Cardiovascular disorder

This trial tests whether transplanting neural stem cells directly into the brain can help people who have had a chronic ischemic stroke. The study involves adults aged 18-75 who had a stroke 6 to 60 months prior. Participants receive a single dose of stem cells, and the trial eva…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This trial tests whether high-dose vitamin D supplements can improve cognitive function in people who have had a stroke and developed thinking or memory problems. Participants will receive either vitamin D or a placebo for six months, and researchers will measure changes in cogni…

This study tests a device called the Surpass Evolve Flow Diverter, a small mesh tube placed inside an artery to redirect blood flow away from a brain aneurysm. The goal is to safely close the aneurysm and prevent it from rupturing. About 248 adults with unruptured, wide-neck aneu…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study looks at a new way to keep donor hearts healthy during transport for transplantation. It involves 141 adults with heart failure who are on the transplant list. The goal is to see if this method is safe and effective for using hearts from extended criteria donors.

This pilot trial is testing whether a device called the Coronary Sinus Reducer can help people with angina (chest pain) who have no significant blockages in their coronary arteries. The device, shaped like an hourglass, is placed into a vein in the heart to improve blood flow. Th…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This early-stage study tests a single intravenous dose of a gene therapy called LY3884961 in 15 adults with Gaucher disease type 1. The goal is to see if it is safe and can reduce or replace the need for ongoing enzyme replacement or substrate reduction therapy. Participants must…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study tests whether special force feedback instruments, used with the da Vinci surgical robot, can safely and effectively repair leaky mitral valves. The trial includes 30 adults with moderate-to-severe mitral regurgitation. Researchers will check for major complications and…

This study tests an experimental drug called QCZ484, given as an injection under the skin every 6 months, for people with mild to moderate high blood pressure. About 385 adults aged 18 to 75 are taking part. The goal is to see if the drug safely lowers blood pressure compared to …

This early study tests a new catheter technique called VINTAGE for people with ventricular arrhythmia that hasn't improved with standard treatment. The procedure uses special catheters to reach and destroy heart tissue causing the abnormal rhythm. Thirty adults will be enrolled a…

This trial investigates the best way to treat people who have a heart attack and also have other narrowed arteries. It compares doing an immediate procedure to open those other arteries, guided by a pressure wire, versus waiting and using a heart scan to decide later. The goal is…

This trial tests an automated system called ADIVA that delivers two medications to control blood pressure during spinal anesthesia for cesarean delivery. Low blood pressure is a common side effect of spinal anesthesia and can cause problems for both mother and baby. The system ai…

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This study tests a device that electrically stimulates the vagus nerve to help manage heart failure. About 118 patients with moderate-to-severe heart failure received the implant. The goal is to see if this stimulation can improve heart function and exercise capacity over six mon…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This trial asks whether giving only ticagrelor (a blood thinner) after a heart attack, instead of the usual ticagrelor plus aspirin, is just as safe and might reduce bleeding and heart muscle damage. About 200 people who had a type of heart attack called STEMI and underwent a ste…

This Phase I trial tests whether infusing specially trained immune cells, called TAA-T, can safely target and attack high-risk brain tumors in children and adults. The cells are made from the patient's own blood and are designed to recognize multiple tumor-related proteins, poten…

This trial tests whether taking a 15-minute hot bath after each exercise session improves recovery in people who recently had a heart attack. Half of the 30 participants will do standard exercise rehab plus hot water immersion, while the other half does exercise alone. The study …

This study tests a new growth hormone medicine called somapacitan, given once a week, in 47 children who are very short due to being born small for gestational age, or having Turner syndrome, Noonan syndrome, or idiopathic short stature. The main goal is to see if it is safe and …

This study looks at the long-term safety of relacorilant, a drug for people with Cushing syndrome. It includes 125 adults who previously completed a relacorilant study and may benefit from continued treatment. Researchers will track side effects over time to see if the drug is sa…

This early-phase trial tested whether combining two anti-cancer drugs, pomalidomide (taken as a pill) and liposomal doxorubicin (given through an IV), is safe and tolerable for people with advanced or hard-to-treat Kaposi sarcoma. The study enrolled 62 adults, including those wit…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study follows 284 people with blocked leg arteries (peripheral arterial disease) who are treated with a paclitaxel-coated balloon. The balloon is inflated inside the artery to open it and release a drug that helps prevent it from narrowing again. Researchers are tracking saf…

This study tests whether infusing a cold magnesium sulfate solution directly into the brain during emergency clot removal can improve outcomes for people with acute ischemic stroke. About 42 adults aged 18-80 with severe strokes will be randomly assigned to receive either standar…

This trial is testing whether a supervised exercise program can reduce the risk of death, another heart attack, or stroke in people who have already had a heart attack. About 9,700 participants will be randomly assigned to either a four-year program with a personal trainer or to …

This study tests whether a newer drug, benralizumab, works as well as the current standard, mepolizumab, for people with a rare disease called EGPA that inflames blood vessels. About 140 adults with active EGPA will receive either drug for a year, along with their usual steroids.…

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This study follows 250 people with severe aortic stenosis who receive the SAPIEN 3 transcatheter heart valve as part of their standard care. The goal is to see how safe and effective the valve is over the long term in everyday clinical practice. Researchers will track how many pa…

This trial is testing a temporary stent system designed to open blocked arteries below the knee in people with peripheral arterial disease. The stent is used along with a drug-coated balloon to help keep the vessel open. The study will check how well the treated arteries stay ope…

This study tests a new medicine called ALN-6400 for people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. First, healthy volunteers will receive a single dose to check safety. Then, HHT patients will recei…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This trial tests a new surgical technique for people with tricuspid valve disease, where the valve on the right side of the heart is damaged. Instead of replacing the valve with an artificial one, surgeons will use a piece of the heart's own chamber, called the right atrial appen…

This study tests whether a monthly injection called ziltivekimab can reduce heart failure-related deaths, hospitalizations, and urgent visits in people with heart failure and signs of inflammation. About 5,600 participants will receive either the drug or a placebo for up to 4 yea…

This study tests whether a special placental membrane called BR-AC, applied weekly, can help heal non-healing venous leg ulcers faster than standard care alone. About 60 adults with a leg ulcer between the knee and ankle will be randomly assigned to get either standard care plus …

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This trial tests whether losartan, a common blood pressure medication, can reduce scarring in the heart's main pumping chamber and improve exercise capacity in adults who had surgery to repair coarctation of the aorta. Participants will take losartan, amlodipine, or a placebo dai…

This study tests a device called Barostim that stimulates nerves in the neck to help the heart work better. It involves 2,500 adults with moderate heart failure who still have symptoms despite standard treatments. The goal is to see if the device reduces deaths and hospital stays…

This trial compares standard versus extra pulsed field ablation applications during pulmonary vein isolation in people with atrial fibrillation. The goal is to see if more targeted ablations improve freedom from irregular heart rhythms for up to 18 months. Participants are adults…

This study tests whether pharmacists can encourage doctors and patients to switch to a single pill that combines multiple blood pressure medicines. About 720 adults with high blood pressure will take part. The goal is to see if this approach helps lower blood pressure more effect…

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This Phase 3 trial tests whether a daily pill called AZD0780 can safely lower LDL (bad) cholesterol in adults with heart disease or at high risk. About 3,100 participants will receive either AZD0780 or a placebo for 52 weeks, and neither they nor their doctors will know which the…

This trial is testing a specially modified stent graft—a small mesh tube—to repair complex aortic aneurysms in people who are too high-risk for open surgery. The graft is adjusted by the physician to keep blood flowing to the kidneys and other vital organs during the procedure. T…

This trial tests whether using a larger, expandable balloon during cryoablation for paroxysmal atrial fibrillation better affects the heart's autonomic (automatic) control compared to a standard-size balloon. About 40% of patients show signs of beneficial parasympathetic denervat…

