Can a Five-Day injection drain the fluid that weighs down heart failure patients?
NCT ID NCT06949020
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests an experimental injection called JMKX003142 in people with heart failure who have fluid buildup (edema), causing swelling and congestion. Participants receive either the drug or a placebo once daily for five days. The goal is to see if the drug safely reduces excess fluid, as measured by weight loss, and to understand how it works in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- JMKX003142 injection (an experimental drug given once daily for five days)
- What this could lead to
- If successful, this could lead to a new treatment to quickly relieve fluid overload in heart failure patients, improving comfort and reducing hospital stays.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the drug may not prove effective or safe. Possible side effects are not yet fully known.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Second Affiliated Hospital,School of Medicine,Zhejiang University
Hangzhou, Zhejiang, 310009, China