Cardiovascular disorder

This trial is testing an experimental treatment called FKC289 for people with primary AL amyloidosis that has relapsed or not responded to standard care. FKC289 uses a patient's own immune cells, engineered to recognize and attack the abnormal plasma cells that produce the harmfu…

This trial tests whether specific care strategies used in the intensive care unit after cardiac arrest can improve neurological recovery and survival. Adults who remain comatose after their heartbeat is restored will be cared for using either head elevation or a near-supine posit…

This phase 3 trial investigates whether adding acetazolamide—a drug often used for altitude sickness—to standard diuretics can improve fluid removal in people with heart failure who experience sudden fluid buildup. Participants take the medication for up to five days while being …

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study tests whether huperzine A, an injected drug, can help prevent or reduce memory and thinking problems that often follow surgery for a bleeding brain aneurysm. Adults aged 18-70 who had an aneurysm bleed and underwent endovascular or surgical treatment will receive eithe…

This Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…

This trial investigates whether eating a daily serving of peanuts can reduce stress and improve markers of heart health in adults who report high stress levels. Participants will eat either peanuts or a calorie-matched snack for a period, while researchers measure changes in stre…

This trial is testing the best timing for opening additional blocked arteries in people who have had a severe type of heart attack (STEMI) with multiple blocked vessels. After the main blocked artery is opened, participants are randomly assigned to have the other blockages treate…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This trial is testing a new stent graft system designed to treat abdominal aortic aneurysms—a bulging, weakened area in the main artery. The device is placed inside the aorta to reinforce the wall and prevent rupture. The study includes adults with infrarenal abdominal aortic ane…

This trial is testing whether preparing a blocked leg artery with a special 'scoring' balloon before using a drug-coated balloon improves outcomes compared to using a standard balloon. The study involves people with severe leg artery disease (critical limb-threatening ischemia) w…

This trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like …

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial investigates whether using a temporary heart pump (microaxial flow pump) right after opening a blocked artery improves survival in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. It also tests whether advanced monitor…

This trial tests whether a heart procedure called pulsed field ablation can be guided using only ultrasound, avoiding the use of X-rays (fluoroscopy), in people with paroxysmal atrial fibrillation. The study compares the success of completely isolating the pulmonary veins—a key s…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild brain injury, can reduce headache days and prevent short-term post-traumatic headaches from becoming long-term. About 80 adults with migraine-like post-traumatic headaches will receive eithe…

This phase II trial is testing whether a combination of selinexor, daratumumab, and dexamethasone (called XDd) can help people with advanced light-chain cardiac amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if the regimen can achiev…

This trial tests a 1-month nurse-led program designed to help older adults with coronary heart disease and frailty reduce their daily sitting time. Participants are randomly assigned to either the program or a control group, and the program uses education, goal setting, self-moni…

This trial tests whether adding lumbrokinase, an enzyme derived from earthworms, to standard aspirin treatment can improve recovery in people who have had a moderate-to-severe ischemic stroke. Participants receive either lumbrokinase capsules or a placebo, along with aspirin, for…

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This trial tests whether citicoline, a compound that may support brain cell repair, can improve outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) — brain injury from oxygen deprivation at birth. About 86 infants with signs of birth asphyxia will receive either citic…

This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe and feasible for people with pulmonary arterial hypertension (PAH), a condition of high blood pressure in the lungs. About 24 adults with PAH will be ran…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tests a special stent (a small mesh tube) placed in veins to treat blockages, narrowing, or leg ulcers caused by poor blood flow. About 150 adults will receive the stent and be followed to see if it keeps the vein open and safe. The goal is to improve blood flow and re…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether giving the seizure medicine levetiracetam right after a brain bleed (intracerebral hemorrhage) can prevent seizures and improve long-term recovery. About 580 adults will receive either the drug or a placebo for up to 7 days, and their level of disability …

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This trial tests whether a low-sodium diet can improve blood pressure control in people who had a hypertensive disorder of pregnancy. Participants receive either a provided diet with less than 2000 mg of sodium per day or a standard diet with no salt restrictions for the first we…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial tests whether a newer pacing method, called left bundle branch area pacing, is better than the standard right ventricular pacing for adults with permanent atrial fibrillation and a need for a pacemaker. The goal is to see if the newer technique reduces the risk of deat…

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This trial tests three experimental antibodies—REGN9933, REGN7508, and REGN9533—in people with end-stage kidney disease who are on hemodialysis. The goal is to see if these antibodies can safely reduce blood clot risk during dialysis, potentially offering an alternative to standa…

This trial tests whether adults with pulmonary arterial hypertension (PAH) can safely switch from selexipag, a pill taken by mouth, to LIQ861, an inhaled form of treprostinil. Participants stop selexipag on day one and start taking LIQ861 four times a day using a handheld inhaler…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial investigates whether guanfacine or cromolyn sodium—two drugs already approved for other conditions—can improve physical functioning and reduce symptoms like fatigue, brain fog, and gastrointestinal issues in adults with postural orthostatic tachycardia syndrome (POTS).…

This phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either ele…

This trial investigates whether adding tirofiban, a fast-acting anti-clotting drug, to standard aspirin treatment can improve recovery in people who have had a moderate ischemic stroke. Participants receive either tirofiban or a placebo, both with aspirin, within 24 hours of stro…

This trial tests whether an experimental drug called CS1, taken as a daily pill, can improve blood vessel function in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive CS1 o…

This pilot study tests a 6-session lifestyle program for people with high blood pressure, where each participant brings a supportive partner. The program covers heart-healthy habits like diet, exercise, stress management, and sleep, along with communication skills to help partner…

This trial tests whether starting a temporary balloon pump in the aorta before the standard artery-opening procedure (angioplasty) can improve outcomes for people who arrive at the hospital 4 to 12 hours after a major heart attack. Half of the participants will receive the balloo…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This study tests the long-term safety and tolerability of acoramidis, an oral medication that stabilizes the transthyretin protein, in people newly diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition that can lead to heart failure. Participants who complete…

This trial investigates whether a minimally invasive procedure called mitral valve TEER, added to standard medical therapy, improves outcomes for heart failure patients whose mitral valve leakage becomes severe only during exercise. Participants are randomly assigned to receive e…

This trial tests whether using a portable ultrasound device during coronary artery bypass surgery can improve outcomes by letting surgeons see blood flow through the new grafts in real time. About 380 adults scheduled for elective bypass surgery will be randomly assigned to eithe…

This trial is testing a new device called MRace to repair a leaky mitral valve in people with severe functional mitral regurgitation, a condition where the valve doesn't close properly, causing blood to flow backward. The device is placed through a vein in the leg and guided to t…

This study tests a new device called MRace, designed to repair severe mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The device is implanted through a vein in the leg, avoiding open-heart surgery, and is aim…

This study tests a new device called MRace, designed to repair a leaky mitral valve in the heart without open surgery. The device is placed through a vein in the leg and guided to the heart to help the valve close properly. The trial will include up to 15 people with severe mitra…

This trial asks whether starting dialysis early—within 6 hours—in patients with cardiogenic shock and fluid overload can reduce deaths in the hospital compared to waiting until it's clearly needed. It enrolls adults in intensive care with severe heart pump failure and signs of ex…

This trial compares three different embolic materials—particles, liquid embolics, and coils—used during a procedure called middle meningeal artery embolization to treat chronic subdural hematoma, a type of bleeding on the brain's surface. The study will enroll 30 adults undergoin…

This phase 2 trial tests whether propranolol, a drug usually used for high blood pressure, can treat Kaposi sarcoma. About 25 children and adults will take propranolol pills for up to 24 weeks. Researchers will measure how many participants see their tumors shrink or disappear, a…

