer Amulet, which is implanted to close a part of the heart and reduce stroke risk in people with non-valvular atrial fibrillation who cannot take blood thinners. The study enrolled 50 participants in China and tracked safety and effect…

This phase 2 trial tested an experimental biologic called KER-012 in 113 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. Participants received either KER-012 or a placebo as a shot every 4 weeks, on top of their usual PAH…

This study tested four different cooling treatments for newborns who suffered brain injury from lack of oxygen at birth. The treatments varied in how low the body temperature was lowered (33.5°C or 32.0°C) and how long cooling lasted (72 or 120 hours). The goal was to see which a…

This study tested whether a 14-day course of hydrochlorothiazide (a water pill) could prevent high blood pressure from returning after delivery in women with preeclampsia or gestational hypertension. Over 450 women were planned, but the trial was stopped early. The main goals wer…

This study compared a device called Aquadex, which filters excess fluid from the blood, to standard IV diuretics in 167 hospitalized heart failure patients with fluid overload. The goal was to see which method better prevented heart failure events like rehospitalization. However,…

This study tested an intravenous antiplatelet drug called PRT060128 in 70 people having a severe heart attack (STEMI). The goal was to see if giving the drug before emergency artery-opening treatment improved blood flow and was safe. The trial was terminated early, so the full re…

This study tested an experimental drug called BI 765845 in 160 adults who had just had a heart attack. Participants received either the drug or a placebo, and doctors measured heart damage using MRI scans over 3 months. The trial was terminated early, so it is unclear if the drug…

This study compared two treatments to reduce bleeding after heart valve surgery: a concentrated clotting drug (PCC) versus fresh frozen plasma (FFP). The trial planned to enroll 476 adults undergoing elective valve surgery. It was terminated early, so the full comparison was not …

This early study tested a new device called the Cardiovalve Transfemoral Mitral Valve System in just one person with severe mitral regurgitation who was too high-risk for surgery. The device is inserted through a vein in the leg to replace the faulty mitral valve without open-hea…

This study tested whether a 6-month program of nurse-led phone calls could help women with uncontrolled high blood pressure take their medication as prescribed. The program included 7 phone calls to address barriers to medication adherence. Only 14 women enrolled before the study…

This study compared two antiplatelet drug regimens after transcatheter aortic valve implantation (TAVI) for aortic stenosis. One group received ticagrelor alone, the other received aspirin plus clopidogrel. The goal was to see which caused fewer serious complications like bleedin…

This study tested whether adding timolol gel to pulsed dye laser treatment could improve results for port wine stains on children's faces. Twenty-five children aged 6 months to 18 years were enrolled, but the study was stopped early. The goal was to see if the combination led to …

This trial tests a special pacemaker called the Moderato System in people who need a pacemaker and have high blood pressure that is hard to control with medication. The device is implanted like a regular pacemaker and may help lower blood pressure by adjusting the heart's pacing.…

This study looked at whether the drug riociguat could improve right heart size and function in people with two types of pulmonary hypertension (PAH and CTEPH). It planned to enroll 30 adults, but was terminated early, so results are limited. The goal was to use echocardiograms to…

This trial tests a special pacemaker-like device, the Moderato System, designed to lower blood pressure in people who have resistant hypertension and already need a dual-chamber pacemaker. Participants are randomly assigned to have the device's blood-pressure-lowering feature tur…

This study follows 197 people who previously had a procedure called TCAR to treat carotid artery disease. Researchers will check for strokes, deaths, and whether the artery narrows again over 2 to 5 years. The goal is to see how well the treatment holds up over time.

This study tested a low dose of the drug bevacizumab (Avastin) against standard laser treatment for retinopathy of prematurity, an eye disease that can blind premature infants. Sixteen babies with severe disease were enrolled. The goal was to see if the drug could control the dis…

This study tested a dramatic approach: rapidly cooling trauma patients whose hearts had stopped from severe bleeding. Doctors flushed ice-cold saline into the aorta to induce deep hypothermia, then performed emergency surgery to stop the bleeding before slowly rewarming the patie…

This early study tested a new cell therapy called LUCAR-G79 in just 3 adults with severe autoimmune diseases that did not respond to standard treatments. The therapy uses specially engineered immune cells to target and potentially calm the overactive immune system. The main goals…

This trial tests whether performing balloon aortic valvuloplasty without the blood thinner heparin reduces serious bleeding and blood vessel complications. About 94 adults with severe, symptomatic aortic stenosis will be randomly assigned to receive either heparin or a placebo du…

This study tests whether injections of cells from donated human placentas can help heal foot ulcers in people with diabetes. The trial includes patients with and without peripheral artery disease, a common complication that slows healing. Participants receive either the cell trea…

This study tested two different proton therapy schedules for people with large choroidal melanomas (eye cancer) that would normally require removal of the eye. The goal was to see if a gentler radiation schedule could control the tumor and avoid severe side effects, allowing pati…

This study tests whether using a special tube (EZ-Blocker) to collapse one lung during heart bypass surgery can reduce fluid buildup and the need for chest drains. The trial includes adults having planned coronary artery bypass surgery that uses the internal thoracic artery. The …

This study tested whether the anti-inflammatory drug colchicine could prevent nerve damage in the heart after a heart attack. About 54 adults who had a first heart attack and underwent artery-opening treatment were given colchicine or a placebo for one month. The trial was termin…

This study tested whether repeatedly inflating and deflating a blood pressure cuff on the arm (remote ischemic conditioning) could improve recovery in 458 people who had a severe stroke caused by a blocked artery in the brain. The goal was to see if this simple, non-drug treatmen…

This early-phase trial tested giving chemotherapy drugs directly into the brain's arteries to treat two rare types of choroid plexus tumors. The goal was to shrink the tumor before a second surgery. Only 1 person was enrolled, and the study was terminated, so we have very little …

This study looked at how different amounts of potassium supplements affect blood pressure in adults with high blood pressure. Researchers aimed to find the best potassium level to help lower blood pressure. The study was stopped early and included 25 participants.

This Phase 3 trial tested the drug sotatercept in 321 people newly diagnosed with intermediate- or high-risk pulmonary arterial hypertension (PAH). Participants received either sotatercept or a placebo added to their usual PAH therapy. The goal was to see if sotatercept could del…

This phase II trial tested the drug everolimus in 11 people with classic or endemic Kaposi's sarcoma, a rare skin cancer linked to a virus. The goal was to see if the drug could shrink tumors after 6 months. The study was terminated early, so the full results are not available.

This study aimed to see if combining surgical and catheter ablation (hybrid therapy) works better than standard catheter ablation alone for people with persistent atrial fibrillation. The trial was terminated after enrolling only 7 participants, so no meaningful conclusions can b…

This study looked at two ways to manage older patients (80+) who had a mild type of heart attack (NSTEMI). One group got routine angiography (an invasive look at the heart's arteries), while the other group first had a non-invasive imaging test (SPECT or stress echo) and only got…

This study tested if the beta-blocker propranolol could control the growth of infantile hemangiomas (non-dangerous blood vessel growths) in babies under 4 months old. The trial was terminated early and only enrolled 14 infants. The goal was to measure changes in hemangioma thickn…

This study tested an experimental drug called MYK-224 in 18 adults with a type of heart disease that makes the heart muscle too thick and blocks blood flow. The goal was to see if the drug is safe and helps reduce symptoms. The trial was stopped early, so results are limited.

This study looked at the safety and effectiveness of Pradaxa oral pellets in children aged 3 months to 12 years who had blood clots (venous thromboembolism). The goal was to see how often bleeding or new clots occurred in real-world use. Only 5 children were enrolled before the s…

This study tested whether giving extra oxygen directly to the heart for 60 minutes after angioplasty could improve outcomes for people having a major heart attack. Only 17 patients were enrolled before the study was stopped early. The goal was to see if this oxygen therapy could …

This trial tested a new drug called MT1002 in 6 people having a heart procedure (PCI) after a heart attack. The goal was to see if it could safely control blood clotting. However, the study was stopped early, so we don't have enough information to know if the drug works or is saf…

This study tested an experimental drug called CRD-4730 in people with a rare inherited heart rhythm disorder (CPVT) that can cause dangerous fast heartbeats. Seven adults received two different doses of the drug and a placebo to check safety and how the body processes it. The stu…

This study aimed to see if sodium lactate could improve blood flow in the brain after a severe type of stroke called subarachnoid hemorrhage. Only 3 patients were enrolled before the study was stopped early. The goal was to measure changes in brain blood flow using a special scan…

This study looked at the long-term safety of an inhaled drug called treprostinil in people who have both pulmonary hypertension (high blood pressure in the lungs) and COPD. It included 41 adults who had already completed a previous study. The trial was terminated early, and the m…

This early-stage study tested a new drug called SAR445514, which helps the body's natural killer (NK) cells attack cancer cells in people with multiple myeloma or light-chain amyloidosis that had returned or stopped responding to other treatments. The study was terminated early, …

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This study aimed to find the best dose of MCI-186 for people who had an acute ischemic stroke. It compared a new way of giving the drug (a bolus followed by continuous infusion) with the standard twice-daily dosing for 14 days. The trial was terminated early and included only 17 …

This study tested an experimental drug called AMAG-423 (Digoxin Immune Fab) in pregnant women with severe preeclampsia, a dangerous condition of high blood pressure during pregnancy. The goal was to see if the drug could reduce serious health problems in babies, such as bleeding …

This study looked at whether giving a powerful cholesterol-lowering drug (evolocumab) very early after a major heart attack could help the heart pump better and prevent long-term damage. About 119 adults who were having a heart attack and scheduled for a procedure to open blocked…

This study tested whether giving a clot-busting drug (tenecteplase or alteplase) within 4.5 hours of an eye stroke could restore vision. Eye stroke, or central retinal artery occlusion, is a blockage in the eye's main artery that often causes permanent vision loss. The trial aime…

This study compared two different doses of epinephrine (0.5 vs 1.0 mcg/kg) given to children in the intensive care unit for life-threatening low blood pressure. The goal was to see which dose raised blood pressure more effectively. Only 15 children were enrolled before the study …

This early study tested a device that is surgically placed in the belly to continuously remove extra fluid from the body. It was designed for people with advanced heart failure whose bodies no longer respond to water pills. Only 2 patients were enrolled before the study was stopp…

This study compared two types of heart ablation for people with paroxysmal atrial fibrillation (AFib). One group received standard pulmonary vein isolation, while the other also had the back wall of the left atrium isolated. Both used a newer technique called pulsed-field ablatio…

This study tested a single injection of avoralstat into the eye for people with diabetic macular edema, a condition that causes vision loss in diabetes. Only 3 adults took part before the study was stopped early. The main goal was to check safety and see if the drug might help re…

This study tested two different combinations of eye drops to lower eye pressure in people with open-angle glaucoma or ocular hypertension. The goal was to see which combination worked better over 90 days. The study was stopped early and included 28 participants.

This study looked at whether taking high doses of statins for two weeks before carotid artery surgery could prevent memory and thinking problems after the operation. It included 31 adults with severe carotid artery narrowing. The study was stopped early, so the results are limite…

This study looked at whether using two types of 'ischemic conditioning' (brief cycles of blood flow restriction and release) could improve outcomes for people having a major heart attack. One method used a blood pressure cuff on the arm, the other used a balloon inside the heart …

This study looked at whether people who had heart surgery for endocarditis (a serious heart infection) related to IV drug use could safely switch from IV antibiotics to oral pills after just two weeks. The goal was to see if this shorter hospital stay was safe and effective. The …

This study tested two immunotherapy drugs (durvalumab and tremelimumab) in people with liver cancer who were waiting for a liver transplant. The goal was to see if the drugs could safely shrink tumors and control the disease without causing organ rejection. Only 8 people took par…

This study tested whether taking the blood thinner rivaroxaban for 7 days after heart catheterization via the wrist could prevent the wrist artery from becoming blocked. About 930 adults were planned, but the trial was stopped early. The main goal was to see if the artery stayed …

This study tested whether personalizing blood-thinning drugs based on a patient's genetics and risk factors could reduce bleeding after a heart attack. It enrolled 39 patients who had already been on standard dual therapy for a year. The trial was terminated early, so the finding…

This study compared two approaches to reduce shocks in people with an implantable defibrillator (ICD) who had dangerous heart rhythms. One group received antiarrhythmic drugs, the other had a catheter ablation procedure. The trial was a small pilot with only 3 participants and wa…

This phase 2 trial tested KVD824, an oral pill, to prevent swelling attacks in people with hereditary angioedema types I and II. The study planned to compare three doses against a placebo over several months. However, the trial was terminated early with only 33 participants, so t…

This phase 2 study tested whether a single infusion of a patient's own blood stem cells (CLBS16) could ease chest pain in people with coronary microvascular dysfunction, a condition where the heart's tiny blood vessels don't work properly. The trial enrolled 34 adults with freque…

This study compared two drugs, obinutuzumab and rituximab, for treating a rare autoimmune disease that inflames blood vessels (ANCA-associated vasculitis). The goal was to see if obinutuzumab could help more patients achieve remission and clear disease markers. However, the trial…

This study looked at whether a procedure called renal denervation could help people with recurrent atrial fibrillation (an irregular heartbeat) that keeps coming back even after standard treatment. The procedure uses energy to calm certain nerves near the kidneys. Only 6 people t…

This study tested whether adding acetaminophen to standard ibuprofen treatment could better close a blood vessel (ductus arteriosus) that stays open too long in very premature infants. The trial was planned for preterm babies born at or before 27 weeks and 6 days who needed breat…

This study tested whether pacing three spots in the heart instead of the usual two could improve cardiac resynchronization therapy (CRT) for people with heart failure. About 30% of patients don't respond well to standard CRT. The trial planned to enroll 36 adults with severe hear…

This study looked at whether long-term treatment with vitamin C+E and statins could reduce artery spasms and plaque buildup in people with variant angina, a type of chest pain. The trial planned to enroll 320 adults aged 30 and older, but it was terminated early. The main goal wa…

This study tested whether a single dose of the drug abciximab given directly into the heart artery works as well as the standard approach of a dose into a vein followed by a 12-hour infusion. The goal was to reduce heart muscle damage in people having their first non-ST elevation…

This study looked at whether adding the drug pioglitazone to a keyhole brain surgery (MIPS) could help people recover from a severe bleeding stroke. Only one person took part before the study was stopped early. The goal was to see if the combination was safe and helped clear the …

This study tested whether hydroxychloroquine, a drug used for lupus and arthritis, could help control ANCA vasculitis—a group of autoimmune diseases that cause blood vessel inflammation. Adults with mild disease activity were randomly assigned to receive hydroxychloroquine or a p…

This study tested a new device called Envi™-SR for removing blood clots in people having a severe ischemic stroke. The goal was to see if it works as well as devices already approved by the FDA. However, the trial was stopped early after enrolling only 12 people, so we don't have…

This early-phase trial tested OMX-0407, a new drug that blocks certain enzymes, in 68 adults with advanced solid tumors that had stopped responding to other treatments. The study aimed to find a safe dose and check if the drug could shrink tumors. However, the trial was terminate…

This study tested whether a once-daily dose of Torsemide (a water pill) works as well as the standard twice-daily Furosemide in heart failure patients. The goal was to see how much sodium the body gets rid of and if body weight changes. The study was stopped early and included 20…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This study tested a device called the BlueLeaf System to fix faulty valves in leg veins of people with chronic venous insufficiency (CVI). The goal was to see if it could safely reduce backward blood flow and improve symptoms. Only 14 people took part before the trial was stopped…

This phase 3 trial tested a new drug, abelacimab, against a standard blood thinner (dalteparin) to prevent dangerous blood clots from returning in people with gastrointestinal or genitourinary cancers. The study enrolled 417 adults with advanced cancer and a recent clot. It was t…

This early-stage trial tested an oral drug called TNO155, alone or with another drug (nazartinib), in 227 adults with advanced solid tumors like lung cancer, melanoma, and head/neck cancer. The main goal was to check safety and find the right dose. The study was terminated early,…

This study looked at a hybrid approach for treating multiple blocked heart arteries: a minimally invasive bypass for the main artery plus stents for others. Only 6 people took part before the study was stopped early. The goal was to see if this combination is safe and effective i…

This study tested a medical device that freezes small areas of heart tissue to treat atrial fibrillation (AFib) and related irregular heartbeats. The goal was to see if the procedure safely stops abnormal rhythms for at least 12 months. The study enrolled 91 people, but was termi…

This study tested a drug called IgPro20 (HIZENTRA) to see if it could help people with post-COVID POTS, a condition that causes a rapid heart rate and dizziness when standing. The trial was stopped early after enrolling only 16 adults. The goal was to see if the drug could reduce…

This study tested a new steerable guidewire called SmartGUIDE for treating unruptured brain aneurysms. The wire has a bendable tip that doctors can control during the procedure, potentially making it easier to reach the aneurysm. Only 5 people took part before the study was stopp…

This study tested whether taking people with severe stroke symptoms directly to the angio-suite for clot removal, instead of first doing a CT or MRI scan, leads to better recovery at 3 months. About 120 adults aged 18-85 with severe stroke were randomly assigned to either direct …

This trial tested whether giving two quick electrical shocks instead of one could better restore a normal heart rhythm in people with atrial fibrillation. It focused on patients with factors that make standard shock treatment less likely to work, such as obesity or lung disease. …

This study tested a drug called edaravone dexborneol (Sanbexin IV) in 80 people who had a brain bleed (intracerebral hemorrhage). The goal was to see if it is safe and helps recovery when added to standard care. The trial was stopped early, so the results are limited and more res…

