New hope for rare lung disease: sotatercept trial targets worsening

NCT ID NCT04811092

First seen Apr 29, 2026 · Last updated May 06, 2026 · Updated 1 time

Summary

This study tested a drug called sotatercept in people newly diagnosed with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. The goal was to see if adding sotatercept to standard treatment could delay worsening of the disease. The trial was stopped early, but results may still help researchers understand how to better manage PAH.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AHEPA University General Hospital of Thessaloniki ( Site 3601)

    Thessaloniki, 546 36, Greece

  • Aarhus Universitetshospital, Skejby ( Site 3801)

    Aarhus, Central Jutland, 8200, Denmark

  • AdventHealth Medical Group Advanced Lung Disease ( Site 1058)

    Orlando, Florida, 32804, United States

  • Arizona Pulmonary Specialists ( Site 1010)

    Scottsdale, Arizona, 85258, United States

  • Assuta Ashdod Medical Center ( Site 1710)

    Ashdod, 7747629, Israel

  • Attikon University General Hospital of Athens ( Site 3604)

    Haidari, Attica, 124 62, Greece

  • Azienda Ospedaliera R. N. V. Monaldi ( Site 2407)

    Naples, 80131, Italy

  • Azienda Ospedaliera San Gerardo di Monza ( Site 2406)

    Monza, Monza E Brianza, 20900, Italy

  • Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) ( Site 2405)

    Trieste, Friuli Venezia Giulia, 34149, Italy

  • Boston Medical Center ( Site 1012)

    Boston, Massachusetts, 02118, United States

  • C.H.U. de Nancy. Hopital de Brabois Adultes ( Site 1308)

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France

  • C.H.U. de Tours - Hopital Bretonneau ( Site 1310)

    Tours, Indre-et-Loire, 37000, France

  • CHU - Hopital de Bicetre ( Site 1304)

    Le Kremlin-Bicêtre, Val-de-Marne, 94270, France

  • CHU Angers ( Site 1313)

    Angers, Maine-et-Loire, 49933, France

  • CHU Caen Normandie ( Site 1325)

    Caen, Calvados, 14033, France

  • CHU de Besancon ( Site 1303)

    Besançon, Doubs, 25000, France

  • CHU de Poitiers ( Site 1316)

    Poitiers, Vienne, 86000, France

  • CHU de Toulouse - Hopital Larrey ( Site 1315)

    Toulouse, Haute-Garonne, 31059, France

  • Cardiologia Palermo ( Site 1911)

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425BNG, Argentina

  • Centre Hospitalier Universitaire de Saint-Etienne ( Site 1302)

    Saint-Priest-en-Jarez, Pays de la Loire Region, 42270, France

  • Centro Cardiovascular Colombiano Clínica Santa María Clínica Cardio VID ( Site 3402)

    Medellín, Antioquia, 50034, Colombia

  • Centro Hospitalar E Universitário De Coimbra ( Site 3502)

    Coimbra, 3000-075, Portugal

  • Centro Medico Dra De Salvo ( Site 1904)

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1426ABP, Argentina

  • Centro Medico Imbanaco de Cali S.A ( Site 3404)

    Cali, Valle del Cauca Department, 760042, Colombia

  • China Medical University Hospital ( Site 3701)

    Taichung, 40447, Taiwan

  • Chonnam National University Hospital ( Site 3105)

    Gwangju, Kyonggi-do, 61469, South Korea

  • Clinical Center Kragujevac ( Site 2905)

    Kragujevac, Sumadijski Okrug, 34000, Serbia

  • Clinical Center of Serbia ( Site 2901)

    Belgrade, 11000, Serbia

  • DRK Kliniken Berlin Westend ( Site 1507)

    Berlin, 14050, Germany

  • Erasmus MC ( Site 2604)

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Evangelismos General Hospital of Athens ( Site 3605)

    Athens, Attica, 106 76, Greece

  • Fiona Stanley Hospital ( Site 1103)

    Murdoch, Western Australia, 6150, Australia

  • Freeman Hospital ( Site 1205)

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Fundacion Neumologica Colombiana ( Site 3403)

    Bogota, Cundinamarca, 110131, Colombia

  • Fundacion Valle Del Lili ( Site 3401)