This trial tests whether repairing a leaky mitral valve early, using a minimally invasive clip procedure, can help people with heart failure and reduced pumping function tolerate and benefit from standard heart failure medications. Participants are randomly assigned to receive th…

This trial tests whether combining nurse-delivered care with text message check-ins and support can help adults with uncontrolled high blood pressure lower their blood pressure and improve diabetes management. Participants receive either usual care or the enhanced support, which …

This study tests whether motor cortex stimulation – a device that sends mild electrical pulses to the brain's movement area – can reduce chronic pain after a stroke that affects the thalamus. Participants who do not get relief from standard pain treatments will have electrodes te…

This trial is testing a new mechanical heart pump called the DuoCor 2, designed to support both sides of the heart in people with advanced heart failure. The study will enroll 64 patients who are severely ill and need circulatory support. The main goal is to see if the device hel…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This phase II trial is testing whether an experimental drug called LT3001 can help people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will include about 300 participants who receive either a high or low dose of …

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…

This trial is testing a device called the Heli-FX EndoAnchor system, which is used during minimally invasive repair of abdominal aortic aneurysms (a bulging, weakened area in the main artery). The device helps secure the stent graft in place, potentially preventing leaks or movem…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…

This study tests whether a procedure called proximal splenic artery embolization (PSAE) can reduce the need for repeated fluid drainage in adults with cirrhosis and ascites that no longer responds to water pills and diet. Participants will undergo a one-time procedure where small…

This pilot trial is testing a smartphone app that acts like a personal coach to help adults with uncontrolled high blood pressure improve their self-care. The app provides education and interactive coaching to encourage medication adherence and healthy habits. The study will enro…

This study follows people with moderate to severe pulmonary regurgitation or stenosis who receive the PULSTA transcatheter pulmonary valve, a less invasive option for replacing a faulty heart valve. Researchers will track how well the valve works over time, measuring improvements…

This phase 3 trial is testing whether an experimental drug called BHB-1893 works better than the standard beta-blocker metoprolol for adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), a condition where the heart muscle thickens and blocks blood flow. The stu…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This phase 3 trial is testing whether Angong Niuhuang, a traditional Chinese medicine, can improve recovery in people who have had a bleeding stroke (intracerebral hemorrhage). About 1,100 adults who are eligible for non-surgical management will receive either the herbal pill or …

This study tests a new laser system designed to vaporize plaque in blocked coronary arteries before doctors place a stent. The trial compares the new laser device to an existing one in about 218 people with severe heart artery narrowing. The main goal is to see if the new system …

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial tests whether a smartphone app that uses light to measure heart rhythm can reliably detect when atrial fibrillation (AF) spontaneously returns to a normal heartbeat. About 200 adults with AF scheduled for an electrical cardioversion will either receive standard care or…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This trial tests whether ezetimibe, a common cholesterol-lowering medication, can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who undergo catheter ablation. Half of the 120 participants will take ezetimibe daily for six months after the…

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This phase 2 trial is testing an investigational drug called QLS4131 in people newly diagnosed with AL amyloidosis, a condition where abnormal proteins build up in organs and cause damage. QLS4131 is a trispecific antibody designed to target and eliminate the plasma cells produci…

This trial is testing two experimental versions of a blood pressure drug, called D311 and D107, against the original medication, CKD-339. Healthy adults aged 19 to 55 will receive a single dose of each version in a random order to compare how the drug is absorbed and processed in…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This trial tests whether giving adolescent girls a daily multiple micronutrient supplement (with or without extra nutrients) improves their growth, brain function, bone health, and overall well-being compared to the standard weekly iron-folic acid pill. About 3,000 girls aged 10–…

This study tests the long-term safety and effectiveness of an experimental oral drug called S-606001 in adults with late-onset Pompe disease, a genetic condition that causes progressive muscle weakness. Participants who completed a prior S-606001 study can join, and they will rec…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This study tests an experimental drug called elranatamab in people newly diagnosed with AL amyloidosis who have not yet had treatment. The drug helps the body's immune cells find and destroy the abnormal cells causing the disease. Researchers want to see if it can produce deep re…

This study looks at whether giving people with high blood pressure and food insecurity $100 a month for fruits and vegetables can improve their health. It focuses on Native Hawaiian and Pacific Islander adults in Hawaii. Some participants will also get one-on-one help from a comm…

This study looks at two ways to treat atrial fibrillation (a common heart rhythm problem) in people aged 78 and older. One approach uses a procedure called catheter ablation to fix the heart's electrical signals, while the other uses medications to control heart rate or rhythm. R…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This trial tests whether a minimally invasive heart bypass surgery, done through a small incision on the left side of the chest, helps frail adults aged 60 and older recover better than the traditional approach of opening the breastbone. Participants are randomly assigned to one …

This trial tests whether combining two advanced heart-mapping technologies can make ablation for ventricular tachycardia (VT) more accurate and effective. The approach merges a non-invasive 3D electrical map of the heart with detailed scar imaging from an MRI, aiming to better ta…

This trial investigates whether a daily dose of alpha-lipoic acid, a vitamin-like antioxidant, can lower the risk of major heart problems in people with chronic heart failure caused by coronary artery disease. Researchers will compare the supplement against a placebo in over 1,50…

This phase 3 trial tests whether an experimental oral drug called engasertib can reduce the number of nosebleeds in adults with moderate to severe hereditary hemorrhagic telangiectasia (HHT), a genetic condition that causes abnormal blood vessels and frequent bleeding. About 240 …

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

People on maintenance hemodialysis face a high risk of heart disease, and standard cholesterol drugs often fail to help. This trial tests whether high-dose fish oil (4 grams daily for 8 weeks) can improve the function of HDL, the 'good' cholesterol, which may become faulty in kid…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

This study is testing two ways to perform a repeat ablation procedure in people with atrial fibrillation (an irregular heartbeat) that has returned after a first treatment. Both approaches use pulsed-field ablation to isolate the pulmonary veins, but one also adds ablation of the…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This trial tests whether adding a minimally invasive mitral valve repair (transcatheter edge-to-edge repair, or TEER) to standard catheter ablation improves outcomes for people with both atrial functional mitral regurgitation and atrial fibrillation. Participants are randomly ass…

This trial tests whether a virtual world-based cardiac rehabilitation program can improve heart health and participation compared to standard in-person rehab. The program, called Destination Cardiac Rehab, is a 3D interactive telehealth option that patients can use from home. Res…

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This trial tests whether dapagliflozin, a drug used for diabetes, can improve blood flow in the tiny vessels of the heart in people with angina (chest pain) but no blocked coronary arteries. Participants will take either dapagliflozin or a placebo daily for 180 days. The study me…

This trial is testing an experimental drug called NTS-521, given as an intravenous infusion, to see if it can help people recover better after an acute ischemic stroke. The study will include about 140 adults aged 45 to 80 who have moderate to severe weakness on one side of the b…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can improve physical function in adults with heart failure and obesity. Participants will receive either tirzepatide or a placebo for six months, while continuing their usual heart failure…

This trial compares two standard IV medicines—verapamil and metoprolol—to see which controls rapid heart rate better in adults with atrial fibrillation who are otherwise stable. Patients receive one of the drugs in the emergency department, and their heart rate, blood pressure, a…

This trial tests whether a catheter-based procedure called transcatheter edge-to-edge repair (TEER) can improve outcomes in people with atrial functional mitral regurgitation, a condition where the heart's left atrium enlarges and causes the mitral valve to leak. The study will e…

