Cardiovascular disorder

This study compares atogepant and topiramate, two daily pills used to prevent migraines, to see which one people tolerate better. About 545 adults with frequent migraines (at least 4 per month) will take one of the two drugs for 24 weeks, then all eligible participants will recei…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This study tests whether regular video calls with a nurse can help people with heart failure manage their condition better than audio-only calls. About 140 adults with heart failure will be randomly assigned to receive either video or audio calls at 7, 30, 60, 180, and 365 days a…

This study compares a virtual reality (VR) rehabilitation program that combines movement and cognitive training in realistic everyday environments with conventional occupational therapy for people who have had a stroke. The goal is to see if the VR program leads to greater improv…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This trial investigates how the Fontan surgery, which reroutes blood flow in children born with a single heart ventricle, affects the liver and heart. Researchers use MRI scans and blood tests to measure fibrosis (scarring) and lymphatic congestion. They also test whether spirono…

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This study tested a wearable device called Nerivio that delivers mild electrical pulses to the arm to help prevent migraines. 150 people with chronic migraine used the device for 3 months. Researchers tracked changes in monthly migraine days, attack duration, and patient-reported…

This study tests whether having a pharmacist call both patients with heart disease and their doctors can increase the use of high-intensity statins—powerful cholesterol-lowering drugs that prevent future heart problems. The trial includes adults aged 18 to 75 with atherosclerotic…

This study tests a single dose of ravulizumab given before heart surgery to see if it can prevent kidney damage and serious kidney problems in people with chronic kidney disease. About 736 adults will take part. The goal is to reduce the risk of major kidney events within 90 days…

This study tests a device called the Penumbra System with Thunderbolt Aspiration Tubing to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. The goal is to see if the device can safely and effectively restore blood flow within 8 hou…

This study tests whether a web-based coaching program called CardioFit can help people with coronary artery disease become more physically active. Participants use a secure website to create personalized exercise plans with guidance from an online coach. The trial compares Cardio…

This study tests a device that freezes small areas of heart tissue to treat paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. About 200 people with AFib that hasn't responded to medication will receive the procedure. Researchers will track safe…

This study tested whether starting ECMO (a heart-lung bypass machine) right at the location of a cardiac arrest, rather than waiting until the patient reaches the hospital, could improve survival with good brain function. Researchers enrolled 65 adults with refractory cardiac arr…

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tested a new way to help people with high blood pressure take their medication regularly. Researchers worked with 10 primary care clinics and over 1,700 patients, using a team of doctors, nurses, and medical assistants supported by electronic health records. The goal w…

This pilot study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can improve arm and hand movement in people who had a stroke more than six months ago. The study enrolls 7 adults aged 18-80 with stable uppe…

This trial tests a special stent graft system designed to repair a complex type of abdominal aortic aneurysm that involves the arteries to the kidneys and gut. The device is placed inside the aorta using a minimally invasive procedure, aiming to seal the aneurysm while keeping bl…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study tests whether a smart bracelet system can help hospitals treat stroke patients faster. The bracelets track where patients are in the emergency room and send alerts if treatment is delayed. The goal is to shorten the time between arrival and life-saving clot-busting the…

This phase 2 trial tested a new gel called OTR4132 in 60 people who had a stroke and received a clot-removal procedure. The gel is designed to help repair damaged brain tissue. Researchers measured neurological function at 24 hours and disability at 3 months to see if the gel imp…

This study looked at 100 people with hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers compared different surgical techniques—removing part of the thickened heart muscle alone or combined with repairing the mitral valve—to…

This early-phase study tested a new drug called Kylo-11 in 71 healthy adults with high levels of Lp(a), a genetic risk factor for heart disease. The main goal was to check safety and how the drug moves through the body. Researchers gave single doses at different levels to see if …

This study tested whether using ultrasound inside the heart arteries (IVUS) to guide stent placement works better than standard X-ray guidance for people with a blockage in the left main coronary artery. About 800 patients were randomly assigned to one of the two methods and foll…

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This trial tests whether a personalized physical activity plan can help children aged 5–18 with congenital heart disease increase their exercise capacity and daily activity levels. The plan is designed with input from parents, teachers, and a pediatric cardiologist to address saf…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This trial compared two blood thinners—apixaban (a pill) and enoxaparin (a shot)—in 126 bladder cancer patients after bladder removal surgery. The goal was to see which one patients were more likely to take as prescribed, which they preferred, and what it cost them. Participants …

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This study tests whether a 10-week program of balance and multicomponent exercises can improve muscle strength, flexibility, balance, and endurance in adults over 50 who have high blood pressure. Participants will do exercises like sit-to-stand, bicep curls, and walking tests. Th…

This study tests an experimental drug called RO7446603, given alone or with existing medications (aflibercept or faricimab), for people with diabetic macular edema—a condition that causes vision loss due to diabetes. The trial has two parts: an early safety phase (Phase I) and a …

This study tested a bedside device called the Reprieve Decongestion Management System in 100 hospitalized patients with acute decompensated heart failure. The device automatically adjusts the dose of a diuretic (furosemide) and saline based on the patient's real-time urine output…

This study tested a program where HIV nurses were trained to also manage high blood pressure in people living with HIV. The goal was to see if this approach could lower blood pressure over 12 months. The study involved 830 adults at 30 primary health centers in Lagos, Nigeria.

This study tests whether combining two types of electrical stimulation can improve hand and arm movement in people who recently had a stroke. One stimulation is applied to the brain (tDCS) and the other to a nerve in the wrist. Participants receive five daily sessions, and their …

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This study investigates whether a home-based cardiac rehabilitation program, tailored to each patient's readiness to change, can improve self-care, quality of life, and confidence in people with heart failure. The program involves home visits and phone counseling over 12 weeks. R…

This study tested whether the drug sotagliflozin can improve heart function in people with a type of heart failure called HFpEF who do not have diabetes. Eighty-eight participants took either the drug or a placebo for six months. Researchers used heart scans and exercise tests to…

This study compared two blood thinners, rivaroxaban (Xarelto) and apixaban (Eliquis), in 2760 adults with new blood clots in the legs or lungs. The goal was to see which drug causes fewer bleeding problems. Results could help doctors choose the safer option for treating venous th…

This completed trial tested whether giving epinephrine and verapamil directly into the heart arteries could help restore blood flow in heart attack patients whose vessels remain blocked despite standard treatment. 104 adults with ST-elevation heart attacks were enrolled. The stud…

This study looked at 9 people with atrial fibrillation (AFib) that came back after an initial cryoballoon ablation. It compared two repeat ablation methods: another cryoballoon procedure versus radiofrequency ablation guided by a high-fidelity mapping system (Rhythmia). Participa…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study tested whether a combination of small amounts of tube feeding plus extra nutrition through an IV could reduce pneumonia in people with severe stroke. The trial enrolled 546 adults who had trouble swallowing. Researchers compared this approach to standard full tube feed…

This study tested whether sending personalized text messages about lifestyle changes could improve heart health in 700 people who had a stent placed for coronary artery disease. Half received 4 texts per week for 24 weeks, while the other half got standard care. Researchers measu…

