Could a pill replace an IV to cut bleeding in heart surgery?

NCT ID NCT07740330

Not yet recruiting Disease control Sponsor: Clinique Saint-Luc Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial compares two ways of giving tranexamic acid, a drug that reduces bleeding, to adults undergoing off-pump coronary artery bypass surgery. Half receive the drug as a pill before surgery, while the other half get it through an IV during surgery. The goal is to see if the oral form is just as effective at limiting blood loss after surgery, which could make treatment simpler and more affordable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tranexamic acid (oral and intravenous formulations)
What this could lead to: If oral tranexamic acid works as well as the IV form, it could offer a simpler, cheaper way to reduce bleeding during heart bypass surgery.
What could go wrong: This is a single trial with 160 participants, and non-inferiority doesn't guarantee equal effectiveness. There are also risks like blood clots or seizures, though rare.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Postoperative Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE PERIOPERATIVE BLEEDING

Contacts and locations

Locations

Clinique Saint-Luc

Bouge, Namur, 5004, Belgium

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