This study looked at how well the DiamondTemp ablation system controls atrial fibrillation (a type of irregular heartbeat) over three years. It included 84 adults with paroxysmal AF who had not responded to medication. The study was terminated early, so the full results are not a…

This early-stage study tested a new oral drug called K9 for diabetic macular edema, a condition that causes vision loss in people with diabetes. The trial was stopped early and only enrolled one person. The main goal was to check safety and measure changes in retinal swelling and…

This study tested whether adding anakinra, an anti-inflammatory drug, to standard steroid treatment could lower relapse rates in people with giant cell arteritis, a blood vessel disease. The trial planned to include 70 adults over 50 but was stopped early with only 30 participant…

This phase 2 trial tested the drug lenalidomide in 12 people with HIV who had Kaposi sarcoma, a type of cancer. Participants took lenalidomide pills for 21 days each month. The study aimed to see if the drug could shrink tumors, but it was stopped early, so the results are not co…

This study looked at the long-term safety and effectiveness of the STREAMLINE® Surgical System in people with open-angle glaucoma. It included 17 patients who had already taken part in an earlier trial of the same device. The goal was to see if the device continued to safely lowe…

This study looked at the long-term safety and effects of a procedure called renal denervation in 9 patients with resistant hypertension (high blood pressure that doesn't respond to multiple medications). The procedure uses a device to disrupt certain nerves in the kidney arteries…

This pilot study compared a heart ablation procedure (pulmonary vein isolation) to standard medications for managing atrial fibrillation in people with heart failure with preserved ejection fraction. Only 13 participants were enrolled before the study was terminated early. The ma…

This study tested a special balloon that uses sound waves (shockwaves) to crack open hard calcium blockages in the leg arteries of people with critical limb ischemia, a condition where poor blood flow can lead to pain, wounds, or even amputation. The goal was to see if the balloo…

This study looked at whether taking a daily low-dose aspirin could help people with chronic kidney disease avoid their first heart attack or stroke. Over 4,600 participants were randomly assigned to take aspirin or receive usual care. The trial was stopped early, and the final re…

This study tested a new way to manage blood pressure in new mothers with severe postpartum preeclampsia. Participants received standard blood pressure medications, but one group had personalized blood pressure targets based on real-time brain monitoring. The goal was to keep bloo…

This study looked at two types of implantable cardioverter defibrillator (ICD) leads in children and patients with congenital heart disease. The goal was to see which lead type lasts longer without breaking and is easier to remove if needed. The trial was terminated early, so res…

This study looked at whether using a combination of weight-loss medications could help people with obesity lose weight and improve the health of their blood vessels. It involved 128 adults aged 40-75 who were obese and had at least one heart risk factor. The study was stopped ear…

This phase 2 trial tested whether using ultrasound and microbubbles (sonothrombolysis) alongside standard clot-busting drugs could help restore blood flow in people having a severe heart attack. The study planned to enroll 41 participants but was terminated early. The main goal w…

This study tested whether checking blood clotting levels every week with a small finger-prick device is better than the usual monthly lab test for elderly nursing home residents on blood thinners. The goal was to see which method keeps patients in the safe therapeutic range longe…

This study looked at whether fremanezumab (Ajovy), an FDA-approved monthly injection for migraine prevention, could also improve sleep in people with migraines. Researchers planned to track 22 participants over 4 months, comparing their migraine days and sleep quality before and …

This study tested a new blood thinner, abelacimab, against the standard drug apixaban in about 1,150 people with cancer who had a blood clot. The goal was to see which drug better prevented new clots and caused less bleeding. The study was stopped early, but the results may still…

This study tested a drug called inotersen in 31 people with a rare condition where a faulty protein builds up in the heart, causing damage. The drug is designed to lower levels of that protein. The trial was stopped early, so it's unclear if it works, but researchers hoped to see…

This study tested whether a wearable device and digital care plan from the American Heart Association could help people with systolic heart failure. Participants wore the device for 90 days while their care team monitored their data. The trial was terminated early and only enroll…

This study looked at whether screening people for high platelet reactivity (a condition where blood clots easily) before leg artery procedures could improve outcomes. It involved 31 adults with peripheral artery disease who were scheduled for angioplasty or stenting. The trial wa…

This study tested whether a single high dose (2000 mg) of the heart medication amiodarone, taken by mouth, could safely and quickly restore normal heart rhythm in people with acute atrial fibrillation. The trial planned to include both hospital and outpatient settings, but was te…

This study tested an investigational drug called LY3540378 in 332 adults with worsening chronic heart failure where the heart pumps normally but doesn't fill properly (HFpEF). The goal was to see if the drug could improve heart function and safety compared to a placebo. The trial…

This study tested a drug called levosimendan to see if it could help people with severe heart failure successfully come off a temporary heart-lung machine (ECLS). The trial planned to include 82 adults who were ready to try weaning off the machine. Half would get the drug and hal…

This early-phase trial tested a new therapeutic vaccine (EO2401) combined with the immunotherapy drug nivolumab in 70 people with advanced adrenocortical carcinoma or malignant pheochromocytoma/paraganglioma. The goal was to see if the combination is safe and can shrink tumors or…

This study looked at the long-term safety of the drug LTP001 in people with pulmonary arterial hypertension (PAH), a serious lung condition. It was an open-label extension for patients who had completed a previous study. However, the study was terminated early, and no one reached…

This study tested an experimental drug called XXB750 in 136 people with heart failure. The goal was to see if it could improve heart function and symptoms. The trial was terminated early, so the full results are not available.

This early-phase trial tested a single infusion of IMPT-514, a personalized CAR T cell therapy, in 3 adults with severe lupus, vasculitis, or inflammatory myopathy that did not respond to standard treatments. The goal was to check safety and see if the therapy could reset the imm…

This study looked at a device called the Pipeline Flex Embolization Device with Shield Technology to treat ruptured brain aneurysms that are hard to fix with surgery or coils. The goal was to see if it could safely block the aneurysm and prevent rebleeding. The study was stopped …

This early-stage trial tested a modified virus (VSV-IFNbetaTYRP1) in 12 patients with advanced melanoma that had spread or could not be removed by surgery. The virus was designed to infect and kill melanoma cells while also boosting the immune system's attack. The main goals were…

This early-stage trial tested the safety of a new drug called AZD0233 in 84 healthy adults aged 18 to 50. The drug is being developed for dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Participants received either the drug or a placebo, and researc…

This study tested whether kidney transplant recipients with high blood pressure could better control their condition by monitoring their blood pressure at home, compared to standard clinic visits. The trial planned to enroll many participants but was stopped early after only 21 p…

This early-stage study tested a combination of two drugs, niraparib and dostarlimab, in children and teens (ages 6 months to 17 years) with solid tumors that had come back or were not responding to treatment. The goal was to find a safe dose and see if the drugs could shrink tumo…

This study tested the drug riociguat in people with early pulmonary vascular disease, a condition where blood vessels in the lungs narrow, making the heart work harder. The trial included 35 adults with connective tissue disease or an inherited form. Participants received either …

This early-phase trial tested two immunotherapy drugs, ipilimumab and nivolumab, in people with HIV who had advanced solid tumors or Hodgkin lymphoma that had spread or come back. The goal was to find the safest dose and see if the combination could shrink tumors. The study was t…

This study tested a gene therapy called SRP-9003 for people with limb-girdle muscular dystrophy type 2E (LGMD2E), a rare genetic disease that causes muscle weakness. The treatment aimed to deliver a working gene to muscle cells to help them produce a missing protein. Only 6 peopl…

This study tested a single dose of an experimental antibody called REGN5381 in 89 people with chronic heart failure and reduced pumping ability. The goal was to check safety, how the drug moves in the body, and its effects on heart stress markers. The trial was terminated early, …

This pilot study tested three common blood pressure medications—amlodipine, chlorthalidone, and losartan—in 36 young adults aged 18-40 with hypertension. Participants took the drugs at home and monitored their blood pressure regularly. The goal was to see which drug works best an…

This study tested an experimental drug called LTP001 in 47 people with pulmonary arterial hypertension (PAH), a condition where high blood pressure damages the arteries in the lungs. The goal was to see if LTP001 could improve blood flow and exercise ability. However, the trial w…

This early-phase trial tested a radioactive drug designed to seek out and destroy cancer cells in people with advanced solid tumours that had stopped responding to other treatments. The drug targets a protein called IGF-1R found on many cancer cells. The study aimed to find a saf…

This early-phase study tested a sirolimus (rapamycin) cream applied directly to skin lesions in children with vascular anomalies. The goal was to see if the cream could safely reduce pain, bleeding, and lesion size without the side effects of oral medication. Only 5 children were…