This study tested whether atorvastatin, a cholesterol-lowering drug, can protect the heart in breast cancer patients receiving doxorubicin-based chemotherapy. 44 women with newly diagnosed breast cancer took atorvastatin daily for 3 months alongside their chemo. Researchers measu…

This early-phase trial tested a combination of three drugs—daratumumab, ixazomib, and dexamethasone—in 21 people with AL amyloidosis, a rare disease where abnormal protein builds up in organs. The main goal was to find the safest dose and check for side effects. Researchers also …

This study tests whether motivational interviewing—a supportive, goal-oriented counseling approach—can help people who have had a heart stent adopt and maintain healthier habits. Participants receive one-on-one coaching sessions and reminder texts over three months, while researc…

This trial investigates whether replacing red or processed meat with pulses (like beans, lentils, and chickpeas) can improve markers of heart health and change the gut microbiome. Participants are adults aged 18-65 with unhealthy, sedentary lifestyles who eat at least three servi…

This study tests a structured transitional care program for people with heart failure. The program includes discharge education, phone follow-ups, and home care support for three months after leaving the hospital. Researchers want to see if it helps reduce depression, improve con…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This trial investigates whether adding strength training for the tibialis anterior muscle (which lifts the foot) to proprioceptive (balance) exercises improves recovery in people who had a stroke at least six months ago. Participants will be assigned to six weeks of either balanc…

This study tests whether fremanezumab, a monthly injection, can prevent episodic migraine in children aged 6 to 17. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in monthly migraine days. The goal is to see if fremanezumab is safe a…

This trial tests a special pacemaker called the BackBeat Moderato that can adjust its pacing to help control high blood pressure. Researchers will turn the device on and off for short periods in 28 people who already have the pacemaker implanted, measuring how their blood pressur…

This study tested a new drug called R2R01 in 33 people with worsening heart failure. Participants received either R2R01 or a placebo alongside their usual treatments. The goal was to see if the drug is safe and helps reduce fluid buildup in the heart.

This study tests a new medicine called NNC0537-1482, designed to potentially treat heart failure. It is the first time this drug is given to humans, so healthy volunteers receive a single injection under the skin to check for safety and how the body processes it. Participants are…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Twenty adults with end-stage heart failure on the transplant waiting list will receive these hearts and take antiviral medication to prevent infection. The goal …

This study tests a newly designed device to hold arterial pressure monitoring lines in place after coronary artery bypass surgery. The goal is to see if it keeps readings more accurate and stable than standard tape, especially when patients move. Sixty adults undergoing bypass su…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This early-stage trial tested a single injection of a new drug called SRSD107 in 48 healthy adults. The drug is designed to temporarily lower a clotting factor in the liver, potentially preventing dangerous blood clots with less bleeding risk than standard treatments. The main go…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This study compares two different doses of Wii Fit-based virtual reality balance training added to standard physical therapy for people who had a stroke at least six months ago. Participants are randomly assigned to receive either conventional rehab alone, or conventional rehab p…

This study followed 48 people who received the Nellix system, a device that seals abdominal aortic aneurysms from the inside using stents and polymer-filled bags. Researchers tracked how well the device worked right after the procedure and for up to 5 years. The goal was to see i…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This phase 2 trial tests whether baricitinib, an anti-inflammatory drug, can improve neurological outcomes in people who have had a spontaneous intracerebral hemorrhage (a type of stroke caused by bleeding in the brain). About 110 adults in China will receive either baricitinib p…

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meani…

This study looks at whether adding lower-body electrical muscle stimulation (EMS) to resistance training helps postmenopausal women more than exercise alone. After menopause, women face higher risks of muscle loss and stiff arteries. The trial will compare three groups: EMS plus …

This pilot study tested whether a shorter course of blood thinner (LMWH) followed by aspirin is as good as the standard 6 weeks of LMWH for preventing blood clots after childbirth. The study enrolled 30 women at moderate to high risk of clots. The main goal was to see if women wo…

This study tested whether Mongolian medicine ZhenBao Pills help people recover arm function after an ischemic stroke. 216 adults who had a stroke within the past 30 days took either the pills or a placebo twice daily for 90 days. The main goal was to see if arm movement improved …

This study tested whether giving a low dose of the clot-busting drug tPA directly into the heart arteries, during standard angioplasty, improves blood flow and reduces complications in people having a major heart attack. 210 patients were enrolled. The goal was to see if this app…

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This study tested two different catheters (lattice-tip vs standard irrigated-tip) for a heart procedure called ablation, which treats a fast heartbeat (atrial flutter). 102 adults received the procedure to see which catheter works better and faster with fewer side effects. The go…

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This study tested whether starting the drug dapagliflozin during a hospital stay for acute heart failure can reduce the risk of death or worsening heart failure. Over 2,400 adults who were stable after initial treatment were randomly given either dapagliflozin or a placebo. The g…

This large, completed phase 3 trial enrolled over 5,400 people undergoing total hip or knee replacement to compare two approaches for preventing venous thromboembolism (blood clots). Participants received either aspirin alone or a short course of rivaroxaban followed by aspirin. …

This study tested a device called the PQ Bypass System in 78 people with severe peripheral artery disease (blocked leg arteries). The device is designed to create a bypass inside the artery using small tubes (stent grafts) placed through a needle puncture, avoiding the need for t…

This study tested whether briefly stopping blood flow to the aorta before surgery (called ischemic pre-conditioning) could reduce complications in people undergoing open repair of a thoracoabdominal aortic aneurysm. 65 patients were randomly assigned to receive either the pre-con…

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effec…

This study tested whether dapagliflozin (Farxiga), a drug used for diabetes and heart failure, can prevent heart damage caused by anthracycline chemotherapy. 94 adults with cancer took either dapagliflozin or a placebo daily for four months alongside their chemo. Researchers meas…

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This study tested a new way to give the heart failure drug furosemide: as a shot under the skin instead of through an IV. Twenty adults with chronic heart failure received both versions to compare how much drug gets into the body. The goal is to see if the shot works well enough …

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug is designed to relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for saf…

This study tested whether community health workers (CHWs) could help adults with high blood pressure who also struggle with food insecurity. 75 participants were assigned to either CHW education alone or CHW education plus extra support like grocery transportation and cooking cla…

This study tested whether a special balloon procedure, called direct ischemic post-conditioning, can reduce brain injury in people who just had a stroke from a large blocked artery. Sixty patients were randomly assigned to get either standard clot removal alone or clot removal pl…

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday …

This study tested whether giving low-income adults with high blood pressure free fruits and vegetables for 6 months could help lower their blood pressure. 104 participants from West Dallas, Texas received the produce prescription program. Researchers measured blood pressure chang…

This study looked at two common treatments for grade I-III internal hemorrhoids: injection sclerotherapy and rubber band ligation. Researchers followed 984 patients across multiple hospitals to see which treatment worked better and had fewer side effects. The goal is to help doct…

This study tests whether using a blood test to guide antiplatelet medication can reduce the risk of a second stroke. People who have had a non-cardioembolic ischemic stroke and are already taking aspirin will be assigned to either continue standard aspirin or switch to a differen…

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study tests whether a therapeutic education program helps teenagers and young adults with congenital heart disease transition from pediatric to adult medical care. Participants aged 13 to 25 will either receive the education program or standard follow-up. Researchers will me…

This study tested a drug called sotatercept (MK-7962) in 46 Japanese adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took the drug alongside their usual treatments. The main goals were to see if it improve…

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after major leg amputations. 158 adults who had a leg amputation (not due to injury) took part. The goal was to see if this dressing reduces problems like infection, reo…

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether taking anlotinib pills after initial chemotherapy can help keep advanced soft tissue sarcoma from growing. 49 adults with certain types of sarcoma took anlotinib daily. The goal was to see how long the cancer stayed stable and to check safety. Anlotinib …

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This study tested a new care pathway for people hospitalized with acute heart failure. Instead of a standard hospital stay, some patients were discharged early (within 4 days) and received follow-up care at home from both hospital and private practice teams. The goal was to see i…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study looked at how well eptinezumab works and is tolerated for preventing migraines. It included 130 adults with episodic or chronic migraine. Researchers tracked changes in monthly migraine days over 3 to 12 months of treatment.

