Can a nerve stimulator turn down the fire of erythromelalgia?
NCT ID NCT04039633
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This trial tests whether spinal cord stimulation can reduce severe, treatment-resistant pain in people with erythromelalgia, a rare condition causing red, hot, and painful extremities. Participants receive either burst stimulation or sham (inactive) stimulation to see if the therapy truly helps. The study measures changes in pain scores and quality of life, aiming to provide evidence for a condition with few effective options.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Spinal cord stimulation (burst mode) compared to sham stimulation
- What this could lead to
- If effective, this could offer a new treatment option for people with erythromelalgia whose pain does not respond to medication, potentially improving their quality of life.
- What could go wrong
- This is a very small early trial (6 participants), so results may not apply broadly. The procedure is invasive and carries risks like infection or lead migration, and the sham comparison helps check if pain relief is real or a placebo effect.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aleris
Strømmen, Norway
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Halden Dermatology Center
Halden, Norway
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St Olavs Hospital
Trondheim, Norway
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Universitetssykehuset nord-norge hf
Tromsø, Norway
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