This study tested a medical glue called VenaSeal against heat therapy or surgery for treating venous reflux, a condition where leg veins don't pump blood properly. About 500 adults with early to advanced vein disease took part. The goal was to see which method patients liked more…

This early study tested a new procedure called SESAME that uses a wire threaded through blood vessels to slice away excess heart muscle in people with hypertrophic cardiomyopathy. Only one adult participated before the study was terminated. The goal was to see if the technique co…

This study looked at the long-term safety of dexpramipexole in adults with severe eosinophilic asthma. Participants had already completed earlier phase 3 trials. The goal was to track side effects and asthma control over time. However, the study was terminated early, which may li…

This study aimed to see if the antibiotic minocycline could improve outcomes after a stroke. Participants were to receive either standard care plus minocycline pills for five days, or standard care alone. However, the trial was stopped early after enrolling only 2 people, so no m…

This study tested a daily pill called dexpramipexole in 654 people with severe eosinophilic asthma, a type of asthma linked to high levels of certain white blood cells. The goal was to see if the drug could reduce severe asthma attacks over a year. However, the trial was terminat…

This small study tested a drug called PL-3994 in 15 people with a type of heart failure where the heart pumps normally but doesn't relax properly. The goal was to see if the drug improved heart function and if effects differed between men and women. The trial was terminated early…

This phase 3 study tested an experimental drug called birtamimab in 208 people with advanced AL amyloidosis, a rare disease where abnormal proteins damage organs like the heart. Participants received either birtamimab or a placebo, plus standard chemotherapy. The goal was to see …

This Phase 3 trial tested dexpramipexole, an oral drug, in over 1,000 people with severe eosinophilic asthma that was not well controlled by standard treatments. The goal was to see if it could reduce severe asthma attacks over a year. However, the study was terminated early, so …

This study tested a smartphone-based program to help stroke survivors with high blood pressure lower their risk of another stroke. The program involved tracking blood pressure and getting tailored reminders. The study was terminated early, so results are limited.

This study tested whether anti-VEGF injections into the eye could help treat Coats disease, a rare condition that causes abnormal blood vessels and fluid buildup in the retina, potentially leading to blindness. The trial included 18 people with early-stage Coats disease who had n…

This study tested a device called Efferon LPS that filters blood during heart surgery when a heart-lung machine is used. The goal was to see if it could prevent multiple organ failure, especially kidney damage. Only 14 people took part before the study was stopped, so the results…

This early study tested a device that places radioactive seeds directly into skin, mouth, or soft tissue tumors. The seeds release alpha radiation to kill cancer cells from within. Only 2 people took part before the trial was stopped, so we don't have enough information to know i…

This study tested a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in people with chronic heart failure. The goal was to see if it is safe and feasible, and whether it could improve symptoms like walking distance and heart stra…

This study tested an experimental drug called VLX-1005 in people with a rare condition where the blood thinner heparin causes a dangerous drop in platelets (cells that help blood clot). Participants received either VLX-1005 or a placebo alongside standard care. The goal was to se…

This study looked at whether giving the drug octreotide for 24 hours instead of the usual 72 hours could prevent early rebleeding from esophageal varices in people with cirrhosis. The trial included 34 adults with active bleeding from varices who underwent endoscopic banding. The…

This study tested a device called Leaflex™ Performer, which is threaded through a blood vessel to the heart to score and loosen calcium buildup on stiff aortic valves. It was designed for people with severe aortic stenosis who cannot have standard valve surgery or replacement. Ho…

This study tested whether adding an Impella CP heart pump early to standard VA-ECMO support helps people recover from cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The trial planned to enroll adults with severe heart failure but was term…

This study looked at whether the drug dronedarone could prevent atrial fibrillation (AFib) from coming back after a heart ablation procedure. About 22 adults with AFib who had ablation were randomly given either dronedarone or a placebo. The goal was to see if the drug reduced ir…

This study tested an experimental drug called REGN5381 in 34 adults with uncontrolled hypertension (high blood pressure despite taking one or more blood pressure medications). The drug is a monoclonal antibody designed to activate NPR1 receptors, which may help lower blood pressu…

This study looked at the long-term safety of efgartigimod in adults with post-COVID postural orthostatic tachycardia syndrome (POTS), a condition causing rapid heart rate and dizziness upon standing. The trial was an open-label extension for people who completed a previous study.…

This study tested a special contact lens that slowly releases the glaucoma drug latanoprost, aiming to replace daily eye drops. Only one person enrolled before the study was stopped early. The goal was to check safety and whether the lens could lower eye pressure, but no conclusi…

This study tested a gene therapy called VM202 to help heal chronic foot ulcers in people with diabetes and poor leg circulation. The treatment was given as injections into the calf muscle. The study was stopped early after enrolling only 44 participants, so results are limited.

This study looked at whether giving less oxygen (aiming for 90-94% oxygen in the blood) right after a cardiac arrest outside the hospital helps more people survive to leave the hospital. It included 428 unconscious adults who had been revived and were on a breathing tube. The tri…

This study looked at how well the BIOFREEDOM stent works in everyday medical practice for people with narrowed heart arteries. Researchers planned to track 218 patients to see rates of death, heart attack, or need for repeat procedures. The study was stopped early, so results are…

This small pilot study tested whether a special oral appliance (like a mouthguard) could reduce episodes of atrial fibrillation, a common heart rhythm problem. Only 3 people participated, and the study was ended early. The device is already used for snoring and sleep apnea, but i…

This study looked at whether a procedure to remove large blood clots from the brain could help people who had a severe stroke. It included 335 adults with a large stroke who could be treated within 7 hours. The goal was to see if the procedure reduced disability compared to stand…

This early-stage trial tested an experimental drug called AZD3427 in 10 people with heart failure and reduced kidney function. The goal was to see if the drug could improve blood flow to the kidneys, measured with a special PET scan. However, the study was terminated early, so we…

This early study tested a new drug called AZD5462 added to the standard medicine dapagliflozin in people with heart failure and moderate kidney disease. Only 8 participants were enrolled before the study was stopped. The goal was to see if the combination is safe and affects how …

This study tested whether giving lithium carbonate before carotid artery surgery could reduce brain damage and confusion after the operation. The trial planned to include 107 adults undergoing elective carotid surgery, but it was terminated early. The goal was to see if lithium c…

This was a very early Phase 1 study testing a single injection of ART101 in people with high blood pressure. The trial was stopped after only 1 participant was enrolled, so no meaningful results are available. The goal was to check safety and how the drug moves through the body.

This study tested a small, implantable heart pump called the HeartWare MVAD in 11 people with advanced heart failure. The goal was to see if the device could safely help the heart pump blood. However, the trial was stopped early, so we have limited information on how well it work…

This trial tested a stent-retriever device to remove blood clots from the lungs in people with acute pulmonary embolism. Only one participant was enrolled before the study was terminated. The goal was to see if the device could reduce heart strain and avoid major complications wi…

This study looked at whether using a positive airway pressure (PAP) machine at night can reduce the return of atrial fibrillation (an irregular heartbeat) in people who also have obstructive sleep apnea. About 129 participants with both conditions were assigned to receive either …

This study tested a new type of stent (BiOSS LIM C) designed for blockages at the left main coronary artery fork. The trial enrolled 130 people with severe blockages. Unfortunately, the new stent did not work as well as the standard stent, and the study was stopped early.

This study tested an oral drug called duvoglustat in adults with Pompe disease, a rare genetic disorder that causes muscle weakness. Only 3 people took part, and the study was stopped early. Researchers looked at safety and whether the drug could improve walking distance and othe…

This study looked at using the WATCHMAN FLX device, a small plug placed in the heart, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who also had serious gastrointestinal (GI) bleeding. The device is meant to close off a part of the heart where clo…

This was a very early (Phase 1) study testing a drug called HS135 in obese patients who have both pulmonary hypertension and a type of heart failure called HFpEF. The trial was terminated after enrolling only 4 people, so we have no useful information on whether HS135 is safe or …

This study tested whether the drug Avenciguat, taken alone or with empagliflozin, can lower high blood pressure in the portal vein (the main vessel to the liver) in people with cirrhosis. About 90 adults with cirrhosis from hepatitis or fatty liver disease were enrolled. The tria…

This early-stage trial tested a gene therapy called SRP-9004 in just 4 people with limb girdle muscular dystrophy type 2D/R3, a rare muscle-weakening disease. The main goal was to check safety, not effectiveness. The study was terminated early, so results are limited.