This study tested a drug called ALXN2060 (acoramidis) in 25 Japanese patients with a rare heart condition called ATTR-CM, which causes heart failure. The drug is taken as a tablet twice daily. Researchers measured how far patients could walk in 6 minutes and tracked heart-related…

This study tested whether adding vasopressin to the standard drug epinephrine helps more people survive a cardiac arrest that happens outside the hospital. Over 2,400 adults were enrolled. The main goal was to see how many patients were alive when they reached the hospital.

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study looked at whether giving extra help to clinics (called practice facilitation) improves how well they follow a program to help patients take their blood pressure medicine. The study included 652 Latino adults with uncontrolled high blood pressure who were not taking the…

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood…

This study tested whether providing home-delivered DASH diet groceries, with help from a dietitian, could lower blood pressure in Black adults living in urban areas with limited access to healthy food. 180 participants with elevated blood pressure but not on medication took part.…

This study looked at whether eating a plant-based diet for 12 weeks could lower blood pressure and change gut bacteria in 102 kidney transplant recipients. Participants either followed a plant-based diet or their usual diet. The goal was to see if this diet could help manage hear…

This early study tested a new eye injection called ASKG712 in 10 people with diabetic macular edema, a condition where fluid builds up in the retina and blurs vision. The drug targets two proteins that cause leakage and abnormal blood vessel growth. The main goal was to check saf…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This study tested a special stent graft (WRAPSODY) against the usual balloon treatment for vein blockages in people on dialysis. The goal was to see if the stent graft could keep the vein open longer and reduce the need for repeat procedures. A total of 357 patients took part acr…

This study tested a procedure called renal denervation, which uses radiofrequency energy to calm overactive nerves in the kidneys, to see if it can safely lower blood pressure in people whose hypertension is not controlled by up to three medications. The study involved 337 partic…

This small study tested whether transcranial magnetic stimulation (TMS) can lower blood pressure and ease PTSD symptoms in women aged 18-44 who have both conditions. Four participants received 30 TMS sessions over 6 weeks. Researchers measured changes in 24-hour blood pressure an…

This study tested whether a daily oral medication called atogepant (brand name Qulipta) can prevent migraines in Japanese adults who have 4 to 14 migraine days per month. Over 500 participants were randomly assigned to receive one of three doses of atogepant or a placebo for 12 w…

This study tested whether implanting a new aortic valve (TAVI) without first using a balloon to open the narrowed valve is safer and as effective as the standard procedure with balloon predilatation. 250 adults with severe aortic stenosis who were at high risk for open-heart surg…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested whether a newer stent (Supera) works better than a standard stent for people with blocked arteries in the leg. About 300 patients received one of the two stents. The goal was to see which stent kept the artery open longer and reduced the need for another procedu…

This study tested whether adding rituximab to standard steroid treatment helps adults with IgA vasculitis (a disease causing inflamed blood vessels) achieve remission without needing steroids long-term. 75 participants with new or relapsing disease were randomly assigned to recei…

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested a soft robotic sock called VACOM in 19 stroke patients who had trouble moving their ankle. The sock gently moves the ankle to prevent stiffness and improve blood flow, aiming to reduce the risk of blood clots and contractures. The trial is complete, but results …

This study tested a device called ShortCut that splits the leaflets of a failing artificial heart valve before placing a new valve inside it. The goal was to prevent the old leaflets from blocking the coronary arteries, which can cause a heart attack. Eight people at risk for thi…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested a new drug called aficamten against the standard medicine metoprolol in 175 adults with a heart condition that makes the heart muscle thick and blocks blood flow. The goal was to see which drug better improves exercise ability and symptoms like shortness of brea…

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This study tested a new device that uses sound waves to break up calcium deposits in leg arteries of people with peripheral artery disease. Thirty-five participants received the treatment to see if it was safe and could open blocked arteries. The goal was to improve blood flow wi…

This study tested whether adding sacubitril-valsartan to standard care helps people with heart failure (with preserved pumping ability) and a leaky mitral valve. 84 participants were randomly assigned to get the drug or standard care alone. Researchers measured heart function and…

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke could prevent early neurological decline. It included 429 adults with moderate to severe narrowing of brain arteries. The goal was to see if …

This study tests whether a supplement made from seaweed, called rhamnan sulfate, can improve blood vessel function in middle-aged and older adults who have at least one risk factor for heart disease (like high blood pressure or obesity). Participants take the supplement or a plac…

This study looked at how a new oral medication (sebetralstat) works in the bodies of 11 teenagers aged 12 to 17 with hereditary angioedema (HAE) types I or II. The goal was to measure drug levels and timing in the blood. All participants were already in a larger HAE trial. The st…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This study tests an artificial intelligence platform called Willem that analyzes electrocardiograms (ECGs) to detect heart attacks. Researchers will compare how fast and accurately the AI spots heart attack patterns versus human doctors. The study involves 500 adults who have had…

This study looks at whether the ratio of two common blood test results (APTT and fibrinogen) can help diagnose pulmonary embolism, a serious condition where a blood clot blocks an artery in the lung. Researchers will compare this ratio in 1,000 patients who are suspected of havin…

This study tested whether wearing a small heart monitor (MEMO Patch PLUS) for 8 to 14 days finds more cases of hidden atrial fibrillation than wearing it for just 1 day. About 1,000 adults aged 75 or older (or with other stroke risk factors) wore the patch. The goal was to see if…

This study compares cardiac MRI to the standard right heart catheterization for monitoring people with pulmonary arterial hypertension (PAH), a condition that strains the heart. Researchers want to see if the non-invasive MRI can reliably detect when a patient's condition is wors…

This study tests a new contrast agent called HRS-9231 for MRI scans of body parts (excluding the brain and spine). The goal is to see if it makes abnormal blood vessels or lesions show up as clearly as a standard contrast agent. About 309 adults who already need a contrast MRI ar…

This study tests whether a new device called VicorderCS can measure blood pressure accurately. The device uses a standard arm cuff and is designed to be faster and more portable than older models. Researchers will compare its readings to those taken with a traditional stethoscope…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tested whether a special smartwatch (Watch HOP) can help detect heart failure by measuring heart rate, movement, skin temperature, and voice patterns. Researchers compared 56 people with and without heart failure during physical tasks and daily life. The goal is to fin…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study tested a new one-hour diagnostic algorithm using a protein called FABP to quickly confirm or rule out a type of heart attack called NSTEMI. It involved 20 male patients who arrived at the hospital within 4 hours of chest pain. The goal was to see if measuring FABP leve…

