Cardiovascular disorder

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study tests a device called the Hypotension Prediction Index (HPI) that warns doctors when a patient's blood pressure is about to drop dangerously low after surgery. 210 adults having elective surgery under general anesthesia will be randomly assigned to either standard moni…

This study looks at whether the medication Entresto (sacubitril/valsartan) helps Japanese patients with essential hypertension achieve blood pressure targets recommended by Japanese guidelines. Researchers will analyze electronic medical records from a large database, focusing on…

This study tests whether regular video calls with a nurse can help people with heart failure manage their condition better than audio-only calls. About 140 adults with heart failure will be randomly assigned to receive either video or audio calls at 7, 30, 60, 180, and 365 days a…

This trial tests whether a structured support program can help people with coronary artery disease maintain regular exercise after completing cardiac rehabilitation. Participants receive group counseling calls, personal phone check-ins, and introductions to community exercise pro…

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This trial tests whether a short, structured counseling method called BATHE can help people with high blood pressure stick to their treatment plan. Adults with hypertension are randomly assigned to receive either the BATHE interview during clinic visits or standard advice on medi…

This trial tests whether sacubitril/valsartan, a newer heart failure medication, is safer and more effective for the kidneys than ramipril, an older ACE inhibitor, in people hospitalized with acute decompensated heart failure who also have chronic kidney disease. About 515 partic…

This study tested a generic version of the blood pressure drug nifedipine against the brand-name version in 50 adults with mild-to-moderate high blood pressure in Colombia. The goal was to see if the generic pill controls blood pressure just as well after 8 weeks. Participants ha…

This study tests whether a diabetes drug called dapagliflozin can help people with heart failure who also develop kidney injury recover faster. About 30 adults will take the drug or usual care for three days. The main goal is to see if a larger trial is possible, not to prove the…

This trial tests whether a device that gently stimulates the tongue, called PoNS, can improve balance and walking in people who had a stroke at least six months ago. Participants receive either real stimulation or a sham (inactive) device, along with balance training, over severa…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This study tests a new device called the Doraya Catheter for people hospitalized with acute heart failure who still have too much fluid in their body even after taking water pills (diuretics). The catheter is designed to help remove the excess fluid. The study includes 30 adults …

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during e…

This study tests whether giving a drug called sitaxsentan during and after heart bypass surgery can improve blood flow and heart function in patients with a weakened heart (low ejection fraction). The drug blocks a hormone that can narrow blood vessels and strain the heart after …

This study compares two treatments for a severe type of stroke caused by a blockage in a major artery at the base of the brain. Some patients will get a clot-busting drug through a vein followed by a procedure to remove the clot, while others will have the clot removal procedure …

This trial tests whether giving anti-VEGF injections 3, 7, or 14 days before surgery makes a difference for people with proliferative diabetic retinopathy, a complication of diabetes that causes abnormal blood vessels in the eye. Participants are randomly assigned to one of three…

This trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly…

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This trial tests whether injecting a local anesthetic into a nerve cluster in the neck—called a stellate ganglion block—can help stop dangerous heart rhythms in people who suffer a cardiac arrest outside a hospital. The study includes adults whose heart stops with a shockable rhy…

This trial tests whether giving the clot-busting drug alteplase directly into the brain artery, right after a mechanical thrombectomy has reopened a blocked vessel, can improve recovery from acute ischemic stroke. The study enrolls adults with large-vessel blockages in the front …

This study tests whether using a brain-computer interface (BCI) to control a walking robot can improve gait recovery after a stroke. People who had a stroke within the past year will be randomly assigned to either standard exoskeleton training or BCI-controlled exoskeleton traini…

This trial tests whether a web-based program called PATH can help adults with obesity become more physically active and stick to recommended exercise levels. Participants are randomly assigned to either the PATH program, which includes personalized coaching and online resources, …

This study tested whether a brain-computer interface (BCI) system called IpsiHand can help people with chronic stroke improve arm and hand movement when used at home. 109 adults with arm weakness after a stroke used either the BCI system or standard exercises. The BCI system uses…

This study tests whether a program called iHeLP is practical and acceptable for stroke survivors. The program includes a one-on-one interview to set personal goals, followed by six weekly group sessions focused on healthy lifestyle changes. Researchers will measure how many peopl…

This study tested whether a drug called GM-CSF can improve symptoms and blood flow in people with peripheral artery disease (PAD), a condition where plaque narrows leg arteries, causing pain and limiting walking. 151 participants received either GM-CSF or a placebo for two 3-week…

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with group 2 pulmonary hypertension (high blood pressure in the lungs). About 48 participants will take tadalafil or a placebo for 12 weeks. Researchers will measure how far they can w…

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

This study follows up to 300 people with advanced heart failure in South Korea who receive a HeartMate 3, a mechanical pump that helps the heart circulate blood. Researchers will track how long patients survive without a debilitating stroke or the need for a pump replacement, as …

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This study looks at why the heart failure drug LCZ696 (sacubitril/valsartan) can cause a sudden drop in blood pressure when people first start taking it. The researchers think a natural chemical called bradykinin, which the drug prevents from breaking down, might be responsible. …

This pilot study tested whether community pharmacists can manage blood thinner therapy for older adults (60+) with atrial fibrillation who are at high risk for stroke but not on optimal treatment. Fourteen participants received pharmacist-led care for 3 months, then were followed…

This trial tests whether giving stroke or TIA survivors free smoking-cessation medications (like nicotine patches, bupropion, or varenicline) for 12 weeks helps them quit smoking more effectively than just giving a prescription. The study will compare quit rates and cost-effectiv…

This trial tests whether a cardiac rehabilitation program based on a socio-ecological model can improve recovery in adults who have had a first heart attack and undergone a stent procedure. The program goes beyond standard care by providing guidance on exercise, diet, medication,…

This trial tests a new device that uses sound waves to break up calcium deposits in the heart's arteries, which can harden and narrow them. The study includes adults with coronary artery calcification who are eligible for a procedure to open blocked arteries. The goal is to see i…

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This study tested a drug called pelacarsen in 422 Black/African American and Hispanic patients with high Lp(a) levels and existing heart disease. Lp(a) is a genetic risk factor for heart attacks and strokes. The goal was to see if pelacarsen could safely lower Lp(a) levels over 1…

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This study observes Korean adults with chronic heart failure (NYHA class II-IV) who are starting Jardiance (empagliflozin) for the first time. The main goal is to track the drug's safety in everyday clinical practice, including any side effects or serious reactions. Researchers w…

This early-stage trial is testing an investigational drug called SHR-2004, given as multiple injections under the skin, in about 10 adults with atrial fibrillation (an irregular heartbeat). The main goal is to see if the drug is safe and tolerable, and to learn how it moves throu…

This trial asks whether one way of setting a breathing machine is better than another for children born with a hole in the heart who are having surgery to close it. The hole lets extra blood flow to the lungs, which can make them stiff and harder to inflate. During surgery, a mac…

This trial is evaluating a new device called the Bifurcated Multilayer Flow Modulator (BMFM) for treating abdominal aortic aneurysms that involve the iliac arteries. The device is designed to be implanted inside the blood vessel to help stabilize the aneurysm and prevent it from …

This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the metho…

This study tests a new stenting technique called double kissing nano-culotte for people with complex blockages in heart arteries. The procedure uses two stents with minimal overlap to keep arteries open. Researchers will track 12 patients for heart attacks, repeat procedures, or …

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This trial tests whether low-intensity focused ultrasound (LIFU) can safely stimulate the brain to help people recover arm and hand function after a stroke. Researchers will try different intensities and frequencies of ultrasound in stroke survivors to find the best settings that…

