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Real-Time body sensors could make CPR more effective after cardiac arrest

NCT ID NCT04924985

Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study tests whether using real-time measurements of oxygen levels in the brain and carbon dioxide in the breath can guide CPR more effectively than standard audiovisual feedback. Adults who have a cardiac arrest in the hospital and need CPR for at least five minutes may join. Participants are randomly assigned to receive either standard CPR feedback or CPR guided by these physiological targets, and researchers compare how many people regain a heartbeat and their brain function afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
physiological-feedback CPR using cerebral oxygenation and end-tidal carbon dioxide targets
What this could lead to
If successful, this approach could improve survival rates and neurological outcomes for people who suffer cardiac arrest in the hospital.
What could go wrong
This is a small pilot study, so results may not be definitive. The technique requires additional equipment and training, and may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

106 people

The number who actually took part.

Started

Feb 2022

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. In-hospital cardiac arrest patient 2. Age ≥18 years 3. Age \<80 years 4. CPR lasting ≥5 minutes Exclusion Criteria: 1. Patients \< 18 years of age or \> 80 years of age 2. Out of hospital cardiac arrest patients 3. ≥3 acute organ failures (defined as acute renal failure requiring dialysis, fulminant liver failure i.e. liver failure with INR≥1.5, respiratory failure requiring mechanical ventilation) 4. Repeat in-hospital cardiac arrest event within 14 days of a prior cardiac arrest 5. Presence of known raised intracranial pressure 6. Presence of known traumatic brain injury or subarachnoid hemorrhage \<14 days old, frontal lobe brain tumors or subdural hemorrhage 7. Hyperbilirubinemia \>1.0 mg/dl (based on the absorption of near-infrared light by bilirubin) 8. Resuscitation using extra-corporeal membrane oxygenation (ECMO)

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Conditions

The condition(s) this trial relates to.

ischemia reperfusion injury ischemic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemia Reperfusion injury

Contacts and locations

Locations

  • NYU Langone Health

    New York, New York, 10016, United States

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