This study tested whether a special heart scan (SPECT) can predict how well patients with ischemic cardiomyopathy will recover after heart surgery. 120 patients underwent imaging at rest and during stress to measure heart function and blood flow. The goal was to find patterns tha…

This study tested whether a special PET scan using 68Ga-DOTATOC can detect inflammation in the heart muscle of people with myocarditis. 33 adults with suspected acute myocarditis and normal angiograms received the scan. The goal was to see if this method is as good as or better t…

This study tested whether a special heart scan (SPECT) can predict which people with severe chronic heart failure will improve after getting a cardiac resynchronization therapy device. The scan uses a radioactive tracer to measure nerve activity in the heart. Researchers enrolled…

This study tested a new tool called BESTA, designed to quickly diagnose aphasia (language problems) in people who just had a stroke. Researchers compared BESTA to an existing test in 395 participants, including stroke patients and healthy volunteers. The goal was to see if BESTA …

This study tested an AI tool called VeriSee GLC that analyzes color images of the back of the eye to find signs of glaucoma. Researchers looked at 773 adults' existing eye images to see how well the AI could identify people who might have glaucoma, comparing its results to a pane…

This study looked at whether measuring two proteins in the blood (GST-π and PRDX1) can accurately determine if a stroke occurred within the last 4.5 hours. That time window is critical because it determines if patients can receive clot-busting medication. Researchers enrolled 935…

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. Th…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

This completed study tested a structured heart failure screening pathway for adults aged 65 and older during routine general practice visits. The screening involved a questionnaire, a blood test (NT-proBNP), and an echocardiogram. Researchers aimed to see how many patients would …

This study looked at whether an ultrasound of the leg veins can help doctors diagnose a repeat pulmonary embolism (a blood clot in the lung). About 115 adults with symptoms of a new clot were checked. The goal was to see if adding leg ultrasound to the usual tests (like blood wor…

Heart failure is a serious condition with high death and rehospitalization rates. This study tested whether using a blood marker called ST2 to guide treatment could reduce hospital readmissions within one month. Researchers compared standard care with a strategy that adjusts medi…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested a new type of CT scanner (photon-counting detector CT) to see if it gives clearer images of heart arteries and blood flow compared to standard CT and nuclear stress tests. Researchers enrolled 276 adults with suspected coronary artery disease. The goal was to se…

This study tested whether a fingerstick blood test (LumiraDx INR test) gives accurate results for people taking the blood thinner phenprocoumon. Researchers compared fingerstick results to standard lab tests in 102 adults. The goal is to see if this quick test can reliably monito…

This study tested a new approach to diagnose whether a blood clot has returned in the leg. Instead of relying on older methods, doctors used color Doppler ultrasound and a D-Dimer blood test to safely rule out a new clot. Over 400 people with a history of deep vein thrombosis too…

This study uses a non-invasive ultrasound called transcranial Doppler (TCD) to measure blood flow in the brains of pregnant women with preeclampsia. Researchers will compare 50 women with preeclampsia to 50 healthy pregnant women to see if TCD can detect early signs of serious co…

This study tested a new diagnostic tool that uses imaging flow cytometry to examine platelets in blood samples. Researchers compared it to standard lab tests in 31 patients suspected of having platelet disorders or heparin-induced thrombocytopenia. The goal was to see if the new …

This study looks at whether ultrasound can correctly diagnose a repeat deep vein thrombosis (DVT) in the same leg. Researchers will check if the clot changes after 3 months of blood thinner treatment. The goal is to reduce false alarms and unnecessary treatment. The study involve…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study tested a new rapid D-dimer blood test (LumiraDx) in 679 people with symptoms of deep vein thrombosis or pulmonary embolism. The test uses a small blood sample from a finger prick or vein to quickly measure D-dimer levels, which can help rule out dangerous blood clots. …

This study looked at whether a new blood test called the pan-immune-inflammation value (PIN) can help measure disease activity in people with Behçet's syndrome. Researchers compared 80 Behçet's patients to healthy controls. The goal is to find a simple, non-invasive way to monito…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study looks at whether eating two portions of fish per week or taking omega-3 supplements can improve blood vessel health and raise omega-3 levels in young adults aged 18 to 30. Participants with low omega-3 levels and little fish intake will be assigned to one of four group…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This study tested whether giving mannitol, a substance that reduces brain swelling, could prevent delirium in older adults hospitalized for a heart attack. Fifty patients aged 65 and older with high inflammation levels were included. The goal was to see if mannitol could lower th…

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This study tested a care bundle—a set of steps including nurse training, hand washing, and special cleaning solutions—to prevent IV-related problems like swelling and vein inflammation in children. Researchers compared 200 kids in the emergency department who either got the care …

This study tested whether using a device that electrically stimulates arm muscles can prevent blood clots caused by PICC catheters in critically ill patients. 120 adults in intensive care units were randomly assigned to receive either standard care or standard care plus two daily…

This clinical trial tested a new drug called Lu AG09222 to prevent migraines in 874 adults who had already tried 1 to 4 other preventive medications without success. The study compared different doses of the drug against a placebo to find the best dose. The main goal was to see i…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study looks at whether taking omega-3 supplements (fish oil) for 12 weeks can reduce migraine pain and improve quality of life in children aged 10 to 17. Half of the 58 participants will receive omega-3 oil, and the other half will receive a placebo (coconut oil). Researcher…

This study tests whether a technique called flossing (using a stretchy band around the shoulder) can reduce pain, improve movement, and help sleep in people who have had a stroke and have shoulder pain. About 40 adults aged 30-55 who are at least 6 months post-stroke will take pa…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This trial compares a newer, minimally invasive laser procedure to standard surgery for grade II and III hemorrhoids. The laser technique aims to shrink hemorrhoid tissue with less pain and faster recovery. Researchers will measure postoperative pain, patient satisfaction, and ho…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This study tested a robotic hip exoskeleton designed to improve walking in people who had a stroke at least six months ago. Twelve participants walked on a treadmill and over ground with and without the device. The main goal was to see how well the exoskeleton's computer predicte…

This study compares two types of nerve blocks (ESPB and SPSIPB) to manage pain after heart bypass surgery. About 60 adults aged 18-80 having planned bypass surgery will take part. The goal is to see which block reduces the need for painkillers and improves comfort after surgery.