This study tested a drug called ixazomib plus dexamethasone against other standard treatments for people with relapsed AL amyloidosis, a rare disease where abnormal proteins build up in organs. The trial aimed to see if the combination improved blood markers and slowed heart or k…

This study tested a drug called Avenciguat in adults with liver cirrhosis and high blood pressure in the portal vein (the main vessel to the liver). Participants took either a low or high dose of Avenciguat or a placebo twice daily for 24 weeks. The goal was to see if the drug co…

This study tested a drug called KBP-5074 in 652 adults with moderate-to-severe chronic kidney disease and high blood pressure that was not controlled by at least two other medications. Participants received either KBP-5074 or a placebo daily for up to 52 weeks to see if the drug …

This study tests new methods to measure pressure, blood flow, and blockage size in heart arteries. Researchers want to see if these measurements can better identify which blockages are serious enough to cause heart damage. The study involves people with known or suspected coronar…

This study tested whether a cone beam CT scan, done right after a stroke procedure called thrombectomy, could tell the difference between a brain hemorrhage and harmless contrast dye buildup. Only 5 adults were enrolled before the study was stopped early. The goal was to see if t…

This Phase II study tested a radioactive tracer called 68GaNOTA-Anti-MMR-VHH2 to see if it can light up certain immune cells (macrophages) on PET scans. The trial included 29 people with head and neck cancer, lymphoma, atherosclerosis, or sarcoidosis. The goal was to see if the t…

This study looked at whether a special CT scan called FFR-CT can help emergency room doctors better diagnose coronary artery disease in patients with chest pain. The plan was to compare treatment decisions made with and without the FFR-CT results. However, the study was stopped e…

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study tested a new stress echocardiography method using regadenoson and atropine to diagnose coronary artery disease. It involved 45 adults scheduled for cardiac catheterization. The goal was to see if this faster, radiation-free approach could accurately detect significant …

This pilot study tested whether a special PET scan (FDG-PET/CT) can detect hidden heart inflammation in cancer patients receiving immune checkpoint inhibitors (ICIs). The goal was to catch this inflammation early, before it becomes severe. Only 2 participants were enrolled, and t…

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. Howev…

This study tested a new software called AngioScan, used with an already-approved eye camera, to see if it can take better pictures of the back of the eye. Researchers looked at 150 patients with retinal problems like macular degeneration. The goal was to find out if the software …

This study looked at whether measuring the speed of pulse waves in arteries, combined with machine learning, could improve prediction of significant coronary artery disease in people with chest pain or shortness of breath. Researchers planned to enroll 156 patients undergoing a h…

This study tested whether a special CT scan can accurately assess heart muscle damage in people who had a heart attack more than 24 hours earlier. The goal was to see if this CT could replace the need for both an MRI and an invasive angiogram. The study enrolled 31 adults and com…

This study tested a special PET scan tracer to see if it can find fresh blood clots in people with pulmonary embolism (PE) or deep vein thrombosis (DVT). Six adults with confirmed clots received the tracer within 72 hours of diagnosis. The goal was to compare the PET images with …

This study aimed to see if the CONNEQT Pulse blood pressure monitor gives accurate readings in pregnant women, including those with high blood pressure or pre-eclampsia. Researchers compared it to a standard blood pressure cuff in 41 pregnant volunteers. The study was stopped ear…

This study tested whether special MRI sequences can spot leftover brain arteriovenous malformations (AVMs) after embolization treatment. Researchers compared the MRI results to standard angiography in 53 adults. The study was terminated early, so its findings are limited.

This study compared a newer PET heart scan (using XTR004) with a standard SPECT scan to see which gives doctors more confidence in diagnosing borderline blocked arteries. It involved 17 adults with suspected stable heart disease and 30-90% blockages seen on a prior CT scan. The g…

This study tested a wearable device that sits on the neck to detect swallowing problems in people with conditions like stroke, Parkinson's, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. Unfortunately, the device did not meet the a…

This study tested whether wearing a small, waterproof heart monitor (ePatch) for 7 days finds more treatable heart rhythm problems than the usual 24-hour Holter monitor in people who have fainted. About 55 adults with fainting symptoms were randomly assigned to either the 7-day e…

This study tested a drug called belapectin to see if it could prevent the formation of esophageal varices (enlarged veins in the esophagus) in people with NASH cirrhosis and signs of high blood pressure in the liver. The trial enrolled 357 adults and compared belapectin to a plac…

This pilot study aimed to see if giving heart medications (carvedilol and empagliflozin) to women starting HER2-targeted therapy for breast cancer could prevent heart damage. The study planned to enroll 20-40 participants but was terminated early after enrolling only 7. The goal …

This study looked at whether intensive treatment for gum disease (periodontitis) could prevent dementia in older adults who already have mild cognitive impairment and narrowed neck arteries. Participants received either standard dental care or deep cleaning and root planing. The …

This study tested a drug called SPN-538 to prevent migraines in children aged 6 to 11. The trial was a randomized, double-blind, placebo-controlled study, meaning some children got the drug and some got a placebo. However, the study was terminated early and only enrolled 26 parti…

This study tested whether the cholesterol-lowering drug pravastatin could prevent preeclampsia in women who had a previous early preterm delivery due to the condition. The trial planned to enroll 1,550 women but was terminated early with only 102 participants. Because it stopped …

This study tested whether taking roxadustat before heart bypass surgery could prevent sudden kidney damage, a common complication. The trial enrolled 98 adults aged 18-80 with planned bypass surgery. The drug aims to help tissues handle low oxygen better. However, the study was t…

This study tested whether BOTOX injections can prevent migraine attacks in adults who have 6 to 14 migraine days per month (episodic migraine). About 775 participants received either BOTOX or placebo injections into their muscles twice, 12 weeks apart. The main goal was to see if…

This study tested a new oral blood thinner called SHR2285 in people having knee replacement surgery. The goal was to see if it could prevent dangerous blood clots as well as the standard injection enoxaparin. The trial was planned for 64 participants but was terminated early, so …

This study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…

This study looked at whether practicing walking while doing other tasks (multitasking) helps people recovering from a stroke walk faster than just walking practice alone. It included 26 adults who had a stroke within the past 6 months and had trouble walking. The trial was stoppe…

This study tested the migraine drug lasmiditan in children aged 6 to 17 who have migraines. The goal was to see if it is safe and works for quick relief. The trial was stopped early, so the results are limited.

This study tested whether propranolol, a beta-blocker usually used for heart conditions, can reduce nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder that causes abnormal blood vessels. Fifteen adults with HHT took either propranolol or a p…

This study tested whether a drug called Polaramine can prevent dangerous drops in blood pressure when patients come off a heart-lung machine during aortic valve replacement. 18 adults took part. The goal was to see if the drug helps the body keep a stable blood pressure after sur…

This study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…

This study observed 18 chronic stroke patients who received botulinum toxin injections into their elbow muscles as part of routine care. The goal was to see if the injections reduced muscle tightness (spasticity) and improved active arm extension. Researchers measured muscle acti…

This study tested a fast-dissolving film (BXCL501) placed under the tongue to quickly reduce severe agitation in older adults with dementia. The trial aimed to enroll many participants but was stopped early after only 5 people joined. Because it ended so soon, we cannot draw reli…

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization,…

This study tested whether MYOBLOC, a botulinum toxin injection, can safely reduce muscle stiffness in the lower leg of adults with spasticity caused by stroke, brain injury, or spinal cord injury. About 40 participants received either a low or high dose of MYOBLOC or a placebo in…

This study tested a brace called CALIGALOC designed to correct foot drop (ankle varus) in people with hemiparesis after a stroke or other brain injury. The goal was to see if wearing the brace for 15 days improved walking speed and balance. Only 5 people took part, and the study …

This study tested a drug called AVP-786 to see if it could safely reduce disinhibition—impulsive or inappropriate behavior—in people with neurodegenerative disorders like Alzheimer's or frontotemporal dementia. The trial planned to include many participants but was terminated ear…

This study tested a personalized touchscreen device (My PATI) to help people with Alzheimer's or related dementias communicate their care preferences. The goal was to improve quality of life for both patients and their caregivers. The study was terminated early, so results are li…

This study looked at whether breathing air with less oxygen (like at high altitude) during exercise training could help people with heart failure do more physical activity. Only 14 patients were enrolled before the study was stopped early. The main goal was to see if this method …

This study aimed to compare two blood pressure medications—oral nifedipine (a pill) and intravenous labetalol (given through a vein)—for treating dangerously high blood pressure in women who have just given birth. The goal was to see which drug lowers blood pressure faster. Howev…

This study looked at two FDA-approved migraine medications (a dissolving tablet and a nasal spray) given to adults in the emergency department. The goal was to see if these easy-to-use options could relieve pain quickly and shorten ER visits. The study was stopped early with only…

This small pilot study tested whether combining a gentle brain stimulation technique (tDCS) with a thinking-strategies training program could help people who had a stroke more than six months ago perform everyday activities better. Eleven participants were enrolled to see if the …

This study tested whether a mindfulness program (including meditation, body scans, and gentle yoga) could help people with implanted heart devices like ICDs or pacemakers feel less anxious, stressed, and depressed. The study planned to enroll 34 adults who had recently received s…

This study tested whether adding a video to standard discharge education helps patients who have had coronary artery bypass graft (CABG) surgery feel more satisfied and less anxious. 120 patients were randomly assigned to receive either standard education, a standard video, or a …

This small pilot study tested whether placing critically ill patients with low blood pressure in a head-down tilt (Trendelenburg) position could improve organ function by reducing the need for fluids and blood-pressure-raising drugs. The study included 10 sedated, ventilated pati…

This study tested a wearable device that uses gentle vibrations to help stroke survivors improve arm strength and movement. The plan was to have 48 people use the device at home for 4 weeks, but only 4 enrolled before the study was stopped. Researchers measured usability and chan…

This study tested if a gentle nerve stimulation (like a mild electrical pulse on the neck) could improve blood vessel health and memory in people with heart failure. Only 7 people took part before the study was stopped early. The goal was to see if 4 weeks of stimulation could re…

This study looked at whether a cortisone injection into the shoulder joint, combined with physiotherapy, reduces pain and improves movement in people who had a stroke and developed shoulder pain. It included 50 adults in a rehab program. The study was stopped early, so results ar…

This study compared two treatments for varicose veins: Varithena (a foam) and Endothermal Ablation (using heat). It included 43 adults with a faulty great saphenous vein. The goal was to see which treatment better reduced symptoms like heaviness and pain over 3 months.

