Anti-Inflammatory shot near veins may stop blood clots from coming back
NCT ID NCT04858776
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether delivering the anti-inflammatory drug dexamethasone directly around deep veins can prevent blood clots from returning after they are removed. The study involves 60 adults aged 18-89 who have had DVT symptoms for 14-60 days. Participants receive either dexamethasone or a saline placebo via a special catheter, and are followed for up to 24 months to check for re-clotting and symptom improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dexamethasone
What this could lead to
If it works, this could offer a way to prevent blood clots from returning after treatment for deep vein thrombosis, reducing long-term complications.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. The procedure involves risks like bleeding or infection, and the drug may not prevent re-thrombosis as hoped.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CIS Clinical Research
Houma, Louisiana, 70360, United States
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CardioVoyage
Denison, Texas, 75020, United States
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Galway University Hospital
Galway, H91 YR71, Ireland
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Guy's and St. Thomas Hospital
London, SE1 7EH, United Kingdom
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Lake Washington Vascular
Bellevue, Washington, 98004, United States
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Medstar Health Research Institute
Hyattsville, Maryland, 20782, United States
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NC Heart and Vascular Research
Raleigh, North Carolina, 27607, United States
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Northwestern University Hospital
Chicago, Illinois, 60611, United States
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OhioHealth Research Institute
Columbus, Ohio, 43214, United States
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Sentara Norfolk General Hospital
Norfolk, Virginia, 23452, United States
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St John Health System
Bartlesville, Oklahoma, 74006, United States
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Stony Brook University Hospital
Stony Brook, New York, 11794, United States
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University of South Florida
Tampa, Florida, 33060, United States
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University of Texas, Houston
Houston, Texas, 77494, United States
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Vascular Care Connecticut
Darien, Connecticut, 06820, United States