Researchers study digoxin dosing in infants with rare heart condition

NCT ID NCT06613477

Completed Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the infant's treatment plan. About 20 infants under 6 months old will participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: digoxin (Lanoxin)
What this could lead to: If successful, this could lead to more precise digoxin dosing for infants with single ventricle heart disease, potentially improving heart function and reducing side effects.
What could go wrong: This is an early-phase study with only 20 infants, so results may not apply to all patients. The study does not test whether digoxin improves outcomes, only how it is processed.

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Conditions

The condition(s) this trial relates to.

Infant, Newborn, Diseases Infant, Premature, Diseases perinatal disease univentricular cardiopathy univentricular heart

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFANT CONDITIONS INFANT, NEWBORN, DISEASES INFANT, PREMATURE, DISEASES SINGLE-VENTRICLE

Contacts and locations

Locations

Duke University Medical Center

Durham, North Carolina, 27701, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States

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