New shot aims to tackle hidden heart risk: high lp(a)

NCT ID NCT07235046

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests an injectable drug called DII235 in 233 adults with high lipoprotein(a), a genetic condition that raises heart disease and stroke risk. Participants have heart disease or type 2 diabetes. The study compares different doses of DII235 against a placebo to see if it safely lowers Lp(a) levels over several months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

DII235 (an injectable drug)

What this could lead to

If successful, this could lead to a new treatment to lower high lipoprotein(a), a genetic risk factor for heart disease and stroke.

What could go wrong

This is a mid-stage trial with only 233 participants, so results may not apply to everyone. The drug may not work as hoped or could have side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder Dyslipidemias hyperlipidemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIPOPROTEIN DISORDER

Contacts and locations

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Locations

AA Medical Research Center

Flint, Michigan, 48504, United States
AB Clinical Trials

Las Vegas, Nevada, 89119, United States
AMR Chicago

Niles, Illinois, 60714, United States
Alliance Clinical

Canoga Park, California, 91303, United States
Alliance for Multispecialty Research

Knoxville, Tennessee, 37909, United States
Anderson Medical Research

Ft. Washington, Maryland, 20744, United States
Angiocardiac Care of Texas PA

Houston, Texas, 77025, United States
Apex Cardiology Research Associates of Jackson

Jackson, Tennessee, 38301, United States
Atlanta Heart Specialists LLC

Tucker, Georgia, 30084, United States
Biopharma Informatic

Katy, Texas, 77479, United States
CV Ins of the South

Lafayette, Louisiana, 70503, United States
Capitol Cardiology Associates

Lanham, Maryland, 20706, United States
Cardiology Associates of North MS

Tupelo, Mississippi, 38801, United States
Cardiology Consultants of Philadelphia

Yardley, Pennsylvania, 19067, United States
Cardiology Partners Clinical Research Institute

Wellington, Florida, 33449, United States
Cardiology and Medicine Clinic PA

Little Rock, Arkansas, 72204, United States
Clinical Trials of Texas

San Antonio, Texas, 78229, United States
Dallas Heart and Vascular Consultants PA

Houston, Texas, 77084, United States
Dominion Medical Associates

Richmond, Virginia, 23219, United States
Excel Medical Clinical Trials LLC

Boca Raton, Florida, 33434, United States
Flourish Res Acq LLC North Miami

Miami, Florida, 33138, United States
Heart Center Research Llc

Huntsville, Alabama, 35801, United States
Inpatient Research Clinical LLC

Miami Lakes, Florida, 33014, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
K and R Research LLC

Marion, Ohio, 43302, United States
Metropolitan Cardiovascular Consultants Llc

Beltsville, Maryland, 20705, United States
Monroe Research Llc

West Monroe, Louisiana, 71291, United States
MultiCare Ins Research Innovation

Puyallup, Washington, 98372, United States
National Heart Institute

Beverly Hills, California, 90211, United States
Northwest Houston Clinical Research PLLC

Tomball, Texas, 77375, United States
Novartis Investigative Site

Luoyang, Henan, 471002, China
Novartis Investigative Site

Shenyang, Liaoning, 110016, China
Novartis Investigative Site

Wenzhou, Zhejiang, 325000, China
Novartis Investigative Site

Beijing, 100034, China
Novartis Investigative Site

Munich, Bavaria, 81377, Germany
Novartis Investigative Site

Potsdam, Brandenburg, 14473, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 60594, Germany
Novartis Investigative Site

Kaiserslautern, Rhineland-Palatinate, 67655, Germany
Novartis Investigative Site

Dresden, Saxony, 01307, Germany
Novartis Investigative Site

Bad Krozingen, 79189, Germany
Novartis Investigative Site

Bad Oeynhausen, 32545, Germany
Novartis Investigative Site

Berlin, 10787, Germany
Novartis Investigative Site

Dortmund, 44137, Germany
Novartis Investigative Site

Essen, 45359, Germany
Novartis Investigative Site

Gladbeck, 45968, Germany
Novartis Investigative Site

Magdeburg, 39120, Germany
Novartis Investigative Site

Münster, 48145, Germany
Novartis Investigative Site

Papenburg, 26871, Germany
Novartis Investigative Site

Rostock, 18057, Germany
Novartis Investigative Site

Warendorf, 48231, Germany
Novartis Investigative Site

Matsudo, Chiba, 270-2251, Japan
Novartis Investigative Site

Takamatsu, Kagawa-ken, 7608557, Japan
Novartis Investigative Site

Miyhazaki, Miyazaki, 8802102, Japan
Novartis Investigative Site

Suita, Osaka, 5650853, Japan
Novartis Investigative Site

Shinjuku Ku, Tokyo, 160-0008, Japan
Novartis Investigative Site

Kyoto, 6078062, Japan
Ocala Cardiovascular Research

Ocala, Florida, 34471, United States
Parkway Medical Center

Birmingham, Alabama, 35215, United States
Progressive Clinical Research

Bountiful, Utah, 84010, United States
SEC Clinical Research

Pensacola, Florida, 32503, United States
TCV Clinical Studies

Linwood, Pennsylvania, 19061, United States
Trinity Health Michigan Heart

Ypsilanti, Michigan, 48197, United States
Zenith Clinical Research

Hollywood, Florida, 33021, United States