Could a common diabetes drug repair heart damage in atrial fibrillation?
NCT ID NCT05993897
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study investigates whether dapagliflozin, a drug typically used for diabetes, can improve the structure and function of the heart's left atrium in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). Researchers will measure changes in heart size and strain using imaging, regardless of whether participants have diabetes. The trial involves 60 adults aged 18–60 with normal to mildly enlarged left atria and adequate kidney function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dapagliflozin (SGLT2 inhibitor)
- What this could lead to
- If successful, this could show that SGLT2 inhibitors help reverse heart damage in atrial fibrillation, potentially reducing complications like stroke and heart failure.
- What could go wrong
- This is a small, early-phase study with 60 participants, so results may not apply broadly. The drug may not improve heart remodeling or could cause side effects like dehydration or kidney issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ATRIAL FIBRILLATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Aswan university
Aswān, Aswan Governorate, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Do antiplatelet drugs work the same in patients over 80? a study puts it to the test.
- Can closing a hole in the heart prevent future strokes? a long-term study seeks answers.
- Brain filter may prevent stroke during heart procedure
- Weight-Loss drug tirzepatide may help keep heart rhythm steady after ablation
- Simple changes to electrode placement could boost heart shock success
- Heart closure device put to the test: does it preserve heart function?