Can a blood test reveal why atrial fibrillation returns after cryoablation?
NCT ID NCT05170607
First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time
Summary
This study looks at blood samples from 120 people with atrial fibrillation who have had a procedure called cryoablation to restore normal heart rhythm. The goal is to find specific proteins in the blood that might indicate whether the irregular heartbeat is likely to come back due to triggers outside the pulmonary veins. By identifying these biomarkers, doctors may eventually be able to personalize treatment and improve long-term outcomes for people with atrial fibrillation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Proteomic analysis by antibody microarrays (a diagnostic test measuring blood proteins)
- What this could lead to
- If specific proteins are found, doctors might better predict which atrial fibrillation patients will need additional treatment beyond standard cryoablation.
- What could go wrong
- This is an early exploratory study focused on finding biomarkers, not testing a treatment. The identified proteins may not prove reliable in larger, more diverse patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2021
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients 18-85 years old with s paroxismal or persistant atrial fibrillation and prior interventional treatment
- Ages
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18 to 85 years
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: • Patient with paroxysmal/persistent atrial fibrillation who underwent interventional treatment Exclusion Criteria: * permanent AF * contraindications to oral anticoagulation or heparin * chronic kidney disease requiring dialysis * untreated hypo- or hyperthyroidism * breast feeding * pregnancy * chronic kidney disease requiring dialysis * decompensated heart failure * stroke within the last 3 months * myocardial infarction within the last 3 months * Percutaneous coronary intervention or Coronary Artery Bypass Grafting within the last 3 months * active myocarditis * artificial valve replacement surgery * severe mitral or aortic stenosis * coronary artery disease requiring revascularization * heart transplant
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Research Center for Preventive Medicine
Moscow, 101990, Russia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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