Anti-Inflammatory shot near veins may stop blood clots from coming back

NCT ID NCT04858776

Ongoing Disease control Sponsor: Mercator MedSystems, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests whether delivering the anti-inflammatory drug dexamethasone directly around deep veins can prevent blood clots from returning after they are removed. The study involves 60 adults aged 18-89 who have had DVT symptoms for 14-60 days. Participants receive either dexamethasone or a saline placebo via a special catheter, and are followed for up to 24 months to check for re-clotting and symptom improvement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexamethasone
What this could lead to: If it works, this could offer a way to prevent blood clots from returning after treatment for deep vein thrombosis, reducing long-term complications.
What could go wrong: This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. The procedure involves risks like bleeding or infection, and the drug may not prevent re-thrombosis as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ILIOFEMORAL; THROMBOSIS

Contacts and locations

Locations

CIS Clinical Research

Houma, Louisiana, 70360, United States
CardioVoyage

Denison, Texas, 75020, United States
Galway University Hospital

Galway, H91 YR71, Ireland
Guy's and St. Thomas Hospital

London, SE1 7EH, United Kingdom
Lake Washington Vascular

Bellevue, Washington, 98004, United States
Medstar Health Research Institute

Hyattsville, Maryland, 20782, United States
NC Heart and Vascular Research

Raleigh, North Carolina, 27607, United States
Northwestern University Hospital

Chicago, Illinois, 60611, United States
OhioHealth Research Institute

Columbus, Ohio, 43214, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23452, United States
St John Health System

Bartlesville, Oklahoma, 74006, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
University of South Florida

Tampa, Florida, 33060, United States
University of Texas, Houston

Houston, Texas, 77494, United States
Vascular Care Connecticut

Darien, Connecticut, 06820, United States