This study follows 246 people who received the Pipeline Shield device to treat brain aneurysms. The device is a small mesh tube that blocks blood flow to the aneurysm, reducing rupture risk. Researchers are checking how well the aneurysm seals, whether the artery narrows, and if …

This early feasibility study tests a new device called the PLAR Implant, designed to treat severe degenerative mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The implant is delivered through a vein in the le…

This Phase 3 trial tests an experimental drug called ALXN2220 in about 1,180 adults with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal protein builds up in the heart, causing heart failure. The drug is designed to remove those protein deposits. Partic…

This study tests a new medicine called INZ-701 in babies up to 1 year old who have a rare genetic condition (ENPP1 deficiency) that causes severe hardening of the arteries and bone problems. The goal is to see if the drug can raise a key substance in the blood, improve survival, …

This study tests the long-term safety and effectiveness of an experimental drug called VX-670 in adults with myotonic dystrophy type 1 (DM1). Participants who completed a previous VX-670 study can join. The drug is given through a vein, and researchers will monitor side effects a…

This early study is testing a new device called HyperQure that uses radiofrequency energy to disrupt nerves around the kidney arteries, which may help lower blood pressure. It involves 10 adults with resistant hypertension who are already taking 3 or more blood pressure medicatio…

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests a new drug called INZ-701 in up to 16 infants (up to 1 year old) with rare genetic conditions (ENPP1 or ABCC6 deficiency) that cause dangerous calcium buildup in arteries and other problems. The main goal is to check the drug's safety and how the body handles it,…

This trial is testing a new device called the PLAR Implant, which is designed to treat severe functional mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The implant is placed via a catheter through a vein in …

This trial tests whether a digital tool that prompts doctors to adjust heart failure medications can improve care. The tool uses home monitoring and patient data to suggest medication changes. The study includes over 1,300 adults with heart failure and will measure hospitalizatio…

This early-phase trial tests a single intravenous dose of LY-M001 gene therapy in 9 children (ages 6 to 17) with type 1 Gaucher disease. The goal is to see if it is safe and can improve key symptoms like liver size and blood markers. Researchers will monitor participants for side…

This study tests a program to help control high blood pressure in adults aged 35 and older living in rural Pakistan. The program includes regular blood pressure checks, home health education, and referrals to doctors. Researchers want to see if this approach can be effectively us…

This study compares two methods for monitoring the blood thinner heparin in hospitalized patients with blood clots. One method uses a standard clotting test (PTT), while the other uses a newer test (anti-Xa). The goal is to see which method helps patients reach the right blood th…

This study tests whether implanted monitors can quickly show if a new PAH drug is working. About 40 adults with stable PAH will try two different approved drug plans while their heart and lung function are tracked. The goal is to see if this approach can help doctors choose the b…

This study tests a new device that uses extreme cold (cryoablation) to treat a fast, dangerous heart rhythm called sustained monomorphic ventricular tachycardia. About 206 adults with this condition will receive the freezing treatment. The goal is to see if it safely stops the ab…

This study tests a new device that replaces a leaky tricuspid heart valve using a thin tube inserted through a leg vein, avoiding open-heart surgery. It includes 150 people with severe tricuspid regurgitation who are too high-risk for surgery. The goal is to see if the device is …

This phase 2 trial tests an injectable drug called DII235 in 233 adults with high lipoprotein(a), a genetic condition that raises heart disease and stroke risk. Participants have heart disease or type 2 diabetes. The study compares different doses of DII235 against a placebo to s…

This phase 3 trial tests whether ziltivekimab, a drug that targets inflammation, can reduce swelling in the arteries of 40 people with coronary artery disease. Participants receive either the drug or a placebo, and researchers use advanced imaging and blood tests to measure chang…

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer and feel better compared to medications alone. About 2000 adults with stable heart disease and symptoms like ch…

This trial tests whether a technique called PICSI, which selects sperm by their ability to bind to hyaluronic acid, can improve pregnancy rates and reduce miscarriage compared to standard ICSI. It involves couples who had poor fertilization in their first IVF cycle and are now tr…

This study compares a device called FlowTriever (used with blood thinners) to blood thinners alone for people with intermediate-risk pulmonary embolism (blood clots in the lungs). About 1,200 adults with clots in major lung arteries and signs of heart strain will be randomly assi…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This trial is testing a new type of heart valve made from a material that the body absorbs over time. It is designed for children and young adults who need surgery to fix a congenital heart defect affecting the passage from the heart to the lungs. The valve is implanted during su…

This phase 4 study tests the drug mavacamten in 63 adults with a type of heart muscle disease called obstructive hypertrophic cardiomyopathy. The goal is to see if the drug can improve heart structure, measured by MRI, and ease symptoms like shortness of breath. Participants take…

This study tests a small device, called the Coronary Sinus Reducer, in 35 people with a type of heart failure where the heart pumps well but still has trouble filling with blood. The device is placed in a vein of the heart to help lower pressure during exercise. The goal is to se…

This study is a long-term follow-up for people who previously received an injection of RGX-314, a gene therapy, for diabetic retinopathy (with or without diabetic macular edema). The purpose is to monitor the safety and effectiveness of the treatment over a total of five years af…

This study looks at whether using a CPAP machine during pregnancy can reduce the chance of developing high blood pressure disorders like preeclampsia. About 1,500 pregnant women with mild to moderate sleep apnea will be randomly assigned to use CPAP or not. The goal is to see if …

This early-stage study tests a new drug called AZD1705 in adults with high cholesterol (dyslipidemia). The main goal is to check if the drug is safe and how the body processes it. About 98 participants will receive either the drug or a placebo. This research helps determine if th…

This study tests if adding a tiny shunt (a small passage) between the upper chambers of the heart can lower pressure after a standard valve repair procedure called MitraClip. Ten people with heart failure and a leaky mitral valve will receive the shunt right after their MitraClip…

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This phase II trial tests the drug pomalidomide in about 45 people with Kaposi sarcoma, a rare skin cancer. Pomalidomide works by stopping blood vessel growth and boosting the immune system to fight cancer cells. The study aims to see how long tumors shrink and how many people re…

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This phase 2 trial tests whether daratumumab, an antibody that targets cancer cells, can improve outcomes for people with multiple myeloma after they receive a stem cell transplant. The study involves 31 participants and is currently active but not recruiting. The main goal is to…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study tests a device called Amulet 2 that is implanted in the heart to seal off a small pouch (the left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. About 4…

This study follows 155 people in Japan with hereditary angioedema (HAE) who are taking TAKHZYRO (lanadelumab) injections every two weeks. Researchers will monitor side effects and check if the drug helps control swelling attacks over 12 months. The goal is to see how well TAKHZYR…

This trial tests whether a personalized exercise prescription, based on a graded exercise test and target heart rate, improves fitness more than standard perceived exertion-based exercise in older adults (60+) recovering from heart events like heart attacks or heart surgery. Part…

This trial tests whether a procedure called renal denervation can safely lower blood pressure in people with chronic kidney disease (stage 3) whose hypertension is not controlled by medication. The procedure uses ultrasound energy to calm overactive nerves in the kidney that may …

This study tests a modified pacemaker designed to improve heart function and quality of life in people with heart failure with preserved ejection fraction (HFpEF). About 105 participants will receive either the active pacing therapy or a non-pacing mode. Researchers will measure …

This study tests a new device that uses pulsed electric fields to treat persistent atrial fibrillation, a type of irregular heartbeat. Researchers will enroll 200 people to see if the procedure is safe and can restore normal heart rhythm. The goal is to offer a more precise and l…

This study tests a new method to preserve hearts from donors after circulatory death. The hearts are kept cool and oxygenated using a special machine during transport. The goal is to see if this helps more people get heart transplants and survive. The study involves 20 adults alr…

This study tests whether adding vericiguat to standard heart failure care can improve heart function in people with breast cancer who developed heart problems after cancer treatment. Participants will be randomly assigned to receive either vericiguat plus usual care or usual care…