    Cali, Valle del Cauca Department, 760032, Colombia

  • Gachon University Gil Medical Center ( Site 3103)

    Namdong-Gu, Incheon, 21565, South Korea

  • Golden Jubilee National Hospital ( Site 1204)

    Glasgow, Glasgow City, G81 4DY, United Kingdom

  • Hadassah Medical Center ( Site 1711)

    Jerusalem, 9112001, Israel

  • Hjart-lungmedicin och klinisk fysiologi ( Site 3204)

    Uppsala, Uppsala County, 751 85, Sweden

  • Hopital Cavale Blanche ( Site 1314)

    Brest, Brittany Region, 29200, France

  • Hopital Erasme ( Site 1402)

    Anderlecht, Bruxelles-Capitale, Region de, 1070, Belgium

  • Hopital Haut Leveque ( Site 1312)

    Bordeaux, Gironde, 33604, France

  • Hopital Louis Pasteur ( Site 1311)

    Nice, Alpes-Maritimes, 06001, France

  • Hopital Louis Pradel ( Site 1317)

    Lyon, Auvergne, 69003, France

  • Hopital Nord Laennec ( Site 1309)

    Nantes, Loire-Atlantique, 44000, France

  • Hopitaux Universitaires de Strasbourg ( Site 1307)

    Strasbourg, Bas-Rhin, 67000, France

  • Hospital Garcia de Orta ( Site 3501)

    Almada, Setúbal District, 2801-951, Portugal

  • Hospital Madre Teresa ( Site 1804)

    Belo Horizonte, Minas Gerais, 30430-142, Brazil

  • Hospital Provincial Dr. Jose M. Cullen ( Site 1902)

    Santa Fe, S3000EOZ, Argentina

  • Hospital Provincial del Centenario ( Site 1912)

    Rosario, Santa Fe Province, 2002, Argentina

  • Hospital Pulido Valente ( Site 3503)

    Lisbon, 1769-001, Portugal

  • Hospital Sao Paulo ( Site 1806)

    São Paulo, São Paulo, 04038-031, Brazil

  • Hospital Universitari Vall de Hebron ( Site 1605)

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre ( Site 1603)

    Madrid, 28041, Spain

  • Hospital Universitario Austral ( Site 1901)

    Pilar, Buenos Aires, B1629ODT, Argentina

  • Hospital Universitario La Paz ( Site 1610)

    Madrid, 28046, Spain

  • Hospital Universitario Marques de Valdecilla ( Site 1601)

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Puerta de Hierro (Majadahonda) ( Site 1604)

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca ( Site 1608)

    Salamanca, 37007, Spain

  • Hospital Universitario de Son Espases ( Site 1611)

    Palma de Mallorca, Balearic Islands, 07120, Spain

  • Hospital Virgen de la Salud ( Site 1607)

    Toledo, 45004, Spain

  • Imperial College Healthcare NHS Trust ( Site 1203)

    London, London, City of, W12 OHS, United Kingdom

  • Institut Klinicke a Experimentalni Mediciny ( Site 2202)

    Prague, Praha 4, 140 21, Czechia

  • Institute for pulmonary diseases of Vojvodina ( Site 2906)

    Kamenitz, Juznobacki Okrug, 21204, Serbia

  • Instituto Cardiovascular de Rosario ( Site 1906)

    Rosario, Santa Fe Province, S2000DSR, Argentina

  • Instituto De Enfermedades Respiratorias E Investigacion Medica ( Site 1910)

    Villa Vatteone, Buenos Aires, B1853AIK, Argentina

  • Instituto Medico Rio Cuarto ( Site 1907)

    Río Cuarto, Córdoba Province, X5800AEV, Argentina

  • Instituto Médico DAMIC ( Site 1909)

    Córdoba, Córdoba Province, 5003DCE, Argentina

  • Instituto de Investigaciones Clinicas Quilmes ( Site 1903)

    Quilmes, Buenos Aires, 1878, Argentina

  • Instituto do Coracao - HCFMUSP ( Site 1803)

    São Paulo, 05403-000, Brazil

  • Instytut Gruzlicy i Chorob Pluc w Warszawie ( Site 2802)

    Warsaw, Masovian Voivodeship, 01-138, Poland

  • Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 1805)

    Porto Alegre, Rio Grande do Sul, 90020-090, Brazil

  • John Hunter Hospital ( Site 1101)

