Could a tiny dose of naltrexone ease vasculitis symptoms?
NCT ID NCT03482479
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a low dose (4.5 mg) of naltrexone, a drug already used for alcoholism, can improve physical health and quality of life in people with vasculitis. Sixty participants took either the drug or a placebo daily for six weeks. The goal was to see if the drug led to better self-reported physical health compared to placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low dose naltrexone (4.5 mg daily)
- What this could lead to
- If it works, this could offer a safe, low-cost option to improve physical health and quality of life for people with vasculitis.
- What could go wrong
- This is a small pilot study with only 60 participants. The main outcome is self-reported, and the placebo effect can be strong. It may not show a clear benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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St. Joseph's Healthcare
Hamilton, Ontario, Canada
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15260, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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