This study looks at how well the iCover stent works when used as a bridging stent during a procedure called fenestrated endovascular aneurysm repair (fEVAR) for complex abdominal aortic aneurysms. The goal is to see if the stent stays open and keeps the aneurysm sealed without co…

This study follows 2000 people who have or will get the OmniaSecure defibrillation lead, a wire that helps control dangerous heart rhythms. Researchers will track how often the lead causes problems over 5 years. The goal is to make sure the lead is safe and works as expected in e…

This study tests a new type of balance training for people who had a stroke within the past few weeks. The training uses controlled wobbles and shifts in the support surface to challenge patients' balance in a safe way, aiming to improve their ability to walk and perform daily ac…

This trial is testing whether a catheter that suctions out blood clots can restore blood flow to the intestine in people with acute mesenteric ischemia, a life-threatening blockage of the artery feeding the gut. Participants will undergo thrombus aspiration, and if needed, laparo…

This trial tests whether adding melatonin to the standard preventive drug propranolol can better reduce migraine attacks in children aged 5 to 15. Sixty children with moderate-to-severe migraine disability will receive either melatonin plus propranolol or propranolol alone for th…

This early-stage trial is testing whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 participants will either receive standard care alone or standard care plus stem cells gi…

This trial tests whether starting physical therapy early—while infants are still in the NICU and continuing until 12 months corrected age—can improve motor function and reduce the severity of motor delays in babies at high risk due to premature birth, brain injury, or other condi…

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascul…

This trial tests whether using optical coherence tomography (OCT) during a procedure to reopen a chronically blocked carotid artery is safe. The blockage can cause strokes, and doctors often need to see what's inside the artery after crossing the blockage. OCT provides high-resol…

This study tracks the safety and effectiveness of the GORE® TAG® Thoracic Branch Endoprosthesis, a stent-graft device used to treat aortic arch and descending aorta conditions such as aneurysms, dissections, and transections. Researchers will follow about 155 patients who receive…

This trial compares two common procedures—carotid endarterectomy (surgery to clean out the artery) and carotid stenting (placing a mesh tube to hold it open)—in people who have recently had an ischemic stroke caused by a blocked carotid artery. The goal is to see which approach l…

This trial tests whether a gentle electrical current applied to the brain — called transcranial direct current stimulation (tDCS) — can help older adults recover the ability to swallow after a stroke. Hospitalized patients aged 60 to 80 with swallowing difficulties will receive e…

This study looks at whether alirocumab, a drug that lowers cholesterol, can reduce the risk of heart attack, stroke, or death in people who have hardened arteries but have never had a heart attack or stroke before. Researchers will analyze data from routine medical care to compar…

This phase 2 trial is testing whether combining daratumumab, venetoclax, and dexamethasone can produce a deep and rapid response in people newly diagnosed with light-chain (AL) amyloidosis who carry a specific genetic marker called t(11;14). The study enrolls 36 participants and …

This trial tests two methods of harvesting the left internal mammary artery for heart bypass surgery. One method strips the artery clean of surrounding tissue; the other leaves the tissue intact. Researchers want to know which approach keeps the graft open longer and reduces the …

This trial tests whether an 8-week course of the immunosuppressive drug prednisone can reduce episodes of ventricular tachycardia (a potentially fatal fast heart rhythm) and improve heart function in people with non-ischemic cardiomyopathy and confirmed heart inflammation. Partic…

This trial compares two types of transcatheter heart valves—one designed to sit above the natural valve opening (supra-annular) and one that sits within it (annular)—in people with severe aortic stenosis and a small aortic annulus (≤23 mm). The goal is to see which valve leads to…

This study tracks the safety of avacopan, a medication for ANCA-associated vasculitis, an autoimmune disease that causes blood vessel inflammation. Researchers will compare side effects like liver injury, heart problems, serious infections, and cancer in people taking avacopan ve…

This study tests whether a home-visit program called PAT+HEALTH can help pregnant women with obesity in Nigeria improve their heart health and manage weight. About 1,000 women will be randomly assigned to receive the program or standard care. Researchers will track weight, lifest…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can treat left-sided endocarditis as safely as the standard 4-6 week regimen. Adults with endocarditis caused by specific bacteria (Streptococci, Enterococcus faecalis, or Staphy…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This pilot study tests whether a new pacing method called LOT-CRT, which paces two areas of the heart at once, works better than standard pacing alone in people with heart failure. Ten patients will each receive a special pacemaker and try both pacing settings for 6 months each. …

This study tests a prototype smartphone app called Appet HEART, designed to support personalized care for people with coronary artery disease after they leave the hospital. Researchers want to see how often patients use the app, who benefits most, and whether it improves recovery…

This trial tests two rehabilitation techniques — synergy-based electrical stimulation and task-oriented training — to see which better improves leg movement and mobility in people who had a stroke 1 to 6 months ago. Participants, aged 40 to 60, will receive one of the two approac…

This study investigates whether a specific leg exercise program can improve how blood vessels, muscles, and nerves work during exercise in people over 65 with heart failure with preserved ejection fraction (HFpEF). The trial focuses on peripheral problems—like reduced blood flow …

This trial compares two group-based education programs for people with serious mental illness who also have chronic physical conditions like diabetes or heart disease. One program, Integrated Illness Management and Recovery (I-IMR), covers both mental and physical health self-man…

This study follows 100 adults with primary open-angle glaucoma who had a goniotomy procedure using the C-Rex surgical instrument. The goal is to see how well the surgery lowers intraocular pressure and reduces the need for glaucoma medications over 12 months. Researchers will als…

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 partic…

This study looks at people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull can damage vision. Researchers will track which patients need a surgical shunt to relieve pressure versus those who improve with weight loss and medication…

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This trial tests whether placing a balloon in the aorta (REBOA) during CPR can improve blood flow to the heart and brain in people who have a cardiac arrest outside the hospital. The study includes 200 adults with non-traumatic cardiac arrest who receive CPR within 10 minutes. Re…

This trial tests a new device called the Edwards SAPIEN M3 System for people with severe mitral regurgitation, a condition where a heart valve leaks blood backward. The device is placed using a thin tube threaded through blood vessels, avoiding open-heart surgery. The study inclu…

This study tests whether giving stroke patients real-time feedback on muscle activity—either through a visual display or sounds—can improve balance, walking, and daily independence when added to standard physical therapy. The trial enrolls adults aged 20-30 who have had a hemiple…

This study tests whether a procedure called spinal cord stimulation can reduce blood vessel spasms that often occur after a brain aneurysm rupture. Participants have already had standard treatment for their aneurysm and will receive either real or sham stimulation. The goal is to…

This trial investigates whether combining neuromuscular electrical stimulation (NMES) with therapeutic ultrasound can help stroke patients who also have sarcopenia—a condition of low muscle mass and strength. Participants receive four weeks of daily therapy, and researchers measu…

This trial tests whether adding posterior wall isolation to standard pulmonary vein isolation reduces atrial fibrillation recurrence in people with persistent AF. About 482 adults aged 20 to 80 will be randomly assigned to one of the two procedures using pulsed-field energy. Part…

This study evaluates a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. The balloon is used during routine procedures to open blocked heart arteries in people with coronary artery disease. Researchers are tracking h…

This trial tests a device called the Edwards PASCAL system, which is used to repair a leaky tricuspid valve in the heart without open-heart surgery. The study includes 300 people with severe tricuspid regurgitation who are candidates for this procedure. Researchers are checking h…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study investigates whether long-acting parathyroid hormone (PTH) analogues can reduce signs of early heart and blood vessel damage in adults with chronic hypoparathyroidism. Researchers will compare artery stiffness and heart function in people taking the PTH analogue palope…

This study tests whether combining two drugs, droxidopa and pyridostigmine, can improve a sudden drop in blood pressure when standing up (orthostatic hypotension) without making high blood pressure worse when lying down. The trial enrolls people with neurogenic orthostatic hypote…

This trial tests a new artificial valve, called LuX-Valve Plus, for people with severe tricuspid regurgitation (a leaky heart valve) who are not candidates for open-heart surgery. Participants are randomly assigned to receive either the valve implant plus standard medical therapy…

This study tests whether a structured 5-part nursing care bundle can reduce dangerous blood clots (venous thromboembolism) after total hip replacement surgery. The bundle includes patient education, ankle exercises, early walking, fluid management, and compression stockings. Abou…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study compares standard high-intensity gait training and gait training with electrical stimulation against a new approach that uses real-time feedback on how muscles work together (muscle synergies). The goal is to see if this biofeedback method helps people with chronic str…

This study tests a new way to control leg exoskeletons by reading muscle signals in real time. Researchers use high-density electrodes to capture nerve activity and predict a person's intended movement, then have the exoskeleton assist accordingly. The trial includes both healthy…

This study looks at whether people with an On-X mechanical aortic heart valve can safely take a lower dose of the blood thinner warfarin. The goal is to reduce bleeding complications while still preventing dangerous blood clots. Researchers will follow 510 adults for up to 5 year…

This study tests a new treatment called NXC-201 CAR-T for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The therapy uses a patient's own immune cells, modified to target and destroy the cells producing these proteins. The trial is open to …

This trial investigates whether pulsed field ablation (PFA) can safely isolate the pulmonary veins in adults with congenital heart disease who experience atrial tachycardia. Participants will undergo PFA during a standard ablation procedure. The study measures how well the veins …

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study tests a program called PIXI that coaches parents of infants diagnosed with rare neurogenetic disorders (such as Fragile X, Angelman, or Down syndrome) during the first year of life. The program combines education about the disorder, guided parent-child interaction acti…

This pilot study investigates whether stimulating a nerve in the earlobe (vagal nerve stimulation), alone or combined with two medications (galantamine and pyridostigmine), can help control heart rate and reduce symptoms in women with Postural Tachycardia Syndrome (POTS). Partici…

This study follows about 3000 people with complex coronary artery disease who receive the Ultimaster Nagomi stent, a device that slowly releases a drug to keep arteries open. The goal is to see how often the stent fails—meaning heart-related death, heart attack, or need for anoth…

This study tests whether a fully online exercise program is practical and acceptable for people with heart failure. Participants are randomly assigned to either a supervised online exercise group or a self-managed home exercise program for 8 weeks. The goal is to see if people st…

This trial tests a drug called ivarmacitinib in people with Behçet's disease who have not improved with standard treatments. Ivarmacitinib blocks a key inflammation pathway (JAK-STAT) to reduce symptoms. Participants take the drug daily for 24 weeks, and researchers monitor their…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This study tests a combination of two drugs, venetoclax and dexamethasone, in people with a rare blood disorder called AL amyloidosis that has come back or not improved after treatment. The trial includes 53 adults with a specific genetic marker (t(11;14)). The goal is to find th…

This study follows 2,500 people with moderate heart failure (NYHA Class II or III) who already have a CardioMEMS sensor implanted in their lung artery. The sensor wirelessly sends pressure readings to doctors, who use the data to adjust medications. Researchers will track surviva…

This clinical trial tests an implant called PA5108 that is placed inside the eye to lower pressure in adults with open-angle glaucoma or ocular hypertension. The implant is compared to standard latanoprost eye drops. The study aims to find the right dose that is both safe and eff…

This trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…

This trial tests a long-acting injection of leuprolide acetate in children with central precocious puberty, a condition where puberty starts too early. The goal is to suppress puberty-related hormones, slowing or stopping early development. The study includes children aged 4 to 9…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experi…

This trial tests whether a special training that uses unexpected slips on a low-friction platform can help stroke survivors improve their balance and reduce falls. Participants will practice recovering from slips in a safe lab setting, and researchers will track whether these ski…

This study tests a transitional care model for older adults (65+) hospitalized with heart failure, COPD, or pneumonia. The model provides extra education, social services, and coordination among doctors after discharge. Researchers compare this to usual care to see if it reduces …

This study compares two versions of a three-drug combination eye drop for glaucoma: one with preservatives and one without. Researchers want to see if the preservative-free version is gentler on the eye surface and leads to better treatment adherence. Participants will also use a…

This trial tests whether offering remote video exercise sessions, as an alternative to center-based rehab, helps more people attend cardiac rehabilitation after a heart attack. About 1,500 adults aged 18–79 who had a type 1 heart attack will be assigned to either remote or center…

This trial looks at the best time to reopen other blocked arteries in people who have just had a major heart attack (STEMI) and have multiple narrowed heart arteries. Participants are randomly assigned to have all blockages fixed right away or in a separate procedure later. A spe…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study tests whether strengthening the muscles used for breathing can improve exercise capacity, heart function, and quality of life in people with chronic heart failure. Participants with reduced or mildly reduced heart pumping ability will be randomly assigned to one of two…

This study looks at whether starting daily low-dose aspirin in the first trimester (weeks 1–12) is safer and more effective than starting in the second trimester (weeks 13–27) for pregnant women with sickle cell disease. Researchers will track maternal deaths, preterm births, and…

This study tests whether a mechanical heart pump called the HeartMate III (an LVAD) helps people with end-stage heart failure live longer and with fewer strokes compared to taking standard heart failure medications. About 80 adults with severe heart failure are randomly assigned …

This study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can help improve arm and hand movement in people who have had a stroke. The trial involves 7 adults aged 18-80 who had a stroke at least 12 months …

This study looks at how prostate cancer treatments, especially hormone therapy, affect heart health. It includes two parts: one that follows men over time to track heart problems, and another that tests whether a program of healthy eating, exercise, smoking cessation, and medicat…

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication…

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests a new drug called TS23, a monoclonal antibody designed to help break down blood clots in the lungs. It is for people with intermediate-risk pulmonary embolism, a serious condition where clots block blood flow. The trial compares different doses of TS23 against a …

This study looks at whether giving people a heart-lung machine (ECPR) right where they collapse from a cardiac arrest can help more of them survive to leave the hospital. Researchers will compare people who get this extra treatment with those who get standard CPR and care. The st…

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study tests whether a reduced dose of the clot-dissolving drug alteplase, given alongside standard blood thinners, can improve outcomes for people with intermediate-high-risk pulmonary embolism (a serious blood clot in the lungs). About 800 adults with confirmed acute pulmon…

This study tests whether hearts from donors who died from circulatory death (DCD) are as safe for transplant as hearts from brain-dead donors (DBD). About 40 adult heart transplant recipients will receive either a DCD or DBD heart. The goal is to see if using DCD hearts can safel…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart fu…

This early study tests a new stent system designed to treat blockages at artery branch points in the heart. It involves 13 people with heart disease who need a procedure to open these blockages. The main goal is to see if the stent can be safely placed and work as intended.

This study tests whether showing people images of their own carotid arteries (the main arteries in the neck) can improve how they and their doctors manage heart disease risk. Participants are adults aged 40, 50, or 60 who are already part of a health program in Sweden. Some recei…

This study tests a new drug called EYE103 (Restoret) against an existing treatment, ranibizumab (Lucentis), for people with diabetic macular edema, a condition that causes vision loss in diabetes. About 984 participants will receive injections into the eye every 4 weeks for a yea…

This study tests a new device called the DurAVR™ THV System, a replacement heart valve placed through a small tube in an artery, for people with severe aortic stenosis (a narrowed heart valve). The trial involves 150 participants and aims to see if the device is safe and works we…

This study tests a virtual clinic where pharmacists monitor blood pressure, adjust medications, and provide telehealth support to older adults (65+) with high blood pressure. The goal is to see if better blood pressure control can also help prevent cognitive decline. About 1,000 …

This study compares two surgical techniques to fix a leaky mitral valve caused by degenerative disease. One method replaces the tiny chords that support the valve, while the other moves existing chords to a better position. The trial will follow 64 adults for one year after surge…

This study follows 16 infants aged 6 months or younger with infantile-onset Pompe disease, a rare genetic disorder that weakens muscles and breathing. All receive alglucosidase alfa (Myozyme) as part of their routine care. Researchers track how many survive without needing a brea…

This Phase 2 trial tests whether delivering the anti-inflammatory drug dexamethasone directly around deep veins can prevent blood clots from returning after they are removed. The study involves 60 adults aged 18-89 who have had DVT symptoms for 14-60 days. Participants receive ei…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study monitors the safety of the intravenous drug Samtasu (tolvaptan sodium phosphate) in people with heart failure who have fluid overload. Researchers will track side effects, including serious events and off-label use, in about 1,600 patients. The goal is to confirm the d…

This study tests a new device called the MOTIV Sirolimus-Eluting Bioresorbable Vascular Scaffold for people with severe leg artery disease (critical limb ischemia). The scaffold slowly releases medicine to keep the artery open and then dissolves over time. Researchers compare it …

This study tests whether switching to avalglucosidase alfa is safe and more effective for people with late-onset Pompe disease whose condition has worsened on the standard treatment, alglucosidase alfa. Participants receive biweekly infusions of the new drug and are monitored for…

This trial aimed to test whether anti-CD19 CAR-T cells could safely and effectively treat children with refractory ANCA-associated vasculitis, a rare autoimmune disease. The study was withdrawn before enrolling any participants, so no results are available. It was designed for ch…

This early study tests a special scaffold that dissolves over time in 10 people with severe leg artery disease (critical limb-threatening ischemia). The scaffold is placed in arteries below the knee to help keep them open after balloon treatment. Researchers check safety and how …

This study tests a smartphone app called Liebria designed to help people manage high blood pressure. 328 adults with high blood pressure used the app at home to track and lower their readings. The goal is to see if the app can help control blood pressure and improve daily life.

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This early-phase trial tests an investigational biologic called EA5 in adults with antiphospholipid syndrome (APS) who have had two or more blood clots despite standard blood-thinning therapy. The study enrolls about 12 participants and gives EA5 by intravenous infusion followed …

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This trial is testing whether a new PET imaging tracer, 18F-flurpiridaz, can detect coronary artery disease as accurately as the current standard, 82Rb-chloride. The study will involve 60 adults scheduled for a clinically indicated PET scan. Researchers will compare the diagnosti…

This trial tests whether a coronary CT angiography (CCTA) scan can safely identify heart attack patients who do not need invasive angiography. About 300 patients with non-ST-elevation myocardial infarction (NSTEMI) will undergo CCTA before the standard invasive test. The goal is …

This phase 3 trial is testing whether a special PET scan using radioactive water ([15-O]-H2O) can accurately detect coronary artery disease. About 215 adults with suspected heart disease will receive the injection at rest and during stress, then compare results to standard tests.…

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This study tests whether a new MRI technique, called 5D flow, can measure blood flow and pressure in the heart as accurately as the standard invasive procedure, right-left heart catheterization. People with congenital heart conditions who already need a catheterization will also …

This study investigates how well different imaging methods—ultrasound, CT, and MRI—can identify the cause of neck swellings in children. Researchers will compare imaging results with the final diagnosis from biopsy, lab tests, or follow-up. The goal is to see if imaging can relia…

This trial is developing an artificial intelligence system that reads electrocardiograms (ECGs) to detect congenital heart disease in children. Researchers are collecting ECG data from thousands of children, including those with common and rare heart defects, to train a deep-lear…

This study is testing whether artificial intelligence can detect transthyretin amyloid cardiomyopathy (ATTR-CM), a serious and often underdiagnosed heart condition, earlier than usual. Researchers will use AI algorithms to analyze routine ECGs and heart ultrasounds from up to 1.5…

This study tests whether a non-invasive device called Vivio can accurately track heart failure status by measuring blood pressure in the lungs. Researchers will compare Vivio readings to those from an implanted CardioMEMS sensor in 500 adults over age 21 who already have or will …

This trial tests whether improving how clinics measure and record blood pressure, height, and weight can help identify people with undiagnosed hypertension or diabetes. About 800 adults visiting family medicine clinics will be part of a study where some clinics use the FOR-Care m…

This trial tests whether an artificial intelligence tool can improve the accuracy and speed of measuring heart wall thickness on echocardiograms compared to standard sonographer measurements. About 4,000 adults receiving a transthoracic echocardiogram will have their images asses…

This study tests whether a compact 3-lead ECG device can accurately detect acute coronary syndrome (heart attack) in adults arriving at the emergency department with chest pain. Participants receive a HeartBeam ECG recording within 10 minutes of the standard 12-lead ECG. The goal…

This study is developing and testing an artificial intelligence model that analyzes images of skin biopsies to tell the difference between malignant lymphomas (like mycosis fungoides) and benign conditions that look similar. The AI will be trained on hundreds of archived slides a…

This Phase 3 trial tests whether NH002, a contrast agent made of tiny gas-filled microspheres, can improve the quality of heart ultrasound images in people with heart disease. Participants receive NH002 through an IV before a standard echocardiogram. The study compares the clarit…

This early-phase trial tests a radioactive imaging agent called 18F-mFBG to see how well it can show the nerves in the heart. Researchers will give the agent to 10 adults—some with heart disease and some without—and take PET scans over time. The goal is to measure how the agent m…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This trial tests whether adding a polygenic risk score (a DNA-based estimate of heart disease risk) to standard risk assessment helps better identify who needs preventive measures like statins or lifestyle changes. About 205 adults aged 40–69 with intermediate cardiovascular risk…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study looks at whether a detailed full-body scan called FDG PET/CT can find hidden cancers in people aged 50 and older who have had an unexplained blood clot. About 1,276 participants will get either the scan or standard cancer checks. The goal is to see if the scan catches …

This study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…

This study tests a program called Mom♥Health to help mothers of young children reduce their risk of heart disease. About 40 moms with kids aged 5 or younger will receive support and resources through their child's daycare center. The goal is to see if this approach is practical a…

This trial asks whether hydroxyurea, a daily oral medication, can reduce the risk of a first stroke in children with sickle cell anemia. Researchers will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brain, a key indicator of stroke risk, in children aged…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This study tests a co-created antenatal care program designed for busy urban clinics in Dar es Salaam, Tanzania, where climate risks like heat, flooding, and pollution add to pregnancy challenges. The program includes guidance for pregnant women and their families, provider train…

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

This trial tests whether spinal cord stimulation can reduce severe, treatment-resistant pain in people with erythromelalgia, a rare condition causing red, hot, and painful extremities. Participants receive either burst stimulation or sham (inactive) stimulation to see if the ther…

This pilot study is testing whether providing medically tailored meals to heart failure patients after they leave the hospital is practical and helpful. Researchers will enroll 85 adults who are on Medicaid or Medicare and recovering from a heart failure hospitalization. The meal…

This study tests whether a single dose of intravenous iron (ferric derisomaltose) can improve exercise capacity in people with heart failure with preserved ejection fraction who also have iron deficiency. About 66 adults will receive either the iron infusion or a placebo, and the…

This trial investigates whether adding focused shock wave therapy to standard Botox injections can better ease foot stiffness and improve walking in people with post-stroke spastic equinovarus foot. Participants are randomly assigned to receive Botox alone, shock waves just befor…

This study tests a new exercise therapy called Progressive Abduction Loading Therapy for people who recently had a stroke. The goal is to reduce a common arm problem called 'flexion synergy' that makes it hard to reach outward. 86 participants will receive either the new therapy …

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both…

This trial explores whether an affordable robot can help people with HIV who have had a stroke improve their arm and leg function. Participants will use the robot for rehabilitation exercises, and researchers will measure changes in movement, balance, and quality of life. The goa…

This trial explores whether five daily sessions of a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce fatigue in people who have had a stroke. Participants will receive either real or sham stimulation, and their fatigue levels wi…

This trial tests whether nurse-guided breathing exercises can reduce shortness of breath and anxiety in people with advanced heart failure who come to the emergency department. Participants are randomly assigned to receive either standard care plus guided diaphragmatic and pursed…

