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Nose job brain check: low blood pressure during rhinoplasty under scrutiny

NCT ID NCT07699133

Knowledge-focused Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study looks at whether intentionally lowering blood pressure during elective nose surgery (rhinoplasty) causes any stress to brain cells or affects thinking abilities. Researchers will measure a protein called GFAP in the blood, which can indicate brain cell stress, and test cognitive function before and after surgery using a standard questionnaire. The study includes 40 healthy adults undergoing rhinoplasty and aims to provide safety data on this common anesthesia technique.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If safe, it may confirm that controlled low blood pressure during rhinoplasty does not harm the brain, supporting its continued use.
What could go wrong
This is a small observational study with only 40 people. It cannot prove cause and effect, and results may not apply to longer or more complex surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients, aged 18 to 50 years, who are scheduled to undergo elective primary rhinoplasty or septorhinoplasty under general anesthesia at the Department of Otorhinolaryngology and Plastic Surgery, Kahramanmaras Sutcu Imam University Hospital. Patients will be selected from those with an American Society of Anesthesiologists (ASA) physical status of I or II, ensuring a healthy cohort without severe systemic diseases.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled for elective rhinoplasty or septorhinoplasty under general anesthesia. * ASA physical status I or II. * Literate and willing to provide written informed consent. Exclusion Criteria: * History of neurological (e.g., cerebrovascular event, epilepsy) or psychiatric diseases. * Total septal reconstruction requiring costal (rib) cartilage grafts. * Expected surgical duration exceeding 3 hours. * Preoperative severe cognitive impairment. * Pregnancy or lactation.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Induced hypotension Nasal septum deviation Rhinoplasty

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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