This trial tests whether a newer type of heart ablation, called pulsed-field ablation, can effectively isolate the pulmonary veins in people with paroxysmal atrial fibrillation while using very little or no X-ray guidance. The procedure uses the Farapulse system with a special ma…

This trial tests an automated system that monitors blood pressure and delivers medications to keep it stable during spinal anesthesia for cesarean sections. The system aims to prevent low blood pressure, which can cause side effects for both mother and baby. The study includes wo…

This study tested a special stent designed to open severely narrowed brain arteries in 194 people with symptomatic intracranial atherosclerosis. The goal was to see if the stent is safe and effective at keeping arteries open for at least 12 months. Researchers measured how often …

This study tested a device called iCLAS™ that uses extreme cold to destroy tiny areas of heart tissue causing persistent atrial fibrillation (AFib). 215 adults with AFib lasting more than 7 days but less than a year received the procedure. Researchers tracked safety issues like h…

This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery, right after a standard procedure to remove a clot, can help people who have had a severe ischemic stroke. The study includes adults aged 18-85 with a blocked artery in the fron…

This trial tests a drug called briquilimab for adults with chronic spontaneous urticaria (CSU) — long-lasting hives and itching that don't get better with standard antihistamines or omalizumab. The study has three parts, with some participants getting the drug and others a placeb…

This Phase 3 trial tested a once-daily pill called baxdrostat in 218 adults with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Participants received either baxdrostat or a placebo for 12 weeks. The main goal was to see if bax…

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This study looked at 159 people with granulomatosis with polyangiitis (GPA), a rare disease that causes inflammation of blood vessels. Participants were randomly assigned to either stay on a low 5 mg daily dose of prednisone or slowly stop it over six months. The goal was to see …

This trial tests an automated system that monitors blood pressure continuously and automatically delivers two medications to prevent low blood pressure during cesarean sections under spinal anesthesia. The system is compared to the standard manual approach of giving bolus doses. …

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This study tested a new device called the Volt PFA System, which uses pulsed field ablation to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 392 people with symptomatic AF that didn't respond to medication. The goal was to see if the procedur…

This trial tests a new type of pacemaker for people with heart failure who are having coronary bypass surgery. The pacemaker is designed to mimic a natural pattern called respiratory sinus arrhythmia, where the heart rate speeds up when breathing in and slows down when breathing …

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This study tested whether community health workers can help Black postpartum patients who had preeclampsia or other pregnancy complications. 61 participants were split into two groups: one received usual care, the other also got support from a community health worker. The goal wa…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This pilot study is testing a home-based virtual exercise program called Vivo Heart for older adults with cardiovascular disease. The program involves live, small-group sessions led by certified trainers, combining physical exercises with cognitive challenges to improve strength,…

This trial asks whether giving the thyroid hormone T3 to people with ischemic heart failure is safe and can improve heart function. Participants with reduced pumping ability will receive oral T3 twice daily for five days under medical supervision, with follow-up over a year. A co…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This study tests whether adults with heart failure who have an implanted pulmonary artery pressure sensor can safely adjust their own diuretic (water pill) doses. Participants follow a simple guide to change their medication based on daily pressure readings sent to their phone or…

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. 292 adults with drug-resistant AF took part. The goal was to see if the new method is faster, safer, and more effectiv…

This clinical trial is testing whether two experimental oral medications, AD-224A and AD-224B, can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). About 254 participants will take one of the drugs or a placebo once dail…

This trial compares two techniques for guiding botulinum toxin injections to treat leg spasticity after a stroke: ultrasound and electrostimulation. The goal is to see which method improves ankle flexibility and reduces pain during the procedure. Adults with stroke-related spasti…

This trial tests whether adding vacuum compression therapy — a device that applies cycles of pressure and suction to the leg — can improve healing of chronic lower limb ulcers. Adults with ulcers that have not healed despite standard care will receive either standard wound care a…

This study tested different treatments for autonomic dysfunction, including POTS, in 381 adults with Long COVID. It compared non-drug approaches and medications to see which best eased symptoms like rapid heart rate and dizziness. The goal was to find effective ways to manage the…

This study tested a new device that uses sound waves to break up calcium deposits in leg arteries of people with peripheral artery disease. Thirty-five participants received the treatment to see if it was safe and could open blocked arteries. The goal was to improve blood flow wi…

This trial is testing MYL-1701P, a proposed biosimilar to the existing eye medication Eylea, in people with diabetic macular edema who have already completed an earlier study with the same drug. The goal is to see if continued treatment with MYL-1701P is safe and effective over a…

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This trial tests whether adding a chloride supplement (lysine chloride) to standard IV diuretics helps people with acute heart failure get rid of excess fluid more effectively. Participants take the supplement or a placebo for 7 days while receiving usual care. The study measures…

This trial tests whether a nasal spray containing bevacizumab, a drug typically used for cancer, can reduce frequent nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT). The study enrolls 20 adults who have at least 10 nosebleeds per month. The goal is to see if…

This trial tests whether doctors using mixed reality goggles (HoloLens 2.0) can perform MitraClip heart valve repair more efficiently and with less stress. Twenty adults with leaky mitral valves will undergo the standard clip procedure, but the surgeon will also wear a headset th…

This trial tests whether specially made cookies containing pumpkin seeds and walnuts can improve cholesterol levels in adults with atherosclerosis. For six weeks, one group eats a daily cookie while the other receives usual care alone. Researchers measure changes in LDL and HDL c…

This trial tests whether a wearable ECG patch can help people recover better after heart surgery. Participants wear the MEMO Patch, which continuously records heart signals and activity, while completing a cardiac rehabilitation program that starts in the hospital and continues a…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial investigates whether a 10-week Zumba-based exercise program can help lower blood pressure in adults with hypertension. Participants will either join three 50-minute Zumba sessions per week or maintain their usual lifestyle. Researchers will also measure changes in body…

This study tests whether an implanted device that stimulates the vagus nerve, combined with physical therapy, can improve arm movement in people who have had a stroke. The trial includes adults with chronic upper-limb weakness who have already received the implant and completed r…

This trial investigates whether breathing high-dose oxygen (normobaric hyperoxia) for four hours, given together with standard clot-busting medication, can improve recovery in people having an acute ischemic stroke. The study enrolls adults who arrive at the hospital within 4.5 h…

This phase 2 trial tests whether vericiguat, a drug already used for heart failure, can improve blood vessel function in people with vasospastic angina—a type of chest pain caused by spasms in the heart's small arteries, not by blockages. About 57 adults with frequent angina symp…

This trial investigates whether a single injection of selatogrel can quickly prevent platelets from clumping together in people with stable coronary artery disease. Researchers are also checking how fast the drug works, how long it lasts, and whether injecting it in the thigh or …

This trial investigates whether the antibiotic minocycline can reduce brain injury in people with acute ischemic stroke who undergo mechanical thrombectomy (clot removal). Minocycline may protect the blood-brain barrier and limit damage from restored blood flow. The study enrolls…

This trial investigates whether adding a dexamethasone implant (Ozurdex) to standard aflibercept (Eylea) injections can better control diabetic macular edema that has not responded to anti-VEGF therapy alone. Adults with persistent retinal swelling will receive either the combina…

This phase 2 trial tests whether a single injection of selatogrel can rapidly prevent platelets from clumping together in adults having a heart attack. Participants receive either an 8 mg or 16 mg dose in the thigh, and researchers measure how quickly platelet activity drops. The…

This trial tests whether combining robotic gloves with task-oriented mirror therapy can improve hand motor function in people recovering from a stroke. Thirty sub-acute stroke patients will receive either the combined therapy or mirror therapy alone, alongside standard rehabilita…

This trial tests whether a six-session behavioral program that combines standard hypertension self-management with climate change awareness and heatwave preparedness can improve quality of life, reduce psychological distress, and lower blood pressure in adults with high blood pre…

