New freezing device tackles stubborn heart rhythm disorder
NCT ID NCT04061603
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a device called iCLAS™ that uses extreme cold to destroy tiny areas of heart tissue causing persistent atrial fibrillation (AFib). 215 adults with AFib lasting more than 7 days but less than a year received the procedure. Researchers tracked safety issues like heart damage or stroke, and checked if the heart stayed in normal rhythm after a single treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cryoablation device (iCLAS™)
What this could lead to
If successful, this could provide a new treatment option to control persistent atrial fibrillation and reduce symptoms.
What could go wrong
This is a completed study, but results are not yet published. The procedure carries risks like heart damage, bleeding, or stroke. It is not a cure, and some patients may still need medication or repeat procedures.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Banner Health
Phoenix, Arizona, 85006, United States
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Baylor St. Luke's Medical Center
Houston, Texas, 77030, United States
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Emory St. Joseph's Hospital
Atlanta, Georgia, 30342, United States
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Erasmus University Medical Center
Rotterdam, 3015 GD, Netherlands
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Grandview Medical Center
Birmingham, Alabama, 35243, United States
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Johns Hopkins University
Baltimore, Maryland, 21205, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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New Mexico Heart Institute
Albuquerque, New Mexico, 87102, United States
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Northwestern University
Evanston, Illinois, 60208, United States
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Ohio Health Research Institute
Columbus, Ohio, 43214, United States
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Onze Lieve Vrouwziekenhuis
Aalst, Belgium
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Prairie Heart Research Institute
Springfield, Illinois, 62701, United States
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South Denver Cardiology Associates
Denver, Colorado, 80120, United States
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Southlake Regional Medical Centre
Newmarket, Ontario, L3Y 2P9, Canada
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St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, Netherlands
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St. Bernards Medical Center
Jonesboro, Arkansas, 72401, United States
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Staten Island University Hospital - Northwell Health
Staten Island, New York, 10305, United States
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The Valley Hospital
Ridgewood, New Jersey, 07450, United States
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University of California San Diego
San Diego, California, 92093, United States
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ZNA Middelheim
Antwerp, Belgium