Could immune therapy ease nerve pain? new trial tests IVIG for small fiber neuropathy
NCT ID NCT04153422
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a drug called IVIG (Panzyga) can help people with small fiber neuropathy, a condition causing nerve pain and damage. Researchers will give 20 adults either IVIG or a placebo for 6 months, then check nerve fiber growth in skin biopsies and pain levels. The goal is to see if IVIG can improve nerve health and reduce symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Intravenous immunoglobulin (IVIG) called Panzyga
What this could lead to
If it works, this could point toward a treatment for small fiber neuropathy in people with certain antibodies, potentially reducing pain and improving nerve health.
What could go wrong
This is a small, early-phase trial with only 20 participants, so results may not apply to everyone. IVIG is not yet approved for this condition, and side effects like allergic reactions or kidney issues are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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Endeavor Health
RECRUITINGGlenview, Illinois, 60026, United States
Contact Email: •••••@•••••