This trial tests whether empagliflozin, a drug already used for diabetes and heart failure, can prevent the heart muscle from thickening or developing fibrosis in people with moderate aortic stenosis. Participants will receive either empagliflozin or standard care for six months,…

This trial tests whether a single drop of timolol maleate, given just before Nd:YAG laser capsulotomy, can prevent a short-term rise in eye pressure. The study includes adults who developed clouding of the lens capsule months after cataract surgery. Half receive the timolol drop;…

This trial investigates whether injecting bleomycin directly into low-flow vascular malformations (abnormal clusters of blood or lymph vessels) in the head and neck can shrink them. Twenty participants will receive up to four sessions of the drug under local anesthesia. The main …

This trial tests whether a special compression device called NewMan can reduce bleeding and bruising after a shoulder artery procedure compared to a standard pressure bandage. The study involves 229 adults with blocked leg arteries who need a catheter inserted through the arm. Do…

This trial tests whether providing health education materials and a home blood pressure monitor can help Somali community members in the Greater Mankato area better identify, manage, and prevent high blood pressure. Participants receive simple tools and guidance on diet, exercise…

This trial tests whether a newer cryoballoon device, PolarX, works as well as the standard Arctic Front device for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 200 people having their first pulmonary vein isolation procedure will be randomly assi…

This study collects follow-up data from about 300 people who have already received a stent-graft to repair an abdominal aortic aneurysm (AAA). The goal is to assess how safe, effective, and durable the repair is over time. Participants had an AAA larger than 4 cm or one growing r…

This trial compares two low-cost exercise programs—Cawthorne-Cooksey exercises and Frenkel exercises—to see which better improves balance and coordination in people who had a stroke 3 to 6 months ago. Participants, aged 40 to 75 with moderate balance problems, will be assigned to…

This trial tests a new replacement heart valve, the Neovasc Tiara, that is delivered through a small tube (catheter) inserted into the chest. It is designed for people with severe mitral regurgitation—a leaky heart valve—who are too high-risk for traditional open-heart surgery. T…

This trial examines how two standard heart failure medications—bisoprolol (a beta blocker) and SGLT2 inhibitors (dapagliflozin or empagliflozin)—are processed by the body during an acute decompensated heart failure episode. Researchers will measure drug levels and heart function …

This trial investigates whether an injection of ranibizumab, a drug that blocks abnormal blood vessel growth, can effectively treat aggressive posterior retinopathy of prematurity (AP-ROP) in premature infants. AP-ROP is a fast-progressing eye condition that can lead to retinal d…

This pilot trial tests whether nurse-led motivational interviewing — a counseling style that strengthens a person's own motivation to change — can help adults with heart failure improve self-care behaviors like diet, medication adherence, and symptom monitoring. Participants in O…

This study follows over 500 adults with migraine who have not responded well to other preventive treatments. Participants take atogepant as prescribed by their doctor and are monitored for a year to see how well it reduces headache and migraine days, and how long they stay on the…

This trial tests whether the gas xenon can reduce heart muscle damage during coronary artery bypass surgery compared to two standard anesthetics: sevoflurane and propofol. About 500 adults with coronary artery disease scheduled for elective bypass surgery will be randomly assigne…

This pilot study tests a new type of stent—a drug-coated, spur-shaped device—as a primary treatment for in-stent restenosis, where a previously placed coronary artery narrows again. The trial enrolls up to 9 adults with this condition to see if the device is safe in the short ter…

This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 mon…

This study tests whether teaching people with high blood pressure about the Mediterranean diet can help lower their blood pressure and improve their quality of life. About 70 adults with hypertension will either receive diet education or standard care, and their progress is track…

This study compares two types of walking exercise for people who have had a stroke at least six months ago: walking in virtual reality (wearing VR glasses showing a nature walk) and walking on a treadmill. Both groups also receive standard physical therapy. The goal is to see whi…

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study tests whether an artificial intelligence system called optima4BP can improve blood pressure control in people with hypertension. The AI analyzes a patient's medications and recommends the best drug adjustments—adding, removing, replacing, or changing doses. Researchers…

This study tests the safety of an experimental eye injection called ONS-5010 (bevacizumab) in people with vision loss from wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion. Participants receive the injection and are monitored for side…

This study tests an experimental drug called pelacarsen in people with very high levels of lipoprotein(a), a type of cholesterol linked to heart disease. Participants currently undergo weekly blood-filtering treatments (apheresis) to lower their Lp(a). The trial aims to see if ta…

This Phase 1 trial evaluates the safety, tolerability, and how the body processes a single dose of JS010 injection in healthy adults aged 18 to 45. Participants receive one of six dose levels or a placebo to assess side effects and drug levels in the blood. The goal is to gather …

This pilot study explores whether an eight-week mindfulness course or a short guided forest bathing program can lower stress and blood pressure in women over 60 who are already taking medication for hypertension. Sixty women are split into three groups: one learns mindfulness, on…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This study tests whether an interactive avatar-based game on a tablet can help people who have had a heart attack learn how to manage their health after leaving the hospital. Participants are randomly assigned to either standard face-to-face discharge education or the tablet game…

This study tests whether a six-week program that combines stepping to a metronome (rhythmic auditory stimulation) with walking while carrying objects (motor dual-task training) can improve mobility, balance, and quality of life in people who had a stroke at least six months ago. …

This study tests whether adding an Oxiris membrane—a special blood filter that removes toxins and inflammatory molecules—to the ECMO circuit can reduce the harmful inflammation and organ damage that often occurs when blood flow is restored after cardiogenic shock. The trial enrol…

This study tests whether using real-time measurements of oxygen levels in the brain and carbon dioxide in the breath can guide CPR more effectively than standard audiovisual feedback. Adults who have a cardiac arrest in the hospital and need CPR for at least five minutes may join…

This phase 2 trial tests whether the drug abatacept can safely and effectively treat severe heart inflammation (myocarditis) caused by immune checkpoint inhibitors, a type of cancer immunotherapy. The study enrolls adults with any cancer who develop this rare but often fatal hear…

This study looks at whether heart failure patients with iron deficiency anemia respond better to oral iron supplements when they are also taking a type of heart medication called SGLT2 inhibitors. Participants take oral iron for three to four months, then pause treatment while do…

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This study is testing a special balloon catheter coated with the drug paclitaxel to treat blocked arteries in the legs, a condition called peripheral artery disease. The balloon is inflated inside the artery to open it up, and the drug helps prevent the artery from narrowing agai…

This phase 3 trial tests whether adding Sacubitril/Allisartan to amlodipine can lower blood pressure more effectively than amlodipine alone in people with essential hypertension. Participants are adults aged 18–75 whose blood pressure remains high despite taking amlodipine. The s…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This study tests a new, less invasive procedure called PIMSRA for children with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle is too thick and blocks blood flow. The procedure uses a needle guided by ultrasound to deliver radiofrequency energy to the…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different…

This phase 3 trial tests whether adding amlodipine to Sacubitril/Allisartan can lower blood pressure more effectively than Sacubitril/Allisartan alone in people with essential hypertension. Participants whose blood pressure remains high after four weeks on Sacubitril/Allisartan a…

This study investigates whether replacing missing teeth with fixed dental prosthetics can improve blood sugar and cholesterol levels in people with ischemic heart disease. Participants aged 45 to 70 with stable heart disease and missing teeth receive the dental treatment. Researc…

This study tests whether adding the drug Mexidol to standard care can improve thinking and memory in adults aged 75 and older who have mild cognitive issues due to poor blood flow in the brain, but not dementia. Participants receive Mexidol first as an IV infusion for 5 days, the…

