Steroid showdown: can a tiny daily dose keep a rare disease at bay?
NCT ID NCT01940094
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 159 people with granulomatosis with polyangiitis (GPA), a rare disease that causes inflammation of blood vessels. Participants were randomly assigned to either stay on a low 5 mg daily dose of prednisone or slowly stop it over six months. The goal was to see which approach better prevented disease flares without causing too many side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
prednisone (a steroid drug)
What this could lead to
If successful, this could help doctors decide whether a low maintenance dose of prednisone is better than stopping it entirely to prevent disease flares in people with granulomatosis with polyangiitis.
What could go wrong
This is a completed phase 3 trial, but the results may not apply to all patients. Prednisone has known side effects like weight gain, high blood sugar, and increased infection risk, and the benefit of a very low dose may be small.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02215, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Mount Sinai Hospital
Toronto, Ontario, M5T 3L9, Canada
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St. Joseph's Healthcare
Hamilton, Ontario, Canada
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15261, United States
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University of Utah
Salt Lake City, Utah, 84112, United States