Gentle brain zaps may help stroke survivors regain spatial awareness
NCT ID NCT04458974
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 months ago will receive either real or sham tDCS alongside standard rehabilitation for two weeks. The goal is to see if the brain stimulation reduces neglect symptoms and improves daily functioning.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial direct current stimulation (tDCS) using a multisite device
- What this could lead to
- If successful, this approach could offer a safe, noninvasive way to boost recovery from spatial neglect after stroke, improving independence and quality of life.
- What could go wrong
- This is a small, early-stage trial with only 30 participants, so results may not apply broadly. The treatment effect may be modest or no better than sham stimulation.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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Nov 2019
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 89 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Hemorrhagic or ischemic stroke in the right hemisphere. * Stroke 3 to 12 months since the event (regardless of whether or not they have received prior rehabilitation). * 18 to 99 years-old. * Neuroimaging study. * Absence of previous strokes. * Functional capacity that allows him/her to remain seated and active for one hour (Barthel Index score greater than 5 in the item of transfers between chair and bed; this item can be scored from 0 to 15, being 0 totally dependent and 15 totally independent). * Right-handed manual dominance * Neglect scores on at least two of the three tests administered for the assessment of visuospatial neglect. * Signature of informed consent by the patient or his/her legal guardian. Exclusion Criteria: * Dermatological problems (psoriasis, dermatitis on the scalp or face). * Presence of implants or metal parts in the head excluding fillings. * Pacemakers, medication pumps, stimulators (vagal, cerebral, transcutaneous), ventriculoperitoneal shunts or aneurysm clips. * Presence of previous strokes. * Neurological disease other than stroke described in the inclusion criteria. * Severe cognitive impairment assessed using the Mini-mental state examination (MMSE), excluding patients with scores under 24 (the score of MMSE are between 0 and 30, being 0 severe cognitive impairment and 30 no cognitive impairment). * Significant language difficulties that not allow proper understanding of activities or severely limit expression. * History of alcohol or drug abuse. * Moderate or severe active depression. * Uncontrolled medical problems (pathologies in acute phase without medical or pharmacological treatment with proven efficacy or pathologies with imminent life risk). * Pregnancy or suspected pregnancy that will be checked by pregnancy test at the beginning of the study in patients of childbearing age and with the recommendation of the use of contraceptive methods until the end of the intervention.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Beata María Ana (Brain Damage Unit)
Madrid, Madrid, 28007, Spain
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Other studies related to the condition(s) this trial covers.
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- Brazilian version of a behavior change intervention to support healthy lifestyle adoption after stroke - iVIDAVC: protocol for a pilot randomized study
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