This Phase 2 study tested ponsegromab, an experimental drug, against a placebo in 455 adults with heart failure. Participants received injections every four weeks for about nine months. The goal was to see if ponsegromab could improve symptoms and quality of life. The trial was t…

This study looked at how often infants with hemangiomas wake up at night when taking propranolol either two or three times a day. It aimed to see if a three-times-daily schedule caused less sleep disruption. The trial was terminated early, so the findings are incomplete.

This study tested a drug called CVL-871 to see if it is safe and can help reduce apathy (lack of motivation or interest) in people with dementia. The trial included 41 participants with mild to moderate dementia and clinically significant apathy. The main goal was to check for si…

This study aimed to see if lasmiditan, a migraine medicine, is safe and works for children aged 6 to 17. It planned to treat migraine attacks and measure pain relief. The trial was stopped early, so final results are limited, but it may still provide useful information about trea…

This study tested whether a device called Nanodropper, which makes smaller eye drops, works as well as standard eye drops for lowering eye pressure in people with glaucoma or ocular hypertension. The study enrolled 16 adults who already used a common glaucoma drop. The goal was t…

This study looked at whether a preservative-free eye gel called IRIDIUM® could help relieve dry eye symptoms in people with glaucoma or high eye pressure who were already using multiple eye drop medications. The goal was to see if the gel improved comfort and quality of life. The…

This study tested whether a personalized pacing algorithm (myPACE+) could improve quality of life and exercise capacity in people with non-obstructive hypertrophic cardiomyopathy who already have an implantable defibrillator. Only one person was enrolled before the trial was term…

This study tested whether EEG neurofeedback—a type of brain training that uses real-time brainwave readings—can help people with aphasia (trouble speaking or understanding language) improve their communication, sleep, and anxiety. Seven adults with aphasia from stroke or primary …

This study tested a device called CoolStat that is placed in the nose to cool down brain-injured patients with fever in the ICU. The goal was to see if it could safely and quickly bring their temperature to normal. Only 9 patients were enrolled before the study was stopped early,…

This study tested whether a nasal spray version of the migraine drug Ketorolac, combined with oral Prochlorperazine and Diphenhydramine, could relieve migraine pain in children as effectively as the standard IV treatment. The trial aimed to enroll children aged 4 and older with m…

This study tested whether a magnetic device (rTMS) placed on the scalp could help people who had a stroke regain movement in their arm. The trial planned to include 60 adults with recent ischemic stroke. However, the study was terminated early, so the results are not complete.

This study tested whether a single-use negative pressure wound therapy system (PICO) helps heal hard-to-treat venous leg ulcers better than standard care. About 142 adults with leg ulcers that had lasted at least 6 weeks took part. The main goal was to see if more ulcers healed c…

This study tested a personalized walking and balance training program using a KineAssist robotic treadmill for people recovering from traumatic brain injury, stroke, or other acquired brain injuries. The goal was to safely challenge and improve walking speed, balance, strength, a…

This study compared two types of nerve blocks (serratus anterior plane block and erector spinae plane block) using the same dose of ropivacaine to manage pain after hybrid arrhythmia ablation surgery. It enrolled 28 adults aged 18-80. The trial was terminated early, so findings a…

This study tested whether adding physical rehabilitation and personalized nutrition to standard care helps patients with infective endocarditis (a serious heart infection) feel better during their hospital stay. The goal was to improve mental health and quality of life. The study…

This study tested a program called HEART Camp Connect, which uses a virtual coach to help adults with heart failure exercise 150 minutes per week. Only 11 people enrolled before the trial was stopped. Researchers wanted to see if the program improved exercise habits and heart-rel…

This study looked at whether adding functional electrical stimulation (FES) to robotic hand therapy could improve arm movement in people who had a stroke within the past year. Researchers planned to compare two groups: one getting standard rehab plus robotic therapy and FES, and …

This study tested an experimental drug called K-645 for people having a migraine attack. It aimed to see if the drug could stop pain and other bothersome symptoms better than a placebo. The trial was stopped early, so results are limited. About 134 adults with a history of migrai…

This study tested whether adding safe balance challenges (called perturbations) to body-weight supported walking therapy helps stroke survivors improve their balance and walking more than standard therapy alone. Participants were adults in inpatient rehab after a stroke. They use…

This study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…

This study tested a wearable armband called Nerivio that uses mild electrical pulses to reduce pain from Botox injections in people with chronic migraine. About 80 participants were planned, but the study was stopped early. The goal was to see if the device could make the injecti…

This study tested whether a special breathing exercise program could help people with systolic heart failure walk farther and feel better. The trial planned to enroll 65 adults with moderate heart failure, but it was terminated early. Participants would have been assigned to eith…

This early-stage trial tested a single dose of a drug called briquilimab in 27 adults with chronic hives caused by cold or friction that did not improve with standard allergy pills. The main goal was to check safety and see if the drug could reduce symptoms. However, the trial wa…

This study looked at whether a common painkiller (diclofenac potassium) works as well as a newer migraine drug (rimegepant) for stopping migraine pain within 2 hours. About 300 adults with migraine took one of the two medicines during a single attack. The goal was to see if both …

This study tested whether providing palliative care at home, through a team of doctors, nurses, social workers, and chaplains, could improve symptoms and quality of life for people with advanced cancer, heart failure, or COPD. The plan was to enroll over 1,100 patients, but the t…

This study looked at whether slow, deep breathing for 10 minutes daily could help lower blood pressure in pregnant women with pregnancy-induced hypertension. Only 1 participant was enrolled before the study was terminated, so no meaningful conclusions can be drawn. The goal was t…

This study tested a program called PROPEL that combines group aerobic exercise with weekly self-management discussions for people recovering from a stroke. The goal was to see if this approach helps participants stay physically active for six months after leaving rehabilitation. …

This study tested whether combining a computer-based speed-of-processing training with a gentle electrical brain stimulation (alpha-tACS) could improve how quickly people with mild cognitive impairment process visual information. The trial planned to enroll 40 adults aged 65 and …

This study followed 98 people with chronic migraine who used a device that delivers gentle oscillations inside the nose. The goal was to see if regular use could cut down on severe headache days. The trial was terminated early, so the full results are not available, but the appro…

This study tested whether reactive balance training—exercises that involve sudden pushes, pulls, or quick movements—can improve aerobic fitness and leg strength in people who had a stroke at least six months ago. The researchers expected that this training would be as good as sta…

This study tested whether adding clorazepate (a sedative) to standard migraine medications could provide faster pain relief for people having a migraine attack in the emergency room. The trial included 323 adults with moderate to severe migraine. However, the study was terminated…

This study tested whether a gentle electrical current applied to the scalp (tDCS) during speech therapy could help stroke survivors with aphasia name objects better. Only 5 people took part, and the study was stopped early, so the results are not reliable enough to draw conclusio…

This study looks at how high blood sugar combined with a medication called moxifloxacin (an antibiotic known to affect heart rhythm) impacts the heart's electrical activity in people with insulin-resistant type 2 diabetes. Researchers will measure changes in heart tracings (ECGs)…

This study observes people who have already been treated with the Pipeline Embolization Device for brain aneurysms. Researchers track neurological complications like stroke or bleeding to better understand the device's safety in everyday use. The goal is to expand knowledge on ho…

This study looked at how diuretics (water pills) affect kidney and heart function in people who just had heart surgery. The goal was to see if removing extra fluid changes how well the kidneys and right side of the heart work. Only 9 people took part, and the study was stopped ea…