This trial tests an investigational drug called BAT5906, given as an eye injection, for people with diabetic macular edema—a condition where fluid builds up in the retina and blurs vision. The study compares two doses (2.5 mg and 4 mg) given multiple times to see which works best…

This study investigates whether combining two drugs that block brain-damaging overactivity—ketamine and perampanel—can stop super-refractory status epilepticus in people who remain in a coma after cardiac arrest. Researchers will compare outcomes in 84 patients who received this …

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in leg arteries, a condition called peripheral artery disease. About 75 adults with moderate to severe symptoms will receive the treatment. The goal is to see if the device safely …

This study tests whether a robotic hand device can improve grip strength and fine motor skills in people who had a stroke at least six months ago. Participants use the HWARD exoskeleton, which assists hand opening and closing, during 45-minute sessions three times a week for 12 w…

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This phase 2 trial tests whether a new combination pill, QR12000, can lower blood pressure more effectively than existing medications in people with moderate to severe essential hypertension. Participants are randomly assigned to receive either QR12000, one of its components, or …

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This study tests whether adding an anti-gravity treadmill and high-intensity electromagnetic stimulation to standard physical therapy helps people recover walking and balance after a recent stroke. Participants are adults aged 18 to 74 who had a stroke and need help moving. They …

This trial tests two techniques for treating severely calcified coronary arteries before placing a stent. One uses a super high-pressure balloon to crack the calcium; the other uses intravascular lithotripsy, which sends shockwaves through the artery wall. The study includes 80 a…

Autistic children drown at 160 times the rate of their peers, yet standard swim lessons often fail them. This study tests a new approach that adapts instruction based on a child's sensory profile—whether they seek, avoid, or have mixed reactions to sensory input. Researchers will…

This study investigates whether dapagliflozin, a drug typically used for diabetes, can improve the structure and function of the heart's left atrium in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). Researchers will measure changes…

This study investigates whether a 12-week moderate aerobic exercise program can improve brain function, cardiovascular health, and cognition in sedentary adults aged 45-65 with borderline or stage 1 hypertension. Participants are randomly assigned to either aerobic exercise or a …

This study looks at whether vericiguat, a drug that stimulates a key enzyme, can improve exercise ability and heart pressure during activity in people with chronic heart failure and reduced ejection fraction. Participants take vericiguat alongside their usual heart medications an…

This trial evaluates a device called the TORUS Stent Graft, a mesh tube placed inside the leg artery to keep it open in people with peripheral artery disease (PAD). The study includes about 188 adults with blockages in the thigh or behind-the-knee arteries. The goal is to see if …

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This trial tests a gene therapy called valoctocogene roxaparvovec for people with severe hemophilia A who have developed inhibitors (antibodies that block standard treatment). The therapy uses a harmless virus to deliver a working copy of the gene for clotting factor VIII, so the…

This study tests whether a new generic tablet containing selexipag works the same as the brand-name drug Uptravi. Healthy adults aged 18 to 55 take a single dose of each version under fed conditions, and researchers compare how much drug gets into the bloodstream. The goal is to …

This trial tests a special implantable cardioverter-defibrillator (ICD) that uses a single lead to sense both heart chambers, aiming to detect atrial fibrillation and other arrhythmias early. It includes 56 people who need a single-chamber ICD and are in normal sinus rhythm at th…

This study tests whether adding mixed reality games to standard physical therapy helps people who have had a stroke regain arm movement and trunk stability. Participants will either receive traditional therapy alone or traditional therapy plus sessions using a mixed reality heads…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This trial is testing a new stent called Renzan to treat blockages in the leg arteries (superficial femoral or popliteal arteries). The study includes about 135 people with moderate to severe peripheral artery disease. Researchers want to see if the stent is safe and effective at…

This pilot study tests whether the DASH diet, lifestyle advice, or a combination of both can lower blood pressure in adults with prehypertension—a condition where blood pressure is higher than normal but not yet in the high blood pressure range. Researchers randomly assigned 32 p…

This trial compares a generic extended-release tablet containing three diabetes drugs (empagliflozin, linagliptin, and metformin) to the brand-name Trijardy XR. The study involves 36 healthy adults who take a single dose of each version under fed conditions to see if the generic …

This trial tests whether a special cooling probe placed in the esophagus can protect it from heat damage during a common heart procedure for atrial fibrillation (AF). AF is a heart rhythm disorder that can cause serious symptoms, and ablation uses heat to fix it, but the esophagu…

This trial investigates whether a one-year, app-supported home exercise program can improve quality of life and reduce the time spent in atrial fibrillation (AF) compared to usual care. Participants have paroxysmal or persistent AF, are in sinus rhythm at the start, and use a sma…

This clinical trial tests whether adding the drug glenzocimab to standard endovascular therapy (a procedure to remove blood clots) improves recovery in people with acute ischemic stroke. The study includes adults aged 18 and older who are eligible for clot removal within 24 hours…

This study tests whether injections of ranibizumab, a drug that blocks abnormal blood vessel growth, can help clear bleeding inside the eye in people with diabetes. The bleeding, called diabetic vitreous hemorrhage, can blur or block vision. Participants receive the injection and…

This trial tests whether an experimental drug called Y-3, given as an injection for 10 days, helps people recover better after an acute ischemic stroke. The study includes Chinese adults who had a stroke within the past 48 hours and have moderate to severe symptoms. Participants …

This study tests whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban reduce the risk of stroke, major bleeding, or heart-related death in people with atrial fibrillation who have an intermediate stroke risk (CHA2DS2-VASc score of 1 in men or 2 in women). About…

This study tests whether a 12-week vinyasa (flow) yoga program done at home via Zoom can improve heart health in people with high blood pressure. Thirty adults with elevated blood pressure will be split into two groups: one does yoga three times a week, the other continues their …

This study tests whether playing motion-controlled video games—like boxing, bowling, and table tennis—using a Kinect sensor can improve trunk control, balance, and arm function in people recovering from a stroke. Forty participants aged 40 and older, at least three months post-st…

This trial compares two approved treatments for ascites (fluid buildup in the belly) caused by portal hypertension. One group receives large-volume paracentesis (draining fluid with a needle) plus albumin infusion, while the other gets an early TIPS procedure, which creates a new…

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This study tests whether a simple foot exercise called the soleus pushup can improve cholesterol, blood sugar, and hormone levels in people with thyroid problems, high blood pressure, or diabetes. Participants will perform the exercise, and researchers will measure changes in blo…

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This study tests whether a case manager—who provides phone support, a home visit, and lifestyle counseling—can help women attend cardiac rehabilitation after a heart attack or heart surgery. Cardiac rehab is proven to reduce mortality and improve quality of life, but women are le…

This study tests whether adding a traditional Chinese herbal decoction (Buyang Huanwu Decoction combined with Wuling Powder) to standard stroke care helps people recover better after an acute ischemic stroke. Participants receive either standard care alone or standard care plus t…

This study tests whether a structured nursing program, based on the Plan-Do-Check-Act quality improvement cycle, can reduce lung infections in stroke patients who have a tracheostomy (a breathing tube in the neck). The program includes careful airway care, suctioning, and early r…

This trial investigates whether a daily dose of olive leaf extract (atherolive) can help control blood pressure and improve cholesterol levels in adults with hypertension. Participants are randomly assigned to receive either the extract or a placebo for three months. The study ai…

This study investigates whether 12 weeks of moderate aerobic exercise can improve heart health, metabolism, and menopause symptoms in postmenopausal women who have two or more chronic conditions like high blood pressure and high cholesterol. Participants will exercise three times…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This trial tests whether a newer, simpler 2-lead cardiac resynchronization therapy defibrillator (CRT-DX) works as well as the standard 3-lead system (CRT-D) in people with heart failure. The study includes 640 adults who need a CRT-D and have a normal heart rhythm. The main goal…