This trial compares two surgical implants—the Baerveldt Glaucoma Implant and the Paul Glaucoma Implant—in people with glaucoma that is not well controlled by eye drops. Both devices are tiny tubes placed in the eye to drain fluid and lower pressure. The study will track which imp…

This study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

This trial is testing whether an experimental drug called HRS-4029 can improve outcomes for people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will compare the drug against a placebo in about 340 participants wh…

This trial compares two ways of giving tranexamic acid, a drug that reduces bleeding, to adults undergoing off-pump coronary artery bypass surgery. Half receive the drug as a pill before surgery, while the other half get it through an IV during surgery. The goal is to see if the …

This phase 3 trial is testing an investigational drug called abelacimab in about 2,500 people with atrial fibrillation (an irregular heartbeat) who are at high risk for stroke but cannot take standard oral blood thinners. Participants will receive either abelacimab or a placebo, …

This pilot study tests whether adding dipyridamole, an approved drug that improves blood flow, to standard care is feasible and safe for pregnant women with early-onset preeclampsia. The trial will enroll 15 hospitalized women between 26 and 34 weeks of pregnancy with high levels…

This trial asks whether people with severe aortic stenosis can safely go home the same day after a minimally invasive heart valve replacement (TAVI) instead of staying in the hospital. About 764 patients who are stable six hours after the procedure will be randomly assigned to ei…

This trial tests whether wearing a portable heart monitor for two weeks after a TAVI procedure can reduce the risk of sudden death, dangerous heart rhythms, or stroke within the following year. People who have had a successful TAVI and show certain electrical abnormalities on the…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This trial tests an investigational medicine called ATR 1072 in adults with PRKAG2 syndrome, a genetic condition that causes abnormal heart muscle thickening and rhythm problems. The drug is designed to reduce the activity of the faulty PRKAG2 gene. Researchers are evaluating its…

This trial investigates whether semaglutide, a GLP-1 agonist, can shift how the heart produces energy in people with pulmonary arterial hypertension (PAH). The heart in PAH often relies on inefficient fuel sources, and the drug may help it switch to a more efficient form. Researc…

This study tests whether a supervised group exercise program, called EINTER, can improve muscle strength and walking ability in adults recovering from stroke. The program combines cycling and strength training, tailored to each person, and runs for up to four weeks. Researchers w…

This trial tests whether heart attack patients who have had complete artery-opening procedures can safely stop aspirin after 3-6 months and continue with only a P2Y12 inhibitor. The goal is to see if this approach reduces bleeding problems without increasing the risk of another h…

This registry follows adults newly diagnosed with pulmonary arterial hypertension (PAH) who are starting treatment with parenteral treprostinil, a medication given as a continuous infusion under the skin or into a vein. Researchers will collect data from routine care—including do…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This study tests a new biological graft, LineMatrix®, for replacing or bypassing damaged arteries in the lower body. About 15 adults with peripheral artery disease or other artery damage will receive the graft during surgery. Researchers will track how well the graft stays open w…

This trial investigates whether tirzepatide, a drug approved for diabetes and obesity, can improve recovery in people who have had a severe stroke caused by a large artery blockage. Participants receive two injections of tirzepatide—one before a clot-removal procedure and another…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This trial tests whether a 3-month dietary program, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure in Chinese adults with hypertension. About 800 participants from workplace canteens will either receive standard hypertension care or also get specially…

This trial investigates whether eating purple-fleshed potatoes daily for four weeks can improve blood pressure and other heart health markers in men with prehypertension. Participants will consume either purple or white potato puree in a crossover design, with measurements taken …

This phase 3 trial compares an experimental drug, tabirafusp tedromer, against the standard treatment aflibercept for people with diabetic macular edema (DME), a leading cause of vision loss in diabetes. About 910 adults with DME will receive injections into the eye and be follow…

This trial tests whether angiotensin receptor blockers (ARBs), a type of blood pressure medication, can reduce the risk of death or heart failure in people who have had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis and still have a thickened heart mus…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This trial is testing a new device called the Crea Aortic Valve, a replacement heart valve that can be implanted through a catheter without open-heart surgery. It is designed for people aged 60 and older with severe aortic stenosis—a narrowing of the heart's main valve—who are co…

This trial tests whether a telemedicine program can help Black patients with high blood pressure get better control. The program includes home blood pressure monitoring, medication management, and support from pharmacists, nurses, community health workers, and social workers. Res…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This trial tests whether a lab-grown, tissue-engineered blood vessel can be safely used as a bypass graft in people with coronary artery disease undergoing heart bypass surgery. Ten participants will receive the artificial vessel alongside a standard graft, and researchers will m…

This trial investigates whether a high-protein diet, with or without an HMB supplement, can improve muscle mass, strength, and physical function in people with heart failure. Participants are randomly assigned to one of three groups: a standard-protein diet, a high-protein diet, …

This study compares two ways to guide a minimally invasive procedure that opens blocked arteries below the knee in people with chronic limb-threatening ischemia, a severe form of peripheral artery disease. One group receives standard X-ray guidance (angiography) alone; the other …

This trial tests whether adding eccentric cycling—a type of exercise where muscles lengthen under tension—to standard cardiac rehabilitation can improve recovery in people who have had a heart attack. Eccentric exercise may allow higher muscle loads with less cardiovascular deman…

This study tests whether a best-practices checklist can help emergency doctors manage acute heart failure more effectively. The checklist guides assessment, treatment, and decisions about whether to admit or discharge patients. Researchers are introducing the checklist in four la…

This trial tests whether a procedure called pulsed field ablation can safely treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. About 30 people with frequent premature heartbeats or ventricular tachycardia will receive the treatment using a special…

This trial investigates whether a specific type of breathing exercise — functional inspiratory muscle training — can improve walking patterns in people who had a stroke more than six months ago. Sixty participants will be randomly assigned to either this new training or conventio…

This trial tests whether a year-long, supervised exercise program — including aerobic, resistance, and breathing exercises — can improve outcomes for people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either usual care or usu…

This trial tests whether an AI system can help doctors choose better ventilator settings for children (ages 1 month to 18 years) in the pediatric ICU who need a breathing machine. Half of the children will receive standard care, while the other half will have their ventilator adj…

This trial tests a new suture system designed to close a patent foramen ovale (PFO), a small hole in the heart that can increase stroke risk. Researchers will compare the new device to an existing occluder in about 244 adults aged 18 to 65 with moderate-to-large PFOs. The goal is…

This phase 2 trial tests whether an experimental oral drug, SAL0137, can safely lower high levels of lipoprotein(a) — a genetic risk factor for heart attacks and strokes that currently has no approved medication. About 120 adults with elevated Lp(a) and high cardiovascular risk w…

This trial tests whether a 10-week program called MomHeartHealth2.0 can help mothers of young children improve their cardiovascular health. The program includes weekly phone coaching, in-person group sessions at childcare centers, and referrals to medical care and social services…

This trial tests whether adding either high-repetition task-oriented training or high-intensity gait training to standard neurodevelopmental therapy helps people with chronic stroke walk farther and move more easily. Forty-five participants who had a stroke at least six months ag…

This trial tests whether a nurse-led education program can improve self-care knowledge in people with heart failure in Rwanda. About 400 participants from three district hospitals will receive illustrated flip-book teaching and a simplified handout. The study measures changes in …

This trial tests whether a mechanical, spring-driven device called FreedomEDGE® can safely and effectively deliver daratumumab, a standard treatment for multiple myeloma and amyloidosis. Currently, nurses give these injections by hand, which can be physically demanding. About 100…

This trial tests whether a 9-month program called STEP COACH can help people with coronary artery disease stay physically active after completing cardiac rehab. Participants use their own smartwatch or smartphone to track steps and receive coaching on increasing both step volume …

This pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…

This trial investigates whether a new pulsed field ablation system can safely and effectively treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The system uses short electrical pulses to destroy tiny areas of heart tissue causing the abnormal rh…

This trial tests whether a personalized exercise program before heart surgery can improve physical fitness in adults with congenital heart disease. Participants are randomly assigned to either usual care or a 6-week prehabilitation plan with aerobic, breathing, and strength exerc…

This study looks at whether using a smartphone app to guide slow breathing, combined with aerobic exercise, can help lower blood pressure in people with essential hypertension. Seventy-five adults aged 40-50 with stage 1-2 hypertension will be split into three groups: breathing p…

This trial tests whether adding an oral Chinese herbal formula called Tongluo Huayu to standard care (eye injections and laser therapy) can improve vision and reduce retinal swelling in people with retinal vein occlusion. Eighty participants will receive either standard treatment…

This trial tests whether a TeleStroke network can help peripheral hospitals in Oman safely give clot-busting drugs (alteplase or tenecteplase) to people having an acute ischemic stroke. A remote neurologist will assess patients via video, review scans, and guide the local medical…

This study compares two blood-thinning medicines given after delivery to prevent dangerous blood clots: apixaban (a pill taken twice a day) and enoxaparin (a daily shot). The trial enrolls women at high risk for clots after vaginal or cesarean birth. The main goal is to see which…

This trial tests whether giving high-concentration oxygen during a clot-removal procedure can improve recovery for people having a major stroke who arrive at the hospital 6 to 24 hours after symptoms began. Participants are randomly assigned to receive either the oxygen therapy o…

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The…

This study tests a new type of bypass graft made from a biodegradable polymer for people with peripheral artery disease who need leg bypass surgery. The graft is designed to restore blood flow and then gradually be replaced by the body's own tissue. The trial will enroll 15 parti…

This trial tests whether adding tirzepatide (Mounjaro) to a structured lifestyle program reduces the return of atrial fibrillation within a year after catheter ablation in obese patients. About 710 participants with symptomatic AF and a BMI of 28 or higher (or 24 with other risk …

This study tests whether sending patients home on the same day of surgery, with follow-up care via phone calls, home visits, and a mobile app, is as safe and less costly than keeping them in the hospital overnight. The trial includes adults in Uganda having low-risk procedures su…

This trial investigates whether maintaining a higher blood pressure (85 mmHg or above) during surgery can reduce the risk of postoperative delirium—a sudden confusion that can occur after surgery—in older adults (65+) with high blood pressure. About 3,400 participants having non-…

This study compares two innovative therapies—immersive virtual reality and proprioceptive neuromuscular facilitation (PNF)—against standard physical therapy for improving quality of life in people who had a stroke at least six months ago. Participants will complete 12 sessions ov…

This study tests whether a virtual team of clinical pharmacists and cardiologists can help doctors prescribe the right heart failure medications for Veterans. Many patients do not receive all recommended drugs at effective doses after a hospital stay. The team reviews patient rec…

This study looks at how well a device can close a common heart hole called a ventricular septal defect (VSD) in children aged 6 months to 18 years. Instead of open-heart surgery, doctors use a small tube to place a device that plugs the hole. The goal is to see if this method is …

This study looks at whether eating a daily serving of peanut butter at breakfast can improve blood sugar control, thinking skills, and heart health in middle-aged adults with prediabetes. Participants will either add peanut butter to their first meal or stick with their usual die…

People who have spine surgery for cancer that has spread are at high risk for dangerous blood clots in the legs or lungs. Currently, blood-thinning medicine is stopped when patients leave the hospital. This trial tests whether taking apixaban (Eliquis) by mouth for 30 days after …

This study tests a device called the Globe Pulsed Field System, which uses short bursts of electric energy to destroy tiny areas of heart tissue that cause abnormal rhythms in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). The tria…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study looks at whether a minimally invasive surgical procedure can help people with a spontaneous deep brain hemorrhage (bleeding in the basal ganglia) recover better than standard medical treatment alone. Researchers will follow 300 adults for 180 days, measuring survival, …

This study investigates whether two common vaccines—the shingles vaccine (RZV) and an RSV vaccine (RSVPreF3)—can slow the buildup of fatty plaque in the coronary arteries. The trial enrolls adults aged 50 and older who are at risk for cardiovascular events. Participants receive e…

This trial tests a device called the Corheart 6, a left ventricular assist system that helps pump blood in people with advanced left ventricular heart failure. The study includes 100 adults aged 18 to 75 with severe heart failure symptoms despite optimal medical therapy. The main…

This study compares two surgical techniques for hemorrhoids: Doppler-guided artery ligation alone versus the same procedure combined with mucopexy (stitching up the prolapsed tissue). Researchers will measure pain levels and the sensation of incomplete evacuation (tenesmus) in 15…

This phase 2b trial tests whether injecting allogeneic neural stem cells (CC-101) into the brain near a prior stroke lesion can improve motor function in adults with chronic ischemic stroke and lasting movement problems. About 36 participants will receive either stem cells plus s…

This study tests an experimental drug called HRS-1780 in people with uncontrolled or resistant hypertension—high blood pressure that stays high despite treatment. The trial compares three different doses of HRS-1780 against a placebo to see if it safely lowers blood pressure. Par…

This study tracks how well the FLOWRUNNER Aspiration System removes symptomatic blood clots from veins in the arms or legs during routine care. About 218 adults with deep-vein clots will be followed to see if the device safely restores blood flow and reduces clot-related disabili…

This trial tests whether a liquid called Theravex can improve healing and stability when a dental implant is placed right after a tooth is pulled. Theravex is applied directly into the gap between the implant and the bone socket to stimulate bone growth. Researchers compare it to…

This study investigates whether Songling Xuemaikang capsules, a traditional Chinese herbal formula, can help people with both high blood pressure (hypertension) and insomnia. About 260 adults aged 18–79 with mild hypertension and sleep difficulties will take either the herbal cap…

This pilot study tests whether a program called GRIP—which combines a soft robotic glove with a virtual reality system—can help adults recovering from a recent stroke improve hand and arm function. About 20 participants in inpatient rehabilitation will be randomly assigned to rec…

This phase 3 trial compares an experimental CAR-T cell therapy, NXC-201, with a standard drug combination (daratumumab plus CyBorD) in people newly diagnosed with AL amyloidosis, a rare condition where abnormal proteins damage organs. Participants receive either a single infusion…

This trial tests whether tocilizumab, an anti-inflammatory drug, can stop the progression of calciphylaxis—a rare condition where calcium buildup blocks skin blood vessels, causing painful, non-healing wounds. Ten adults with calciphylaxis and end-stage kidney disease will receiv…

This trial tests whether adding a 3D holographic visualization tool, called EchoPixel Holographic Therapy Guidance, helps doctors perform two common heart procedures more accurately. The procedures are left atrial appendage occlusion (for atrial fibrillation) and mitral valve rep…

This study tests whether a nurse-led discharge education program helps heart failure patients avoid unplanned hospital readmissions within 30 days. The program includes an educational assessment, a discharge session using the teach-back method, and a follow-up phone call. Researc…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

This study tests whether people with pulmonary arterial hypertension (PAH) who are doing well on the drug sotatercept can safely stop their background prostacyclin therapy. Prostacyclin drugs can cause side effects and are hard to manage. The trial compares patients who slowly st…