This study aimed to understand why some people develop heart failure after a heart attack. Researchers used special PET scans and blood tests to measure blood vessel function and scarring in the heart muscle of 30 patients who had a first heart attack. The goal was to see if thes…

This study aimed to identify brain areas outside the main motor region that help arm recovery after a severe stroke. Researchers followed 28 patients over time, using MRI and movement tracking to see which brain areas became active as arm function improved. The goal was to find n…

This study tested whether a small implanted device that stimulates the vagus nerve could improve arm and hand function in people who had a stroke at least a year ago. Four participants received either real or sham stimulation paired with physical therapy. The goal was to see how …

This pilot study aimed to see if a blood test called thromboelastography (TEG) and platelet mapping could predict clotting or bleeding complications after non-cardiac surgery. The study included 200 patients who were taking aspirin or clopidogrel for at least 10 days before elect…

This study aimed to understand why people with autism or schizophrenia sometimes struggle to recognize emotions on faces. Researchers used brain wave recordings (EEG) and eye-tracking to see how participants processed facial expressions. The study included people with autism, sch…

This study collects small skin samples from children aged 2 to 17 with Costello syndrome or a related condition. Researchers will analyze the cells to understand how a mutation in the HRAS gene affects energy use and mitochondria. The goal is to learn more about the disease's und…

This study looked at why some people who have a heart attack develop extra fluid around the heart (pericardial effusion). Researchers planned to use MRI scans to see if the amount of fluid was linked to other health factors and to survival one year later. Only 3 people took part …

This study looked at whether measuring a natural clot-busting substance (t-PA) released from heart arteries could predict future heart attacks or death in people with mild to moderate coronary artery disease. Researchers gave a small dose of bradykinin into the heart artery durin…

This study compared two breathing techniques (CPAP and eSigh) in 18 patients with brain injury and acute respiratory distress syndrome (ARDS). The goal was to see which method better maintains oxygen levels in the brain without causing harm. The trial was terminated early, so fin…

This pilot study tested whether a small wearable sensor called the Spire Health Tag could reliably track heart rate, activity, sleep, and stress in heart failure patients after they leave the hospital. The goal was to see if the device could capture useful data for at least 80% o…

This study looked at how the heart's pumping function recovers after a short, controlled blockage of a coronary artery using a balloon. Six adults with stable coronary artery disease undergoing angioplasty had a balloon inflated in their artery for 90 seconds. Researchers measure…

This study looked at how stroke changes the brain's ability to recognize emotions like fear and happiness. Researchers used MRI and EEG to compare stroke patients with healthy volunteers. The study was stopped early and only included 2 participants, so findings are very limited.

This study tested a new, non-invasive way to measure blood flow in the legs of people with peripheral artery disease (PAD). Researchers compared the new method to standard ultrasound in 29 patients scheduled for a procedure to open blocked leg arteries. The goal was to see if the…

This study tested whether a single session of magnetic brain stimulation (called rTMS) over a specific brain area could improve pointing movements in people who had a stroke. Only one person took part, and the study was stopped early. The goal was to see if the stimulation could …

This study looked at how tiny blood vessels in the skin of healthy volunteers respond to substances that make them widen or narrow. Researchers used a mild electrical current to deliver these substances through the skin and measured changes in blood flow with light. The goal was …

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…

This study looked at whether implantable defibrillators (ICDs) help people with heart failure and a lower risk of deadly heart rhythms live longer compared to not having an ICD. It involved over 3,000 adults with weak heart pumps. The goal was to see if the benefits of ICDs still…

This study looked at how platelets (small blood cells) might cause long-term complications like leg swelling or breathing problems after a blood clot. Researchers measured specific receptors on platelets in 44 patients to see if they were linked to these lasting issues. The goal …

This study looked at whether pain-relief drugs given during labor (ropivacaine and sufentanil) can pass into the mother's blood and cause abnormal heart rhythms in the baby. It involved 40 first-time mothers with a single baby in head-first position. The goal was to measure drug …

This study aimed to understand why some people with genetic early-onset atrial fibrillation (AF) are at risk for a dangerous heart rhythm called ventricular tachycardia (VT). Researchers used special heart mapping during a standard AF ablation procedure in 32 adults. The goal was…

This study aimed to see if a new device called the EyeCheck monitor can measure eye pressure as accurately as standard tools in people with glaucoma or suspected glaucoma. Twenty-two participants used the device during a clinic visit. The study was stopped early, so results are l…

This study aimed to find biomarkers (measurable substances in the blood) that could help doctors diagnose bradykinin angioedema and predict how severe attacks might be. The condition causes sudden, unpredictable swelling, and current tests don't work well for all types. Researche…

This study tested a software platform called ICU Cockpit that collects and displays vital signs and other data from brain-injury patients in the intensive care unit. The goal was to help doctors make faster, better decisions and to predict complications like strokes or unstable c…

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study aimed to see if a blood test measuring platelet function could predict neurological events like stroke in people undergoing carotid artery surgery. Researchers planned to enroll 650 patients but the study was terminated early. The test uses a device called Multiplate t…

This study looked at whether special eye scans (OCT-angiography) can predict how well the remaining kidney will work one year after kidney removal for cancer. Researchers enrolled 30 adults scheduled for total nephrectomy. The goal was to see if retinal blood vessel patterns coul…

This study looked at 212 patients who woke up after a cardiac arrest outside the hospital. Researchers compared getting a heart angiogram right away versus waiting 12-24 hours. The goal was to see if immediate imaging reduces the risk of death, shock, or another cardiac arrest. T…

This study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring…

This study looked at whether a new blood test called SomaSignal could help doctors make better treatment decisions for people at higher risk of heart disease. The test measures proteins in the blood to predict heart risks. Only 12 people took part before the study was stopped ear…

This study tested whether starting with a low-cost coronary calcium scan (about $100) could safely avoid the need for a more expensive heart stress test (over $1,500) in people with chest pain. Researchers planned to enroll 48 adults aged 50 and older with suspected heart disease…

This study aimed to see if the heart-lung machine used during heart surgery changes blood flow in the gut. Researchers checked blood flow under the tongue as a way to measure gut health. The study was stopped early and included only 21 adults having aortic valve replacement. It w…

This study tested a new, non-invasive eye imaging method called hyperspectral imaging. It takes pictures of the back of the eye using many different colors of light to find details not visible with standard cameras. About 679 adults with healthy eyes or eye diseases like diabetic…

This study looked at using a special wire that measures blood pressure inside heart arteries (called FFR) to help doctors decide which blockages to treat with stents. It included 438 people with two or more blockages in the same artery. The study was stopped early, so the results…

This study looked at whether follow-up calls from a headache nurse could help patients with migraines, tension headaches, cluster headaches, or hemicrania continua stay on their preventive medication. 147 participants were randomly assigned to receive nurse calls at 2 and 6 weeks…

This study tested a wearable system called SimpleSense to see if it could accurately measure heart function during right heart catheterization. Researchers enrolled 13 adults undergoing the procedure and compared data from the wearable to standard measurements. The goal was to de…

This study aimed to develop a wearable system that could predict heart failure hospitalizations by collecting data from sensors. It planned to enroll up to 500 people but was terminated early with only 13 participants. The goal was to create an algorithm to detect worsening heart…

This study was a large registry that planned to follow 180,000 patients in Germany with aortic valve problems (leaky or narrowed valves). The goal was to compare newer, less invasive treatments like TAVI with standard open-heart surgery to see which works best and for whom. Resea…

This study looked at how different pacing modes affect blood pressure in people with heart failure who have a special pacemaker called a CRT device. Researchers measured the highest blood pressure achieved with each mode to see which one works best. The study included 50 adults w…

This study looked at whether using a VQ scan (which doesn't use kidney-harming dye) instead of a CT scan can prevent acute kidney injury in emergency patients being checked for lung clots. About 253 adults at risk for kidney problems were enrolled. The trial was terminated early,…

This study looked at whether a new anti-shivering protocol helped reduce the need for muscle relaxants in patients cooled after cardiac arrest. Researchers reviewed records of 165 patients treated between 2017 and 2021. The study was terminated early, so results are limited.

This study tested whether using a special image-guidance system (AxiEM Stealth) helps doctors place a brain drain more accurately at the bedside compared to the usual freehand method. The drain is needed to relieve pressure in the brain. The study included 31 adults who needed th…

This study looked at a common heart rhythm problem called atrial fibrillation (AF). The goal was to find better ways to predict which patients would benefit from a procedure called ablation, which creates scar tissue in the heart to stop abnormal rhythms. Researchers planned to u…

This study looked at whether healthcare workers without ultrasound training could use AI software to perform heart scans on people with hypertrophic obstructive cardiomyopathy (HOCM) who are eligible for the drug mavacamten. Participants had two scans on the same day: one by a no…

This study looked at how Medtronic heart devices detect and manage atrial fibrillation (AF) in Indian patients. It tracked whether the condition became persistent over time. The study enrolled 79 people over 55 with heart devices. It was terminated early, so results are limited.