This study tests whether 8 weeks of phone-based mindfulness training can improve self-care and thinking skills in 176 adults with heart failure and mild cognitive impairment. Participants practice techniques like breath awareness and body scanning for 20 minutes daily. The goal i…

This phase 3 trial tests whether aficamten, an oral drug, can improve quality of life and exercise capacity in 500 adults with symptomatic non-obstructive hypertrophic cardiomyopathy, a heart condition that makes the heart muscle thick and stiff. Participants receive either afica…

This trial tests whether a structured therapeutic education program, delivered by general practitioners, can improve quality of life for people with heart failure. Around 200 patients in primary care will be randomly assigned to receive the program or usual care, and their qualit…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This trial compares two ultrasound-guided nerve blocks—erector spinae plane block and modified pectoral fascial plane block—for pain control in children undergoing congenital heart surgery. Forty children will be randomly assigned to receive one of the blocks before their incisio…

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

Slow-flow vascular malformations — abnormal clusters of veins, capillaries, or lymph vessels — can cause pain, swelling, and appearance concerns. This study follows 60 children and adults who receive bleomycin electrosclerotherapy (BEST), a procedure that injects the drug bleomyc…

This study compares a structured pulmonary rehabilitation program — including breathing exercises, aerobic conditioning, and education — against standard medical care for people with pericarditis (inflammation around the heart). The goal is to see if the program can reduce chest …

This study investigates whether keeping a headache diary helps adults with migraine feel better and manage their condition. Participants track their headaches in a virtual diary, and researchers measure changes in quality of life and disability. The goal is to see if this low-cos…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This study investigates whether a 16-week individually tailored exercise program, guided by a physiotherapist, can help adults with post-COVID POTS (postural orthostatic tachycardia syndrome) spend more time upright and feel better. Participants are randomly assigned to either th…

This study explores whether dry needling — a technique where thin needles are inserted into tight muscles to trigger a twitch — can reduce spasticity (stiffness) in people who have had a stroke. Researchers will measure changes in nerve pathways and movement over two visits. The …

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study compares two types of exercise—open kinetic chain (like leg raises) and closed kinetic chain (like squats)—to see which better reduces knee hyperextension in stroke survivors. Sixty adults who have had a stroke and can walk with some help will be randomly assigned to o…

This trial tests whether wearing compression stockings with a higher (32 mmHg) or lower (21 mmHg) pressure after radiofrequency ablation for varicose veins leads to less pain and swelling. About 64 adults with varicose veins and leg swelling will wear one of the two stocking type…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, exercise ability, and quality of life in 150 adults with a type of heart failure called HFpEF who also have iron deficiency. Participants will receive either the iron infusion …

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medi…

This study tests two different movement training methods—sprinter-style and skater-style—to see which better improves balance and coordination in people who had a stroke at least six months ago. Twenty-two participants will do 30-minute sessions three times a week for four weeks.…

This study tests whether taking extra salt (5 grams per day in capsules) can improve symptoms and quality of life in older adults (65+) who experience dizziness and falls due to orthostatic hypotension. The trial involves 42 participants and lasts 12 months, focusing on whether s…

This study tests whether an 8-week mindfulness meditation program (MBSR) can reduce anxiety and depression in heart patients who have completed cardiac rehab. About 74 participants will either take the meditation course or continue with standard rehab. Researchers will measure ch…

This study tests whether applying shockwave therapy to the calf muscles can improve blood flow and reduce pain in people with peripheral artery disease. About 138 adults with stable leg pain when walking will receive the treatment. The goal is to see if it helps them walk longer …

This study compares two physical therapy approaches—Rood's techniques (using touch, stretch, and ice) and PNF patterns (diagonal movements)—to improve arm and hand function in people who recently had a stroke. 28 adults aged 40-60 with a first-time stroke will receive one of the …

This study tests whether a probiotic supplement called Neuralli® MP can help adults aged 18 to 50 who have autistic traits. Participants take two capsules daily and set their own personal goals to track progress. The trial is small and open-label, meaning everyone knows they are …

This study follows 500 adults under 45 who have narrowing of a major brain artery, a condition that can raise stroke risk. Researchers will track participants over time to see how the narrowing progresses and who goes on to have a stroke. The goal is to better understand the natu…

This study is developing a digital twin—a virtual model of the heart and blood vessels—to better understand and manage hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will gather detailed health data from 2500 people with HCM or the gen…

This study tests a new device called the EDEN system that records and classifies electrical signals from the heart during medical procedures. About 50 adults having heart procedures for ventricular arrhythmia or pacing will participate. The device works alongside standard equipme…

This early-stage study will check if two different tablet forms of the drug HRS-1893 are processed the same way in the body. Thirty-six healthy adults will take both versions and have blood tests to measure drug levels. The goal is to see if the two formulations are equivalent, n…

This study follows 46 people with gyrate atrophy, a rare genetic condition that causes vision loss, over 4 years. Researchers measure ornithine levels in the blood and track changes in the retina using eye scans and photos. The goal is to learn how the disease progresses under st…

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to hea…

This study will collect blood, urine, stool, and DNA samples from 2000 adults with heart failure to better understand how the disease progresses. Researchers will analyze proteins and other factors linked to declining heart function. Participants will be followed for up to 5 year…

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This study looks at whether measuring the arm or finger can help choose the right blood pressure cuff size for pregnant women. Accurate blood pressure readings are vital during pregnancy and childbirth, but the current method of sizing cuffs may not always be correct. Researchers…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study tests a new imaging device called OCT-NIRAF that takes detailed pictures inside heart arteries during a standard heart procedure. Researchers want to see if the images can predict which plaques (fatty buildups) will grow and become dangerous. Forty adults with heart di…

People recently released from prison face twice the risk of dying from heart disease compared to the general population. This study investigates the barriers and facilitators to healthcare access for this group, following 508 adults released from state prison in the Denver/Aurora…

This study follows 800 adults who have had their first ischemic stroke in Central Norway for up to 10 years. Researchers will track how physical activity, medication use, and control of blood pressure and cholesterol affect the risk of death, another stroke, or severe disability.…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study follows 500 people who survived a cardiac arrest to understand post-cardiac arrest syndrome (PCAS), a complex condition that often leads to death or brain damage. Researchers will compare different temperature management strategies and other treatments to see which mig…

This study collects blood and other samples from people with sickle cell disease and healthy volunteers to help researchers understand how inflammation affects blood vessels. Up to 2,000 adults aged 18 and older will take part. The samples will be used in lab tests to support fut…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study follows 250 male endurance athletes who were part of an earlier study to see how their heart arteries have changed over time. Researchers will use CT scans and AI to examine plaque buildup and determine if it is stable and harmless or likely to cause heart attacks. The…

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how their aldosterone hormone system changes over time. Participants will eat special high-salt or low-salt diets for a few days each year to test how their body responds. The goal is to better un…

This study looks at whether a forehead EEG monitor (BIS) can be used during out-of-hospital cardiac arrest to track brain activity. Researchers will check if the device works in the ambulance and emergency room, and whether its readings help predict brain injury. The study involv…

This study looks at whether a new computer algorithm can predict if atrial fibrillation (an irregular heartbeat) will come back after a common treatment called pulmonary vein isolation. Researchers will review medical records from 300 patients who had this procedure. The goal is …

This study looks back at 10 years of medical records from a scoliosis referral center to see how frequently adults with scoliosis who had surgery also develop restrictive breathing problems or signs of pulmonary hypertension on echocardiography. By analyzing data from 174 patient…

This trial investigates whether increasing or decreasing salty food intake for just six days changes how pleasant, desirable, or salty foods taste. Healthy young adults aged 18–35 are randomly assigned to eat more salty foods, fewer salty foods, or stick to their usual diet. Rese…

This trial tests whether a treadmill that automatically adjusts its speed to the walker can help people with weakness on one side of the body take more even steps. Participants with hemiparesis from a stroke or traumatic brain injury will walk on both a self-pacing and a fixed-pa…

