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Could exercise be safe for a fragile blood vessel condition?

NCT ID NCT07697573

Disease control Sponsor: Sheffield Hallam University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study explores whether a carefully designed, low-impact exercise program is safe and practical for people with vascular Ehlers-Danlos syndrome (vEDS), a rare condition that weakens blood vessels and organs. Researchers are working with patients and doctors to create a 12-week home-based program of gentle aerobic and functional activities, then testing it in a small group of 40 adults in the UK. The goal is to see if the program is acceptable and can be delivered without harm, before planning a larger trial to measure its effects on health and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Co-designed exercise-based lifestyle intervention
What this could lead to
If successful, this could pave the way for a larger trial to determine whether structured exercise is safe and beneficial for people with vEDS.
What could go wrong
This is a small feasibility study, not designed to prove effectiveness. The intervention may not improve health outcomes, and there is a risk of injury or vascular events during exercise.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2027

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older * Confirmed diagnosis of vascular Ehlers-Danlos syndrome (vEDS) * Living in the UK * Able to provide informed consent * Medically stable, defined as: no arterial dissection, rupture, or other major vEDS-related vascular event within the preceding 6 months; no recent hospitalisation for vEDS complications; and blood pressure considered controlled by their treating clinician * Medical clearance from their treating clinician * Not pregnant at the time of enrolment Exclusion Criteria: * Major vEDS-related vascular event (arterial dissection or rupture) within the previous 6 months * Recent hospitalisation for vEDS complications * Blood pressure not controlled by treating clinician * Pregnancy at enrolment (participants who become pregnant during the intervention are withdrawn from the exercise component but may continue follow-up data collection if they wish) * Unable to provide informed consent

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Conditions

The condition(s) this trial relates to.

connective tissue disorder Ehlers-Danlos Syndrome, Type IV Ehlers-Danlos syndrome, vascular type Motor Activity Rare Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vascular Ehlers-Danlos syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sheffield Hallam University

    Sheffield, South Yorkshire, S10 2BP, United Kingdom

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