This study tested a new blood pressure device called ModPG3 on 7 newborns and infants to see if it meets international accuracy standards. The device uses two methods to measure blood pressure during cuff inflation and deflation. The trial was terminated early, so results are lim…

This study aimed to see if measuring the glycocalyx—a thin, protective layer inside blood vessels—before heart surgery could predict serious problems like shock, kidney failure, or death. Researchers planned to include 130 adults having heart surgery with a heart-lung machine. Th…

This study tested whether a 16-week program of yoga and lifestyle changes could affect gene activity (micro RNA) and heart disease risk factors in 16 adults with coronary artery disease. Participants had either undergone a heart procedure or had non-obstructive heart disease with…

This study looked at how blood clotting and inflammation change over time in adults with serious burns. Researchers examined tiny particles released by cells into the blood, which may play a role in infections and inflammation. The goal was to learn how to reduce bleeding, transf…

This study looked at whether using ultrasound to guide vein puncture reduces complications like bleeding or false aneurysms in people undergoing ablation for atrial fibrillation. Over 1,000 adults scheduled for the procedure were enrolled. The study was terminated early, so resul…

This study tested whether a device that uses near-infrared light (NIRS) can measure blood flow in the remaining leg after a below-knee amputation better than the standard method (TcPO2). Researchers planned to include 50 patients in two groups: those with a permanent prosthetic l…

This study tested whether fentanyl, a painkiller used during heart stent procedures, reduces the effectiveness of ticagrelor, a blood thinner given to prevent clots. Researchers compared crushed versus whole ticagrelor pills in 45 patients. The trial was stopped early, so results…

This study looked at whether a non-invasive cycling test, combined with a muscle oxygen monitor (NIRS), could detect a condition called flow limitation in the iliac artery (FLIA) in endurance athletes. FLIA can cause leg pain and limit performance, and early detection is difficul…

This study looked at whether electrical stimulation of the spinal cord could help widen narrowed brain arteries after a type of stroke called subarachnoid hemorrhage. Only one person was enrolled before the study was stopped early. The goal was to measure changes in blood flow, b…

This study aimed to compare two ways of setting breathing machine pressure (PEEP) in patients with severe lung injury (ARDS). The goal was to see which method better protects the lungs and heart. Only 2 patients were enrolled before the study was stopped, so no meaningful results…

This study aimed to find out how many people experience short-term and long-term pain after a specific type of heart surgery called one-stage hybrid arrhythmia ablation. Researchers surveyed patients who had the procedure at UZ Brussels to see what factors, like medications or ge…

This study looked at whether adding a special imaging test (Cytocam-IDF) to standard monitoring during major vascular surgery could help patients leave the hospital sooner. The trial was planned for more participants but was stopped early after only 22 people took part. Because i…

This study aimed to see if a new urine test can accurately tell whether people with type 2 diabetes are taking their medications as prescribed. Researchers planned to compare the urine test results with standard methods like questionnaires and pharmacy records in 90 participants.…

This study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…

This observational study aimed to understand how stroke affects walking during early recovery. Researchers used motion analysis and brain stimulation to track changes in 6 participants over 6 months. The study was terminated early, so findings are limited.

This study aimed to monitor muscle strength and body composition changes in the first 10 days after a severe stroke. Researchers used a device called an impedancemeter to measure muscle mass and a dynamometer to test grip strength. Only 6 people participated before the study was …

This study looked at whether using a condom catheter instead of a standard indwelling urinary catheter (IUC) lowers the chance of delirium in men aged 70+ who had a stroke. Delirium is a sudden confused state that can happen after a stroke. The trial planned to compare two groups…

This study looked at whether a specific type of immune cell (CD5+ regulatory B cells) can predict relapse risk in people with ANCA vasculitis, a rare autoimmune disease that damages blood vessels. Researchers aimed to see if patients with normal levels of these cells after initia…

This study looked at whether having a family member work closely with hospital staff could improve recovery for stroke survivors with spatial neglect—a condition where people ignore one side of their world. The study planned to include more people but was stopped early, so only 1…

This study aimed to see if a non-invasive device using light (near infrared spectroscopy) could measure how well the heart is pumping in children with heart failure during routine clinic visits. Only 3 children took part before the study was stopped early. The goal was to find a …

This study tested a new questionnaire called the Brain Injury Self-Efficacy Scale to see how well it measures a person's confidence in managing challenges after a brain injury. Researchers compared it with other standard self-efficacy scales. The study involved 150 adults with a …

This study followed 37 migraine patients in the Gulf region who had just started taking erenumab. Researchers measured how satisfied patients were with the treatment over 12 weeks using a questionnaire. The study was observational, meaning patients received their normal care, and…

This study tested two new algorithms (SureBP and StepBP) in a blood pressure device to see if they measure blood pressure accurately in adults and children ages 3 and up. The goal was to check if the device meets international accuracy standards. The study was terminated early, s…

This pilot study aimed to see if antiseizure drugs like phenobarbital and levetiracetam change brain connectivity patterns in people with severe acute brain injury and reduced consciousness. Only 5 participants were enrolled before the study was terminated. Researchers used resti…

This study looked at whether a wearable defibrillator (WCD) can accurately record heart sounds in people with heart failure. About 60 adults with heart failure and weak heart pumping (ejection fraction 40% or less) took part. The goal was to compare the WCD's recordings to a stan…

This study aimed to see if a wireless sensor could collect health information from babies with heart defects at home, replacing wired devices. Only 2 infants were enrolled before the study was stopped. The goal was to understand if the wireless device was easy to use and worked w…

This study tested a special type of scan (SPECT/CT) to see how well it measures liver function in people with liver cancer who are getting radiation or surgery. The goal was to learn if this scan can help doctors see which parts of the liver are working well before, during, and a…

This study tested a non-invasive blood pressure monitor (CNAP) against the standard invasive method (using a needle in the artery) in 20 pregnant women with placenta accreta undergoing scheduled C-sections. The goal was to see if the gentler method gives equally accurate readings…

This study looked at stored tumor samples from 139 children with brain and central nervous system tumors. Researchers wanted to find DNA changes and biomarkers that could help understand these cancers better. The study was terminated early, so results may be limited.

This study looked at whether proteins that control our body's daily rhythms (clock proteins) can predict how severe asthma will get. Researchers monitored these proteins in the blood and sputum of 50 adults with severe eosinophilic asthma before and during treatment with mepolizu…

This study looked at whether an early heart MRI can help doctors know which patients with severe heart damage after a heart attack will get better on their own. The goal was to see if MRI could identify patients who would benefit from getting a defibrillator sooner rather than wa…

This study looked at how stimulating the ear with mild electrical pulses affects the body's automatic functions, like blood flow and temperature. Ten healthy volunteers had their skin temperature measured after ear stimulation. The goal was to understand if precise ear points mat…

This study aimed to find out how often infections happen after a procedure called TEVAR, which repairs the main artery in the chest. Researchers looked at data from 457 patients who had this surgery in the past five years. They measured infection rates, fever, and lab results to …

This study tested whether a near-infrared spectroscopy device could detect early signs of poor blood flow in tissue flaps used for breast reconstruction after mastectomy. The device was placed on the reconstructed breast and compared to standard physical exams. Only 18 people too…

This study aims to find out how common transthyretin amyloidosis cardiomyopathy (ATTR-CM) is in Russian patients with a certain type of heart failure. Researchers will review medical records and then invite some patients for extra heart tests to confirm or rule out ATTR-CM. The g…

This pilot study tested an e-health system that uses tele-monitoring, tele-notification, and tele-coaching to help manage adults with at least two chronic conditions like heart failure, COPD, or diabetes. The goal was to see how well the system could detect health problems early.…

This study looked at how well the COVID-19 vaccine triggers an immune response in people with autoimmune or inflammatory diseases who take immunosuppressants or biologics. Researchers took blood samples before vaccination and at several points after to measure antibodies and T-ce…

This pilot study aimed to compare two standard surgical methods for creating an arteriovenous (AV) fistula in the arm for dialysis patients with kidney failure. The goal was to see if a single procedure or two separate procedures leads to better outcomes and quality of life. Howe…

This study aimed to compare two common sedatives, propofol and midazolam, in patients with traumatic brain injury who needed a breathing tube. Researchers wanted to see if one drug led to better recovery or different levels of inflammation markers called cytokines. However, the t…

This study looked at whether a device called Vendys II, which measures blood vessel function by tracking finger temperature after a brief blood flow restriction, could be used in children and young adults (ages 6-26) undergoing stem cell transplants. The goal was to see if it was…

This study looked at whether blocking certain nerve signals can improve how the body uses insulin and reduce inflammation in people with obesity and high blood pressure. Ten participants took two drugs—moxonidine and amlodipine—to lower nerve activity. The goal was to see if this…