Erythromelalgia
MONDO:0016028A rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders.
13 clinical trials for this condition and its sub-types.
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Can a nerve stimulator turn down the fire of erythromelalgia?
Symptom relief OngoingThis trial tests whether spinal cord stimulation can reduce severe, treatment-resistant pain in people with erythromelalgia, a rare condition causing red, hot, and painful extremities. Participants receive either burst stimulation or sham (inactive) stimulation to see if the ther…
Phase: NA • Sponsor: St. Olavs Hospital • Aim: Symptom relief
Last updated Aug 18, 2026 02:00 UTC
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New hope for rare burning pain: drug trial targets genetic cause
Symptom relief ENROLLING_BY_INVITATIONThis early-stage study tests whether BHV-7000 can reduce chronic pain in people with inherited erythromelalgia, a rare condition causing severe burning pain due to a genetic mutation. Only 5 adults with a specific NaV1.7 mutation will participate, comparing the drug to a placebo …
Phase: PHASE1 • Sponsor: Biohaven Therapeutics Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Could spinal cord stimulation help repair nerves in small fiber neuropathy?
Knowledge-focused ENROLLING_BY_INVITATIONThis pilot study looks at whether spinal cord stimulation can improve nerve health in people with small fiber neuropathy, a condition that causes chronic pain. Researchers will measure changes in nerve fiber density from skin biopsies taken before and after 12 months of routine c…
Phase: NA • Sponsor: TriCity Research Center • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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New registry monitors VBX stent graft in Real-World use
Knowledge-focused OngoingThis study is a registry that collects safety and performance data on the GORE® VIABAHN® VBX Stent Graft when used in peripheral vessels. It involves 280 adults who need this device to treat peripheral vascular disease. The goal is to see how well the stent graft works and if the…
Sponsor: W.L.Gore & Associates • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC