New heart procedure aims to tame atrial fibrillation without drugs

NCT ID NCT06223789

Completed Disease control Sponsor: Abbott Medical Devices Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study tested a new device called the Volt PFA System, which uses pulsed field ablation to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 392 people with symptomatic AF that didn't respond to medication. The goal was to see if the procedure is safe and effective at stopping abnormal heart rhythms for at least 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pulsed field ablation using the Volt PFA System
What this could lead to: If successful, this could provide a new, safer option for controlling atrial fibrillation without long-term medication.
What could go wrong: This is a completed study, but results are not yet published. Risks include serious complications like heart damage or stroke, and the procedure may not prevent all future arrhythmias.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation paroxysmal atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL ARRHYTHMIA ATRIAL FIBRILLATION PAROXYSMAL ATRIAL FIBRILLATION PERSISTENT ATRIAL FIBRILLATION

Contacts and locations

Locations

A.o. Krankenhaus der Elisabethinen Linz

Linz, 4020, Austria
AZ Sint Jan

Bruges, 8000, Belgium
AdventHealth Orlando

Orlando, Florida, 32803, United States
AdventHealth Tampa

Tampa, Florida, 33613, United States
Affinity Cardiovascular Specialists, LLC

Birmingham, Alabama, 35243, United States
Arkansas Heart Hospital

Little Rock, Arkansas, 72211, United States
Az. Osp. Universitaria Osp. Riuniti Umberto I-Lancisi-Salesi

Ancona, 60126, Italy
California Pacific Medical Center - Van Ness Campus

San Francisco, California, 94109, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Doylestown Hospital

Doylestown, Pennsylvania, 18901, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Hightower Clinical

Oklahoma City, Oklahoma, 73102, United States
Hopital Pitie Salpetriere

Paris, 75651, France
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Inova Fairfax Hospital

Falls Church, Virginia, 22042, United States
Johns Hopkins University Hospital

Baltimore, Maryland, 21287, United States
Kansas City Cardiac Arrhythmia Research Foundation

Overland Park, Kansas, 66211, United States
McGill University Health Centre General Hospital

Montreal, Quebec, H4A3J1, Canada
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Memorial Hermann Hospital

Houston, Texas, 77030, United States
Monash Health

Clayton, 3168, Australia
Motol and Homolka University Hospital

Prague, 15030, Czechia
Northside Hospital

Atlanta, Georgia, 30322, United States
Northwell Health - Lenox Hill Hospital

New York, New York, 10021, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Ohio State University

Columbus, Ohio, 43210, United States
Royal Adelaide Hospital

Adelaide, 5000, Australia
Royal Melbourne Hospital

Parkville, 3050, Australia
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
South Denver Cardiology Associates PC

Littleton, Colorado, 80120, United States
Southcoast Hospitals Group - Charlton Memorial Hospital

Fall River, Massachusetts, 02720, United States
St. Bartholomew's Hospital

London, EC1A 7BE, United Kingdom
Texas Cardiac Arrhythmia

Austin, Texas, 78705, United States
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
The Prince Charles Hospital

Chermside, 4032, Australia
Trident Medical Center

Charleston, South Carolina, 29406, United States
UMC Utrecht

Utrecht, 3584 CX, Netherlands
UZ Brussel

Brussels, 1090, Belgium
Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States

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