Promising drug combo for rare amyloidosis hits snag: trial ends early
NCT ID NCT01659658
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested a drug called ixazomib plus dexamethasone against other standard treatments for people with relapsed AL amyloidosis, a rare disease where abnormal proteins build up in organs. The trial aimed to see if the combination improved blood markers and slowed heart or kidney damage. It enrolled 177 adults but was terminated early, so the full benefits and risks are not yet clear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ixazomib (a cancer drug) plus dexamethasone (a steroid)
What this could lead to
If successful, this could offer a new treatment option for people with relapsed AL amyloidosis, potentially improving blood responses and delaying organ damage.
What could go wrong
The trial was terminated early, so results are limited. It is unclear if ixazomib is better than other treatments, and side effects like nausea, fatigue, and low blood counts are possible.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RELAPSED OR REFRACTORY SYSTEMIC LIGHT CHAIN AMYLOIDOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Alexandra Hospital
Athens, 11528, Greece
-
Arhus Universitetshospital Arhus Sygehus
Aahus, 800, Denmark
-
Boston Medical Center
Boston, Massachusetts, 02118, United States
-
Box Hill Hospital
Box Hill, Victoria, 3128, Australia
-
Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
-
Centre Hospitalier et Universitaire de Limoges
Limoges, 87042, France
-
Centro de Pesquisas Oncologicas
Florianópolis, Santa Catarina, 88034-000, Brazil
-
Chaim Sheba Medical Center
Ramat Gan, 52621, Israel
-
Charite - Universitatsmedizin Berlin
Berlin, 12200, Germany
-
Cleveland Clinic
Cleveland, Ohio, 44195, United States
-
Clinica Universidad de Navarra
Pamplona, Navarre, 31008, Spain
-
Columbia University Medical Center
New York, New York, 10032, United States
-
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z, Canada
-
Fakultni nemocnice Ostrava
Ostrava, Moravskoslezsk Kraj, 708 52, Czechia
-
Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, 2710, Italy
-
Froedtert and The Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
-
Gachon University Gil Medical Center
Incheon, 405-760, South Korea
-
Hadasit Medical Research Services and Development Ltd
Jerusalem, 911, Israel
-
Hopital Claude Huriez
Lille, 5903, France
-
Hopital Saint Louis
Paris, 75010, France
-
Hopital de Rangueil
Toulouse, 31059, France
-
Hospital Clinic de Barcelona
Barcelona, 8036, Spain
-
Hospital Israelita Albert Einstein
São Paulo, 05652-900, Brazil
-
Hospital Universitario Clementino Fraga Filho (UFRJ)
Rio de Janeiro, 21941-913, Brazil
-
Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda, 28222, Spain
-
Hospital Universitario de La Princesa
Madrid, 28006, Spain
-
Hospital Universitario de Salamanca
Salamanca, 37007, Spain
-
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, 5403000, Brazil
-
Hotel Dieu
Nantes, Loire-Atlantique, 44093, France
-
Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
-
Institute of Hematology "Seragnoli" University of Bologna
Bologna, 40138, Italy
-
Irmandade Da Santa Casa de Misericordia de Sao Paulo
São Paulo, 01223-001, Brazil
-
Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
-
Maastricht University Medical Center
AZ Maastricht, 620, Netherlands
-
Manchester Royal Infirmary
Manchester, MI3 9WL, United Kingdom
-
Mayo Clinic
Rochester, Minnesota, 05590, United States
-
Meir Medical Center
Kfar Saba, 44281, Israel
-
Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
-
Oxford University Hospitals NHS Trust
Oxford, OX3 7L, United Kingdom
-
Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
-
Princess Margaret Hospital
Toronto, Ontario, M5G2M9, Canada
-
Queen Elizabeth Hospital
Birmingham, B152TH, United Kingdom
-
Rabin Medical Center - PPDS
Petah Tikva, 49100, Israel
-
Rambam Health Corporation
Haifa, 31096, Israel
-
Rigshospitalet
Copenhagen, 2100, Denmark
-
Royal Free and University College Medical School
London, NW3 2P, United Kingdom
-
Samsung Medical Center - PPDS
Seoul, 135-710, South Korea
-
Seoul National University Hospital
Seoul, 110744, South Korea
-
Severance Hospital at Yonsei University Health System - PPDS
Seoul, 120-752, South Korea
-
Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009, Australia
-
The Catholic University of Korea, Seoul St Mary's Hospital
Seoul, 137-70, South Korea
-
Tom Baker Cancer Centre
Calgary, Alberta, T2N 4N2, Canada
-
Tufts Medical Center
Boston, Massachusetts, 00211, United States
-
Universitair Medisch Centrum Utrecht
Utrecht, 3508, Netherlands
-
Universitat Heidelberg
Heidelberg, 69120, Germany
-
Universitatsklinikum Hamburg Eppendorf
Hamburg, 20246, Germany
-
University General Hospital of Patras
Pátrai, Achaia, 26500, Greece
-
University of Chicago
Chicago, Illinois, 60637, United States
-
University of Cincinnati
Cincinnati, Ohio, 45267, United States
-
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
-
VU Medisch Centrum
Amsterdam, North Holland, 1081 HV, Netherlands
-
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M, Canada
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
-
Vseobecna fakultni nemocnice v Praze
Prague, Praha, Hlavni Mesto, 128 08, Czechia
-
Washington University
St Louis, Missouri, 63110, United States
-
Westmead Hospital
Westmead, New South Wales, 214, Australia