Engineered immune cells take aim at a rare Protein-Folding disease
NCT ID NCT07765524
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial is testing an experimental treatment called FKC289 for people with primary AL amyloidosis that has relapsed or not responded to standard care. FKC289 uses a patient's own immune cells, engineered to recognize and attack the abnormal plasma cells that produce the harmful protein deposits. The study aims to assess the safety of this therapy and determine the best dose, as well as to see how effective it is at reducing signs of the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- FKC289, a CAR-T cell therapy that targets BCMA and CD19 on plasma cells
- What this could lead to
- If successful, this could offer a new treatment option for people with AL amyloidosis that has returned or not responded to other therapies, potentially leading to remission.
- What could go wrong
- This is an early-stage trial with a small number of participants, so results may not be conclusive. CAR-T therapy carries risks like severe immune reactions and infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Henan Cancer Hospital
Zhengzhou, Henan, 450000, China
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Jiangsu Province Hospital
Nanjing, Jiangsu, 210029, China
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Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
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Sichuan Provincial People's Hospital
Chengdu, Sichuan, 610000, China
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Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, 510700, China
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The Frist Affiliated Hospital of Guangxi Medical university
Nanning, Guangxi, 530021, China
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The Frist Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510600, China
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The Second Affiliated Hospital Zhejiang University school of Medicine
Hangzhou, Zhejiang, 310009, China
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Tongji Mecial college of HUST
Wuhan, Hubei, 430030, China
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West China Hospital Sichuan Hospital
Chengdu, Sichuan, 610000, China
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Zhongshan Hospital Fudan University
Shanghai, Shanghai Municipality, 200032, China