    Newcastle, New South Wales, 2308, Australia

  • Johns Hopkins Hospital ( Site 1036)

    Baltimore, Maryland, 21287-0005, United States

  • Kaohsiung Veterans General Hospital ( Site 3702)

    Kaohsiung City, 81362, Taiwan

  • Klinicki Bolnicki Centar Zagreb ( Site 3902)

    Zagreb, Zagreb County, 10000, Croatia

  • Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 2801)

    Krakow, Lesser Poland Voivodeship, 31-202, Poland

  • Krankenhaus Neuwittelsbach ( Site 1510)

    Munich, Bavaria, 80639, Germany

  • La Sapienza-Università di Roma-Policlinico Umberto I ( Site 2402)

    Roma, 161, Italy

  • Lady Davis Carmel Medical Center ( Site 1705)

    Haifa, 3436212, Israel

  • Maastricht University Medical Center ( Site 2603)

    Maastricht, Limburg, 6229 HX, Netherlands

  • McMaster University - HSC ( Site 2105)

    Hamilton, Ontario, L8N 4A6, Canada

  • Medical University of South Carolina ( Site 1003)

    Charleston, South Carolina, 29425-8900, United States

  • Medizinische Hochschule Hannover ( Site 1505)

    Hanover, Lower Saxony, 30625, Germany

  • Medizinische Universitat Innsbruck ( Site 2004)

    Innsbruck, Tyrol, 6020, Austria

  • Medizinische Universitat Wien ( Site 2001)

    Vienna, State of Vienna, 1090, Austria

  • Medizinische Universität Graz ( Site 2003)

    Graz, Styria, 8036, Austria

  • NYU Langone Health ( Site 1052)

    New York, New York, 10016-9196, United States

  • National Cheng Kung University Hospital ( Site 3703)

    Tainan, 704, Taiwan

  • Nazih Zuhdi Transplantation Institute ( Site 1084)

    Oklahoma City, Oklahoma, 73112-4421, United States

  • Norrlands Universitetssjukhus ( Site 3205)

    Umeå, Västerbotten County, 90185, Sweden

  • Onassis Cardiac Surgery Center ( Site 3602)

    Athens, Attica, 176 74, Greece

  • Ordensklinikum Linz GmbH Elisabethinen ( Site 2002)

    Linz, Upper Austria, 4020, Austria

  • Oregon Health & Science University ( Site 1054)

    Portland, Oregon, 97239, United States

  • Ospedale S. Giuseppe Multimedica ( Site 2403)

    Milan, Lombardy, 20123, Italy

  • Papworth Hospital NHS Foundation Trust ( Site 1208)

    Cambrigge, Cambridgeshire, CB23 0AY, United Kingdom

  • Prince Charles Hospital ( Site 1104)

    Chermside, Queensland, 4032, Australia

  • Princess Alexandra Hospital ( Site 1108)

    Woolloongabba, Queensland, 4102, Australia

  • Radboud University Nijmegen Medical Centre ( Site 2605)

    Nijmegen, Gelderland, 6500 HB, Netherlands

  • Rigshospitalet ( Site 3802)

    København Ø, Capital Region, 2100, Denmark

  • Royal Adelaide Hospital ( Site 1109)

    Adelaide, South Australia, 5000, Australia

  • Royal Brompton Hospital ( Site 1206)

    London, London, City of, SW3 6HP, United Kingdom

  • Royal Free London NHS Foundation Trust ( Site 1202)

    London, London, City of, NW3 2QG, United Kingdom

  • Royal Hobart Hospital ( Site 1107)

    Hobart, Tasmania, 7000, Australia

  • Royal Prince Alfred Hospital ( Site 1106)

    Camperdown, New South Wales, 2050, Australia

  • Samsung Medical Center ( Site 3106)

    Seuol, Seoul, 06351, South Korea

  • Sanatorio Allende ( Site 1908)

    Córdoba, X5021FPQ, Argentina

  • Sanatorio Parque ( Site 1905)

    Rosario, Santa Fe Province, S2000DSV, Argentina

  • Santa Barbara Pulmonary Associates ( Site 1060)

    Santa Barbara, California, 93105-5316, United States

  • Seoul National University Hospital ( Site 3102)

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System - PPDS ( Site 3101)