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This study looks at how well the migraine drug ubrogepant works in everyday life for Canadian adults. About 178 participants will take the drug as prescribed and report their ability to function normally after a migraine attack. The goal is to see if ubrogepant helps people get b…

This study tested whether fast arm movement training helps people who had a stroke regain arm function better than standard accuracy training. 44 chronic stroke survivors with mild to moderate arm weakness participated. The training focused on moving quickly, and researchers meas…

This study tested whether adding virtual reality-based mirror therapy or electrical stimulation-assisted cycling to standard rehab helps stroke survivors regain arm function better than rehab alone. Sixty adults who had a stroke within the past six months took part in a four-week…

This study tested a sensorimotor program for infants with hypoxic-ischemic encephalopathy (HIE), a brain injury from lack of oxygen at birth. Eleven babies received play-based therapy sessions in the NICU and at home for the first 6 months. The goal was to see if the program was …

This study tested whether adding a steroid called dexamethasone to a standard occipital nerve block (using numbing medicines) provides extra headache relief. 120 adults with various headache types received injections at the back of the head. Researchers tracked changes in headach…

This pilot study tests a home-based rehabilitation program called TASSRET for stroke survivors who have limited access to physiotherapy. Fifty participants will use either a video or a manual guide to practice specific tasks aimed at improving arm and leg function, balance, and q…

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study tested whether a slow, rhythmic breathing technique called resonant breathing can help lower blood pressure, heart rate, and stress in adults with mild hypertension. Fifty adults aged 30-65 with stage I hypertension and no serious health issues practiced this breathing…

This study tested whether adding mental practice of swallowing to standard therapy helps people who have trouble swallowing after a stroke. 43 adults were split into three groups: one watched swallowing videos then imagined the action, one just imagined swallowing, and one had on…

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This study tested a new occupational therapy program called PRO-MAMA for older mothers (70+) who have had a stroke. The program focuses on helping them take part in meaningful activities related to their role as a mother. Fourteen women completed the program, and researchers meas…

This trial tests whether giving a continuous infusion of phenylephrine (a drug that raises blood pressure) can prevent shivering after spinal anesthesia in women having a C-section. About 108 non-laboring women will be randomly assigned to receive either the phenylephrine infusio…

This study tested whether regular phone calls from a nurse after coronary artery bypass surgery could help patients manage symptoms and take better care of themselves at home. 72 patients were split into two groups: one received standard care, and the other got scheduled phone co…

This study tested a new occupational therapy called HABIT, designed to help stroke survivors use their affected hand more in everyday activities. Eleven adults with mild hand weakness after stroke participated. Researchers measured hand use and satisfaction with daily tasks befor…

This study tested whether adding augmented cues—like visual and auditory feedback from a sensor-based glove—to standard physical therapy could improve hand function in people recovering from a stroke. Fifty patients with subacute ischemic stroke were randomly assigned to receive …

This study compared two non-invasive therapies—radiofrequency (TECAR) and ultrasound—for treating shoulder pain in 45 stroke survivors. Participants had shoulder pain for at least 3 months after their stroke. Researchers measured pain, range of motion, and daily function to see w…

This study tested whether listening to music and applying acupressure before needle insertion can reduce pain in dialysis patients. 72 participants were split into four groups: music plus acupressure, acupressure alone, music alone, or standard care. Pain was measured during thre…

This study tested whether a live-video-supervised exercise program could improve fitness in children and teens (ages 8-19) born with a single ventricle, a condition often treated with the Fontan procedure. Participants exercised three times a week for three months, then a mainten…

This study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. T…

This study tested a treatment that shines a laser light inside a vein to help people recover after an ischemic stroke. 22 adults with mild to moderate stroke symptoms received the laser therapy. Researchers measured their disability and stroke symptoms before treatment, and again…

This study tested a web-based tool called MigraineManager for teens with migraines. The tool helps teens, their parents, and doctors track headaches and manage symptoms. The goal was to see if it could reduce how often headaches happen. 40 teens with frequent migraines took part.

This study tested a modified pacemaker in 34 people with heart failure (NYHA class II or III). The device delivers special pacing signals to reduce overactive sympathetic nerve activity, which can strain the heart. Researchers measured changes in arterial elastance, a sign of rel…

This study tested a device called the Hypotension Prediction Index (HPI) to see if it can reduce low blood pressure during planned C-sections. Low blood pressure after spinal anesthesia can harm both mother and baby. The device alerts doctors before blood pressure drops, so they …

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This study tested a single dose of an investigational drug called RT234 in 42 adults with pulmonary arterial hypertension (PAH), a condition that makes it hard to exercise due to high blood pressure in the lungs. The main goals were to see if the drug is safe and if it improves e…

This study tests whether starting cardiopulmonary rehabilitation (exercise and breathing training) early in the hospital helps people with acute decompensated heart failure recover faster. About 40 adults who are stable enough will take part. The goal is to see if early rehab imp…

This study tested whether wearing a pressure splint on the leg during rehab exercises helps stroke patients with one-sided weakness (hemiplegia) improve leg movement, balance, and strength. Thirty participants were split into two groups: one did exercises with the splint, the oth…

This study looked at how two types of arm exercises—open and closed kinetic chain activities—affect muscle tightness and hand skill in people who had a stroke. Thirty stroke survivors with arm weakness did one type of exercise, and their muscle stiffness and dexterity were measur…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested a computer algorithm called CartoFinder to help doctors better identify and treat complex heart rhythm problems (arrhythmias). 70 adults with persistent atrial fibrillation (a type of irregular heartbeat) took part. The goal was to see if the algorithm could imp…

This study looked at whether giving a sour liquid early on can improve swallowing function in people who have trouble swallowing after a stroke. Researchers worked with 95 patients who had an acute ischemic stroke and developed dysphagia. They measured swallowing ability at the s…

This study tested whether task-oriented gait training combined with core stabilization exercises can improve mobility, balance, and walking in people who had a stroke. Fifty-four adults aged 45-75 with left-side weakness took part in an 8-week program. The goal was to see if thes…

This study tested a nurse-led home care guide for stroke patients to help with daily activities. The goal was to see if the guide could reduce the burden on caregivers and improve their quality of life. The study involved 60 caregivers of stroke patients who were cared for at hom…

This study tested whether using a device that electrically stimulates the thigh muscles at home, for 4 weeks after a hospital stay, could help people with heart failure walk farther and feel stronger. Only 8 people took part, so the results are very early. The goal is to find a s…

This completed study tested whether combining a gentle brain stimulation technique (HD-tDCS) with virtual reality therapy could help people who had a stroke more than three months ago recover arm function. Fifty-eight participants received either real or sham stimulation during V…

This study tested whether metformin, a standard diabetes drug, could help older adults with a specific type of heart failure (HFpEF) feel better and move more easily. Over 20 weeks, 86 participants took either metformin or a placebo. Researchers measured exercise capacity, qualit…

This study tested a personalized brain stimulation technique called iTBS to help people with long-term thinking and memory problems after a stroke. Sixty participants received either real or sham stimulation over three weeks. The goal was to see if this approach could safely impr…

This study tested a mobile robot designed to help people who have had a stroke regain their ability to walk. 37 stroke survivors used the robot for 16 sessions along with their usual physical therapy. The goal was to see if the robot improved their balance and walking more than s…

This study tested two different therapies—mirror therapy and action observation therapy—to see which better helps chronic stroke survivors improve arm movement and quality of life. 76 participants received one of the therapies plus standard physiotherapy for six weeks. The goal i…

This study tested whether adding foot pressure feedback to robot-assisted walking training helps improve walking symmetry and balance in people who have had a stroke and have weakness on one side. Sixteen adults with chronic hemiplegia completed a 4-week program using a Lokomat r…