This study tests a nurse-led program designed to help elderly patients (age 60+) adopt healthier behaviors after undergoing a heart stent procedure (PCI). The program provides information, motivation, and practical skills through in-person sessions, phone calls, and hands-on trai…

This study compares three rehabilitation techniques—mirror therapy, proprioceptive neuromuscular facilitation (PNF), and constraint-induced movement therapy (CIMT)—for helping stroke survivors regain arm and hand function. Ninety adults with arm weakness after stroke receive one …

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This clinical trial is testing a new medication called HGP2102 for people with essential hypertension, or high blood pressure. The study compares HGP2102 to a control drug to see how well it lowers blood pressure over a full 24-hour period. Participants are adults with high blood…

This study tests whether a non-invasive light-based monitor, called near-infrared spectroscopy (NIRS), can detect kidney injury early in newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. The monitor measures oxygen levels in the kidneys and b…

This study tests whether a software tool called AutocathFFR can accurately measure the severity of coronary artery blockages from standard 2D angiogram images, compared to the gold-standard invasive FFR measurement. The software uses machine learning to analyze images taken durin…

This study tests whether a tablet version of the Oxford Cognitive Screen (OCS) can accurately identify cognitive issues like spatial neglect and attention problems in people who have had a stroke. Researchers will compare results from the tablet test with the traditional paper ve…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study investigates whether advanced heart imaging and blood tests can detect early signs of heart damage in adults who received anthracycline chemotherapy as children. Anthracyclines are effective cancer treatments but can increase the risk of cardiomyopathy years later. Cur…

This study tests whether a bedside ultrasound measurement called 'bubble time' can help diagnose pulmonary embolism (a blood clot in the lungs). Researchers will measure bubble time in 250 emergency department patients with suspected embolism and compare it to standard CT scans. …

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This trial evaluates the safety and feasibility of a portable, low-field MRI device called Axana for imaging the brain in people with suspected stroke. Researchers will compare scans from the Axana device with standard hospital MRI scans in 60 adults, including healthy volunteers…

This study tests whether artificial intelligence can read a standard ECG to predict how much heart muscle is damaged after a heart attack. Researchers will compare AI-ECG results with MRI images, the current gold standard, in 461 patients who had a heart attack and underwent a pr…

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tested whether an electronic stethoscope can help doctors detect narrowing (stenosis) of the arteriovenous fistula in hemodialysis patients. Researchers collected sound recordings from 30 adults on long-term dialysis over 3 months. The goal was to see if the device cou…

This study is testing whether an artificial intelligence system can accurately identify congenital heart disease in children by analyzing heart sounds. It will involve thousands of children, with and without heart conditions, to compare the AI's performance against traditional me…

This trial tests whether an AI software called Vital-PICASO can predict if a hospital patient will have a cardiac arrest within the next 24 hours. The software analyzes routine vital signs like blood pressure, heart rate, and breathing rate from electronic health records. Researc…

This completed Phase 3 study tested whether a radioactive tracer called [18F]Florbetaben, used in PET scans, can accurately diagnose cardiac AL amyloidosis—a condition where abnormal proteins build up in the heart. 244 adults with suspected cardiac amyloidosis received a single P…

This trial tests an AI software called Vital-PICASO that analyzes vital signs like blood pressure, heart rate, and oxygen levels to predict whether a hospital patient will experience hypotension (dangerously low blood pressure) within the next 24 hours. Researchers will review me…

This study tests whether a 7-day adhesive ECG patch (MEMO Patch) can detect more heart rhythm abnormalities than a conventional 24-hour Holter monitor in adults who experience palpitations or dizziness. Participants wear both devices at the same time for the first day, then conti…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This trial tests whether a wearable patch called MEMO Patch V2 can detect heart rhythm disorders (arrhythmias) more effectively than the standard 24-hour Holter monitor. Adults with symptoms like palpitations or dizziness, or those who have had a stroke of unknown cause, will wea…

This early study tests a new radioactive dye, F-18 rhodamine 6G, to see if it can produce clearer PET scans of the heart. The dye is injected and then images are taken to measure blood flow in the heart muscle. The trial includes both healthy volunteers and people with stable cor…

This trial checks whether a wrist-worn blood pressure monitor (Model: RIV-B10) can measure blood pressure as accurately as the traditional arm cuff and mercury device. About 158 adults aged 18 and older with wrist sizes between 13 and 21 cm will have their blood pressure taken wi…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study looks at whether measuring the optic nerve sheath (the lining around the nerve connecting the eye to the brain) combined with blood tests for angiogenic factors can better diagnose severe pre-eclampsia in pregnant women. Pre-eclampsia is a serious condition that can ha…

This study investigates whether an Apple Watch can accurately detect heart rhythm problems (arrhythmias) in children aged 6 to 21 who are already scheduled for standard heart monitoring. Researchers will compare the watch's ECG and heart rate readings to those from conventional c…

This study tests whether the inferior vena cava (the body's main vein) can serve as a reliable reference point for measuring blood pressure in the liver during an endoscopic ultrasound. Normally, doctors use a hepatic vein for this, but in people with advanced liver scarring, tho…

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study aims to improve how doctors diagnose acute heart failure in the emergency department. Currently, diagnosis can be slow and uncertain because symptoms like shortness of breath are vague. Researchers are testing a blood test that measures 21 different proteins to see if …

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This trial tests whether screening for chronic kidney disease (CKD) in trusted community settings, like churches, can identify people with early kidney damage who don't yet have symptoms. Participants are adults aged 18-70 without known kidney disease who attend community health …

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study tests whether taking a daily vitamin D supplement (4000 IU) can lower the chance of preeclampsia returning in pregnant women who have had it before. Researchers will randomly assign 146 women to receive either vitamin D or a placebo from enrollment until 36 weeks of pr…

This trial tests whether a short 5-day course of the blood thinners rivaroxaban (Xarelto) or apixaban (Eliquis) can prevent blood clots that sometimes form after laser treatment for varicose veins. Adults with symptomatic vein reflux undergoing laser ablation of the great sapheno…

This study tests a specially designed set of infection-prevention steps (a 'bundle') for people undergoing coronary artery bypass graft (CABG) surgery. The goal is to see if this bundle reduces surgical wound infections, both superficial and deep. The trial includes 200 participa…

This study will test whether using an intermittent pneumatic compression device on the leg can improve ankle joint awareness (proprioception) and balance in people who have had a stroke. Fifty-six participants aged 50-65 with moderate balance problems will receive the treatment. …

This study tests whether intensive robotic arm training can help people recovering from a stroke improve arm movement and reduce stiffness. Participants will use two types of robotic devices in 12 sessions over four weeks. Researchers will also use a technique called muscle syner…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This early study tests a motor-assisted pedaling device called CUped to help stroke survivors recover leg movement and improve walking. The device forces use of the affected leg and prevents bad habits that slow recovery. Only 12 people will take part to check if it is safe, tole…

This study tests whether pairing a mild electrical stimulation to the ear with arm exercises can improve motor recovery in people who had a stroke at least six months ago. Participants will do task-specific training at home three times a week for two weeks, with the ear stimulati…

This trial tests whether a 12-week Nordic walking program—walking with poles—improves exercise capacity and quality of life in people with heart failure better than standard cardiac rehabilitation. Participants attend twice-weekly sessions, and researchers measure walking distanc…

This trial explores whether exposure to artificial light that mimics natural sunlight can improve brain activity, heart rate regulation, and movement in people who have had a stroke. Thirty chronic stroke survivors will undergo light sessions while their brain waves and heart rhy…

