Stem cell shot for stubborn chest pain? early trial cut short

NCT ID NCT04614467

Terminated Disease control Sponsor: Lisata Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study tested whether a single infusion of a patient's own blood stem cells (CLBS16) could ease chest pain in people with coronary microvascular dysfunction, a condition where the heart's tiny blood vessels don't work properly. The trial enrolled 34 adults with frequent angina but no blocked arteries. It was terminated early, so we have limited data on whether the treatment works or is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CLBS16 (a patient's own blood stem cells, called CD34+ cells, collected after a drug to boost their numbers)
What this could lead to: If it worked, this could point toward a new way to reduce chest pain and improve quality of life for people with small-vessel heart disease who don't have blocked arteries.
What could go wrong: This trial was terminated early with only 34 participants, so results are very limited. It is a small, early-phase study, and the treatment may not prove effective or safe in larger groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris coronary microvascular disorder Microvascular Angina

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY MICROVASCULAR DISEASE CORONARY MICROVASCULAR DYSFUNCTION MICROVASCULAR CORONARY ARTERY DISEASE

Contacts and locations

Locations

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
Memorial Regional Hospital

Hollywood, Florida, 33021, United States
Minneapolis Heart Institute at Abbott Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
The Christ Hospital

Cincinnati, Ohio, 45219, United States
University of Florida - College of Medicine/ div of Cardiovascular Medicine

Gainesville, Florida, 32606, United States

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