Brain injury study aims to sharpen diagnosis with MRI

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: Suspected TBI Subjects Suspected TBI subjects must meet the following inclusion criteria: 1. History of acute head injury with or suspected non-penetrating acute TBI 2. Age 18 years or older 3. Deemed medically safe for study participation by the subject s attending physician 4. Able to provide consent or have a legally-authorized representative provide consent. Healthy Volunteers Healthy volunteers must meet the following inclusion criteria: 1. Healthy without past or present history of TBI or other brain disease, as evaluated by medical history and physical exam 2. Age 18 or older. 3. Able to provide informed consent EXCLUSION CRITERIA: Suspected TBI Subjects Suspected TBI subjects are not eligible for participation in this research study if any of the following conditions exist: 1. Considered to be psychiatrically unstable by the patient s attending physician 2. Contraindication to MRI scanning including: pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments. 3. Conditions precluding entry into the scanner such as morbid obesity or claustrophobia or conditions requiring sedation. 4. In female subjects, pregnancy. Healthy Volunteers Healthy volunteers are not eligible for participation in this research study if any of the following conditions exist: 1. Presence of cognitive impairment based on medical history and/or Mini Mental State Examination (MMSE) score of \< 27 2. Current or past DSM-IV diagnosis of a psychiatric disorder including substance use disorder as determined by self-report, medical history, and/or clinical exam 3. Major medical problems that can impact brain function (e.g., problems of the CNS including seizures and psychosis; cardiovascular disease including hypertension and arrhythmias; metabolic, autoimmune, endocrine disorders) as determined by self-report, medical history and/or clinical exam; 4. Contraindication to MRI scanning including certain metal implants or devices such as: cardiac pacemaker, insulin infusion pump, implanted drug infusion device, cochlear, otologic, or ear implant, transdermal medication patch (Nitroglycerine) that cannot be removed for the study, body piercing(s), bone/joint pin, screw, nail, plate, wire sutures or surgical staples, shunts, cerebral aneurysms clips, shrapnel or other metal imbedded in a subject s body (such as from war wounds or accidents or previous work in metal fields or machines that may have left any metallic fragments in or near the subject s eyes). 5. Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophobia, etc.). 6. In female subjects, pregnancy or breastfeeding. 7. Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Currently Phase-1 of enrollment for healthy volunteers in the A Beta PET pilot is complete. At this time enrollment of healthy volunteers is on hold until analysis complete. Enrollment of A Beta PET pilot TBI subjects and healthy matches may resume under Phase-2 if analysis of initial data suggests update