Can smartphones and wearables unlock the secrets of atrial fibrillation?
NCT ID NCT04404465
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This study aims to better understand atrial fibrillation (AFib), the most common abnormal heart rhythm. Researchers will use mobile devices like ECG patches and a smartphone app to monitor heart rhythm, activity, and sleep in 3,000 adults, some with AFib and some without. Participants will also provide blood and saliva samples and undergo annual heart imaging for three years. The goal is to find markers that can predict who will develop AFib, whose condition will worsen, or who will respond best to treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better ways to predict who is at risk for atrial fibrillation and who will respond best to treatment.
- What could go wrong
- This is an observational study, not a treatment trial, so it will not directly test any new therapy. The findings may not lead to immediate clinical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 3,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2020
- Expected to finish
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Sep 2040
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Subjects with a diagnosis of AF (i.e. new onset AF, paroxysmal AF, persistent AF, Permanent AF), those undergoing AF ablation or DCCV, those with a PAC greater or equal to 5% PAC burden, those undergoing SVT ablation, subjects with high risk of AF and healthy volunteers at least 18 years of age or older who have been seen at UCSF, who meet the inclusion and exclusion criteria will be eligible for participation in this study.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. At least 18 years of age or older 2. English speaking 3. Able to consent 4. ANY one of the following criteria: 1. Patients undergoing ablation for AF. 2. A history of non-valvular AF or AFL (not due to a reversible cause) documented on ECG or ambulatory monitoring within 1 year of enrollment and not on chronic anti-arrhythmic drugs (AAD). 3. A history of newly diagnosed persistent AF with documented normal sinus rhythm within 6 months of enrollment and undergoing cardioversion fot AF. 4. Two or more of the following criteria if no history of AF: * Age \> 65 years of age * A diagnosis of hypertension * A diagnosis of diabetes * A diagnosis of sleep apnea * A BMI ≥ 30 * Stable HF with preserved or reduced ejection fraction (NYHA Class I, II or III) * CKD not requiring dialysis 5. More than 5% PAC burden on ambulatory ECG monitoring (e.g. Holter, Ziopatch, Lifewatch, etc.) 6. Patients undergoing EP study or ablation for SVT with no history of AF and not meeting any of the above criteria (a-c). Exclusion Criteria: 1. Life expectancy \< 1 year 2. Reversible causes of AF (e.g., post-operative AF, cardiac surgery, pulmonary embolism, untreated hyperthyroidism) 3. Pregnant at the time of enrollment 4. Unwilling/unable to perform follow-up using digital follow-up 5. CKD requiring dialysis 6. Presence of a condition or abnormality that, in the opinion of the Investigator, would compromise the safety of the patient or the quality of the data 7. Patients undergoing active treatment for cancer or diagnosed with cancer requiring treatment in the last 2 years 8. Severe Valvular Disease (eg. Rheumatic Heart Disease, Severe Mitral Valve Regurgitation, severe tricuspid regurgitation, severe aortic stenosis, or valve replacements) 9. History of organ transplant 10. History of any significant congenital heart defect 11. Existing Pacemakers and ICDs if not undergoing an ablation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of California, San Francisco
San Francisco, California, 94143, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Hidden heart rhythm problems after stroke: can longer monitoring prevent a second stroke?
- Can a blood test reveal why atrial fibrillation returns after cryoablation?