This study surveys doctors who use Concerto Versa detachable coils to treat various blood vessel conditions like aneurysms and varicose veins. About 30 patients will be included, and doctors report how well the coils work and any problems within 72 hours. The goal is to collect e…

This study looks at how a soft robotic exosuit can help people who have had a stroke walk better. Researchers will measure muscle activity and walking patterns in 22 adults who are at least six months past their stroke. The goal is to see if customizing the exosuit's assistance b…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. About 800 participants at higher risk will receive either usual care or a personalized program with nutrition, exercise, and stress management advice. T…

This study at Mayo Clinic looks at how renin, a protein in the blood, changes when patients are on the heart-lung machine during open heart surgery. Researchers want to see if renin levels can help guide treatments for low blood pressure. The study will enroll 100 adults having e…

This study follows 1,000 patients in China who are already receiving faricimab for diabetic macular edema, retinal vein occlusion, or wet age-related macular degeneration. Researchers will collect data from routine clinic visits over one year to see how well the drug works and ho…

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how well participants can keep their balance and walk. The goal is to learn more about these issues so that rehabil…

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference…

This 5-year study follows 250 people with von Hippel-Lindau disease who have brain or spinal cord tumors. Researchers use regular MRI scans and blood tests to see how fast tumors grow and what factors like hormones might affect growth. The goal is to better understand which tumor…

This observational study follows about 198 patients in Spain who are already taking inclisiran (Leqvio) for high cholesterol linked to heart disease or a genetic condition. Researchers will check if patients reach their LDL cholesterol goals after 6 and 12 months. The goal is to …

This study looks at whether sensors inside implanted heart devices can warn of worsening heart failure. Researchers will track 500 adults with heart failure or cardiomyopathy who have a Boston Scientific ICD or CRT-D equipped with HeartLogic, Sleep Incline, and Apnea Scan functio…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

This study is testing a new video game designed to help teenagers with congenital heart disease learn how to manage their own healthcare. The game teaches skills like talking to doctors, understanding medical information, and keeping track of appointments and medications. About 1…

This observational study looks at why some untreated coronary artery blockages get worse over time in people who have already had a stent or balloon procedure for heart disease. Researchers will follow 1,400 adults aged 18-80 who are scheduled for a repeat angiogram, tracking the…

This study tested a new MRI method to better predict stroke risk in people with intracranial atherosclerosis, a condition where arteries in the brain become narrowed. Researchers measured how well different parts of the brain responded to changes in blood flow. The goal was to fi…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study aims to improve how doctors communicate with patients facing serious illnesses like cancer, heart failure, COPD, or dementia. Researchers will give doctors detailed feedback on their conversations about goals of care. The goal is to help patients receive care that matc…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study follows individuals with autism who carry a PTEN gene mutation, along with comparison groups, to track changes in thinking, language, and behavior over time. Researchers will also collect blood samples and medical data to build a large database for future studies. The …

This study looks at whether stroke patients who do high-intensity rehab at home recover just as well as those who go to a rehab facility. Researchers will follow 500 patients who choose home rehab and compare their progress to patients who went to inpatient rehab. The goal is to …

This study is tracking over 5,000 adults who had a cardiac arrest outside the hospital to learn what causes it and who is at risk. Researchers will look at health habits, chronic diseases, and develop a prediction model. The goal is to find new ways to prevent these life-threaten…

This study is for women with breast cancer who are receiving a treatment that greatly lowers estrogen levels. Researchers want to see if this treatment changes how the heart works. They will use heart scans to measure blood flow in 90 women over two years. The goal is to learn mo…

This study follows 60 people with abdominal aortic aneurysm who are scheduled for endovascular repair (EVAR). Researchers will measure artery stiffness, heart structure and function, and certain blood markers before the procedure and at several points afterward. The goal is to un…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study follows 50 people who previously received an INSPIRIS RESILIA aortic valve and now need a valve-in-valve procedure because their original valve is not working well. Researchers will track complications like death, stroke, bleeding, and valve movement, as well as how we…

This study is a registry that will follow 6,000 people who had a heart attack and were treated with emergency angioplasty at Zhongshan Hospital. Researchers will collect information on their health, procedures, and medications, and track their recovery for up to two years. The go…

This study is testing an implantable heart monitor (LUX-Dx ICM) in 525 people with heart failure. The goal is to collect sensor data to better understand when heart failure events happen. Participants have moderate heart failure (NYHA class II or III) and certain heart structure …

This study looks at whether standard blood tests for heart failure show different results in African American and Caucasian patients. Researchers will compare levels of cardiac biomarkers in 400 adults newly diagnosed with heart failure. The goal is to see if current tests miss o…

This study looks at children diagnosed with a ventricular septal defect (a hole in the heart) to understand if and when the hole might close without treatment. Researchers will follow children from birth to age 14 and use echocardiography to track the defect. The goal is to build…

This study explores whether artificial intelligence (AI) combined with data from a smartwatch can predict serious heart failure events, such as hospitalizations or worsening symptoms. Adults with heart failure will wear a smartwatch for six months and take weekly ECG readings. Th…

This study tests new strategies to make sure that decisions about who gets a heart transplant or a heart pump are fair and based on objective medical criteria, not bias. Researchers will work with over 1,400 patients and doctors at heart centers across the U.S. to reduce racial a…

This study follows people who previously received NTLA-2001, an experimental gene-editing therapy, for a type of amyloidosis that can affect nerves or the heart. The goal is to monitor long-term safety and see if the therapy's effects on disease markers persist over time. Partici…

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study compares blood vessel function in healthy adults who have taken estrogen-based contraceptives for at least a year versus those who have not. Researchers will measure how small vessels in the skin and under the tongue respond to drugs that affect blood flow. The goal is…

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This study follows about 400 adults with liver cirrhosis admitted to internal medicine wards across Italy. Researchers will track how doctors manage hepatic encephalopathy—a brain complication of liver disease—during hospitalization and after discharge. The goal is to identify pr…

This pilot study is testing whether a specialized blood test called thromboelastography (TEG) can better evaluate clotting problems in people with severe burns. Researchers will track clotting patterns over the first four weeks after injury and see if they relate to burn size or …

This study aims to create and test a new scoring system called HeQAS that uses a microscope to evaluate the technical quality of hemorrhoid removal surgery. Researchers will check if the score is reliable and whether a newer, less invasive surgical method causes less tissue damag…

This study tests whether pairing vagus nerve stimulation (VNS) with language training can improve memory and learning in people who have already used VNS for movement recovery after a stroke. Participants, who already have a VNS implant, will try learning a new language while the…

This study looks at whether heart rate variability (small changes in heartbeat timing) and early signs of inflammation can help predict breathing or heart problems in children having their tonsils or adenoids removed. Researchers will monitor heart rhythms and measure immune mark…

This study explores whether a special 3D ultrasound technique, called vector flow imaging, can predict where blood clots form inside abdominal aortic aneurysms. Researchers will scan 14 people with small aneurysms (under 5.5 cm), half with existing clots and half without. They wi…

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…

This trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The study is small and early-stage, focused on understanding how the device works and whether it is safe. No results are available yet, and the device is not ready for widespread use.