This study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…

This study tested whether a 24-session program of functional electrical stimulation (FES) on the tibial nerve could improve walking in people who had a stroke more than a year ago. Fifteen participants with chronic stroke and leg weakness were enrolled. The main goal was to see i…

This study tested whether a nature-based walking program called GREEN Walk can improve quality of life for people who have had a stroke. Eleven chronic stroke survivors took part in 60-minute sessions walking on grass, slopes, and uneven ground to mimic real-world movement. Resea…

This study tested whether combining somatotherapy (body awareness and movement exercises) with occupational therapy (training in daily tasks like dressing and cooking) could improve cognitive function in 50 adults who had a stroke. Participants received 35-minute sessions five da…

This study tested whether an 8-week cardiac rehabilitation program using a stationary bike could improve cardiorespiratory fitness in 20 adults with atrial fibrillation. Participants exercised for 6 minutes, three times a week. The goal was to see if exercise capacity could incre…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study compared two common treatments for second-degree hemorrhoids: injection sclerotherapy and rubber band ligation. Researchers looked at how well each method stopped bleeding and worked overall. The study involved 128 adults aged 18 to 75 with second-degree hemorrhoids.

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study looked at how satisfied people with migraines were using Sumavel DosePro, a needle-free injector for migraine medication. 246 adults who already used triptan drugs took part. The goal was to see if they liked this new method better than their usual treatment.

This study looked at whether percussion massage therapy (like using a massage gun) can help people who had a stroke more than 6 months ago. 34 adults with leg stiffness and trouble walking took part. The goal was to see if the massage could reduce muscle tightness and improve wal…

This study looked at whether adding TENS (a device that sends mild electrical pulses through the skin) and exercise to usual migraine medication can reduce pain and disability in women with migraine. Thirty-eight women participated, all continuing their prescribed meds. The goal …

This study looked at whether electroacupuncture (a type of acupuncture with mild electric pulses) can lower inflammation and help people recover after a stroke. 17 adults who had their first ischemic stroke took part. Researchers measured changes in symptoms and blood markers to …

This study looked at 50 adults having heart bypass surgery to see if one sedative (dexmedetomidine) causes less confusion after surgery than another (midazolam). The goal was to find a way to reduce postoperative delirium, a common problem after heart surgery. Researchers checked…

This phase 2 trial tests whether daily injections of unacylated ghrelin, a natural hormone, can improve walking ability in people aged 55 and older with peripheral artery disease (PAD). Participants receive either the hormone or a placebo for four months. The study measures chang…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better u…

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looks at how high blood pressure and its medications affect blood flow and blood pressure when patients lie face-down for spinal surgery. Researchers will monitor 70 adults to see if those with hypertension have different changes in heart function compared to healthy p…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study tested whether an internet-based support program helps caregivers of people with heart failure feel more prepared and supported. About 202 caregivers from four healthcare regions took part. The program provided education and a chance to share experiences. Results showe…

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study looks at how well existing risk models predict dangerous blood clots in people with diffuse large B-cell lymphoma (DLBCL), a common type of blood cancer. Researchers will review medical records from over 1,500 patients across multiple hospitals to see which factors are…

This study looks at medical records from France to see how doctors prescribe blood thinners to people with atrial fibrillation (an irregular heartbeat) who also have a high risk of stomach bleeding. The goal is to understand which treatments are used and how often serious bleedin…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study follows adults with migraine who have been prescribed rimegepant (a dissolving tablet) for acute attacks. Researchers want to see how consistently the drug provides meaningful pain relief across multiple attacks and how satisfied people are with it. The study also look…

This study investigates whether certain genetic differences make children with nephroblastoma (kidney cancer) or acute lymphoblastic leukemia (blood cancer) more likely to develop a serious liver condition called hepatic veno-occlusive disease (VOD) during chemotherapy. Researche…

This study tests a multi-component behavioral intervention to find the minimum number of weeks needed to help adults on statin therapy increase their daily walking by 2,000 steps. Participants wear a Fitbit to track steps and receive techniques like goal setting, action planning,…

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This study looks at people with severe but symptom-free narrowing of the carotid artery in the neck. It tests whether opening the artery with surgery or stenting can improve memory and thinking problems caused by poor blood flow to the brain. About 385 participants from a larger …

This completed pilot study tested a 6-week web-based program called Mind Your Heart in 37 adults who were university employees. The program combined DASH diet education with mindful eating training to improve eating habits and health measures like blood pressure and cholesterol. …

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This study looked at how moderate aerobic exercise affects blood pressure in people with hypertension living in cold regions. Researchers measured changes in blood pressure, heart rate variability, and stress-related markers after 16 weeks of exercise. The goal was to understand …

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This pilot study looked at whether it's possible to run a larger trial comparing two types of exercise—moderate steady exercise and high-intensity interval training—on symptoms of atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 25 men and women with …

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study aims to identify short-term triggers of acute ischemic stroke caused by large vessel occlusion, a severe type of stroke. Researchers will ask 302 patients about their exposure to potential triggers—such as infection, mood changes, smoking, alcohol, diarrhea, and extrem…

This completed study from France looked at health records of 2 million adults to see if having pneumonia increases the chance of later heart problems like heart attacks, strokes, or heart failure. Researchers compared people who had pneumonia with similar people who did not. The …

This study looked at 200 men and women who had surgery to repair a small ascending aortic aneurysm (5.0-5.5 cm). Researchers wanted to see if gender affects early and long-term outcomes like death, heart attack, or bleeding. The goal is to understand why women might have worse re…

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study follows 340 people with atrial fibrillation who are having their first ablation procedure. Researchers will track heart rhythm using remote monitoring, along with imaging and blood tests, to find which factors—like patient health, heart structure, or electrical signals…

This study looked at how well surgery works for people with an enlarged aorta (aneurysm) in the chest. Researchers compared outcomes in 50 patients who had surgery versus those who did not, tracking deaths and how fast the aorta grew over time. The goal was to better understand w…

This study tests a guidance algorithm that tracks the position of an ultrasound probe in real time to help non-specialists capture standard heart images. Researchers will compare the probe positions suggested by the algorithm with those chosen by experts. The goal is to make echo…

This study looked at 179 heart failure patients who used remote monitoring after a hospital stay. Researchers tracked how long patients kept using the system and interviewed some who stopped to understand why. The goal is to learn what helps or hinders sticking with remote monito…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This completed study looked at blood samples from 47 patients in France (part of a larger European study) to find biological markers linked to diastolic heart failure in people with metabolic syndrome. The goal was to confirm earlier findings about these markers. Participants had…

This study followed 72 adults with pulmonary hypertension caused by chronic lung diseases, like interstitial lung disease, who were treated with inhaled iloprost in routine care. Researchers tracked changes in their risk levels over time using a standard scoring model. The goal w…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study looked back at 80 French patients with calciphylaxis, a rare and often fatal condition causing painful skin ulcers, mostly in people with severe kidney disease. Researchers aimed to describe patient characteristics, how doctors diagnose and treat the condition, and wha…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study looked at 70 people aged 75 and older with atrial fibrillation who were taking a Xaban blood thinner (dabigatran, rivaroxaban, or apixaban) during an unplanned hospital stay. Researchers wanted to see if certain clinical or lab factors were linked to higher drug levels…

This study observed over 1,600 adults in French emergency rooms to understand how patients are managed in the resuscitation area and whether being admitted directly to that area versus later affects their need for intensive care within 24 hours. Researchers recorded patient detai…

This study looked at how doctors make decisions about dosing the blood thinner warfarin based on a patient's genetic background. Researchers used virtual reality to simulate patient visits with different racial and socioeconomic backgrounds. 196 internal medicine residents partic…

This study followed 380 people who had COVID-19 pneumonia for one year after they left the hospital. Researchers used heart ultrasounds, lab tests, and CT scans to check for heart problems. The goal was to understand how COVID-19 affects the heart over time.