This study will test if a low-intensity leg workout using blood flow restriction cuffs can improve strength and balance in stroke survivors as well as traditional high-intensity exercises. Eighty people who had an ischemic stroke 3 to 12 months ago will take part. The goal is to …

This trial asks whether connective tissue massage, which uses pulling strokes to trigger reflex effects, can reduce migraine pain, attack frequency, and disability better than classical massage. About 30 adults with migraines who only use painkillers will receive one of the two m…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests whether walking to a metronome beat—called rhythmic auditory stimulation—can help people who have had a stroke walk farther and with a more steady, automatic gait. It will also see if older adults without stroke show similar benefits. Participants will complete t…

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This trial investigates whether injecting Botox near a nerve bundle in the face, called the sphenopalatine ganglion, can reduce the number of severe headache days in people with chronic migraine that hasn't improved with other treatments. Participants receive either Botox or a pl…

This pilot study is testing whether a low-cost, portable driving simulator can help retrain driving skills in people who have had a stroke or who live with Parkinson's disease or multiple sclerosis. Participants will be randomly assigned to train on either the portable simulator …

This trial tests whether auricular acupuncture—using tiny needles on specific ear points—can ease constipation in hospitalized stroke patients. Participants receive either real ear acupuncture or a sham version, alongside standard care, for eight daily sessions. Researchers will …

This study in Japan looked at 32 children (ages 2 to under 18) with hereditary angioedema who received Firazyr injections for acute attacks. Researchers tracked side effects and how quickly symptoms resolved over 3 months. The goal was to gather real-world safety and effectivenes…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This trial tests an experimental injection called JMKX003142 in people with heart failure who have fluid buildup (edema), causing swelling and congestion. Participants receive either the drug or a placebo once daily for five days. The goal is to see if the drug safely reduces exc…

This study tests whether an 8-week machine-based resistance training program can improve muscle strength and physical function in older adults (60+) who have both chronic heart failure and sarcopenia (age-related muscle loss). Researchers will measure handgrip strength and sit-to…

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This study tested two types of nerve blocks (SAP and PECS II) to see if they could reduce pain after coronary artery bypass grafting. 243 adults received one of the blocks or standard care. Researchers measured pain scores, opioid use, and recovery times. The goal was to find a b…

This study compares two sizes of IV cannulas (18-gauge vs 20-gauge) in emergency patients to see if the larger one causes more pain or is harder to insert. About 204 adults with low-to-moderate difficulty for IV access will be randomly assigned to one size. Patients will wear gog…

This trial tests whether a structured nurse-led program can improve sleep quality in adults with chronic heart failure. Participants will receive education on healthy sleep habits and cognitive-behavioral techniques, alongside their usual care. The study measures changes in sleep…

This study tested a drug called sebetralstat in 36 children aged 2 to 11 with hereditary angioedema (HAE) types I or II, a condition that causes sudden, painful swelling. The goal was to see if the drug is safe and how well it works to relieve attacks. The trial was open-label, m…

This study tests whether combining kinesiotaping (a specialized tape applied to the skin) with a steroid injection into the shoulder can reduce pain and improve arm function in people who have had a stroke and experience shoulder pain on one side. Participants will receive the co…

This trial tests whether adding a double nerve block (femoral and sciatic) before general anesthesia can reduce pain and morphine use after femoropopliteal bypass surgery in people with peripheral arterial disease. The block, using levobupivacaine and clonidine, may also widen bl…

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This trial tests whether a structured self-management program, based on the Common-Sense Model of Self-Regulation, can help people recover after a procedure to treat atrial fibrillation (an irregular heartbeat). Participants will be randomly assigned to receive either routine nur…

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This trial tests whether injecting botulinum toxin into the fingers can improve blood flow and temperature in people with Raynaud's phenomenon that has not responded to standard treatments. Participants are randomly assigned to receive a placebo, a low dose, or a higher dose of t…

This study tests whether online cognitive-behavioral therapy (CBT) for insomnia, combined with CBT for pain, can reduce headaches and improve sleep in adolescents aged 11-17 who have both migraine and insomnia. Participants receive internet-delivered programs focusing on sleep hy…

This pilot trial tests a technique called cryoanalgesia, which uses extreme cold to temporarily freeze nerves in the chest during heart surgery. The goal is to block pain signals, potentially reducing the need for opioid painkillers and improving recovery. The study enrolls adult…

Many stroke survivors are left with a stiff, hard-to-move arm due to spastic cocontractions—muscles that contract at the wrong time. This small study tests whether injecting botulinum toxin A into the elbow flexor muscles can reduce those cocontractions and improve active arm mov…

This study tests whether health education videos redesigned using semiotics—the science of signs and symbols—can help stroke survivors improve daily activities, sleep, anxiety, and depression. Two hundred stroke patients will be randomly assigned to watch either these optimized v…

This study tests whether a 12-week home-based breathing exercise program (inspiratory muscle training) can improve physical function, fatigue, and quality of life in adults aged 70 and older with advanced heart failure who are receiving palliative care. Participants use a handhel…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This pilot study tests whether a type of non-invasive brain stimulation called accelerated repetitive transcranial magnetic stimulation (rTMS) can safely reduce apathy in people who have had a stroke. Apathy — a lack of motivation or interest — is common after stroke and can hind…

This study compares a smartphone app that tracks migraine attacks, sends pill reminders, and includes a community blog against a traditional paper diary. About 400 adults with migraine will use both methods in a crossover design. The goal is to see if the app reduces headache imp…

This trial tests whether a topical ointment containing two numbing agents (lidocaine and tetracaine) can reduce pain after hemorrhoid surgery. Adults scheduled for elective hemorrhoidectomy will apply the ointment or a placebo every 12 hours for 10 days after surgery. Researchers…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study follows adults receiving maintenance hemodialysis for end-stage kidney disease to develop a model that predicts the risk of dying from cardiovascular disease. Researchers will track routine lab results, including how often blood phosphate levels stay in a target range,…

This study looks back at the medical records of over 100,000 hospitalized patients to identify which health conditions and factors are linked to a higher risk of death in people with venous thromboembolism (VTE) — blood clots in the veins, including deep vein thrombosis and pulmo…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study looked for genetic causes of congenital heart disease (heart problems present at birth) in families from Uganda and Nigeria. Over 1,200 people took part, including affected children and their parents. Researchers used advanced DNA testing to find gene changes linked to…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study tested a computer alert that pops up in doctors' electronic health records to remind them to prescribe recommended heart failure medications. Over 1,100 patients with a specific type of heart failure (reduced ejection fraction) took part across four health systems. The…

This study looked at 150 stroke patients in a rehab hospital to see if changes in their ability to do daily activities, walk, balance, think, and use their hands were linked to whether they went home or to another facility after discharge. Researchers used existing medical record…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study looks at whether children born with heart defects who need surgery might also have delays in speech and thinking. Researchers will check the children's cognitive and language skills before their operation and again one and two years after. The goal is to see if speech …

This completed study looked at how a person's total daily-life exposure—called the 'exposome'—affects health after a stroke. Researchers tracked 150 stroke survivors, measuring biological, environmental, social, and lifestyle factors alongside motor and cognitive tests. The goal …

This study aims to establish national reference levels for radiation exposure during X-ray guided procedures to correct heart rhythm disorders, such as pacemaker insertions and ablations. Researchers will collect radiation dose data from over 4,000 adult patients undergoing these…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…

This study explores whether using minimally invasive surgery tools during standard hemorrhoid removal can reduce pain and speed up recovery. It involves a small group of adults with grade III hemorrhoids who are scheduled for surgery. The main goal is to see if the technique is t…