This study investigates whether muscle mass, measured automatically from CT scans using artificial intelligence, can help predict recovery in people who survive a cardiac arrest. Researchers will also test an enhanced rehabilitation program that includes muscle stimulation and gu…

This study tests whether a 12-lead wearable Holter monitor can be worn during MRI, CT, X-ray, and echocardiography without affecting image quality or the device's ability to record heart signals. Researchers will enroll 500 adults who need these imaging exams and will check for e…

This study aims to better understand atrial fibrillation (AFib), the most common abnormal heart rhythm. Researchers will use mobile devices like ECG patches and a smartphone app to monitor heart rhythm, activity, and sleep in 3,000 adults, some with AFib and some without. Partici…

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study uses a non-invasive eye scan called OCTA to examine tiny blood vessels in the retina of adults with type 1 diabetes. The goal is to detect early signs of diabetic retinopathy, a leading cause of vision loss, before symptoms appear. Researchers will measure vessel densi…

This pilot study looks at whether spinal cord stimulation can improve nerve health in people with small fiber neuropathy, a condition that causes chronic pain. Researchers will measure changes in nerve fiber density from skin biopsies taken before and after 12 months of routine c…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study looks at whether a quick, simple test—standing up and sitting down from a chair as many times as possible in one minute—can help predict how heart failure patients will fare after leaving the hospital. Researchers will follow 68 adults hospitalized for decompensated he…

This study scans over 16,000 adults aged 18 to 70 without known heart disease to find hidden (silent) plaque in their arteries using ultrasound and CT scans. The goal is to measure how common silent atherosclerosis is and build a risk calculator that combines imaging, lifestyle, …

This study collects blood and tissue samples from up to 500,000 adults, including heart patients, their family members, and healthy individuals. Researchers will analyze these samples to find molecular and genetic markers linked to heart disease. The goal is to improve understand…

This study investigates how the brain coordinates muscle activity during walking rehabilitation in people recovering from a stroke. Researchers use high-density electromyography (HD-EMG) to track neural synergies—groups of muscles that receive common signals from the brain—over t…

This study examines how ankle impairments affect walking ability in people who had a stroke at least six months ago. Researchers use a robotic device to measure ankle control and sensation, comparing results with standard walking tests and clinical scales. The goal is to develop …

This study uses a non-invasive ultrasound device to monitor blood flow and detect tiny clots traveling to the brain during placement of a specialized stent-graft for thoracic aortic aneurysms or dissections. Researchers aim to understand how often these microemboli occur and how …

This study investigates whether a drug called XBD173, which targets a protein (TSPO) on blood vessel lining cells, can help understand how these cells contribute to pulmonary artery hypertension (PAH). PAH is a rare condition where narrowed lung blood vessels strain the heart. Si…

This pilot study investigates whether a continuous remote ECG monitor, worn as a chest patch, can predict hospital readmission or death within 30 days after discharge in patients with heart failure and atrial fibrillation. Fifty participants will wear the Vivalink ECG patch at ho…

This study compares two procedures—rotational atherectomy and intravascular lithotripsy—used to treat severe calcium deposits in heart arteries. The goal is to see how each technique affects the tiny blood vessels (microcirculation) of the heart and whether one leads to better lo…

This study looks at whether pausing sedation each day in mechanically ventilated ICU patients can reduce the amount of blood pressure medication they need. Researchers will compare medication doses before and during these daily awakening trials. The goal is to see if this simple …

This study looks at how a stroke affects the jaw joint and chewing muscles. Researchers will use ultrasound to measure jaw structures in 70 stroke survivors and see if these measurements relate to their recovery. The goal is to better understand jaw problems after a stroke, which…

This study looks at whether detailed analysis of heart MRI images (called radiomics) can better predict life-threatening heart rhythms in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will also see if the drug mavacamten, …

This study follows 172 adults over two years to compare cardiovascular function among four groups: vapers who previously smoked, vapers who never smoked, people who both vape and smoke, and ex-smokers who do not vape. Researchers measure blood vessel health, lung function, and bl…

This pilot study tests whether keeping the lungs gently ventilated during cardiopulmonary bypass (heart-lung machine) reduces lung collapse after heart surgery. Adults having elective coronary artery bypass surgery will be randomly assigned to receive ventilation or not during by…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study investigates whether a protein called DISC1, known for its role in schizophrenia, is also linked to heart function in people with the condition. Researchers will measure DISC1 levels in blood and use heart imaging (echocardiograms, cardiac MRI, and ECGs) to assess hear…

This trial investigates whether kidney transplant candidates on dialysis can safely skip routine heart screening after being placed on the waiting list. Participants are randomly assigned to either no further screening or regular annual screening for hidden coronary artery diseas…

This study tests a new non-invasive blood pressure (NIBP) measurement method in adults who already have an arterial line in place. The goal is to see how well the cuff-based readings match the direct arterial measurements. Participants must be 18 or older and have an arm or thigh…

This study evaluates whether artificial intelligence models can accurately interpret ROTEM blood clotting tests and recommend treatments for coagulopathy. Researchers will compare AI decisions to those of a panel of clinical experts using data from adults undergoing elective card…

This study looks at whether a hormonal implant containing gestrinone affects blood vessel function and heart health in young women. Researchers will compare women who have used the implant in the last six months with those who have never used it. The goal is to understand any pot…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study looks at how often pelvic congestion syndrome (a condition where veins in the pelvis become enlarged and painful) occurs in women who are about to have a standard procedure for leg varicose veins. Researchers want to know if having this pelvic condition affects how muc…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This observational study looks back at 22,000 adults in Sweden diagnosed with infective endocarditis, a serious heart valve infection, since 1997. By linking national health records, researchers aim to understand which patients benefit most from valve surgery and what factors aff…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study tests whether combining standard monitoring tools with new light-based sensors can better detect a dangerous narrowing of the aorta in newborns. Infants under one month old with suspected aortic arch obstruction will be monitored using resonance Raman spectroscopy, pul…

This study follows 100 people with and without varicose veins to see how often the condition appears and how it changes over time. Participants get yearly checkups including ultrasound exams. The goal is to learn what factors make vein disease worse and how it naturally progresse…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study looks at whether bosentan, a drug that blocks a natural vessel-constricting substance, can improve blood flow in the tiny heart vessels of people with angina who have no major blockages. About 45 participants will get bosentan for 4 weeks and have MRI scans before and …

This study looks at how a brain procedure called embolization affects the immune system. Researchers will take blood samples from 78 patients before and after the procedure to measure immune markers. They want to understand why patients with brain arteriovenous malformations (AVM…

This study is gathering health information from 4,600 people in rural areas of Alabama, Kentucky, Louisiana, and Mississippi. Researchers will look for risk factors that lead to heart and lung disease. No treatments or drugs are being tested. The goal is to learn more about what …

This study follows over 3,400 adults who have had a heart stent procedure to understand how continuity of care, health literacy, and medication adherence influence their long-term health. Researchers will track hospital readmissions, medication use, and patient-reported outcomes …

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This study looks at whether an ultrasound measurement of a large vein near the heart (the inferior vena cava) can predict when a patient's blood pressure will drop dangerously during hip replacement surgery. Researchers will measure this vein's flexibility before cement is used t…

This study explores whether artificial intelligence can predict which children with a type of heart hole (perimembranous ventricular septal defect) will later develop complications like valve problems or blockages. Researchers will analyze past echocardiogram reports and medical …

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study was designed to compare electrical and mechanical activation of the right ventricle in adults who had surgery for Tetralogy of Fallot, a congenital heart condition. Researchers planned to use 3D mapping and imaging to see if electrical signals match the heart's physica…

This study was designed to see how a low dose of bevacizumab (Avastin) behaves in the body and whether it safely lowers a certain protein (VEGF-A) in people with kidney failure on dialysis. The goal was to gather information for a future trial on preventing dialysis access failur…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study tests whether a special CT scan (CCTA) of the heart can predict if atrial fibrillation will come back after a standard ablation procedure. Researchers will scan patients before their first ablation and then follow them for a year. The goal is to see if heart structure …

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study looks at people with persistent atrial fibrillation (an irregular heartbeat) and moderate-to-severe functional mitral regurgitation (a leaky heart valve). Researchers want to see if a procedure called catheter ablation—which zaps abnormal heart tissue to restore normal…

This study follows 280 people with mitral valve prolapse over 3 years to see if heart MRI scans and blood tests can predict who will develop dangerous heart rhythms or heart muscle changes. Participants undergo MRI, blood draws, and heart monitoring. The goal is to find early war…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study tests a machine-learning tool built into electronic health records to help emergency doctors quickly assess risk in adults with acute heart failure. The tool predicts which patients are at high risk of complications and likely need hospital admission, and which low-ris…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will fo…