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This completed study followed 81 adults who had stroke-like symptoms to see how damage to the blood-brain barrier relates to white matter changes in the brain. Over 6 years, participants had regular MRI scans and thinking tests. The goal was to better understand why some people d…

This study looked at why some people have trouble balancing while sitting after a stroke. Researchers used a special pressure-sensing pad and motion trackers to measure how 32 stroke survivors shifted their weight and moved their head and trunk. The goal was to better understand …

This study examined how being obese (BMI over 30) affects hospital outcomes after coronary artery bypass grafting (CABG) in 500 patients with chronic ischemic heart disease. Researchers tracked death rates, neurological injury, kidney injury, breathing machine time, and need for …

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study tested two different methods of closing the main leg artery after a minimally invasive heart valve replacement (TAVR). One method used two small stitch-like devices, the other used one stitch device plus a plug. The goal was to see which approach caused fewer bleeding …

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This study looked at two ways to improve CPR during cardiac arrest: changing how often rescuers switch (every 2 vs. 4 minutes) and using a device called CPRmeter that gives real-time feedback on chest compressions. Researchers measured the quality of compressions in 51 patients. …

This study tested whether a newer type of MRI called 4D flow can more accurately measure leakage in the pulmonary valve and heart chamber size in people born with tetralogy of Fallot who had corrective surgery. Researchers compared 4D flow MRI with standard 2D MRI in 21 patients …

This study looked at whether brain scans (fMRI) can predict how well stroke survivors will recover arm and hand function after physical therapy. Fourteen people with chronic stroke completed 12 therapy sessions. Researchers measured brain connectivity before and after therapy to …

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This completed study analyzed microRNAs in carotid artery plaques from 30 patients who had surgery to remove them. Researchers compared plaques from people who had already had a stroke (symptomatic) with those who had not (asymptomatic) to see if certain microRNAs are linked to s…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This study tested whether giving personalized nutrition training to mothers of children with congenital heart disease helps their kids grow better after heart surgery. The training covered feeding from birth to age 3, including breastfeeding and starting solid foods. Researchers …

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This study tests whether special low-energy MRI settings can make it safe to use guidewires during heart catheterization. Guidewires help position catheters but can heat up in standard MRI. Researchers will enroll 22 adults who need a right heart catheterization to see if this ap…

This study follows 200 adults who have elective coronary bypass or heart valve surgery to see how their physical abilities, lung function, and muscle strength change after the operation. Researchers measure walking speed, balance, handgrip strength, and breathing tests before and…

This small, completed study tested whether special pacing signals from a pacemaker could help control blood pressure in people with slow heartbeats. Five adults who needed a pacemaker or similar device took part. Researchers measured blood pressure and heart function during brief…

This study explores whether ultrasound can help evaluate swallowing difficulties in people who have had a stroke. Researchers will measure the size and movement of throat muscles in 52 stroke patients with swallowing problems. The goal is to see if these ultrasound measurements r…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This study looked at 130 adults who survived a cardiac arrest outside the hospital and were treated with cooling therapy. Researchers measured two simple tests—a blood protein level and a motor response score—to see if they could predict brain function 6 months later. The goal is…

This study looked at how certain gene variations affect the health of blood vessels in 178 healthy adults. Participants had an ultrasound and a short-acting medication to measure blood flow. The goal was to learn more about genetic risks for heart disease, not to provide treatmen…

This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the foc…

This study tested a mobile health program called Heart2Heart for teens aged 12-18 with congenital heart disease. The goal was to see if teens liked the program and found it easy to use. Seventeen teens completed surveys, used the app, and gave feedback in interviews.

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at 50 trained to elite female athletes to understand how not getting enough energy (low energy availability) might harm their hearts. Researchers measured heart disease risk factors and checked DNA changes that could be linked to these risks. The goal was to lea…

This completed study looked at 140 stroke patients to understand what affects how long they stay in the hospital for rehabilitation. Researchers measured things like functional independence, balance, mental state, and depression in both patients and caregivers. The goal is to hel…

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study looks at whether special pacing signals from a pacemaker can improve heart function and lower blood pressure in people who need a pacemaker and also have high blood pressure. Researchers will measure heart pressure and volume using a thin catheter inside the heart. The…

This study looks at whether the position of a pacemaker lead in the right ventricle can improve how well the BackBeat Moderato system controls blood pressure. Five people with hypertension who already have a pacemaker will have their heart pressures and volumes measured with the …

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study looked at whether using a very low flow of the anesthesia gas sevoflurane during heart surgery is safe and reduces environmental impact. 92 adults having planned heart surgery were randomly assigned to receive either ultra-low-flow or normal-flow anesthesia. Researcher…

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes d…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This study reviewed records of 630 adults who survived a cardiac arrest and were treated in an ICU in Italy over 14 years. Researchers compared outcomes across three time periods when different official treatment guidelines were in use. The goal was to see if newer guidelines led…

This completed study looked at whether four easy-to-use nutrition scoring tools (GNRI, MNA-SF, PNI, and NAF) can predict serious lung complications after heart surgery in 217 patients aged 60 and older. Researchers tracked problems like pneumonia, blood clots in the lungs, and ne…

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach b…

This study looked at how sleep, body clocks, and daily habits affect nighttime blood pressure in Black adults. Researchers monitored 30 participants in a lab for a week to measure blood pressure changes. The goal is to find better ways to treat high blood pressure by targeting sl…

This study looked at 63 women having laparoscopic hysterectomy to see if two different anesthetics (sevoflurane and desflurane) affect pressure inside the head differently. The researchers measured the optic nerve sheath diameter using ultrasound as a non-invasive way to check br…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This completed study observed over 4,500 adults with atherosclerotic cardiovascular disease who had never had a heart attack or stroke. Researchers compared those taking alirocumab (a cholesterol-lowering drug) to those not on similar therapy, using real-world data to see if the …

This study looked at whether using concept maps—diagrams that show how ideas connect—helps third-year medical students learn and remember information better. 26 students were split into three groups: one with no concept map, one with a map made by the teacher, and one where stude…

This study tested whether a wearable sensor (Baiobit®) can reliably measure walking patterns in stroke survivors. Twenty-two adults who had a stroke walked with the sensor on their lower back, and two evaluators compared the results. The goal is to see if this low-cost device can…

This study tested whether a new 3D ultrasound technique can predict how well patients with pulmonary hypertension will do. Researchers followed 150 patients for six months, collecting heart images and tracking deaths and hospitalizations. The goal was to see if this non-invasive …