This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better u…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to under…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study looks at whether fear of movement (kinesiophobia) affects how well heart failure patients with a Left Ventricular Assist Device (LVAD) can move and function. Researchers will measure fear levels and physical capacity before and one month after patients leave the hospit…

This study is testing a chatbot platform called PROMBot that lets people with hypertension report their blood pressure and other health information via text messages. The goal is to see if the chatbot is easy and enjoyable to use, and whether it can help patients stay engaged in …

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study tests whether a specialized training program called off-script diagnosis and differential diagnosis (D&D) training can improve neurology residents' ability to diagnose and manage acute ischemic stroke. The training focuses on structured analysis of stroke causes, mimic…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study tests whether using the wrist (radial artery) instead of the groin (femoral artery) as a second access point during a minimally invasive heart valve replacement (TAVI) reduces bleeding and other complications. About 542 patients will be randomly assigned to one of the …

This study follows 500 heart bypass patients for 10 years to see if taking two blood thinners (ticagrelor plus aspirin) for one year after surgery reduces the risk of heart attacks, strokes, or death compared to taking just one. Participants will be contacted by phone to report t…

This study looks at whether a new digital stethoscope can help parents of infants with fast heart rates (tachyarrhythmia) record clear heart readings at home. About 100 babies under 1 year old will take part. The goal is to see if parents can capture good-quality ECGs, which migh…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This study compares two methods of placing a breathing tube during general anesthesia without using opioid painkillers. The goal is to see which method—fiberoptic or direct laryngoscopy—causes less change in heart rate and blood pressure. Researchers will study 90 adults aged 18 …

This completed study looked at 32 people with known genetic changes in connective tissue genes to better understand how these changes affect overall health. Participants underwent a range of medical tests and exams over 3-5 days. The goal was to gather information, not to test a …

This study looked at how doctors make decisions about dosing the blood thinner warfarin based on a patient's genetic background. Researchers used virtual reality to simulate patient visits with different racial and socioeconomic backgrounds. 196 internal medicine residents partic…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study looks at how leg muscle size and strength affect circulation in people born with a single-chamber heart, a condition where the heart can't pump blood to the lungs on its own. Researchers will measure muscle mass, oxygen use, and quality of life in 40 adults aged 16-50 …

This study looked at markers of inflammation, blood clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. Researchers collected blood samples to understand how these markers relate to HIV and risks like heart disease or stroke. The goal was to gat…

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study compares two drug combinations (ketamine-lidocaine vs ketamine-fentanyl) used to put patients to sleep before heart bypass surgery. The goal is to see which combination better maintains blood flow to the brain during the procedure. The study includes 40 adults with cor…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study looked at the safety of the blood thinner rivaroxaban in 1500 Japanese patients with peripheral arterial disease (PAD) who had surgery to improve blood flow in their legs. Researchers used existing health records to track bleeding events and heart-related deaths. No ne…

This study is developing and testing computer models, called FORECAST-PC, to predict how well people will recover 90 days after a stroke caused by a blockage in the back of the brain. The models use information from when a patient arrives at the hospital and 24 hours later to est…

This study reviews records from 240 people who experienced cardiac arrest outside a hospital and were treated by an emergency medical service in Switzerland. The goal is to identify which factors, such as initial heart rhythm, response time, and whether CPR was started by a bysta…

This study tested how well blood pressure cuffs work on the upper arm, forearm, thigh, and lower leg compared to a standard arterial line. Researchers measured 84 adults during planned surgery. The goal was to see if other sites give accurate readings when the upper arm can't be …

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This study tests whether nurses using an AI tool can plan care as well as doctors for common problems like high blood pressure, diabetes, fever, and shortness of breath. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and their visits wi…

This study tests four different ways to encourage parents to register their children for FAST Heroes, a school-based program that teaches kids and families to recognize stroke symptoms and act fast. The approaches range from a printed letter sent home to an email combined with te…

This study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…

This study checks how well a small, wearable heart monitor (Zio monitor) works when worn for up to 30 days. About 150 adults will wear the device to see how long it stays on, how much usable heart data it records, and if it causes any skin irritation. The goal is to make sure the…

This study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or hardened brain arteries. Researchers will measure changes in blood flow using MRI and check if thinking skills improve. The study…

This study looks at whether combining two types of attention-focus instructions (internal and external) in the same session helps stroke survivors improve arm function more than using them one after the other. It involves 36 adults who had a stroke within the past 6 months. The g…

This study looked at 63 women having laparoscopic hysterectomy to see if two different anesthetics (sevoflurane and desflurane) affect pressure inside the head differently. The researchers measured the optic nerve sheath diameter using ultrasound as a non-invasive way to check br…

This study looked at how certain gene variations affect the health of blood vessels in 178 healthy adults. Participants had an ultrasound and a short-acting medication to measure blood flow. The goal was to learn more about genetic risks for heart disease, not to provide treatmen…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study compares three ways of delivering genetic counseling to adults with inherited heart conditions. Some participants get counseling before testing, others get it after, with or without a required phone call. The goal is to see which approach is most efficient and empoweri…

This study looks at how the Impella CP, a small mechanical heart pump, changes blood flow and heart function in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. Researchers will measure pressures inside the heart and use ultrasou…

This study looks at how people with coronary artery disease (CAD) respond to arm versus leg exercise. Researchers will measure blood vessel stiffness, muscle oxygen levels, and energy use during both types of exercise. The goal is to better understand exercise limitations in CAD …

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study looks back at medical records of people with two rare genetic conditions—ENPP1 deficiency and the early-onset form of ABCC6 deficiency—to map how these diseases progress over time. By collecting information on symptoms, imaging, and growth, researchers hope to better u…

This study looked at data from over 1,600 African Americans aged 30-55 with severe high blood pressure. Researchers examined genetic, behavioral, and social factors to find out why this group is more affected by hypertension. No new participants were enrolled; the goal was to lea…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…

This study looks at whether substances produced by gut bacteria, called TMAO, can help predict high blood pressure during pregnancy. Researchers will track 200 pregnant women by collecting blood and urine samples throughout their pregnancies. The goal is to find early warning sig…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study looks back at medical records of people with severe spontaneous brain bleeding (intracerebral hemorrhage) to see if vital signs measured before arriving at the hospital—like blood pressure and heart rate—are linked to recovery and survival six months later. The goal is…

This study looks at whether getting a yearly LDL cholesterol test could help cancer survivors avoid serious heart problems like heart attacks and strokes. Researchers will analyze health records from over a million cancer survivors in Korea, comparing those who had the test with …

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This trial tests two methods for taking children off mechanical ventilation after heart surgery: pressure support ventilation (PSV) and automatic tube compensation (ATC). The goal is to see which approach reduces the work of breathing and improves lung function. The study include…

This trial compares spinal anesthesia (using bupivacaine) with general anesthesia in men undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia. Researchers measure blood clotting and breakdown markers before surgery and at 1 and 24 hours after…

This study looks at whether people who have paralysis on one side after a stroke also have hidden nerve problems in their arms or legs. Researchers will use nerve tests and movement assessments to see how common these nerve issues are and whether they relate to how well a person …

Severe aortic stenosis narrows the heart's aortic valve, and current guidelines recommend waiting until symptoms appear before replacing it. But MRI scans show that up to half of patients already have heart scarring by then, which doesn't fully reverse after surgery. This study w…

This trial tests whether an Apple Watch paired with a special app can accurately measure how far people with pulmonary arterial hypertension (PAH) can walk in six minutes — both in the clinic and at home. Researchers want to see if daily home-based walk tests can detect changes i…

This study investigates how loss of sensation in the foot and uneven weight distribution between legs affect posture, balance, and walking in people who had a stroke at least six months ago. Researchers will measure foot sensation, joint position sense, and weight-bearing asymmet…