This trial compares a minimally invasive surgery that closes off a small heart pouch (the left atrial appendage) to standard blood-thinning medication in people with atrial fibrillation who have a high risk of bleeding. The goal is to see if the surgery can prevent strokes, major…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This phase 3 trial compares an experimental drug, MK-8748, to the standard treatment aflibercept for diabetic macular edema (DME), a condition where fluid buildup in the retina blurs vision. About 1,100 adults with diabetes and vision loss from DME receive either MK-8748 or aflib…

This study tests a 3-month home program for people aged 50+ who recently had a stroke and are returning home. The program combines guided stepping training with tips to reduce long periods of sitting. Researchers measure changes in daily steps, mobility, and disability over 12 mo…

This study tests whether a personalized high-intensity interval training (HIIT) program can improve exercise capacity and quality of life in people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either a 24-week HIIT plan tailor…

This trial investigates whether AI-assisted written patient information, given alongside standard medical treatment, helps adults with mild to moderate hemorrhoids follow their treatment plan more completely. Participants receive either standard verbal counseling or an AI-generat…

This study looks at whether giving doctors—and sometimes patients—personalized reports on recommended heart failure treatments helps more people get the right medications. It involves adults with heart failure and reduced ejection fraction (HFrEF) in the Netherlands. The goal is …

This study tests a multilevel care model designed to help low-income adults with hard-to-control hypertension. The model combines patient education, electronic health record alerts for providers, and support from community health workers. Researchers will measure changes in blood…

This study tests whether a patient navigator — a trained staff member who helps connect people with health services — can improve long-term heart health for those who had high blood pressure disorders during pregnancy. About 60 participants will be randomly assigned to receive ei…

This study tests whether giving high-risk heart attack patients personalized education before they leave the hospital can reduce their chances of being readmitted. The education covers disease management, medication adherence, lifestyle changes, and recognizing warning signs. Res…

This study investigates whether a standardized microsurgical procedure can safely and effectively remove large spontaneous brain hemorrhages (bleeds) located near the brain's surface. The procedure uses a microscope and computer guidance to evacuate the clot, with the goal of lea…

This trial tests whether a wearable hand robot, used at home with remote therapist support, is a feasible way to deliver intensive hand therapy to people who had a stroke at least six months ago. Participants will either use the robot for 12 weeks or receive the same amount of st…

This study tests whether a specially formulated omega-3 supplement, with a high ratio of EPA to DHA, can reduce inflammation and improve blood vessel function in people with pulmonary arterial hypertension (PAH). Participants take four capsules daily for 12 weeks alongside their …

This trial investigates whether photobiomodulation—applying low-level laser light to the surgical wound—can improve healing and reduce complications after coronary artery bypass grafting (CABG). It compares two methods of harvesting the saphenous vein (the conventional technique …

This trial tests whether an absorbable gelatin sponge works as well as cyanoacrylate glue for closing off enlarged stomach veins that can bleed. Both treatments are delivered via endoscopy with small coils. Participants are adults with a history of bleeding from these veins, and …

This trial investigates whether vericiguat, added to standard treatment, can improve quality of life and reduce hospitalizations in adults with heart failure and reduced ejection fraction. Participants receive either vericiguat or a placebo for six months, and their health status…

This study explores whether a carefully designed, low-impact exercise program is safe and practical for people with vascular Ehlers-Danlos syndrome (vEDS), a rare condition that weakens blood vessels and organs. Researchers are working with patients and doctors to create a 12-wee…

This trial compares a procedure to reopen blocked brain arteries (using balloons and stents) against standard medical therapy in people with chronic blockages. The goal is to see if the procedure reduces the risk of stroke or death within a year. Participants have had symptoms fr…

This study compares a long-acting antibiotic called dalbavancin to standard therapy for treating infective endocarditis, a serious infection of the heart valves caused by certain bacteria. Dalbavancin is given as one or two intravenous infusions, while standard therapy requires d…

This study tests two experimental drugs, REGN7508 and REGN9933, to see if they can prevent blood clots in people who have a peripherally inserted central catheter (PICC). People with PICCs are at higher risk for venous thromboembolism (VTE), which can be serious. The trial compar…

This study explores whether virtual group medical appointments focused on lifestyle changes can help people with high blood pressure lower their readings. Participants attend four online sessions over eight weeks, track their blood pressure at home, and get medication adjustments…

This study looks at different methods to restore blood flow to the left subclavian artery when it must be covered during aortic repair. Covering this artery can raise the risk of stroke and arm problems. The trial compares surgical bypass with newer endovascular techniques to see…

This trial tests whether using a detailed CT scan of the heart's arteries before a procedure to open blockages (PCI) can make the procedure more efficient. About 200 adults with coronary artery disease will be randomly assigned to either have their procedure guided by a pre-plann…

This trial tests whether ciprofol, a newer anesthetic, can keep blood pressure more stable than the standard drug propofol in people having general anesthesia for endovascular thrombectomy after an ischemic stroke. Stable blood pressure during the procedure may improve outcomes. …

This clinical trial is testing a new heart valve replacement system called Encantor, which uses software to guide placement of the valve. The study includes 150 adults with severe aortic stenosis who are candidates for a minimally invasive procedure. Researchers will track how ma…

This study tests a small, hourglass-shaped device implanted in the heart's upper chambers to lower pressure and reduce fluid buildup in the lungs. It is for people with advanced heart failure whose heart pumps weakly (ejection fraction 40% or less). The trial randomly assigns som…

This trial investigates whether giving two drugs—remifentanil and dexmedetomidine—soon after a spontaneous brain hemorrhage can safely lower blood pressure and improve recovery. The study includes adults with a brain bleed who have high blood pressure and are treated within six h…

This study tests whether extra support from a navigator can help pregnant people with high blood pressure use a home monitoring program (Connected MOM) and follow up after giving birth. The trial includes about 2,000 participants who have a smartphone and speak English or Spanish…

This trial investigates whether edaravone dexborneol sublingual tablets can improve blood-brain barrier function in people with CADASIL, a genetic condition that causes small strokes and cognitive decline. About 60 adults aged 18 to 80 with confirmed CADASIL will be observed for …

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

Many children with complex congenital heart disease struggle with executive functions like attention, planning, and self-control, which are crucial for school and daily life. This study tests a 12-week program called E-Fit that combines computer-based cognitive training, one-on-o…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This trial asks whether adding artificial intelligence (AI) to radiologists' reading of liver CT scans can match or improve standard reporting. It involves 40,000 adults who had contrast-enhanced CT scans of the abdomen. On some days, radiologists first read scans on their own, t…

This trial evaluates a new device called the Photobionic IOP Tonometer (PIB) that measures eye pressure without touching the eye or using an air puff. It uses a low-power infrared light and a gentle sound to detect tiny movements on the eye's surface, which a computer analyzes to…

This trial tests whether a special ultrasound technique can detect heart muscle ischemia (reduced blood flow) in people with suspected acute coronary syndrome. The approach uses microbubbles that stick to activated immune cells and blood vessel linings, potentially revealing infl…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This study aims to build a comprehensive prediction rule for diagnosing acute heart failure in the emergency department. It will enroll 560 adults with suspected heart failure or acute shortness of breath. Participants will undergo standard tests, including blood work, lung ultra…

This trial is testing whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) can help doctors quickly and safely identify which people with non-cardiac chest pain are truly low risk. Half of the participants will receive the AI-ECG in addition to standard care, wh…

This trial tests whether a new device, Pro9000X, can measure spleen stiffness to detect esophageal varices—enlarged veins in the esophagus that can bleed dangerously—in people with chronic liver disease. Currently, the only reliable way to diagnose these varices is an invasive en…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This study looks at whether measuring the collapsibility of the internal jugular vein in the neck using ultrasound can predict low blood pressure after general anesthesia. Researchers will measure the vein in 42 adults before gallbladder surgery and track blood pressure changes r…

This study tests whether a handheld, ultra-widefield eye scanner (OCT) can accurately identify preterm infants with severe retinopathy of prematurity (ROP), a condition that can harm vision. The scanner takes detailed images of the retina without touching the eye, potentially red…

This trial tests whether an experimental contrast agent called NH002 can improve the quality of heart ultrasound images in adults with suspected or known heart disease. The agent is given as an injection or infusion and contains tiny microbubbles that help outline the heart's inn…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

This study explores whether the electrical signal measured by a pacemaker or defibrillator during implantation can help identify cardiac amyloidosis — a condition where abnormal proteins build up in the heart. Researchers will enroll 242 adults aged 65 and older who already need …

This trial tests whether a portable handheld Doppler device can help nurses quickly detect arterial insufficiency in people with diabetes who have foot ulcers. The device checks for blood flow in the great toe, and the goal is to see if it can reliably flag patients who need furt…

This trial tests whether an accelerated heart MRI scan, taking only 15 to 20 minutes, can diagnose coronary artery disease as accurately as the standard 45- to 50-minute scan. About 2,000 adults with suspected coronary heart disease will be randomly assigned to receive either the…

This trial tests whether a Doppler ultrasound patch placed on the neck can quickly and accurately detect when a cardiac arrest patient's heart starts beating again during emergency resuscitation. The patch's readings are compared to those from an arterial line, the gold standard …

This study enrolls children and young adults scheduled for heart surgery or catheterization under general anesthesia. Researchers place a forehead sensor that measures tissue oxygen levels and use an algorithm to estimate blood hemoglobin. The goal is to see if this noninvasive m…

This study tests whether an artificial intelligence software, SMD-AFECG, can predict the risk of atrial fibrillation (AF) within the next two hours using data from a single-lead electrocardiogram (ECG). Researchers will analyze nearly 800 ECG recordings from a hospital database, …

This study tests whether an artificial intelligence software called SMD-RVECG can predict the risk of atrial fibrillation with rapid ventricular response (a fast, irregular heart rhythm) within the next two hours. Researchers will analyze 348 existing single-lead electrocardiogra…

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study translates two standard questionnaires—the Hemorrhoidal Disease Symptom Score and the Short Health Scale for Hemorrhoidal Disease—into Mandarin Chinese and checks whether they are reliable and accurate for Chinese-speaking patients with hemorrhoids. About 115 adults di…

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests a new ultrasound method called super-resolution ultrasound (SRUS) to see tiny blood vessels in liver tumors. Current scans show only larger vessels, but SRUS can detect vessels as small as 20 micrometers. Researchers will compare blood flow patterns in different …

This trial tests whether a structured oral hydration plan—drinking at least 1,500 mL of fluid within 12 hours around the procedure—can reduce the risk of contrast-induced acute kidney injury (CI-AKI) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary P…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether anticoagulant medications (like rivaroxaban or apixaban) are better than aspirin at preventing a second stroke in people who have had an ischemic stroke of unclear cause. Participants are adults who had a stroke within the past two weeks and show signs th…

This trial tests whether combining electroacupuncture with a sedative drug called dexmedetomidine can prevent depression in people who recently had an ischemic stroke. Participants at high risk for post-stroke depression will receive either the combined treatment, a sham version,…

This phase 3 trial tests whether zastaprazan, a stomach-acid-blocking drug, can prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or anticoagulant medications. Participants take…

This trial tests whether eplerenone, a drug that blocks the hormone aldosterone, can prevent the onset of high blood pressure in people aged 30–55 who have a mild, early form of primary aldosteronism but normal blood pressure. Participants will receive either eplerenone or a plac…

This phase 3 trial tests whether taking rimegepant once daily can prevent migraine attacks in people with chronic migraine (15 or more headache days per month). About 400 adults will receive either rimegepant or a placebo for 12 weeks, then all participants may receive rimegepant…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This trial tests whether personalized lifestyle programs—delivered via an app or in-person with a trainer—can improve early signs of heart disease risk in women going through menopause. The study enrolls women over 35 who are perimenopausal or within five years of menopause and h…

This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve bladder control in people who have had a stroke. Participants will receive either real or sham tDCS alongside standard pelvic floor muscle training, thr…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This study tests an investigational nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. About 750 adults will be randomly assigned to use either the real spray or a placebo at home when symptoms start. Th…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo duri…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. The drink is given three times a day for five days. Researchers will measure changes in heart stress markers and symptoms. The goal is to see if ketones can improve energy for t…

This trial tests whether a neck-focused rehabilitation program can reduce the burden of chronic migraine. Adults aged 18-55 with chronic migraine will be randomly assigned to either an eight-week program of cervical sensorimotor exercises or conventional physiotherapy. The study …

This trial tests whether slow-paced breathing—reducing breaths to 4-7 per minute—can improve heart rate variability, a marker of heart health, in hospitalized heart failure patients. Participants will be randomly assigned to either standard cardiac rehab alone or rehab plus slow-…

This trial tests whether adding a second nerve block—targeting the greater auricular nerve—to the standard occipital nerve block provides better pain relief for people with chronic migraine. About 80 adults with chronic migraine will receive either the combined block or the stand…

This trial tests whether placing a small catheter near the breastbone to deliver local anesthetic can reduce pain after coronary artery bypass surgery. Half of the participants will receive this catheter-based pain relief, while the other half gets standard care. Researchers will…

This trial tests whether a single application of Kinesio Taping can quickly reduce symptoms and improve grip strength and hand dexterity in adults with thoracic outlet syndrome, a condition where nerves or blood vessels are compressed in the shoulder area. Participants are random…

This trial tests whether a set of self-help booklets, based on cognitive behavioural therapy for insomnia (CBT-I), can improve sleep quality in adults with pulmonary hypertension (PH). Participants will be randomly assigned to receive the booklets during the study or after a wait…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This pilot trial tests whether NeuroEyeCoach, a computer-based eye movement training program, can help stroke survivors who have lost part of their visual field. Sixty participants will be randomly assigned to receive either the training plus usual care or usual care alone. The s…

This study tests an inhaled powder called LIQ861 (treprostinil) in adults with scleroderma who have frequent, painful Raynaud's attacks—episodes where fingers or toes turn color and become numb or tingly. About 75 participants will be randomly assigned to receive either a dose th…

This study tests whether a mobile health program can help people with heart failure increase their physical activity and stay active. The program includes a smartphone app for goal-setting and self-monitoring, an AI-based health coach trained in motivational interviewing, and occ…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

This trial tests whether spinal cord stimulation (SCS) can reduce muscle spasticity in adults who have had a stroke. Participants will have a small device implanted that sends electrical pulses to the spinal cord. Half will receive active stimulation for six weeks, while the othe…

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce the number of headache days in people with chronic migraine. Participants will receive either real or sham (inactive) stimulation over the motor co…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This trial tests whether an 8-week daily resistance exercise program can reduce chest pain and improve daily function in women who have angina without blocked coronary arteries (ANOCA). Around 76 to 152 women across 13 hospitals in the UK and Netherlands will be randomly assigned…

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This trial is testing whether a bilingual (English and Urdu) mobile app can help stroke survivors improve movement in their affected arm and hand. The app guides users through structured exercises over eight weeks, starting with gentle range-of-motion activities and progressing t…

This trial tests whether a six-week personalized behavioral sleep program, called ISleepFAST, can improve sleep and daily functioning in adults who have had a stroke and still struggle with sleep or circadian problems. Forty participants will be randomly assigned to either the sl…

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

Stroke survivors often face unmet needs long after the initial event, especially younger adults who must balance rehabilitation with work and family. This trial tests a 12-month digital education and peer support program, co-designed with patients and delivered through LINE commu…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This trial tests whether different types of pressure garments can improve touch sensation in the hand after a stroke. Adults aged 21 to 60 with hand stiffness will wear one of three garment designs for at least 12 hours daily over four weeks. Researchers will measure how the pres…

This study tests whether placing an ice pack inside the anal canal for one minute right after hemorrhoid removal surgery can reduce pain. Adults with severe (grade III or IV) hemorrhoids will be randomly assigned to receive either standard surgery alone or surgery plus this quick…

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This pilot study tests whether zavegepant nasal spray can quickly relieve pain from episodic cluster headaches. About 40 adults with episodic cluster headaches will use the spray at the start of an attack. The main goal is to see how many achieve minimal or no pain within 30 minu…

This trial investigates whether a structured, moderate-intensity cardiac rehabilitation program is safe for people with arrhythmogenic cardiomyopathy who carry high-risk genetic mutations. Participants will be randomly assigned to either the exercise program or standard physical …

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study tests whether a 4-7-8 breathing exercise can reduce pain when needles are inserted into the arm for hemodialysis. About 80 adults on dialysis will either learn the breathing technique or receive standard care. The goal is to see if this easy, drug-free method makes the…

This study tests an 8-week online group program designed to help adults with congenital heart disease become more aware of internal body sensations like breathing, heart rate, and fatigue. The goal is to see if this approach is feasible and acceptable, and whether it can improve …

This trial investigates whether adding radial shock wave therapy to standard botulinum toxin injections can further reduce ankle muscle stiffness and improve walking in people who have had a stroke. Participants receive either shock wave therapy plus physical therapy or physical …

This study gathers real-world data from medical records of patients with complex vascular anomalies treated with targeted therapies like mTOR inhibitors, MEK inhibitors, or PI3K inhibitors. Researchers will look at patient characteristics, treatment patterns, and side effects acr…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This trial tests a website called Heart2Heart, created for teens living with congenital heart disease. The site provides health information and interactive tools to help them stay healthy. Researchers want to see if teens will use and enjoy the site, and whether it changes their …

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study looks at whether two simple bedside tests—the Passive Leg Raising (PLR) test and the Pleth Variability Index (PVI)—can predict a temporary drop in blood pressure that sometimes happens during a lung-opening procedure called an Alveolar Recruitment Maneuver (ARM). ARM i…

This study aims to develop and validate a questionnaire called the ProChange scale, designed to measure the barriers and facilitators to lifestyle changes in people at risk for chronic diseases. The scale will be tested in adults aged 45 and older who receive prevention advice on…

This study looks at whether people with cystic fibrosis (CF) who take newer modulator drugs are developing heart disease. Researchers will use ultrasound to measure blood vessel and heart health, then repeat the tests a year later to see how things change. They will also check if…

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study aims to build a specialized AI model, called CorAI, for coronary artery disease (CAD). Researchers will collect de-identified medical data from about 640 patients with suspected or confirmed CAD to create a rich dataset. Using this data, they will develop and test CorA…

This study looks at whether a digital tool called Luscii is practical and acceptable for people with a rare heart condition called ATTR-CM. About 60 adults in Austria, Germany, and Italy will use a smartphone app and home devices to share health information with their care team. …

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study tests whether a new device called Blood'up can help locate the radial artery in the wrist better than the traditional method of feeling for the pulse. Healthy volunteers will have arterial blood samples taken from both wrists, one using the device and the other using m…

This observational study looks at whether changes in a blood marker called NT-proBNP, measured at the bedside, can reflect how well fluid is being removed in patients hospitalized with acute decompensated heart failure. Participants receive standard care, and researchers track NT…

This study looks at whether a specific type of stroke called branch atheromatous disease (BAD) is linked to cognitive decline. Researchers will follow 60 adults aged 18-80 who had this stroke, tracking their thinking and memory over a year. They will also examine if early neurolo…

This study is a large, observational registry in Türkiye that will track the real-world practice and outcomes of a procedure called percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) — a complete blockage of a coronary artery that has been present for at l…

This study investigates whether levels of a protein called neurofilament light chain (NFL) in the blood can predict neurological recovery in people who remain comatose after a cardiac arrest. Researchers will measure NFL at several time points over the first week in the ICU and c…

This study uses imaging scans to measure the size and blood flow speed in three key arteries—the carotid, renal, and femoral—in adults with high blood pressure. The goal is to see how hypertension affects these blood vessels, both structurally and functionally. By comparing measu…

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least thr…

This study tests whether a small implanted sensor, called CardioMEMS, can continuously track blood pressure in the lung arteries after surgery for chronic thromboembolic pulmonary hypertension (CTEPH). The surgery, called pulmonary endarterectomy, can cure CTEPH, but some patient…

This study investigates how often muscle relaxants used during general anesthesia remain in the body after surgery, a condition called residual neuromuscular blockade. It will follow 160 adults aged 18-90 who are scheduled for post-anesthesia care unit admission after elective su…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known a…

This study explores whether the type of symptoms a person has at the start of a stroke influences how quickly they get to the hospital and how well they recover. Researchers will follow 120 adults with a first-ever ischemic stroke, comparing those with classic, high-urgency sympt…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study looks at whether an AI-based tool that helps doctors shape a microcatheter can improve the safety and success of coil embolization, a procedure to treat brain aneurysms. Researchers will follow about 1,400 adults who are scheduled for this procedure, comparing cases wh…

This study reviews existing research to understand how aldosterone, a hormone that regulates blood pressure, contributes to hypertension. It looks at the proteins and genetic factors involved in aldosterone production and how the body's signals might be able to block its effects.…

This study looks at whether tiny plastic particles in the blood are linked to problems with the heart's small blood vessels. Researchers will measure microplastic levels in 184 people who are already having a heart procedure, and then check their heart vessel function and track t…

This study looks at whether patients recovering from a first acute stroke do better in a specialized stroke unit than in a conventional neurology ward. Researchers will follow 140 adults admitted within 48 hours of symptom onset, comparing outcomes like daily independence, disabi…

This observational study looks at how the blood thinner apixaban is processed in the bodies of Asian patients with atrial fibrillation. Researchers will analyze existing medical records and blood concentration data from about 200 patients to understand how factors like kidney fun…

This study looks at a rare liver condition called porto-sinusoidal vascular disease (PSVD), which is diagnosed with a liver biopsy. The researchers are collecting detailed medical information from 150 patients to track their health over time, including survival and liver-related …

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study tests whether AI-generated avatar videos and a chatbot can better engage older Veterans in cardiovascular clinical trials compared to standard mailed letters. Veterans aged 65 and older with heart conditions will receive either a routine invitation or a link to a websi…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study looks back at medical records of about 350 people who had a specific stent graft placed during a complex aortic surgery called a frozen elephant trunk procedure, used to treat aortic aneurysms or dissections. The goal is to see how often major complications like stroke…

About one in three people who have open-heart surgery develop an irregular heartbeat called postoperative atrial fibrillation (POAF), which raises the risk of stroke and other complications. This study is testing whether a blood marker called lipoprotein(a), or Lp(a), can identif…

This study is testing whether a simple, non-invasive brain wave recording (EEG) taken within days of a stroke can help predict how well a person will recover. Researchers will record the brain activity of 400 stroke patients and track their recovery over three to six months. The …

This study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…

This study compares two common prostate medications, tamsulosin and silodosin, to see how they affect pupil size and the thickness of a layer at the back of the eye called the choroid. Men aged 50 and older with benign prostatic hyperplasia (BPH) who have not used these drugs bef…

This study asks whether nurses in geriatric departments have the knowledge needed to properly screen for orthostatic hypotension—a sudden drop in blood pressure when standing that can cause falls and other serious problems in older adults. About 30 nurses will complete a question…

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…

This study looks at whether a simple calculation called the modified shock index (MSI) — which combines heart rate and blood pressure — can predict serious heart complications after non-cardiac surgery in people who already have heart disease. Researchers will review medical reco…

This study follows people with Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) over time to learn how the condition progresses and affects daily life. Researchers will collect health data and patient feedback to identify patterns and potential markers of the disease. The goal i…

This study follows 100 adults with myotonic dystrophy (types 1 or 2) for two years to understand how muscle stiffness, daily function, and heart health change over time. Researchers will look back at up to 18 months of past medical records and then track participants with clinic …

This study looks at people whose coronary arteries are abnormally widened (coronary artery ectasia). Researchers want to see if exercise stress tests and certain blood markers can detect when the heart muscle isn't getting enough blood. The goal is to better understand the link b…

This study tests whether occlusal splints (night guards) made using a fully digital workflow are as comfortable and effective as those made with a traditional wax bite registration. Healthy volunteers aged 18 to 45 will wear both types of splints overnight for three weeks each. T…

People with interstitial lung disease (ILD) can suddenly get much worse, but it is hard to tell if the cause is a lung flare-up or a blood clot in the lungs (pulmonary embolism). This observational study will follow 70 adults with ILD who come to the hospital with worsening breat…

This study uses a special eye scan called OCTA to examine how blood sugar control relates to tiny blood vessel changes in the retinas of people with diabetic retinopathy. Researchers will compare patients with well-controlled and poorly controlled blood sugar levels. The goal is …

This observational study examines how antiplatelet medications affect platelet function in people over 80 with atrial fibrillation who have received a Watchman implant. Researchers will measure various markers of platelet reactivity before and after treatment to see if clotting r…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study uses cone-beam CT scans to map the alveolar antral artery, a small blood vessel in the upper jaw that can be injured during dental implant or sinus lift procedures. Researchers will analyze 1,000 existing scans to document the artery's typical location, size, and varia…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identif…

This trial investigates whether analyzing electrical signals from the heart during pulsed field ablation can tell doctors how well the catheter is touching tissue and whether the resulting scar will be permanent. About 60 people with paroxysmal atrial fibrillation will undergo th…

This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will fol…

This study looks at whether insurance claims data can be used to reliably identify two serious complications in people with Alzheimer's disease: brain hemorrhages larger than 1 cm and new-onset seizures. Researchers will analyze records from 600 Alzheimer's patients, linking insu…

This trial tests whether wearable devices like smartwatches can measure blood pressure as accurately as standard arm cuffs or invasive arterial lines. Hospitalized patients will wear multiple devices using light-based (PPG) and wrist-cuff methods, with readings compared to clinic…

Septic shock is a life-threatening condition with high mortality. This study investigates whether patients with septic shock have a deficiency of angiotensin II, a hormone that helps regulate blood pressure. Researchers will measure hormone levels in blood and urine samples from …

This pilot study is investigating how quickly C-reactive protein (CRP), a key marker of inflammation, drops after starting steroid treatment in people newly diagnosed with giant cell arteritis. By measuring CRP levels daily, then weekly and monthly for up to a year, researchers h…

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study tests two different formulations of an experimental drug called AD-118 in healthy adults aged 19 to 64. Participants receive a single dose of each version in a random order, and researchers measure how the drug moves through the body and check for side effects. The goa…

This study looks at how tiny particles called extracellular vesicles travel through the bloodstream in people with systemic sclerosis, an autoimmune disease that affects blood vessels and organs. Researchers will take blood samples from different points in the circulation to see …

This study looks at people with obstructive hypertrophic cardiomyopathy — a condition where the heart muscle is abnormally thick and blocks blood flow. Researchers want to see if certain abnormalities in the mitral valve or its supporting structures affect how well the drug mavac…

This study tests whether an artificial intelligence analysis of standard electrocardiograms (ECGs) can track heart muscle recovery in people with atrial fibrillation and mild heart failure who undergo catheter ablation. Researchers will follow 1,000 participants for a year, using…

This study looks at how the stiffness and function of blood vessels change in people newly diagnosed with heart failure. Researchers will measure these factors at the start, after a few weeks of standard medication, and after a cardiac rehab program. All tests are non-invasive an…

This study investigates how often atrial fibrillation (AF), a type of irregular heartbeat, occurs in people with certain blood cancers who are starting a targeted cancer drug called a Bruton's tyrosine kinase inhibitor (BTKI). Researchers will follow 500 participants—400 starting…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This observational study looks at whether heart rate variability — a measure of the nervous system's control over the heart — is linked to how well people with resistant hypertension take their medications. Researchers will use a blood test to objectively check drug levels and co…

This study looks at how well the right side of the heart works with the lungs in people who have high blood pressure in their lung arteries caused by schistosomiasis, a parasitic infection common in parts of Africa and South America. Researchers will use echocardiography to measu…

This study follows 600 older adults (age 60+) who have had a heart attack to see if aging-related markers in their blood and body can predict future heart problems or death. Researchers collect medical data, blood samples, and heart scans over at least two years. The goal is to b…

This study looks at children with Von Hippel-Lindau (VHL) disease, a rare genetic condition that causes tumors in the brain and spinal cord. Researchers want to understand how these tumors grow over time and what factors predict when a child will need surgery. By reviewing medica…

This study looks at heart function and rhythm in children and young adults up to age 25 who have had surgery to repair Tetralogy of Fallot, a congenital heart defect. Researchers will use echocardiography, a 12-lead ECG, and Holter monitoring to detect changes such as arrhythmias…

This study looks at whether intentionally lowering blood pressure during elective nose surgery (rhinoplasty) causes any stress to brain cells or affects thinking abilities. Researchers will measure a protein called GFAP in the blood, which can indicate brain cell stress, and test…

This study investigates genetic and molecular markers in pregnant women with severe preeclampsia, a dangerous condition involving high blood pressure and organ damage. Researchers will analyze blood, urine, and placental samples from 100 women to identify changes in genes and cel…

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study uses ultrasound to examine how the right side of the heart and the lungs' blood vessels work together during severe COPD flare-ups. Researchers will measure changes in heart-lung coupling in 115 patients admitted to intensive care, comparing readings during the acute e…

This study looks at how certain cancers develop in people with HIV and what factors might increase their risk. Researchers will analyze medical data from 1,000 HIV-positive adults to track which types of cancer occur most often and why. The goal is to improve early detection and …

This study tracks how a pregnant person's heart and lungs change over the course of pregnancy and after childbirth. Researchers will use non-invasive tests to measure blood flow and airway function, aiming to understand how these changes relate to the development of preeclampsia,…

This study tests whether four popular AI chatbots — ChatGPT, DeepSeek, Gemini, and Claude — can correctly classify surgical risk using anonymous patient vignettes. Researchers compare the AI's risk scores to those given by a panel of senior anesthesiologists. If successful, AI co…

This study tests a new wearable system called M2VS that measures heart activity (ECG) and blood pressure continuously for 24 hours. Researchers want to see if it works as well as standard monitors like Holter ECG and ambulatory blood pressure monitors. The study involves 20 adult…

This study tests whether wearable devices and artificial intelligence can help personalize the timing of valve replacement in people with moderate to severe aortic stenosis who have no symptoms. Participants wear a smartwatch to track heart rate, activity, and blood pressure, and…