This study looked at 250 adults with stable coronary artery disease to see if feeling empowered and having a sense of purpose (called 'ikigai' in Japanese) are connected. Researchers used surveys to measure these feelings and how they relate to each other. The goal is to help nur…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study looked at a new way of managing chronic heart failure using nurse-led consultations. Researchers reviewed the records of 138 patients to understand how these consultations helped with adjusting medications and monitoring health. The goal was to see if this approach can…

This completed study aimed to find biological markers that could predict which migraine patients respond best to a new class of drugs called CGRP monoclonal antibodies. Researchers studied 243 adults with severe migraine, using genetic, brain imaging, and other tests. The goal is…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looked at a protein called FSTL-1 in the blood of 80 adults with Behcet's disease. The goal was to see if higher or lower levels of this protein are linked to how active the disease is. No treatments were tested; the study only measured and compared protein levels with…

This completed study looked at the natural course of two ultra-rare genetic disorders: GACI and ARHR2. Researchers collected medical records and blood samples from 48 affected individuals and their family members. The goal was to better understand how these diseases progress over…

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looked at whether a substance in the blood called D-dimer can help predict how well people recover after a stroke. Researchers measured D-dimer levels in 102 stroke patients who had received treatment to restore blood flow. They then compared these levels with standard…

This study reviewed information from 683 adults with obstructive hypertrophic cardiomyopathy who took mavacamten through a support program in Canada. Researchers looked at patient characteristics and how long they stayed on the medication. The goal was to understand real-world us…

This study looked at whether a quick bedside test (Hemochron Jr) gives the same results as standard lab tests for measuring blood clotting in people having planned heart bypass surgery. Twenty patients were tested before and after being placed on a heart-lung machine. The goal wa…

This study tested a new X-ray-based imaging tool called 3DStent against the standard IVUS method to measure calcium buildup in heart arteries. Thirty adults with coronary lesions were enrolled. The goal was to see if 3DStent can accurately identify and measure calcium deposits, w…

This study looked at whether using best-practice physical therapy and giving stroke survivors an activity monitor can help them walk better. About 306 people who had a stroke and were in rehab took part. The main goal was to see if they could walk farther in 6 minutes after the p…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This completed study looked at 208 people with cerebral aneurysms who were treated with clopidogrel, a blood thinner. Researchers wanted to find out how many patients are overly sensitive to the drug and what happens to them. The goal is to better understand risks and improve car…

This study tested whether the Corsano CardioWatch 287-2, a smartwatch that measures blood pressure using light sensors, can accurately track blood pressure changes in people starting or adjusting their blood pressure medication. Eighty adults with uncontrolled high blood pressure…

This study examined blood samples from 119 adults with sickle cell disease, sickle cell trait, or no condition to understand why some develop dangerous blood clots. Participants gave blood and had health check-ins over two years. The goal was to find biomarkers that could lead to…

This study looked at hormone levels in 26 people within 48 hours of a brain bleed from a burst aneurysm. Researchers checked cortisol and thyroid hormones and did a stimulation test to see if the pituitary gland was working properly. They then tracked complications like rebleedin…

This study tested a new tool called a linear cognitive aid to help emergency medical teams treat children during critical situations like cardiac arrest. The tool gives simple, step-by-step instructions based on the child's age and emergency type. Researchers compared teams using…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study looks back at 20 years of medical records from 25 people who had a freezing treatment (cryotherapy) for retinal hemangioblastoma, a rare eye tumor often linked to von Hippel-Lindau disease. Researchers want to see how well the treatment controlled the tumors and affect…

This completed study looked at 114 adults with a type of brain bleed called subarachnoid hemorrhage from a ruptured aneurysm. Researchers measured the optic nerve sheath on early CT scans to see if the size could predict whether a patient would survive for 6 months. The goal was …

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This study looked at how doing isometric (static) exercises with a cuff that limits blood flow affects blood pressure and heart function. Twenty-one healthy young adults did exercises under three conditions: no cuff, a wide rigid cuff, and a narrow elastic band. The goal was to s…

This study looked at a thin layer of proteins and sugars that lines blood vessels, called the glycocalyx, in 28 people having heart surgery. The goal was to see if changes in this layer relate to fluid leaking out of blood vessels, which can cause swelling. By measuring glycocaly…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This completed early-phase study looked at how sex and stress influence blood flow in the brain. Researchers gave 42 healthy young adults indomethacin (an anti-inflammatory drug) or a placebo to test whether a specific mechanism (COX signaling) explains differences between men an…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study tested whether a brain-computer interface (BCI) device is ready for commercial use to help people with minimal movement communicate. Researchers worked with 8 device users, plus speech therapists and support staff, to evaluate how well the device worked at home. The go…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at whether it's safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD). The test involves purposely triggering a dangerous heart rhythm to make sure the device can stop it. About 965 people took part. T…

This study tested if using the lower leg to push on the chest during CPR works as well as the standard hand method. About 99 paramedic and nursing students performed two minutes of chest compressions on a manikin, either with their hands or their dominant foot. The goal was to se…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study tested whether a brain-computer interface (BCI) system, combined with electrical stimulation and virtual reality, can improve arm movement in chronic stroke survivors. Thirty participants were split into three groups, each receiving different combinations of BCI, elect…

This study tested whether helping people sleep longer (through sleep hygiene and extending sleep time) could lower their blood pressure during sleep. 66 adults who slept less than 7 hours per night took part. Researchers measured blood pressure during sleep and awake periods at t…

This study tested a new strategy for collecting patient-reported outcome measures (PROMs) to make them more relevant and less burdensome. Researchers compared usual PROMs with an enhanced version in 200 English- and Spanish-speaking patients. The goal was to see if the new approa…

This study tested whether specially designed educational videos, sent through a mobile messaging app, could help people with coronary heart disease improve their fitness and heart health knowledge during a 12-week home-based cardiac rehabilitation program. Twenty-one participants…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looks at people with end-stage heart failure who have a mechanical heart pump (LVAD). It checks whether the pump's flow rate, adjusted for body size, is linked to liver and kidney function and the chance of being readmitted to the hospital. The goal is to see if this m…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested whether individually adjusting the timing (atrioventricular delay) of a pacemaker improves heart function in 39 adults with conduction system pacing. Researchers used echocardiography to optimize settings and measured changes in heart strain, pumping ability, an…

This study tested whether doctors could safely and correctly use a new prefilled syringe (SCD411) for eye injections. It included 33 adults with wet age-related macular degeneration, retinal vein occlusion, diabetic macular edema, or diabetic retinopathy. The main goal was to see…

This study tested whether a single, one-hour education session using the BEFAST mnemonic (Balance, Eyes, Face, Arm, Speech, Time) could improve stroke patients' knowledge and emergency response. Researchers enrolled 112 hospitalized stroke patients in Malaysia, measuring their kn…

This study looked at damage to the protective lining of blood vessels during heart bypass surgery. Researchers measured a substance called syndecan-1 in the blood of 147 patients to see when and why this damage happens. The goal was to understand how surgery affects the body and …

This completed study looked at 26,000 adults with chronic heart failure in France who used a web app for remote monitoring. Researchers compared those who were digitally literate with those who were not, tracking hospitalizations and death rates. The goal was to understand whethe…