Erythromelalgia
MONDO:0016028A rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders.
13 clinical trials for this condition and its sub-types.
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Broader categories
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Massive new registry tracks Drug-Coated devices in real patients
Disease control Recruiting nowThis study is collecting information from 5,000 people with peripheral vascular disease who are being treated with Boston Scientific drug-eluting devices in everyday medical practice. The goal is to see how well these devices work and how safe they are in a wide range of patients…
Sponsor: Boston Scientific Corporation • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Gene therapy targets chronic nerve pain in new trial
Disease control Recruiting nowThis study tests a one-time gene therapy called ST-503 for people with chronic pain from small fiber neuropathy that hasn't improved with standard treatments. The therapy aims to block pain signals before they reach the brain. The trial involves 27 adults and compares the gene th…
Phase: PHASE1, PHASE2 • Sponsor: Sangamo Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Could immune therapy ease nerve pain? new trial tests IVIG for small fiber neuropathy
Disease control Recruiting nowThis study tests whether a drug called IVIG (Panzyga) can help people with small fiber neuropathy, a condition causing nerve pain and damage. Researchers will give 20 adults either IVIG or a placebo for 6 months, then check nerve fiber growth in skin biopsies and pain levels. The…
Phase: PHASE2 • Sponsor: Endeavor Health • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Tiny probes to unlock secrets of amputation healing
Knowledge-focused Recruiting nowThis study will use tiny probes called microdialysis to measure chemicals related to blood flow, inflammation, and antibiotics right inside the amputation stump after surgery. Researchers will compare results between diabetic and non-diabetic patients to understand why some stump…
Phase: NA • Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Hidden nerve pain in Sjögren's: study reveals true toll on life and wallet
Knowledge-focused Recruiting nowThis study looks at how small fiber neuropathy (nerve damage causing pain, burning, and numbness) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure their symptoms, daily functioning, and …
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Surgery black box aims to cut errors in hybrid operating rooms
Knowledge-focused Recruiting nowThis study installs a 'black box' recording system in hybrid operating rooms to capture and analyze errors during vascular procedures. Researchers will study how teamwork, leadership, and the environment affect surgical performance and patient safety. The goal is to identify high…
Sponsor: University Ghent • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC