Could a simple salt supplement boost fluid removal in heart failure?
NCT ID NCT03446651
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This trial tests whether adding a chloride supplement (lysine chloride) to standard IV diuretics helps people with acute heart failure get rid of excess fluid more effectively. Participants take the supplement or a placebo for 7 days while receiving usual care. The study measures changes in blood volume and a heart failure biomarker to see if chloride supplementation improves fluid balance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lysine chloride
- What this could lead to
- If effective, this could lead to a simple oral supplement that helps heart failure patients clear excess fluid faster and more safely.
- What could go wrong
- This is an early-stage trial with a small number of participants, so results may not be conclusive. The supplement may cause taste issues or other side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Yale University
New Haven, Connecticut, 06510, United States
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