Tiny doses of avastin tested against laser for preemie eye disease
NCT ID NCT04634604
First seen Jun 22, 2026 · Last updated Jun 22, 2026
Summary
This study tested a low dose of the drug bevacizumab (Avastin) against standard laser treatment for retinopathy of prematurity, an eye disease that can blind premature infants. Sixteen babies with severe disease were enrolled. The goal was to see if the drug could control the disease as well as laser, but the trial was stopped early, so the results are not conclusive.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Arizonia Pediatric Eye Specialists
Phoenix, Arizona, 85006, United States
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Arkansas Childrens Hospital/ University of Arkansas Medical Sciences
Little Rock, Arkansas, 72202, United States
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Boston Children's Hospital
Boston, Massachusetts, 02215, United States
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CHU - Sainte-Justine
Montreal, Quebec, H3T 1C5, Canada
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Casey Eye Institute
Portland, Oregon, 97239, United States
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Children's Hospital & Medical Center
Omaha, Nebraska, 68114, United States
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Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
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Connecticut Childrens Medical Center
Farmington, Connecticut, 06032, United States
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Denver Health and Hospital Authority
Denver, Colorado, 80204, United States
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Duke University Eye Center
Durham, North Carolina, 27710, United States
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Greater Baltimore Medical Center
Baltimore, Maryland, 21204-5809, United States
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IWK Health Centre
Halifax, Nova Scotia, B3K 6R8, Canada
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Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
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New York Presbyterian David H Koch Center
New York, New York, 10065, United States
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Pediatric Ophthalmology Associates, Inc.
Columbus, Ohio, 43205, United States
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Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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St. Louis University Ophthalmology
St Louis, Missouri, 63104, United States
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Storm Eye Institute
Mt. Pleasant, South Carolina, 29464, United States
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Texas Children's Hospital - Dept. Of Ophthalmology
Houston, Texas, 77030, United States
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The Emory Eye Center
Atlanta, Georgia, 30322, United States
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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The Woman's Hospital of Texas
Houston, Texas, 77054, United States
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U of Illinois at Chicago Eye and Ear Infirmary
Chicago, Illinois, 60612, United States
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UK Ophthalmology and Visual Sciences, The Eye Clinic
Lexington, Kentucky, 40508, United States
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UPMC Children's Eye Center of Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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Univ of California, Irvine- Gavin Herbert Eye Institute
Irvine, California, 92697, United States
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University of California San Francisco Department of Ophthalmology
San Francisco, California, 94143, United States
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University of California, Davis
Sacramento, California, 95817, United States
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University of Chicago
Hyde Park, Illinois, 60637, United States
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University of Colorado Health Sciences Center
Aurora, Colorado, 80045, United States
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University of Missouri- Columbia Mason Eye Institute
Columbia, Missouri, 65201, United States
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University of North Carolina
Chapel Hill, North Carolina, 27599, United States
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University of Utah Moran Eye Center
Salt Lake City, Utah, 84132, United States
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Virginia Pediatric Eye Center
Norfolk, Virginia, 23502, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bevacizumab (Avastin)
What this could lead to
If successful, this could offer a less invasive treatment option for retinopathy of prematurity, potentially reducing side effects compared to laser.
What could go wrong
The trial was terminated early with only 16 participants, so results are very limited. It is unclear if low-dose bevacizumab is as effective as laser, and there may be unknown risks.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.