This trial investigates whether two simple, non-invasive tests can detect changes in brain oxygen levels in unconscious patients who have survived a cardiac arrest. The tests involve a controlled infusion of a blood-pressure-raising drug and a passive leg raise to increase blood …

This study tracks thousands of heart-surgery patients to identify factors that may increase the risk of postoperative delirium — a state of sudden confusion. Researchers are examining whether medications like statins and beta blockers, the use of a heart-lung machine, or the leng…

This trial investigates whether a common genetic variation in the CES1 gene affects how the body processes two antiplatelet drugs, clopidogrel and ticagrelor. Healthy volunteers of Amish descent will take each drug for eight days in a crossover design, and researchers will measur…

This study investigates whether people with acute decompensated heart failure are taking their prescribed medications as directed. Researchers will test urine samples from 100 patients at the emergency department to directly measure drug levels, and use questionnaires to explore …

This study looks at how mental stress affects the heart in men and women who have had a heart attack within the past 8 months. Participants undergo a stress challenge and are followed for up to 3 years to see if stress-induced changes in the heart are linked to future heart probl…

This study uses video-based movement tracking to measure how people walk after a stroke — both in the clinic and at home. Researchers want to see if walking improvements made in therapy actually carry over into everyday life. The study includes stroke survivors and healthy adults…

This study surveys 3,000 people with coronary heart disease who are about to start cardiac rehabilitation for the first time. Participants choose from 15 common questions about rehab—covering its purpose, methods, benefits, risks, and cost—or write their own. The goal is to under…

This study looks at people who have had a stroke to understand which factors — such as muscle stiffness, arm function, thinking skills, and overall physical ability — most affect their ability to take part in daily activities. Researchers will measure these factors and see how th…

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gin…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study investigates whether changes in a brain network called the default mode network (DMN) are linked to the nocebo effect — experiencing side effects from negative expectations rather than from a treatment itself. Researchers will use functional MRI to scan the brains of 4…

This study checks whether implanted heart devices (ICDs and CRT-Ds) can measure breathing rates as accurately as a standard capnography machine. Researchers will compare readings from the device's special Holter mode with those from capnography in people with heart failure. If th…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This pilot study investigates whether certain blood markers (DIC markers and thrombin generation parameters) can predict thrombotic and hemorrhagic complications in adults on ECMO life support. Researchers will observe these markers in patients with and without complications. The…

This study tests a new way of delivering breaths during CPR called chest compression synchronized ventilation (CCSV), which times each breath to occur between chest compressions. Researchers will compare it to standard ventilation in 50 adults who suffer cardiac arrest outside th…

This study explores whether a special type of PET/CT scan, using a radioactive tracer called 18F-FDG, can accurately measure disease activity in people with granulomatosis with polyangiitis (GPA), a rare condition that causes inflammation of blood vessels. Researchers will compar…

This study reviews published research on artificial intelligence models that analyze retinal images to predict how well patients with diabetic macular edema will respond to treatments like anti-VEGF injections or laser therapy. By evaluating the accuracy of these AI tools, the re…

This study looks at how young people with conditions like cerebral palsy, spina bifida, and spinal cord injury move from pediatric to adult medical care. Researchers will review medical records from the past 10 years and interview patients who have already made the switch. The go…

This study investigates whether inflammation and stress compounds in the blood are linked to depression after a stroke. Researchers measure inflammatory markers and stress hormones in blood samples from 25 adults who have had an acute ischemic stroke. Participants also complete d…

This study looks at whether a score based on heart-support medications (the vasoactive-inotropic score, or VIS) can help doctors decide the best time to start ECMO in patients who develop severe heart failure after cardiac surgery. Researchers will review medical records from nea…

This study examines whether closing the left atrial appendage with a device called AMULET changes how well the heart relaxes. It includes 100 adults with atrial fibrillation who are at high risk for stroke but cannot take blood thinners. Researchers measure heart function using u…

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study looks at how well the Melody valve holds up when used to replace the mitral or tricuspid heart valves. Researchers will review medical records from patients who had this valve surgically placed before December 2014. They will measure valve function, any narrowing or le…

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study compares three devices that measure how well blood clots — ClotPro, ROTEM, and TEG — in patients undergoing liver surgery, neurosurgery, or cesarean section. The goal is to see how closely the results from these devices agree with each other. The findings may help doct…

This study looks at how blood flow to the fetal brain is affected in babies with congenital heart disease and whether it relates to their development after birth. Pregnant women with a fetus known or suspected to have a heart defect will have a fetal echocardiogram, then breathe …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study compares four different chest compression techniques for infant CPR using a manikin. Emergency medicine residents will perform two minutes of CPR with each technique—two-finger, three-finger, heel-of-one-hand, and two-thumb—in a random order. Researchers measure compre…

This study compares two ways to access blocked leg arteries during a procedure to restore blood flow: through the arm (brachial artery) or the groin (femoral artery). The goal is to see which approach leads to fewer complications, such as bleeding or artery damage. Participants a…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study looks at whether a substance in the blood called suPAR can help predict serious health events in people with severe aortic stenosis or regurgitation. Researchers will measure suPAR levels and track participants for two years to see if higher levels are linked to death,…

This observational study investigates fear of falling in adults who have had a stroke. Researchers will assess motor, cognitive, and psychological factors to understand what contributes to this fear. The goal is to help clinicians design better, more personalized rehabilitation s…

This study tests whether a single training session can improve police officers' ability to recognize agonal breathing — an abnormal gasping pattern that can be mistaken for normal breathing during cardiac arrest. Over 3,400 officers in New Taipei City will take a 20-minute CPR re…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study examines the best time to start blood thinners in women who have had severe bleeding after childbirth. Researchers are looking at whether starting blood thinners within 24 hours or later affects the risk of blood clots or further bleeding. The goal is to find a balance…

This study explores whether a web-based gamification app can improve nursing students' knowledge and skills in cardiopulmonary resuscitation (CPR). About 86 students will use the app, which includes practice questions, a timer, and a leaderboard to track scores. Researchers will …

This study investigates how sex and stress influence blood flow in the brain, and whether antioxidants can alter that regulation. Healthy adults aged 18 to 40 will take either an antioxidant cocktail or a placebo, then undergo MRI scans to measure brain blood flow under normal an…

This pilot study looks at how common iron deficiency is in people who have recently had a heart attack. Researchers will test iron levels in up to 70 patients and review their medical records. The goal is to gather early data to plan a larger study on whether treating low iron co…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study investigates how a high-salt diet versus a low-salt diet influences blood pressure and the immune system in middle-aged adults. Participants follow each diet for one week while their blood pressure and inflammatory markers are measured. The goal is to understand why so…

This study tests whether a tool called the HEART score can accurately predict the risk of serious heart problems in people who come to the emergency room with chest pain. The HEART score uses medical history, EKG results, age, risk factors, and a blood test to classify patients a…

This study investigates whether people with late-onset Pompe disease have a higher risk of severe blood vessel problems in the brain and aorta. Researchers will collect medical and genetic data from adults with Pompe disease and from those who have had a brain aneurysm or bleedin…

This study watches and records pain levels at four key moments during radiofrequency ablation for varicose veins—from needle insertion to the end of the procedure. Researchers will look at how factors like age, gender, and body mass index relate to pain. The goal is to find patte…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study follows about 800 people undergoing angiographic procedures with redesigned Beacon Tip catheters. The goal is to see if the catheters can be safely navigated to the intended location and used for tasks like releasing contrast dye or taking anatomical measurements. Rese…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study follows children aged 2 to 18 with confirmed ENPP1 deficiency or early-onset ABCC6 deficiency to understand how these rare diseases progress. Researchers will measure blood markers, check for calcification in arteries and organs, and track bone health and movement over…