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Can a noble gas protect the heart during bypass surgery?

NCT ID NCT01294163

Completed Disease control Sponsor: Air Liquide Santé International Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether the gas xenon can reduce heart muscle damage during coronary artery bypass surgery compared to two standard anesthetics: sevoflurane and propofol. About 500 adults with coronary artery disease scheduled for elective bypass surgery will be randomly assigned to one of the three anesthesia methods. The main measure is the level of troponin I in the blood 24 hours after surgery, a marker of heart injury.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
xenon gas, sevoflurane gas, or propofol intravenous anesthetic
What this could lead to
If xenon proves as good as or better than standard anesthetics, it could become a preferred option for heart surgery patients, potentially reducing heart damage after the procedure.
What could go wrong
This is a phase 3 trial, but xenon is already used in some countries. The main risk is that xenon may not protect the heart any better than existing options, and it is expensive and requires special equipment.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder drug allergy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY BYPASS GRAFT SURGERY CORONARY ARTERY DISEASE GENERAL ANESTHETIC DRUG ALLERGY

Contacts and locations

Locations

  • Academic Medical Center - University of Amsterdam

    Amsterdam, 1100 DD, Netherlands

  • CHU de Caen

    Caen, 14033, France

  • Centre Hospitalier de Rangueil

    Toulouse, 31059, France

  • Centre Hospitalo-Universitaire Pitié-Salpetrière

    Paris, 75013, France

  • Hôpital Cardiovasculaire et Pneumologique Louis Pradel

    Bron, 69677, France

  • Hôpital G&R Laennec - Centre Hospitalier Universitaire de Nantes

    Nantes, 44093, France

  • Hôpital Pontchaillou

    Rennes, 35033, France

  • Hôpital du Haut-Lévêque

    Pessac, 33600, France

  • Hôpitaux Universitaires de Strasbourg - Nouvel Hôpital Civil

    Strasbourg, 67091, France

  • Klinikum Links der Weser - Senator-Wessling-Str. 1

    Bremen, 28277, Germany

  • Policlinico Umberto I

    Rome, 00161, Italy

  • Thorax Center - Erasmus MC

    Rotterdam, 3000 CA, Netherlands

  • UniversitatsKlinikum Schleswig-Holstein

    Lübeck, 23538, Germany

  • University Hospital Aachen

    Aachen, 52074, Germany

  • University Hospital Frankfurt AM Main

    Frankfurt, 60590, Germany

  • University Hospital ROSTOCK

    Rostock, 18057, Germany

  • Universitätsklinikum Schleswig-Holstein

    Kiel, Schleswig-Holstein, 24105, Germany

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