    Seoul, 03722, South Korea

  • Sheba Medical Center ( Site 1701)

    Tel Litwinsky, 52621, Israel

  • Sheffield Teaching Hospital NHS Foundation Trust ( Site 1207)

    Sheffield, Derbyshire, S10 2JF, United Kingdom

  • Sir Mortimer B Davis Jewish General Hospital ( Site 2103)

    Montreal, Quebec, H3T 1E2, Canada

  • Skanes Universitetssjukhus Lund ( Site 3203)

    Lund, Skåne County, 22185, Sweden

  • St Boniface General Hospital ( Site 2106)

    Winnepeg, Manitoba, R2H 2A6, Canada

  • The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001)

    Cincinnati, Ohio, 45219, United States

  • The Catholic University of Korea St. Mary s Hospital ( Site 3104)

    Seoul, 06591, South Korea

  • The Cleveland Clinic Foundation Taussig Cancer Center ( Site 1065)

    Cleveland, Ohio, 44195, United States

  • Tufts Medical Center - PPDS ( Site 1014)

    Boston, Massachusetts, 02111-1526, United States

  • UCLA Medical Center ( Site 1068)

    Los Angeles, California, 90095, United States

  • UZ Gasthuisberg ( Site 1401)

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Uniklinik Köln ( Site 1511)

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Universitaetsklinik Regensburg ( Site 1503)

    Regensburg, Bavaria, 93053, Germany

  • Universitaetsklinik und Poliklinik Halle/Saale ( Site 1502)

    Halle, Saxony-Anhalt, 06120, Germany

  • Universitaetsklinikum Carl Gustav Carus ( Site 1501)

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Giessen und Marburg GmbH ( Site 1512)

    Bad Oeynhausen, North Rhine-Westphalia, 35392, Germany

  • Universitaetsklinikum Heidelberg ( Site 1509)

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitatsklinikum Leipzig ( Site 1508)

    Leipzig, Saxony, 04103, Germany

  • Universitatsklinikum des Saarlandes ( Site 1513)

    Homburg, Saarland, 66421, Germany

  • University Clinical Center Nis ( Site 2904)

    Niš, Nisavski Okrug, 18000, Serbia

  • University Hospital Centre Split city ( Site 3901)

    Split, Split-Dalmatia County, 21000, Croatia

  • University of Alberta Hospital ( Site 2101)

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Arizona ( Site 1006)

    Tucson, Arizona, 85724, United States

  • University of California Davis Medical Center ( Site 1064)

    Sherman Oaks, California, 95817, United States

  • University of California Irvine ( Site 1086)

    Orange, California, 92868, United States

  • University of California San Diego ( Site 1002)

    La Jolla, California, 92037, United States

  • University of Cincinnati ( Site 1035)

    Cincinnati, Ohio, 45219, United States

  • University of Colorado Hospital ( Site 1013)

    Aurora, Colorado, 80045, United States

  • University of Iowa Hospital and Clinics ( Site 1050)

    Iowa City, Iowa, 52242, United States

  • University of Kansas Medical Center ( Site 1020)

    Kansas City, Missouri, 66160, United States

  • University of Michigan ( Site 1011)

    Ann Arbor, Michigan, 48109, United States

  • University of New Mexico, Health Sciences Center ( Site 1048)

    Albuquerque, New Mexico, 87131, United States

  • University of North Carolina at Chapel Hill ( Site 1042)

    Chapel Hill, North Carolina, 27514, United States

  • University of Texas Southwestern Medical Center ( Site 1038)

    Dallas, Texas, 78701, United States

  • University of Utah ( Site 1049)

    Salt Lake City, Utah, 84132-0001, United States

  • UniversitätsSpital Zürich ( Site 3301)

    Zurich, 8091, Switzerland

  • VU Medisch Centrum ( Site 2601)

    Amsterdam, North Holland, 1081 HV, Netherlands

  • Vanderbilt University Medical Center ( Site 1027)

    Nashville, Tennessee, 37232, United States

  • Vseobecna fakultni nemocnice v Praze ( Site 2201)

    Prague, 128 08, Czechia

  • Waikato District Health Board ( Site 2702)

    Hamilton, Waikato Region, 3204, New Zealand

  • Washington University School of Medicine ( Site 1022)

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.